tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Trautmann A et al. | Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis. | 2001 | J. Allergy Clin. Immunol. | pmid:11692113 |
| Fukada J et al. | Long-term survival of rat cardiac allografts by intrathymic plus portal venous injections of donor bone marrow cells and short-term tacrolimus immunosuppression. | 2001 | Transpl. Int. | pmid:11692215 |
| Cristillo AD and Bierer BE | Identification of novel targets of immunosuppressive agents by cDNA-based microarray analysis. | 2002 | J. Biol. Chem. | pmid:11694517 |
| Miyauchi T et al. | Experimental study of combined treatment with tacrolimus and donor splenocytes via the portal vein in small bowel transplantation. | 2001 | J. Med. Invest. | pmid:11694955 |
| Amberg GC et al. | Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11698261 |
| Kogan-Liberman D et al. | The role of quantitative Epstein-Barr virus polymerase chain reaction and preemptive immunosuppression reduction in pediatric liver transplantation: a preliminary experience. | 2001 | J. Pediatr. Gastroenterol. Nutr. | pmid:11698761 |
| Fukatsu S et al. | Population pharmacokinetics of tacrolimus in adult recipients receiving living-donor liver transplantation. | 2001 | Eur. J. Clin. Pharmacol. | pmid:11699612 |
| Tsukamoto T et al. | The effects of FK506, a specific calcineurin inhibitor, on methamphetamine-induced behavioral change and its sensitization in rats. | 2001 | Psychopharmacology (Berl.) | pmid:11702083 |
| Scammell JG et al. | Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. | 2001 | Gen. Comp. Endocrinol. | pmid:11703081 |
| Okano A et al. | Subcutaneous infection with Mycobacterium fortuitum after allogeneic bone marrow transplantation. | 2001 | Bone Marrow Transplant. | pmid:11704796 |
| Takahata M et al. | Cyclosporin A-induced encephalopathy after allogeneic bone marrow transplantation with prevention of graft-versus-host disease by tacrolimus. | 2001 | Bone Marrow Transplant. | pmid:11704797 |
| Yamada T et al. | Role of T cells in development of chronic pancreatitis in male Wistar Bonn/Kobori rats: effects of tacrolimus. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11705744 |
| Trancassini M et al. | Microbiologic investigation on patients with cystic fibrosis subjected to bilateral lung transplantation. | 2001 | Transplantation | pmid:11707748 |
| Waldman WJ et al. | Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide. | 2001 | Transplantation | pmid:11707749 |
| Lash LH et al. | Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11708895 |
| Hernández G et al. | Resolution of oral ulcerations after decreasing the dosage of tacrolimus in a liver transplantation recipient. | 2001 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:11709689 |
| Chu FC et al. | Oral health status, oral microflora, and non-surgical periodontal treatment of renal transplant patients receiving cyclosporin A and FK506. | 2000 | Ann R Australas Coll Dent Surg | pmid:11709958 |
| Milting H et al. | FK506 does not affect cardiac contractility and adrenergic response in vitro. | 2001 | Eur. J. Pharmacol. | pmid:11711047 |
| Sakuma S et al. | FK506 is superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis. | 2001 | Inflamm. Res. | pmid:11713905 |
| Almawi WY et al. | Inhibition of cytokine production and cytokine-stimulated T-cell activation by FK506 (tacrolimus)1. | 2001 | Cell Transplant | pmid:11714196 |
| Alemdar AY et al. | Liposomal tacrolimus administered systemically and within the donor cell suspension improves xenograft survival in hemiparkinsonian rats. | 2001 | Exp. Neurol. | pmid:11716565 |
| Nemoto H et al. | FK506 suppressed the inflammatory change of EAM in SJL/J mice. | 2001 | J. Neurol. Sci. | pmid:11718743 |
| Granlund H et al. | Treatment of lichenified atopic eczema with tacrolimus ointment. | 2001 Aug-Sep | Acta Derm. Venereol. | pmid:11720192 |
| CÃfková R and Hallen H | Cyclosporin-induced hypertension. | 2001 | J. Hypertens. | pmid:11725176 |
| Krentz AJ | Posttransplantation Diabetes Mellitus in FK-506-Treated Renal Transplant Recipients: Analysis of Incidence and Risk Factors. Transplantation 2001; 72: 1655. | 2001 | Transplantation | pmid:11726815 |
| Bruce DS et al. | Multicenter survey of daclizumab induction in simultaneous kidney-pancreas transplant recipients. | 2001 | Transplantation | pmid:11726823 |
| Maes BD et al. | Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors. | 2001 | Transplantation | pmid:11726827 |
| Washburn K et al. | Steroid elimination 24 hours after liver transplantation using daclizumab, tacrolimus, and mycophenolate mofetil. | 2001 | Transplantation | pmid:11726831 |
| Pilmore HL et al. | Tacrolimus for the treatment of gout in renal transplantation: two case reports and review of the literature. | 2001 | Transplantation | pmid:11726837 |
| Mayer K et al. | [FK 506 ointment 0.1 % - A new therapeutic option for atopic blepharitis. Clinical trial with 14 patients]. | 2001 | Klin Monbl Augenheilkd | pmid:11731901 |
| Bartynski WS et al. | Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity. | 2001 Nov-Dec | AJNR Am J Neuroradiol | pmid:11733324 |
| Dubowchik GM et al. | 2-Aryl-2,2-difluoroacetamide FKBP12 ligands: synthesis and X-ray structural studies. | 2001 | Org. Lett. | pmid:11735566 |
| Bigby M | A thorough systematic review of treatments for atopic eczema. | 2001 | Arch Dermatol | pmid:11735714 |
| Sugiura H et al. | An open study of a lotion formulation to improve tolerance of tacrolimus in facial atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11736904 |
| Klein AW | Commentary on topical tacrolimus in the treatment of bovine collagen hypersensitivity. | 2001 | Dermatol Surg | pmid:11737142 |
| Sano N et al. | High trough levels of oral FK506 induced by loss of small intestine. | 2001 | Pediatr Transplant | pmid:11737769 |
| Flynn JT et al. | Indications, results, and complications of tacrolimus conversion in pediatric renal transplantation. | 2001 | Pediatr Transplant | pmid:11737770 |
| Vanrenterghem YF | Tailoring immunosuppressive therapy for renal transplant recipients. | 2001 | Pediatr Transplant | pmid:11737774 |
| Khouri IF et al. | Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality. | 2001 | Blood | pmid:11739162 |
| Hodgson T et al. | Topical tacrolimus and Crohn disease. | 2001 | J. Pediatr. Gastroenterol. Nutr. | pmid:11740245 |
| Yang CW et al. | Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney. | 2001 | Transplantation | pmid:11740384 |
| Benito N et al. | Alternariosis after liver transplantation. | 2001 | Transplantation | pmid:11740399 |
| Boukriche Y et al. | Severe axonal polyneuropathy after a FK506 overdosage in a lung transplant recipient. | 2001 | Transplantation | pmid:11740402 |
| Nagano Y et al. | Lack of binding observed between human alpha-synuclein and Bcl-2 protein family. | 2001 | Neurosci. Lett. | pmid:11742726 |
| Avramut M et al. | The immunosuppressant drug FK506 is a potent trophic agent for human fetal neurons. | 2001 | Brain Res. Dev. Brain Res. | pmid:11744119 |
| Keogh AM et al. | A randomized trial of tacrolimus (FK506) versus total lymphoid irradiation for the control of repetitive rejection after cardiac transplantation. | 2001 | J. Heart Lung Transplant. | pmid:11744418 |
| Chan SA and Smith C | Physiological stimuli evoke two forms of endocytosis in bovine chromaffin cells. | 2001 | J. Physiol. (Lond.) | pmid:11744761 |
| Kihara M et al. | A small dose of the immunosuppressive agent FK506 (tacrolimus) protects peripheral nerve from ischemic fiber degeneration. | 2001 | Muscle Nerve | pmid:11745968 |
| Chen JC and Ma P | Mechanism of FK506-induced renal hypoperfusion and its reversion in rats. | 2001 | Acta Pharmacol. Sin. | pmid:11749797 |
| Keshavamurthy M et al. | Single-center study utilizing C(2) level as monitoring tool in de novo renal transplant recipients treated with Neoral. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750338 |
| Shapiro R | The development of tacrolimus in renal transplantation. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750356 |
| Blume C et al. | Conversion from cyclosporine to tacrolimus prevents transplant function loss due to acute steroid-resistant or chronic rejection in renal allograft recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750357 |
| Jørgensen KA et al. | Optimal time for determination of blood tacrolimus level. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750358 |
| Ott R et al. | Conversion from tacrolimus to Neoral in liver and kidney transplant recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750359 |
| Boggi U et al. | Use of basiliximab in conjunction with either Neora/MMF/steroids or Prograf/MMF/steroids in simultaneous pancreas-kidney transplantation. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750373 |
| Lawen J et al. | Sirolimus and low-dose tacrolimus with antibody induction in kidney transplantation: preliminary results of a pilot study. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750382 |
| Hartwig T et al. | Low-dose sirolimus and tacrolimus in kidney transplantation: first results of a single-center experience. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750383 |
| Pridöhl O et al. | Low-dose immunosuppression with FK 506 and sirolimus after liver transplantation: 1-year results. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750384 |
| Diekmann F et al. | Conversion to rapamycin in renal allograft recipients with biopsy-proven calcineurin inhibitor-induced nephrotoxicity. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750386 |
| Sterneck M et al. | Steroid withdrawal in long-term liver transplant recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750398 |
| Charpentier B | Induction versus non-induction protocols in anti-calcineurin-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750425 |
| Miura S et al. | Long-term results of spousal renal donor transplants with donor-specific blood transfusions. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750463 |
| Meier-Kriesche HU and Kaplan B | Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared to Sandimmune. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750465 |
| Loinaz C et al. | A single-centre experience with cyclosporine microemulsion versus tacrolimus in 100 randomized liver transplant recipients: midterm efficacy and safety. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750472 |
| Tolba RH et al. | Conversion to Neoral for tacrolimus-related adverse effects in liver transplant recipients and improvement in quality of life. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750475 |
| Ferraresso M et al. | Conversion from cyclosporine to tacrolimus for refractory acute rejection in pediatric kidney transplant recipients: a single-center experience. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750525 |
| Garcia CD et al. | Renal transplantation in children less than six years old. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750527 |
| Risaliti A et al. | Cardiovascular and metabolic complications after liver transplantation: Neoral- versus tacrolimus-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750569 |
| Tanabe K et al. | Prospective analysis and successful treatment of thrombotic microangiopathy in renal allografts under tacrolimus immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750571 |
| Scheel AK et al. | Severe neurotoxicity of tacrolimus (FK506) after renal transplantation: two case reports. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750573 |
| van Duijnhoven EM et al. | Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based immunosuppression. | 2002 | J. Am. Soc. Nephrol. | pmid:11752040 |
| Boots JM et al. | Glucose metabolism in renal transplant recipients on tacrolimus: the effect of steroid withdrawal and tacrolimus trough level reduction. | 2002 | J. Am. Soc. Nephrol. | pmid:11752041 |
| Takamatsu H et al. | FK506 attenuates early ischemic neuronal death in a monkey model of stroke. | 2001 | J. Nucl. Med. | pmid:11752082 |
| Sakamoto Y et al. | Higher intracerebral concentration of tacrolimus after intermittent than continuous administration to rats. | 2001 | Liver Transpl. | pmid:11753909 |
| Evoli A et al. | Successful treatment of myasthenia gravis with tacrolimus. | 2002 | Muscle Nerve | pmid:11754194 |
| Rozycki TW et al. | Topical tacrolimus in the treatment of symptomatic oral lichen planus: a series of 13 patients. | 2002 | J. Am. Acad. Dermatol. | pmid:11756942 |
| Kaliakatsou F et al. | Management of recalcitrant ulcerative oral lichen planus with topical tacrolimus. | 2002 | J. Am. Acad. Dermatol. | pmid:11756943 |
| Schnopp C et al. | Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: a randomized, observer-blinded trial. | 2002 | J. Am. Acad. Dermatol. | pmid:11756949 |
| Wondimu B et al. | Oral health in liver transplant children administered cyclosporin A or tacrolimus. | 2001 | Int J Paediatr Dent | pmid:11759102 |
| Dudzik B et al. | [Use of Cyclosporine A and new immunosuppressive drugs in the therapy of glomerulonephritis]. | 2001 | Prz. Lek. | pmid:11769390 |
| Cheer SM and Plosker GL | Tacrolimus ointment. A review of its therapeutic potential as a topical therapy in atopic dermatitis. | 2001 | Am J Clin Dermatol | pmid:11770393 |
| Tang S et al. | Necrotizing fasciitis in a renal transplant recipient treated with FK 506: the first reported case. | 2001 | Clin. Nephrol. | pmid:11770800 |
| Eichenfield LF | Tacrolimus and pimecrolimus. Introduction. | 2001 | Semin Cutan Med Surg | pmid:11770907 |
| Bekersky I et al. | Tacrolimus pharmacology and nonclinical studies: from FK506 to protopic. | 2001 | Semin Cutan Med Surg | pmid:11770909 |
| Stuetz A et al. | Pimecrolimus (Elidel, SDZ ASM 981)--preclinical pharmacologic profile and skin selectivity. | 2001 | Semin Cutan Med Surg | pmid:11770910 |
| Robinson N et al. | Safety of the new macrolide immunomodulators. | 2001 | Semin Cutan Med Surg | pmid:11770911 |
| Bergman J and Rico MJ | Tacrolimus clinical studies for atopic dermatitis and other conditions. | 2001 | Semin Cutan Med Surg | pmid:11770912 |
| Hebert AA et al. | Pimecrolimus cream 1%: a new development in nonsteroid topical treatment of inflammatory skin diseases. | 2001 | Semin Cutan Med Surg | pmid:11770913 |
| Ling MR | Topical tacrolimus and pimecrolimus: future directions. | 2001 | Semin Cutan Med Surg | pmid:11770914 |
| Gonwa TA et al. | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | 2001 | Transplantation | pmid:11773892 |
| Kamiya H et al. | Calcineurin inhibitor attenuates cardiac hypertrophy due to energy metabolic disorder. | 2001 | Can J Cardiol | pmid:11773940 |
| Boucher M | Tacrolimus ointment for the treatment of atopic dermatitis. | 2001 | Issues Emerg Health Technol | pmid:11776288 |
| Tang L et al. | FK506 enhanced osteoblastic differentiation in mesenchymal cells. | 2002 | Cell Biol. Int. | pmid:11779223 |
| Limke TL and Atchison WD | Acute exposure to methylmercury opens the mitochondrial permeability transition pore in rat cerebellar granule cells. | 2002 | Toxicol. Appl. Pharmacol. | pmid:11781080 |
| Jacobson P et al. | Factors affecting the pharmacokinetics of tacrolimus (FK506) in hematopoietic cell transplant (HCT) patients. | 2001 | Bone Marrow Transplant. | pmid:11781626 |
| Menillo SA et al. | Intraoral psoralen ultraviolet A irradiation (PUVA) treatment of refractory oral chronic graft-versus-host disease following allogeneic stem cell transplantation. | 2001 | Bone Marrow Transplant. | pmid:11781637 |
| Reeves CD et al. | A new substrate specificity for acyl transferase domains of the ascomycin polyketide synthase in Streptomyces hygroscopicus. | 2002 | J. Biol. Chem. | pmid:11786554 |
| Holtmeier J and Leuschner U | Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis. | 2001 | Digestion | pmid:11786661 |
| Uchida T et al. | Identification of genes coding enzymes for ascomycin tetra-hydropyranose ring formation. | 2002 | Int. J. Mol. Med. | pmid:11786924 |
| Aitio ML | [Is it possible to prevent kidney problems caused by immunosuppression?]. | 2000 | Duodecim | pmid:11787104 |