tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mercuri A et al. | In vitro and in silico characterisation of Tacrolimus released under biorelevant conditions. | 2016 | Int J Pharm | pmid:27737809 |
| Ochi H et al. | Notalgia paresthetica: treatment with topical tacrolimus. | 2016 | J Eur Acad Dermatol Venereol | pmid:25388817 |
| Jain A et al. | Tacrolimus and curcumin co-loaded liposphere gel: Synergistic combination towards management of psoriasis. | 2016 | J Control Release | pmid:27725194 |
| Stienstra NA et al. | Development of a Simple and Rapid Method to Measure the Free Fraction of Tacrolimus in Plasma Using Ultrafiltration and LC-MS/MS. | 2016 | Ther Drug Monit | pmid:27805928 |
| Quist SR et al. | Effects of Topical Tacrolimus and Polyunsaturated Fatty Acids on In Vivo Release of Eicosanoids in Atopic Dermatitis During Dermal Microdialysis. | 2016 | Acta Derm. Venereol. | pmid:26911315 |
| Prytula A et al. | Tacrolimus Predose Concentration Is Associated With Hypertension in Pediatric Liver Transplant Recipients. | 2016 | J. Pediatr. Gastroenterol. Nutr. | pmid:26910645 |
| Wang X et al. | Trans-11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro. | 2016 | Mol Nutr Food Res | pmid:27061233 |
| Deng S et al. | Mechanism of tacrolimus-induced chronic renal fibrosis following transplantation is regulated by ox-LDL and its receptor, LOX-1. | 2016 | Mol Med Rep | pmid:27633115 |
| Tang J et al. | ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts. | 2016 | Cell. Physiol. Biochem. | pmid:27771715 |
| Størset E et al. | Low-target tacrolimus in de novo standard risk renal transplant recipients: A single-centre experience. | 2016 | Nephrology (Carlton) | pmid:26854648 |
| Ghareeb M and Akhlaghi F | Development and validation of a sensitive and selective LC-MS/MS method for determination of tacrolimus in oral fluids. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27771258 |
| Chen YF et al. | Tacrolimus inhibits vasoconstriction by increasing Ca(2+) sparks in rat aorta. | 2016 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:26838733 |
| Pathak S et al. | Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-co-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method. | 2016 | Chem. Pharm. Bull. | pmid:26833445 |
| Jannot AS et al. | A Lack of Significant Effect of POR*28 Allelic Variant on Tacrolimus Exposure in Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26829596 |
| Sayar E et al. | The Ineffectiveness of Tacrolimus in an Infant With a Mutation in the IL-10 Receptor. | 2016 | J. Clin. Gastroenterol. | pmid:26828243 |
| Coghill AE et al. | Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. | 2016 | Am. J. Transplant. | pmid:26824445 |
| Novosel MK and Bistrup C | Discontinuation of steroids in ABO-incompatible renal transplantation. | 2016 | Transpl. Int. | pmid:26706618 |
| Gathogo E et al. | Impact of Tacrolimus Compared With Cyclosporin on the Incidence of Acute Allograft Rejection in Human Immunodeficiency Virus-Positive Kidney Transplant Recipients. | 2016 | Transplantation | pmid:26413990 |
| Dayal S et al. | Treatment of Childhood Vitiligo Using Tacrolimus Ointment with Narrowband Ultraviolet B Phototherapy. | 2016 | Pediatr Dermatol | pmid:27699846 |
| Bakardzhiev I et al. | Unilateral unique Lupus tumidus: pathogenetic mystery and diagnostic problem. | 2016 | Wien Med Wochenschr | pmid:26762262 |
| Sienkiewicz B et al. | The impact of CYP3A5 on the metabolism of cyclosporine A and tacrolimus in the evaluation of efficiency and safety of immunosuppressive treatment in patients after kidney transplantation. | 2016 | Pharmazie | pmid:29441922 |
| Borges-Costa J et al. | Kaposi's sarcoma presenting as violaceous macules on the chest of a kidney transplanted patient. | 2016 | BMJ Case Rep | pmid:26759393 |
| Cortes X et al. | Successful use of infliximab and tacrolimus combination therapy in a patient with ulcerative colitis refractory to infliximab dose intensification plus azathioprine. | 2016 | Int J Clin Pharmacol Ther | pmid:26754306 |
| Vanhove T et al. | Clinical determinants of calcineurin inhibitor disposition: a mechanistic review. | 2016 | Drug Metab. Rev. | pmid:26912097 |
| Bae JM et al. | Repigmentation of poliosis in a patient with segmental vitiligo. | 2016 | J. Am. Acad. Dermatol. | pmid:27317537 |
| Tamhankar MA et al. | Tacrolimus-induced cerebral blindness in a liver transplant patient. | 2016 | Indian J Ophthalmol | pmid:23619482 |
| Jones-Hughes T et al. | Immunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model. | 2016 | Health Technol Assess | pmid:27578428 |
| Tsipotis E et al. | Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis. | 2016 | Am. J. Nephrol. | pmid:27576318 |
| Kravljaca M et al. | The importance of MDR1 gene polymorphisms for tacrolimus dosage. | 2016 | Eur J Pharm Sci | pmid:26705892 |
| Wang J et al. | Evaluation of mycophenolate mofetil or tacrolimus in children with steroid sensitive but frequently relapsing or steroid-dependent nephrotic syndrome. | 2016 | Nephrology (Carlton) | pmid:26697959 |
| Yang Y et al. | STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. | 2016 | Neuroreport | pmid:26694943 |
| Ganetsky A et al. | Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation. | 2016 | Bone Marrow Transplant. | pmid:26691423 |
| Åžavk E | Neurologic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578080 |
| Georgiou GK et al. | Calcineurin inhibitors and male fertility after renal transplantation - a review. | 2016 | Andrologia | pmid:26341518 |
| Herden U et al. | Early Initiation of Everolimus After Liver Transplantation: A Single-Center Experience. | 2016 | Ann. Transplant. | pmid:26842532 |
| Yamaguchi Y et al. | Plasma cell cheilitis successfully treated with topical calcineurin inhibitors. | 2016 | Eur J Dermatol | pmid:27502182 |
| Early CR et al. | Effect of metronidazole use on tacrolimus concentrations in transplant patients treated for Clostridium difficile. | 2016 | Transpl Infect Dis | pmid:27501504 |
| Okuda K et al. | Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. | 2016 | PLoS ONE | pmid:27501378 |
| Liu S et al. | The POR rs1057868-rs2868177 GC-GT diplotype is associated with high tacrolimus concentrations in early post-renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:27498776 |
| Uemoto S et al. | Advantage of tacrolimus/mycophenolate mofetil regimen for cytotoxic T cell-mediated defence and its inhibition by additive steroid administration in high-risk liver transplant recipients. | 2016 | Clin. Exp. Immunol. | pmid:26560892 |
| Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
| Delli K et al. | Comment on: 'Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature' by Ribero et al. (2015). | 2016 | J Eur Acad Dermatol Venereol | pmid:26616360 |
| Niioka T et al. | Influence of everolimus on the pharmacokinetics of tacrolimus in Japanese renal transplant patients. | 2016 | Int. J. Urol. | pmid:26990259 |
| Shijo T et al. | A mismatch between MRI lesions and SPECT hypoperfusion in tacrolimus-related encephalopathy. | 2016 | J. Neurol. Sci. | pmid:27423609 |
| Chen Y et al. | Clinicopathological features and prognosis of Kimura's disease with renal involvement in Chinese patients. | 2016 | Clin. Nephrol. | pmid:27142199 |
| Hermans C et al. | Atypical discrete papular lichen myxedematosus associated with monoclonal gammopathy: report of four cases and review of the literature. | 2016 | J Eur Acad Dermatol Venereol | pmid:27422288 |
| Zhang Y et al. | Effect of FK506 on apoptosis of facial motor neurons in rats and its possible mechanism. | 2016 | Eur Arch Otorhinolaryngol | pmid:25784181 |
| Ibrahim MA et al. | Study of intercurrent infection pattern in hepatitis C seropositive renal transplant recipients, relationship with T-cell function. | 2016 | Ren Fail | pmid:27418152 |
| Bessa AB et al. | Prospective Randomized Trial Investigating the Influence of Pharmaceutical Care on the Intra-Individual Variability of Tacrolimus Concentrations Early After Kidney Transplant. | 2016 | Ther Drug Monit | pmid:27414973 |
| Mehraj V et al. | The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response. | 2016 | EBioMedicine | pmid:27397514 |
| MacDonald C et al. | Acute kidney injury after heart transplant in young children: risk factors and outcomes. | 2016 | Pediatr. Nephrol. | pmid:26559064 |
| Pastor-Clerigues A et al. | Evaluation of the Ocular Tolerance of Three Tacrolimus Topical Pharmaceutical Preparations by Bovine Corneal Opacity and Permeability Test. | 2016 | Curr. Eye Res. | pmid:26554729 |
| Mittal A et al. | Pilot Study to Evaluate the Efficacy and Safety of Oral Tacrolimus in Adult Patients With Refractory Severe Plaque Psoriasis. | 2016 | J Cutan Med Surg | pmid:26553734 |
| Vanhove T et al. | Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance. | 2016 | Br J Clin Pharmacol | pmid:27501475 |
| Roblin E et al. | Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients. | 2016 | Pediatr Transplant | pmid:26750745 |
| Dunyak BM and Gestwicki JE | Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds. | 2016 | J. Med. Chem. | pmid:27409354 |
| Stiehl SR et al. | Tacrolimus interaction with dexmedetomidine--a case report. | 2016 | Pediatr Transplant | pmid:26493547 |
| Kim JD et al. | Single-Center Experience of ABO-Incompatible Living-Donor Liver Transplantation With a New Simplified Intravenous Immunoglobulin Protocol: A Propensity Score-Matching Analysis. | 2016 | Transplant. Proc. | pmid:27320573 |
| Kato H et al. | Long-Term Influence of CYP3A5 Gene Polymorphism on Pharmacokinetics of Tacrolimus and Patient Outcome After Living Donor Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27320564 |
| Oetting WS et al. | Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. | 2016 | Am. J. Transplant. | pmid:26485092 |
| Sun W et al. | Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes. | 2016 | Pflugers Arch. | pmid:27318696 |
| Federico S et al. | Sublingual administration improves systemic exposure of tacrolimus in kidney transplant recipients: comparison with oral administration. | 2016 | Eur. J. Clin. Invest. | pmid:27240092 |
| Kang SW et al. | Inhibition of senescence and promotion of the proliferation of chondrocytes from articular cartilage by CsA and FK506 involves inhibition of p38MAPK. | 2016 | Mech. Ageing Dev. | pmid:26704447 |
| Yoshimura N et al. | Effectiveness of the Combination of Everolimus and Tacrolimus With High Dosage of Mizoribine for Living Donor-Related Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234736 |
| Yamanaka K et al. | Induction Immunosuppressive Therapy With Everolimus and Low-Dose Tacrolimus Extended-Release Preserves Good Renal Function at 1Â Year After Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234735 |
| Baek CH et al. | Usefulness of Tacrolimus without Basiliximab in Well-Matched Living-Donor Renal Transplant Recipients in Korea. | 2016 | Exp Clin Transplant | pmid:27228054 |
| Hošková L et al. | Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation. | 2016 | Ann. Transplant. | pmid:27226081 |
| Lazelle RA et al. | Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension. | 2016 | J. Am. Soc. Nephrol. | pmid:26432904 |
| Yousef AM et al. | Effects of Genetic Polymorphism in CYP3A4 and CYP3A5 Genes on Tacrolimus Dose Among Kidney Transplant Recipients. | 2016 | Iran J Kidney Dis | pmid:27225724 |
| Hannah J et al. | Tacrolimus use in lupus nephritis: A systematic review and meta-analysis. | 2016 | Autoimmun Rev | pmid:26427983 |
| Schmidt KJ et al. | Long-term Outcomes in Steroid-refractory Ulcerative Colitis Treated with Tacrolimus Alone or in Combination with Purine Analogues. | 2016 | J Crohns Colitis | pmid:26419459 |
| Sommerer C and Giese T | Nuclear Factor of Activated T Cells-Regulated Gene Expression as Predictive Biomarker of Personal Response to Calcineurin Inhibitors. | 2016 | Ther Drug Monit | pmid:26418701 |
| Prytuła AA et al. | The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients. | 2016 | Clin Pharmacokinet | pmid:27138785 |
| Yamamoto T et al. | Letter: which patient profile for tacrolimus in ulcerative colitis? Authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27137731 |
| Laharie D and Poullenot F | Letter: which patient profile for tacrolimus in ulcerative colitis? | 2016 | Aliment. Pharmacol. Ther. | pmid:27137730 |
| Kim MJ et al. | Effect of Immunosuppressive Drugs on the Changes of Serum Galactose-Deficient IgA1 in Patients with IgA Nephropathy. | 2016 | PLoS ONE | pmid:27930655 |
| Wei Q et al. | Efficacy and Safety of a Steroid-Free Immunosuppressive Regimen after Liver Transplantation for Hepatocellular Carcinoma. | 2016 | Gut Liver | pmid:27074818 |
| Wowro SJ et al. | Effects of mTOR and calcineurin inhibitors combined therapy in Epstein-Barr virus positive and negative Burkitt lymphoma cells. | 2016 | Int. Immunopharmacol. | pmid:26613512 |
| Shin J et al. | Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. | 2016 | Skelet Muscle | pmid:26949511 |
| Bianic F et al. | Cost-effectiveness of everolimus plus reduced tacrolimus in de novo liver-recipients in the Italian setting. | 2016 | J Med Econ | pmid:27081739 |
| SelimoÄŸlu MA et al. | Evaluation of renal functions in pediatric liver transplantation. | 2016 | Pediatr Transplant | pmid:26607307 |
| Gambarino S et al. | Human Cytomegalovirus Impact on mir-146a Expression Levels in Kidney Transplant Patients. | 2016 | Viral Immunol. | pmid:27077822 |
| Saeki H et al. | Clinical Practice Guidelines for the Management of Atopic Dermatitis 2016. | 2016 | J. Dermatol. | pmid:27076388 |
| Ueda Y and Uemoto S | Decreased tacrolimus concentration following a temporal increase during interferon-free therapy with asunaprevir and daclatasvir in patients with recurrent hepatitis C after liver transplantation. | 2016 | Transpl. Int. | pmid:26270021 |
| Jung H and Oh ES | FK506 positively regulates the migratory potential of melanocyte-derived cells by enhancing syndecan-2 expression. | 2016 | Pigment Cell Melanoma Res | pmid:27060922 |
| Mettang T | Uremic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578082 |
| Mok CC et al. | Tacrolimus versus mycophenolate mofetil for induction therapy of lupus nephritis: a randomised controlled trial and long-term follow-up. | 2016 | Ann. Rheum. Dis. | pmid:25550339 |
| Brito-Costa A et al. | Factors Associated With Changes in Body Composition Shortly After Orthotopic Liver Transplantation: The Potential Influence of Immunosuppressive Agents. | 2016 | Transplantation | pmid:27136260 |
| Suarez Benjumea A et al. | Hepatitis C Virus in Kidney Transplant Recipients: A Problem on the Path to Eradication. | 2016 | Transplant. Proc. | pmid:27932111 |
| Xie L et al. | Pretransplantation Risk Factors Associated With New-onset Diabetes After Living-donor Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27931572 |
| Hitzeman N and Kinnevey C | Topical Tacrolimus for Eczema. | 2016 | Am Fam Physician | pmid:27929217 |
| Rodriguez Cubillo B et al. | Risk Factors of Recurrence of Diabetic Nephropathy in Renal Transplants. | 2016 | Transplant. Proc. | pmid:27932117 |
| Myers AL et al. | Stability of tacrolimus injection diluted in 0.9% sodium chloride injection and stored in Excel bags. | 2016 | Am J Health Syst Pharm | pmid:27919876 |
| Awdishu L and Joy MS | Role of Pharmacogenomics in Kidney Disease and Injury. | 2016 | Adv Chronic Kidney Dis | pmid:26979149 |
| Song GW et al. | A Pilot Study of the Pharmacokinetics of the Modified-Release Once-Daily Tacrolimus Formulation Administered to Living-Donor Liver Transplant Recipients. | 2016 | Exp Clin Transplant | pmid:26976646 |
| Saadi A and Schmahmann JD | Pearls & Oy-sters: Tacrolimus neurotoxicity presenting as an isolated brainstem lesion. | 2016 | Neurology | pmid:26976521 |
| Fix OK et al. | Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis. | 2016 | Amyloid | pmid:26972447 |
| Thervet É | [Applied pharmacogenetic]. | 2016 | Nephrol. Ther. | pmid:26972091 |
| Stockwell J et al. | Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury. | 2016 | Neuropharmacology | pmid:26626486 |
| Moiseev IS et al. | Graft-versus-Host Disease Prophylaxis in Unrelated Peripheral Blood Stem Cell Transplantation with Post-Transplantation Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil. | 2016 | Biol. Blood Marrow Transplant. | pmid:26970381 |