tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rafecas A et al. | Immunosuppression with calcineurin inhibitors and polyclonal antibodies in liver transplantation. | 2002 | Transplant. Proc. | pmid:11959209 |
| Asensio M et al. | Experience with tacrolimus as primary immunosuppressor in pediatric liver transplant. | 2002 | Transplant. Proc. | pmid:11959208 |
| Machado PG et al. | Use of reduced dose of OKT3 (2.5 mg) after renal transplantation. | 2002 | Transplant. Proc. | pmid:11959207 |
| GarcÃa-Meseguer C et al. | Efficacy and safety of basiliximab in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:11959206 |
| Facundo C et al. | Results of a triple induction regime with tacrolimus, mycophenolate mofetil, and prednisone in renal transplantation. | 2002 | Transplant. Proc. | pmid:11959203 |
| Herrero JC et al. | Role of immunosuppressive treatments based on mycophenolate mofetil in posttransplantation renal surgical complications. | 2002 | Transplant. Proc. | pmid:11959201 |
| Pascual J et al. | One-center comparison between primary immunosuppression based on neoral cyclosporine and tacrolimus for renal transplantation. | 2002 | Transplant. Proc. | pmid:11959200 |
| Pascual J and Ortuño J | Simple tacrolimus-based immunosuppressive regimens following renal transplantation: a large multicenter comparison between double and triple therapy. | 2002 | Transplant. Proc. | pmid:11959198 |
| Urbizu JM et al. | Immunosuppression using tacrolimus/mycophenolate versus neoral/mycophenolate following kidney transplantation: a single-center experience. | 2002 | Transplant. Proc. | pmid:11959197 |
| Latorre A et al. | Clinical management of renal transplant patients with hepatitis C virus infection treated with cyclosporine or tacrolimus. | 2002 | Transplant. Proc. | pmid:11959186 |
| Norris CM et al. | Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture. | 2002 | Neuroscience | pmid:11958864 |
| Macleod MR and Butcher SP | Nitric-oxide-synthase-mediated cyclic guanosine monophosphate production in neonatal rat cerebellar prisms is resistant to calcineurin inhibition. | 2002 | Neurosci. Lett. | pmid:11958839 |
| Son IJ et al. | Pharmacokinetic changes of intravenous tacrolimus in rats with uranyl nitrate-induced acute renal failure. | 2000 Nov-Dec | Res. Commun. Mol. Pathol. Pharmacol. | pmid:11958289 |
| Trompeter R et al. | Randomized trial of tacrolimus versus cyclosporin microemulsion in renal transplantation. | 2002 | Pediatr. Nephrol. | pmid:11956848 |
| Robichaud GA et al. | Nuclear factor of activated T cells is a driving force for preferential productive HIV-1 infection of CD45RO-expressing CD4+ T cells. | 2002 | J. Biol. Chem. | pmid:11956207 |
| Deppe CE et al. | Cyclosporine a and FK506 inhibit transcriptional activity of the human mineralocorticoid receptor: a cell-based model to investigate partial aldosterone resistance in kidney transplantation. | 2002 | Endocrinology | pmid:11956176 |
| Xie H et al. | [Effect of FK506 eye-drop combined with keratoplasty on recurrent Mooren's ulcer]. | 2002 | Zhonghua Yan Ke Za Zhi | pmid:11955293 |
| Schwertfeger E et al. | Contractile effects of tacrolimus in human and rat isolated renal arteries. | 2001 | J Auton Pharmacol | pmid:11952876 |
| Turton-Weeks S et al. | Pretransplant evaluation of a patient with acute intermittent porphyria. | 2001 | Prog Transplant | pmid:11949465 |
| Li ZY et al. | Dimerizer-induced proliferation of genetically modified hepatocytes. | 2002 | Mol. Ther. | pmid:11945069 |
| Chen GF et al. | [Peripheral nerve regeneration under immunosuppression]. | 2002 | Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi | pmid:11944523 |
| Passos E et al. | Ocular toxicity of intravitreal tacrolimus. | 2002 Mar-Apr | Ophthalmic Surg Lasers | pmid:11942546 |
| Reich K et al. | Evidence for a role of Langerhans cell-derived IL-16 in atopic dermatitis. | 2002 | J. Allergy Clin. Immunol. | pmid:11941319 |
| Udina E and Navarro X | [Immunophilins: neuroprotective agents and promoters of neural regeneration]. | 2002 | Neurologia | pmid:11940408 |
| Regentin R et al. | Production of a novel FK520 analog in Streptomyces hygroscopicus: improving titer while minimizing impurities. | 2002 | J. Ind. Microbiol. Biotechnol. | pmid:11938465 |
| Nör JE et al. | Ablation of microvessels in vivo upon dimerization of iCaspase-9. | 2002 | Gene Ther. | pmid:11938459 |
| Goffin E et al. | Tacrolimus and low-dose steroid immunosuppression preserves bone mass after renal transplantation. | 2002 | Transpl. Int. | pmid:11935163 |
| Shapiro AM et al. | Combination therapy with low dose sirolimus and tacrolimus is synergistic in preventing spontaneous and recurrent autoimmune diabetes in non-obese diabetic mice. | 2002 | Diabetologia | pmid:11935154 |
| Schwarz NT et al. | Protective effects of ex vivo graft radiation and tacrolimus on syngeneic transplanted rat small bowel motility. | 2002 | Surgery | pmid:11935132 |
| Armenti VT et al. | National Transplantation Pregnancy Registry looks at outcomes with Neoral and Tacrolimus. | 2000 | Nephrol News Issues | pmid:11933431 |
| Nishino K et al. | Suppression of experimental immune-mediated blepharoconjunctivitis in Brown Norway rats by topical application of FK506. | 2002 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:11931080 |
| Drosos AA | Newer immunosuppressive drugs: their potential role in rheumatoid arthritis therapy. | 2002 | Drugs | pmid:11929337 |
| Jacobsohn DA and Vogelsang GB | Novel pharmacotherapeutic approaches to prevention and treatment of GVHD. | 2002 | Drugs | pmid:11929336 |
| Wellington K and Jarvis B | Topical pimecrolimus: a review of its clinical potential in the management of atopic dermatitis. | 2002 | Drugs | pmid:11929333 |
| Vitulo P et al. | Efficacy of tacrolimus rescue therapy in refractory acute rejection after lung transplantation. | 2002 | J. Heart Lung Transplant. | pmid:11927219 |
| Panickar KS et al. | Differential response of neural cells to trauma-induced free radical production in vitro. | 2002 | Neurochem. Res. | pmid:11926270 |
| Bolley R et al. | Tacrolimus-induced nephrotoxicity unmasked by induction of the CYP3A4 system with St John's wort. | 2002 | Transplantation | pmid:11923712 |
| Lauzurica R et al. | Tacrolimus-associated severe bilateral corneal ulcer after renal transplantation. | 2002 | Transplantation | pmid:11923710 |
| Fuchinoue S et al. | Kidney transplantation after liver transplantation from the same donor: four cases of successful steroid withdrawal. | 2002 | Transplantation | pmid:11923698 |
| Bueno OF et al. | Calcineurin and hypertrophic heart disease: novel insights and remaining questions. | 2002 | Cardiovasc. Res. | pmid:11922891 |
| Shimomura M et al. | Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus. | 2002 | J. Surg. Res. | pmid:11922737 |
| Oettinger-Barak O et al. | Periodontal changes in liver cirrhosis and post-transplantation patients. II: radiographic findings:. | 2002 | J. Periodontol. | pmid:11922262 |
| Tamura S et al. | Tacrolimus is a class II low-solubility high-permeability drug: the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats. | 2002 | J Pharm Sci | pmid:11920757 |
| Ikezumi Y et al. | FK506 ameliorates proteinuria and glomerular lesions induced by anti-Thy 1.1 monoclonal antibody 1-22-3. | 2002 | Kidney Int. | pmid:11918741 |
| Segarra A et al. | Combined therapy of tacrolimus and corticosteroids in cyclosporin-resistant or -dependent idiopathic focal glomerulosclerosis: a preliminary uncontrolled study with prospective follow-up. | 2002 | Nephrol. Dial. Transplant. | pmid:11917061 |
| Sugiura R | [Functional analysis of calcineurin-mediated signalling pathway using fission yeast as a model system]. | 2002 | Nippon Yakurigaku Zasshi | pmid:11915517 |
| Gornet JM et al. | Severe CPT-11-induced diarrhea in presence of FK-506 following liver transplantation for hepatocellular carcinoma. | 2001 Nov-Dec | Anticancer Res. | pmid:11911319 |
| Trull A et al. | Influence of albumin supplementation on tacrolimus and cyclosporine therapy early after liver transplantation. | 2002 | Liver Transpl. | pmid:11910567 |
| Taber DJ et al. | Tacrolimus dosing requirements and concentrations in adult living donor liver transplant recipients. | 2002 | Liver Transpl. | pmid:11910566 |
| Trotter JF et al. | Living donor liver transplant recipients achieve relatively higher immunosuppressant blood levels than cadaveric recipients. | 2002 | Liver Transpl. | pmid:11910565 |
| Macario-Barrel A et al. | [Mouth ulcers in patients receiving tacrolimus]. | 2001 | Ann Dermatol Venereol | pmid:11908135 |
| Lacour JP | [Topical tacrolimus in dermatology: what can one expect?]. | 2001 | Ann Dermatol Venereol | pmid:11908129 |
| Dé Tran QH et al. | Tacrolimus in dermatology. | 2001 Jul-Aug | J Cutan Med Surg | pmid:11907845 |
| Eichenfield LF et al. | Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents. | 2002 | J. Am. Acad. Dermatol. | pmid:11907497 |
| Vincenti F et al. | A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: evidence for improved allograft survival at five years. | 2002 | Transplantation | pmid:11907427 |
| Klein IH et al. | Different effects of tacrolimus and cyclosporine on renal hemodynamics and blood pressure in healthy subjects. | 2002 | Transplantation | pmid:11907418 |
| Yang H et al. | Liposomal encapsulation significantly enchances the immunosuppressive effect of tacrolimus in a discordant islet xenotransplant model. | 2002 | Transplantation | pmid:11907415 |
| Holt S and Moore K | Different effects of tacrolimus and cyclosporine on renal hemodynamics and blood pressure in healthy subjects. | 2002 | Transplantation | pmid:11907407 |
| Sakanoue M et al. | Tacrolimus, a specific inhibitor of calcineurin, modifies the locomotor activity of quinpirole, but not that of SKF82958, in male rats. | 2002 | Eur. J. Pharmacol. | pmid:11906716 |
| Ishikawa K et al. | Mycobacterium tuberculosis infection of bilateral cervical lymph nodes after renal transplantation. | 2001 | Int. J. Urol. | pmid:11903693 |
| Fuhrer DK et al. | Insulin release and suppression by tacrolimus, rapamycin and cyclosporin A are through regulation of the ATP-sensitive potassium channel. | 2001 | Diabetes Obes Metab | pmid:11903410 |
| Bos JD | Topical tacrolimus and pimecrolimus are not associated with skin atrophy. | 2002 | Br. J. Dermatol. | pmid:11903264 |
| Vögelin E et al. | Long-term viability of articular cartilage after microsurgical whole-joint transplantation and immunosuppression with rapamycin, mycophenolate mofetil, and tacrolimus. | 2002 | J Hand Surg Am | pmid:11901390 |
| Doi M et al. | Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor. | 2002 | Circulation | pmid:11901051 |
| Reitamo S et al. | Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitis. | 2002 | J. Allergy Clin. Immunol. | pmid:11898005 |
| Reitamo S et al. | Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis. | 2002 | J. Allergy Clin. Immunol. | pmid:11898004 |
| Allen BR | Tacrolimus ointment: its place in the therapy of atopic dermatitis. | 2002 | J. Allergy Clin. Immunol. | pmid:11897982 |
| Cohen SM | Current immunosuppression in liver transplantation. | 2002 Mar-Apr | Am J Ther | pmid:11897926 |
| Tang WX et al. | Role of FKBP12.6 in cADPR-induced activation of reconstituted ryanodine receptors from arterial smooth muscle. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11893565 |
| Beltrani VS | Tacrolimus ointment: advancing the treatment of atopic dermatitis. | 2001 | Curr Allergy Asthma Rep | pmid:11892051 |
| Nishigaki F et al. | FK506 induces chondrogenic differentiation of clonal mouse embryonic carcinoma cells, ATDC5. | 2002 | Eur. J. Pharmacol. | pmid:11890899 |
| Panz VR et al. | Diabetogenic effect of tacrolimus in South African patients undergoing kidney transplantation1. | 2002 | Transplantation | pmid:11889436 |
| Stempfle HU et al. | The role of tacrolimus (FK506)-based immunosuppression on bone mineral density and bone turnover after cardiac transplantation: a prospective, longitudinal, randomized, double-blind trial with calcitriol. | 2002 | Transplantation | pmid:11889427 |
| Margreiter R | Efficacy and safety of tacrolimus compared with ciclosporin microemulsion in renal transplantation: a randomised multicentre study. | 2002 | Lancet | pmid:11888584 |
| del Mar Fernández De Gatta M et al. | Immunosuppressive therapy for paediatric transplant patients: pharmacokinetic considerations. | 2002 | Clin Pharmacokinet | pmid:11888332 |
| Präst I et al. | Nerve cells in transplanted pancreatic islets: no effects of cyclosporin or tacrolimus on immediate neuronal survival. | 2001 | Ups. J. Med. Sci. | pmid:11888070 |
| Paty BW et al. | Inhibitory effects of immunosuppressive drugs on insulin secretion from HIT-T15 cells and Wistar rat islets. | 2002 | Transplantation | pmid:11884930 |
| Barone GW et al. | Increased early rejection rate after conversion from tacrolimus in kidney and pancreas transplantation. | 2002 | JOP | pmid:11884766 |
| Merle M | Some aspects of hand transplantation. | 2001 | J Hand Surg Br | pmid:11884103 |
| Lanzetta M et al. | Hand transplantation: ethics, immunosuppression and indications. | 2001 | J Hand Surg Br | pmid:11884098 |
| McCluskey A et al. | Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. | 2002 | J. Med. Chem. | pmid:11881984 |
| Pascual J | [Toward an evidence-based immunosuppression]. | 2001 | Nefrologia | pmid:11881421 |
| Toyonaga T et al. | Sudden onset of diabetes with ketoacidosis in a patient treated with FK506/tacrolimus. | 2002 | Diabetes Res. Clin. Pract. | pmid:11879716 |
| Cron RQ | HIV-1, NFAT, and cyclosporin: immunosuppression for the immunosuppressed? | 2001 | DNA Cell Biol. | pmid:11879569 |
| Israni A et al. | Conversion to tacrolimus for the treatment of cyclosporine-associated nephrotoxicity in heart transplant recipients. | 2002 | Am. J. Kidney Dis. | pmid:11877596 |
| Lü L and Zhang W | [Immunopathologic studies on the effects of immunosuppressant FK 506 on penetrating keratoplasty rejection model in rat]. | 1998 | Zhonghua Yan Ke Za Zhi | pmid:11877144 |
| Lytton SD et al. | Autoantibodies against cytochrome P450s in sera of children treated with immunosuppressive drugs. | 2002 | Clin. Exp. Immunol. | pmid:11876753 |
| Sarahrudi K et al. | The value of switching from cyclosporine to tacrolimus in the treatment of refractory acute rejection and obliterative bronchiolitis after lung transplantation. | 2002 | Transpl. Int. | pmid:11875609 |
| Dunn SE et al. | Calcineurin and skeletal muscle growth. | 2002 | Nat. Cell Biol. | pmid:11875443 |
| Kosch M et al. | Relationship between muscle sympathetic nerve activity and large artery mechanical vessel wall properties in renal transplant patients. | 2002 | J. Hypertens. | pmid:11875318 |
| Choi SH et al. | A case of persistent anemia in a renal transplant recipient: association with parvovirus B19 infection. | 2002 | Scand. J. Infect. Dis. | pmid:11874173 |
| Lawrence MC et al. | NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1. | 2002 | Diabetes | pmid:11872668 |
| Tanaka K et al. | GPI1046 prevents dopaminergic dysfunction by activating glutathione system in the mouse striatum. | 2002 | Neurosci. Lett. | pmid:11872253 |
| Okoshi Y et al. | [A case of FK 506-induced leukoencephalopathy]. | 2002 | No To Shinkei | pmid:11868353 |
| Parasrampuria DA et al. | Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. | 2002 | J Clin Pharmacol | pmid:11865967 |
| Kato T et al. | Intestinal and multivisceral transplantation. | 2002 | World J Surg | pmid:11865353 |
| Keshavarz R et al. | Diabetic ketoacidosis in a child on FK506 immunosuppression after a liver transplant. | 2002 | Pediatr Emerg Care | pmid:11862133 |
| Wu Y and Anderson ME | Reduced repolarization reserve in ventricular myocytes from female mice. | 2002 | Cardiovasc. Res. | pmid:11861046 |
| O'Connell PJ et al. | Identification of functional type 1 ryanodine receptors in mouse dendritic cells. | 2002 | FEBS Lett. | pmid:11852053 |
| Suehiro A et al. | Enhancement by cyclosporine A and tacrolimus of serotonin-induced formation of small platelet aggregation. | 2002 | Bone Marrow Transplant. | pmid:11850703 |