tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Woodle ES et al. | Tacrolimus therapy for refractory acute renal allograft rejection: definition of the histologic response by protocol biopsies. | 1996 | Transplantation | pmid:8878382 |
| Kershner RP and Fitzsimmons WE | Relationship of FK506 whole blood concentrations and efficacy and toxicity after liver and kidney transplantation. | 1996 | Transplantation | pmid:8878385 |
| Nolan TJ and Schad GA | Tacrolimus allows autoinfective development of the parasitic nematode Strongyloides stercoralis. | 1996 | Transplantation | pmid:8878405 |
| Devine SM et al. | Tacrolimus (FK506)-induced cerebral blindness following bone marrow transplantation. | 1996 | Bone Marrow Transplant. | pmid:8879619 |
| Ikegami S et al. | A facilitatory effect on the induction of long-term potentiation in vivo by chronic administration of antisense oligodeoxynucleotides against catalytic subunits of calcineurin. | 1996 | Brain Res. Mol. Brain Res. | pmid:8883951 |
| Soldin SJ | Receptor assays in the clinical laboratory. | 1996 | Clin. Biochem. | pmid:8884064 |
| Woodle ES et al. | FK 506 therapy for refractory renal allograft rejection: lessons from liver transplantation. | 1996 | Clin Transplant | pmid:8884103 |
| Karashima T et al. | FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0/G1 phases of the cell cycle. | 1996 | J. Dermatol. Sci. | pmid:8884530 |
| Monfar M and Blenis J | Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone. | 1996 | Mol. Endocrinol. | pmid:8885245 |
| Andoh TF et al. | Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. | 1996 | Kidney Int. | pmid:8887267 |
| Kokudo N et al. | Allogeneic hepatocyte and fetal liver transplantation and xenogeneic hepatocyte transplantation for Nagase's analbuminemic rats. | 1996 Sep-Oct | Cell Transplant | pmid:8889223 |
| Furukawa M et al. | Analysis of PCR microchimerism induced by intrathymic inoculation of donor alloantigens in rats. | 1996 Sep-Oct | Cell Transplant | pmid:8889237 |
| Cox KL and Freese DK | Tacrolimus (FK506): the pros and cons of its use as an immunosuppressant in pediatric liver transplantation. | 1996 | Clin Invest Med | pmid:8889279 |
| Bridges ND et al. | Lung transplantation in infancy and early childhood. | 1996 | J. Heart Lung Transplant. | pmid:8889985 |
| Bousvaros A et al. | Tacrolimus (FK-506) treatment of fulminant colitis in a child. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890089 |
| De Rie MA et al. | Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. | 1996 | Acta Derm. Venereol. | pmid:8891007 |
| Timmerman LA et al. | Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. | 1996 | Nature | pmid:8893011 |
| Inutsuka K et al. | Reconstruction of trachea and carina with immediate or cryopreserved allografts in dogs. | 1996 | Ann. Thorac. Surg. | pmid:8893587 |
| Ezeamuzie CI | Anti-allergic activity of cyclosporin-A metabolites and their interaction with the parent compound and FK 506. | 1996 | Int. J. Immunopharmacol. | pmid:8894806 |
| Ockenfels HM et al. | The effect of cyclosporin A and FK 506 on the cAMP content in psoriatic keratinocytes. | 1996 | Skin Pharmacol. | pmid:8896120 |
| Nash RA et al. | FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantation from matched unrelated donors. | 1996 | Blood | pmid:8896434 |
| Dawson S et al. | UCLA liver transplantation: analysis of immunological factors affecting outcome. | 1996 | Artif Organs | pmid:8896726 |
| Kashu Y et al. | Prolongation of rat liver graft survival by splenectomy combined with low dose FK506 therapy. | 1996 | Artif Organs | pmid:8896731 |
| Ohshima S et al. | Immunosuppressive treatment of primary cadaveric renal transplant patients receiving kidneys from non-heart beating donors. | 1996 | Artif Organs | pmid:8896734 |
| Kawashima M et al. | Tacrolimus concentrations in blood during topical treatment of atopic dermatitis. | 1996 | Lancet | pmid:8898050 |
| Drake M et al. | The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. | 1996 | Acta Physiol. Scand. | pmid:8899062 |
| Beauparlant P and Hiscott J | Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis. | 1996 | Cytokine Growth Factor Rev. | pmid:8899295 |
| Kaplan B et al. | Frequency of hyperkalemia in recipients of simultaneous pancreas and kidney transplants with bladder drainage. | 1996 | Transplantation | pmid:8900321 |
| Min DI et al. | Circadian variation of tacrolimus disposition in liver allograft recipients. | 1996 | Transplantation | pmid:8900327 |
| Brazelton TR and Morris RE | Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide. | 1996 | Curr. Opin. Immunol. | pmid:8902398 |
| Corrigan CJ et al. | Glucocorticoid resistant asthma: T-lymphocyte steroid metabolism and sensitivity to glucocorticoids and immunosuppressive agents. | 1996 | Eur. Respir. J. | pmid:8902470 |
| Sakane T and Miura K | [Research for basic and clinical aspects of Behcet's disease--recent advance and future--]. | 1996 | Nippon Rinsho | pmid:8904250 |
| Weinzweig N et al. | Peripheral-nerve allotransplantation in rats immunosuppressed with transient or long-term FK-506. | 1996 | J Reconstr Microsurg | pmid:8905545 |
| Nagai H et al. | The role of interleukin-5 (IL-5) in allergic airway hyperresponsiveness in mice. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906215 |
| Tsunoda SM and Aweeka FT | The use of therapeutic drug monitoring to optimise immunosuppressive therapy. | 1996 | Clin Pharmacokinet | pmid:8906895 |
| Yocum DE | Cyclosporine, FK-506, rapamycin, and other immunomodulators. | 1996 | Rheum. Dis. Clin. North Am. | pmid:8907069 |
| Lu YF et al. | FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus. | 1996 | Neurosci. Lett. | pmid:8907327 |
| Ye Q et al. | Persistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation. | 1996 | Transplant. Proc. | pmid:8907895 |
| Walgenbach KJ et al. | Increased presence of mast cells and interleukin-4 during chronic rejection of rat intestinal allografts. | 1996 | Transplant. Proc. | pmid:8907896 |
| Nüssler NC et al. | CD8+ host cells infiltrate the intestinal mucosa after allogeneic small bowel transplantation even in the absence of acute rejection. | 1996 | Transplant. Proc. | pmid:8907898 |
| Perego C et al. | Orthotopic liver-small bowel transplantation in pigs: study of immunologic parameters during therapy with FK 506-based immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907908 |
| Alessiani M et al. | Combined FK 506 and mycophenolate mofetil immunosuppression prolongs survival after small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907922 |
| Cohen DS et al. | Porcine small bowel transplantation with rapamycin-based induction immunosuppression and short-course cyclosporine or FK 506 therapy. | 1996 | Transplant. Proc. | pmid:8907923 |
| Toyama Y et al. | Prolonged small bowel graft survival using photochemotherapy and low-dose FK 506. | 1996 | Transplant. Proc. | pmid:8907924 |
| Yamada T et al. | Synergistic effect of FK 506 and trifluoperazine on the immunosuppression in rat small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8907927 |
| Rossi G et al. | Results of orthotopic liver-small bowel transplantation in the pig using different immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907932 |
| Platz KP et al. | Immunosuppressive power and limitations of FK 506 for prevention and treatment of graft-vs-host disease after small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8907933 |
| Velio P et al. | Rejection and survival after total orthotopic liver-small bowel allotransplantation in pigs immunosuppressed with FK 506. | 1996 | Transplant. Proc. | pmid:8907936 |
| Bardella MT et al. | FK 506 and cyclosporine: effect on D-xylose absorption in pigs with orthotopic liver-small bowel allotransplants. | 1996 | Transplant. Proc. | pmid:8907937 |
| Sugitani A et al. | Intestinal neurons in acute and chronic rejection after small bowel transplantation in dogs. | 1996 | Transplant. Proc. | pmid:8907941 |
| Ronchetti F et al. | Mucosal hyaluronic acid quantification in small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907950 |
| Costa A et al. | Stimulatory effect of FK506 and erythromycin on pig intestinal motility. | 1996 | Transplant. Proc. | pmid:8907957 |
| Cicalese L et al. | Effect of FK506 on the mucosal perfusion of the rat intestinal allograft. | 1996 | Transplant. Proc. | pmid:8907959 |
| Reggiani P et al. | Oral administration of FK 506 in a swine model of liver-small bowel allotransplantation. | 1996 | Transplant. Proc. | pmid:8907965 |
| Spada M et al. | Bacterial translocation is enhanced in pig intestinal transplantation when the colon is included in the graft. | 1996 | Transplant. Proc. | pmid:8907997 |
| Alessiani M et al. | Intestinal transplantation with and without the colon in FK 506 immunosuppressed pigs. | 1996 | Transplant. Proc. | pmid:8908021 |
| Asfar S et al. | Small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8908039 |
| Reyes J et al. | Intestinal transplantation in children: five-year experience. | 1996 | Transplant. Proc. | pmid:8908042 |
| Rao AS et al. | Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients. | 1996 | Transplant. Proc. | pmid:8908140 |
| Alper G and Small SL | Cerebrospinal fluid after organ transplantation. | 1996 | Transplant. Proc. | pmid:8908142 |
| Namieno T and Uchino J | Comparative study of the effects of cyclosporine and FK 506 on rat hepatocytes cocultured with nonparenchymal liver cells. | 1996 | Transplant. Proc. | pmid:8908147 |
| Rozen TD et al. | Treatment-refractory cyclosporine-associated headache: relief with conversion to FK-506. | 1996 | Neurology | pmid:8909459 |
| Bell A et al. | The antiparasite effects of cyclosporin A: possible drug targets and clinical applications. | 1996 | Gen. Pharmacol. | pmid:8909976 |
| Weigao C | [Limb allograft in rats: studies on optimal maintenance dose of FK506 and development of graft-versus-host-disease (GVHD)]. | 1996 | Fukuoka Igaku Zasshi | pmid:8913057 |
| Yagita Y et al. | Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils. | 1996 | Life Sci. | pmid:8913329 |
| Wang X et al. | Rapamycin inhibits aldolase A expression during human lymphocyte activation. | 1996 | J. Cell. Biochem. | pmid:8913875 |
| Licitra EJ and Liu JO | A three-hybrid system for detecting small ligand-protein receptor interactions. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8917502 |
| Cumming DV et al. | Pharmacological preconditioning of primary rat cardiac myocytes by FK506. | 1996 Sep-Oct | Basic Res. Cardiol. | pmid:8922254 |
| Yamamoto S et al. | Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment. | 1995 | Jpn. J. Ophthalmol. | pmid:8926639 |
| Shuker SB et al. | Discovering high-affinity ligands for proteins: SAR by NMR. | 1996 | Science | pmid:8929414 |
| Shapiro R et al. | "Suboptimal" kidney donors: the experience with tacrolimus-based immunosuppression. | 1996 | Transplantation | pmid:8932264 |
| Devlin J and Williams R | Transplantation for fulminant hepatic failure: comparing tacrolimus versus cyclosporine for immunosuppression and the outcome in elective transplants. European FK506 Liver Study Group. | 1996 | Transplantation | pmid:8932266 |
| Curran CF et al. | Acute overdoses of tacrolimus. | 1996 | Transplantation | pmid:8932293 |
| Bader A et al. | Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8935714 |
| Galat A | A large-scale processing of kinetic data files with derivation of the inhibitory constant Ki: an application to proline isomerases. | 1996 | Comput. Chem. | pmid:8936426 |
| Soin AS and Jamieson NV | Lessons learnt from the multicentre randomized trials of tacrolimus in liver transplantation. | 1996 Sep-Oct | Natl Med J India | pmid:8937063 |
| Andrews PA et al. | Racial variation in dosage requirements of tacrolimus. | 1996 | Lancet | pmid:8937292 |
| Budde K et al. | Clinical pharmacokinetics of tacrolimus in rescue therapy after renal transplantation. | 1996 | Int J Clin Pharmacol Ther | pmid:8937932 |
| Ide T et al. | An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the mongolian gerbil. | 1996 | Neurosci. Lett. | pmid:8938254 |
| Cai W et al. | Transcription-modulating drugs: mechanism and selectivity. | 1996 | Curr. Opin. Biotechnol. | pmid:8939643 |
| Freiberg RA et al. | Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. | 1996 | J. Biol. Chem. | pmid:8940187 |
| Poon M et al. | Rapamycin inhibits vascular smooth muscle cell migration. | 1996 | J. Clin. Invest. | pmid:8941644 |
| Rokaw MD et al. | Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells. | 1996 | J. Biol. Chem. | pmid:8943313 |
| Adachi M et al. | Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain. | 1996 | Blood | pmid:8943845 |
| Przepiorka D et al. | Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after matched unrelated donor marrow transplantation. | 1996 | Blood | pmid:8943876 |
| McCall E et al. | Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. | 1996 | Circ. Res. | pmid:8943949 |
| Winkler M et al. | Evaluation of the Pro-Trac tacrolimus monoclonal whole-blood enzyme-linked immunosorbent assay for monitoring of tacrolimus levels in patients after kidney, heart, and liver transplantation. | 1996 | Ther Drug Monit | pmid:8946659 |
| MacFarlane G et al. | A simplified whole blood enzyme-linked immunosorbent assay (ProTrac II) for tacrolimus (FK506) using proteolytic extraction in place of organic solvents. | 1996 | Ther Drug Monit | pmid:8946668 |
| Brunet M et al. | Comparative analysis of tacrolimus (FK506) in whole blood liver transplant recipients by PRO-TRAC enzyme-linked immunosorbent assay and microparticle enzyme immunoassay IMX methods. | 1996 | Ther Drug Monit | pmid:8946669 |
| Iwata M et al. | Regulation of T cell apoptosis via T cell receptors and steroid receptors. | 1996 | Stem Cells | pmid:8948021 |
| Benelli U et al. | FK-506 delays corneal graft rejection in a model of corneal xenotransplantation. | 1996 | J Ocul Pharmacol Ther | pmid:8951679 |
| Ueda S et al. | In-vitro metabolic studies of tacrolimus using precision-cut rat and human liver slices. | 1996 | J Pharm Biomed Anal | pmid:8951695 |
| Chambraud B et al. | FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. | 1996 | J. Biol. Chem. | pmid:8955134 |
| Williams R et al. | Two-year data from the European multicentre tacrolimus (FK506) liver study. | 1996 | Transpl. Int. | pmid:8959812 |
| Jonas S et al. | Indications for tacrolimus anti-rejection therapy in liver allograft recipients. | 1996 | Transpl. Int. | pmid:8959817 |
| Gruessner RW et al. | Use of FK 506 in pancreas transplantation. | 1996 | Transpl. Int. | pmid:8959841 |
| Fändrich F et al. | Circumvention of natural killer cell and T-cell mediated allogeneic target killing with tacrolimus (FK506) in small bowel transplantation related graft-vs-host disease. | 1996 | Transpl. Int. | pmid:8959843 |
| Antoniou E et al. | Effect of RS61443 in combination with leflunomide or FK506 on rat heart allograft survival. | 1996 | Transpl. Int. | pmid:8959858 |
| Golbaekdal K et al. | The acute effects of FK-506 on renal haemodynamics, water and sodium excretion and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide and vasopressin in pigs. | 1996 | J. Pharm. Pharmacol. | pmid:8961168 |
| Schumacher G et al. | Neurologic symptoms improve in patients with Wilson's disease despite immunosuppression. | 1996 | Transplant. Proc. | pmid:8962200 |