Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Knoop C et al. | FK 506 rescue therapy for irreversible airway rejection in heart-lung transplant recipients: report on five cases. | 1994 | Transplant. Proc. | pmid:7527957 |
Candinas D et al. | Efficacy of leflunomide in combination with current immunosuppressive agents in rat cardiac allotransplantation. | 1994 | Transplant. Proc. | pmid:7527959 |
Kamińska D et al. | Significant infections after hand transplantation in a Polish population. | 2014 | Transplant. Proc. | pmid:25380943 |
Morphological characteristics of renal allografts showing renal dysfunction under FK 506 therapy: is graft biopsy available to reveal the morphological findings corresponding with FK 506 nephropathy? Japanese FK 506 Study Group. | 1993 | Transplant. Proc. | pmid:7679824 | |
Kato H et al. | Spontaneous proliferation of peripheral blood mononuclear cells as an indicator for insufficient plasma levels of FK 506 in the early phase after liver transplantation. | 1994 | Transplant. Proc. | pmid:7513481 |
Tanabe K et al. | Japanese single-center experience of kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119897 |
Alessiani M et al. | Adverse effects of FK 506 overdosage after liver transplantation. | 1993 | Transplant. Proc. | pmid:7679825 |
Nishikawa K et al. | Experimental studies of vascularized joint allografts in rats. | 1994 | Transplant. Proc. | pmid:7513482 |
Morris RE | In vivo immunopharmacology of the macrolides FK 506 and rapamycin: toward the era of rational immunosuppressive drug discovery, development, and use. | 1991 | Transplant. Proc. | pmid:1721257 |
Kobayashi M et al. | FK 506 assay past and present--characteristics of FK 506 ELISA. | 1991 | Transplant. Proc. | pmid:1721258 |
Loss M et al. | Glucose and lipid metabolism in liver transplant patients under long-term tacrolimus (FK 506) monotherapy. | 1996 | Transplant. Proc. | pmid:8623210 |
Bechstein WO et al. | Tacrolimus (FK 506) therapy is associated with a significant reduction in immunosuppressive treatment failures following primary liver transplantation. | 1996 | Transplant. Proc. | pmid:8623211 |
Van Thiel DH et al. | Gastrointestinal and metabolic problems associated with immunosuppression with either CyA or FK 506 in liver transplantation. | 1990 | Transplant. Proc. | pmid:1689893 |
Aktürk S et al. | Pregnancy After Kidney Transplantation: Outcomes, Tacrolimus Doses, and Trough Levels. | 2015 | Transplant. Proc. | pmid:26093738 |
Shoji T et al. | Long-term acceptance of porcine pulmonary allografts without chronic rejection. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808551 |
Mieles L et al. | Oral glucose tolerance test in liver recipients treated with FK 506. | 1990 | Transplant. Proc. | pmid:1689894 |
Rafecas A et al. | Immunosuppression with calcineurin inhibitors and polyclonal antibodies in liver transplantation. | 2002 | Transplant. Proc. | pmid:11959209 |
Platz KP et al. | FK506 for primary and rescue therapy following liver transplantation. | 1998 | Transplant. Proc. | pmid:9636570 |
Qu W et al. | Correlation Between Immunosuppressive Therapy and CD4(+) T-Cell Intracellular Adenosine Triphosphate Levels in Liver Transplant Recipients. | Transplant. Proc. | pmid:27569951 | |
Harihara Y et al. | Correlation between graft size and necessary tacrolimus dose after living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120116 |
Oishi M et al. | A case of hyperkalemic distal renal tubular acidosis secondary to tacrolimus in living donor liver transplantation. | 2000 | Transplant. Proc. | pmid:11120143 |
Gonzalez-Molina M et al. | Mycophenolate mofetil and tacrolimus reduce mortality after deceased donor kidney transplantation. | 2012 | Transplant. Proc. | pmid:23146459 |
van Hooff JP et al. | Tacrolimus and glucose metabolism. | 1999 | Transplant. Proc. | pmid:10576044 |
Lo CM et al. | More effective immunosuppression with the use of FK506 after liver transplantation. | 2000 | Transplant. Proc. | pmid:11120161 |
Kim HC et al. | Primary immunosuppression with tacrolimus in kidney transplantation: three-year follow-up in a single center. | 2004 | Transplant. Proc. | pmid:15518753 |
Soriano S et al. | Single-center experience with initial intravenous dosing of tacrolimus after kidney transplantation. | 1999 | Transplant. Proc. | pmid:10576045 |
Yeung S et al. | Primary immunosuppression with tacrolimus and low-dose mycophenolate mofetil in renal transplant recipients. | 2004 | Transplant. Proc. | pmid:15518754 |
McCauley J et al. | Cyclosporine and FK 506 induced inhibition of renal epithelial cell proliferation. | 1991 | Transplant. Proc. | pmid:1721290 |
Ciancio G et al. | Human donor bone marrow cells can enhance hyporeactivity in renal transplantation using maintenance FK 506 and OKT3 induction therapy. | 1996 | Transplant. Proc. | pmid:8623473 |
Thomas FT et al. | Comparative efficacy of immunosuppressive drugs in xenografting. | 1990 | Transplant. Proc. | pmid:1693452 |
Kawaoka T et al. | Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report. | 2015 | Transplant. Proc. | pmid:25891736 |
Gruessner RW | Antibody induction therapy in pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9636632 |
Stratta RJ | Late acute rejection episodes after vascularized pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9636633 |
Kim SJ et al. | A 6-month, multicenter, single-arm pilot study to evaluate the efficacy and safety of generic tacrolimus (TacroBell) after primary renal transplantation. | 2009 | Transplant. Proc. | pmid:19545705 |
Sánchez-Lázaro IJ et al. | Preliminary results of a prospective randomized study of cyclosporine versus tacrolimus in the development of cardiac allograft vasculopathy at 1 year after heart transplantation. | 2010 | Transplant. Proc. | pmid:20970650 |
Platz KP et al. | Indications for mycofenolate mofetil therapy after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365601 |
Demirbas A et al. | FK 506 in simultaneous pancreas/kidney transplantation: the University of Miami experience. | 1997 | Transplant. Proc. | pmid:9365608 |
Curro G et al. | Transient ischemic attack after rizatriptan administration in a liver transplant recipient: a case report. | 2006 | Transplant. Proc. | pmid:17112920 |
Reyes J et al. | Lymphoproliferative disease after intestinal transplantation under primary FK 506 immunosuppression. | 1994 | Transplant. Proc. | pmid:7518137 |
Murase N et al. | Small bowel transplantation in sensitized recipients: comparison with heart, kidney, and liver grafts. | 1994 | Transplant. Proc. | pmid:7518139 |
Ziolkowski J et al. | Effect of immunosuppressive regimen on acute rejection and liver graft function. | 2003 | Transplant. Proc. | pmid:14529915 |
Yu Y et al. | Mutagenicity of the new immunosuppressive drugs, FK 506, and spergualin. | 1993 | Transplant. Proc. | pmid:7682364 |
Gaweco AS et al. | Common and sequential overexpression patterns of T-helper cytokines during acute (cellular) rejection, and correlation of proinflammatory cytokine expression with chronic (ductopenic) rejection of human liver allografts: a study under cyclosporine, FK 506, and quadruple BT 563 immunosuppression. | 1995 | Transplant. Proc. | pmid:7533370 |
Kato T et al. | FK506 may suppress liver injury during the early period following living-related liver transplantation. | 2003 | Transplant. Proc. | pmid:12591316 |
Takaori K et al. | Effects of FK 506 on in vivo immunity in comparison to cyclosporine. | 1991 | Transplant. Proc. | pmid:1721322 |
Yang YJ et al. | Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency. | 2008 | Transplant. Proc. | pmid:18589147 |
Benedini S et al. | Glucose and leucine metabolism in lung tranplanted patients on low dose of steroids for immunosuppressive therapy. | 2008 | Transplant. Proc. | pmid:18589153 |
Waller JR et al. | Effect of rapamycin in combination with calcineurin inhibitors, FK506 and cyclosporin, following arterial injury. | 2002 | Transplant. Proc. | pmid:12176449 |
Hayes D et al. | Aerosolized tacrolimus: a case report in a lung transplant recipient. | 2010 | Transplant. Proc. | pmid:21094875 |
Krämer BK et al. | Cardiovascular risk estimates and risk factors in renal transplant recipients. | 2005 | Transplant. Proc. | pmid:15919488 |
Funayama Y et al. | Changes in cell adhesion molecules after small bowel transplantation in rats. | 1995 | Transplant. Proc. | pmid:7533426 |
Torre-Cisneros J et al. | The spectrum of aspergillosis in liver transplant patients: comparison of FK 506 and cyclosporine immunosuppression. | 1991 | Transplant. Proc. | pmid:1721353 |
Colak T et al. | Effect of conversion from cyclosporine to tacrolimus on lipid profiles in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12270321 |
Paul AA et al. | CMV retinitis and the use of FK 506. | 1991 | Transplant. Proc. | pmid:1721354 |
Nanni G et al. | Lack of correlation between serum levels of mycophenolate mofetil and kidney transplant outcome in tacrolimus-based immunosupression. | 2002 | Transplant. Proc. | pmid:12270323 |
Reyes J et al. | Posttransplant lymphoproliferative disorders occurring under primary FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721355 |
Miyagi M et al. | Comparison of the therapeutic effects between CsA and FK506 on chronic renal allograft injury and TGF-beta expression. | 2002 | Transplant. Proc. | pmid:12176497 |
Gruttadauria S et al. | Basiliximab in a triple-drug regimen with tacrolimus and steroids in liver transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182762 |
Gojowy D et al. | High Frequency of Arterial Hypertension in Patients After Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27496479 |
Takayama J et al. | Living related liver transplantation in patients with ABO incompatibility. | 1998 | Transplant. Proc. | pmid:9838537 |
Scott JS et al. | Tacrolimus: a cause of hypertrophic cardiomyopathy in pediatric heart transplant recipients? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083017 |
Rayes N et al. | Distribution of lymphocyte subtypes in liver transplant recipients. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123103 |
Asfar S et al. | Small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8908039 |
Masaoka T | Problems of bone marrow transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520634 |
Endoh M et al. | Nonmuscle myosin heavy chain and metalloproteinase-2 expression in concordant pulmonary xenografts. | 2000 | Transplant. Proc. | pmid:10936397 |
Yoshimura N et al. | A new immunosuppressive agent, FK506, inhibits the expression of alloantigen-activated suppressor cells as well as the induction of alloreactivity. | 1989 | Transplant. Proc. | pmid:2468202 |
McCauley J et al. | Renal function after conversion from cyclosporine to FK 506 in liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721387 |
Citterio F et al. | Steroid withdrawal from tacrolimus-based therapy in renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176545 |
Yang HC et al. | Tacrolimus/"low-dose" mycophenolate mofetil versus microemulsion cyclosporine/"low-dose" mycophenolate mofetil after kidney transplantation--1-year follow-up of a prospective, randomized clinical trial. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083501 |
Gu B et al. | Exploration of Fecal Microbiota Transplantation in the Treatment of Refractory Diarrhea After Renal Transplantation. | 2018 | Transplant. Proc. | pmid:29880353 |
Steinmueller T et al. | The effect of cyclosporine vs FK 506 on glucose metabolism. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083504 |
Tsao CI et al. | Unplanned readmission within 1 year after heart transplantation in Taiwan. | 2010 | Transplant. Proc. | pmid:20430212 |
Galvao FH et al. | Experimental animal model of graft-versus-host disease (GVHD) after small-bowel transplantation: characteristics of the model and application to developing treatment strategies. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123488 |
Iacona I et al. | Mycophenolic acid in combination with FK 506: a pharmacokinetic study in piglets after small-bowel transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123489 |
Nakao A et al. | Cytokine mRNA expression on rat small bowel allograft treated with tacrolimus and simultaneous bone marrow transplantation via the portal vein. | 2000 | Transplant. Proc. | pmid:10995965 |
Soltero L et al. | Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects. | 2003 | Transplant. Proc. | pmid:12826147 |
Tzakis AG et al. | FK 506 rescue in chronic graft-versus-host-disease after bone marrow transplantation. | 1991 | Transplant. Proc. | pmid:1721416 |
Watanabe K et al. | Immunosuppressive effect of bactobolamine in rat liver allotransplantation. | 1996 | Transplant. Proc. | pmid:8658697 |
Masaoka T et al. | Phase II study of FK 506 for allogeneic bone marrow transplantation. | 1991 | Transplant. Proc. | pmid:1721417 |
Tojimbara T et al. | Cyclosporine and tacrolimus both suppress activation of Kupffer cells in vitro. | 1996 | Transplant. Proc. | pmid:8658704 |
Glanemann M et al. | Higher immunosuppressive efficacy of mycophenolate mofetil in combination with FK 506 than in combination with cyclosporine A. | 2000 | Transplant. Proc. | pmid:10812095 |
Chang HR et al. | Sirolimus addition is beneficial for renal allograft dysfunction due to simultaneous acute rejection episode and calcineurin inhibitor nephrotoxicity. | 2004 | Transplant. Proc. | pmid:15621119 |
Burke GW et al. | Steroid-resistant acute rejection following SPK: importance of maintaining therapeutic dosing in a triple-drug regimen. | 2002 | Transplant. Proc. | pmid:12176628 |
Aguirrezabalaga J et al. | Lipid profiles in liver transplantation in patients receiving tacrolimus or cyclosporin. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267192 |
Varghese Z et al. | Oxidizability of low-density lipoproteins from Neoral and tacrolimus-treated renal transplant patients. | 1998 | Transplant. Proc. | pmid:9723384 |
Duzova A et al. | Triple immunosuppression with or without basiliximab in pediatric renal transplantation: acute rejection rates at one year. | 2003 | Transplant. Proc. | pmid:14697926 |
Reichenspurner H et al. | First experience with FK 506 for treatment of chronic pulmonary rejection. | 1995 | Transplant. Proc. | pmid:7540775 |
Abu-Elmagd K et al. | FK 506: a new therapeutic agent for severe recalcitrant psoriasis. | 1991 | Transplant. Proc. | pmid:1721449 |
Ueda D et al. | Influence of FK 506 on renal blood flow. | 1993 | Transplant. Proc. | pmid:7689280 |
Ito Y et al. | Complete replacement of tracheal epithelia by the host promotes spontaneous acceptance of orthotopic tracheal allografts in rats. | 2004 | Transplant. Proc. | pmid:15561264 |
Sigal NH et al. | Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A. | 1991 | Transplant. Proc. | pmid:1712132 |
Uber PA et al. | Ethnic disparities in the pharmacologic characteristics of tacrolimus in heart transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267428 |
Banerjee R et al. | Coadministration of itraconazole and tacrolimus after thoracic organ transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267435 |
Fujimura T et al. | Cellular surface molecular and cytokine gene expression in rat heart allografts under optimal doses of cyclosporine and FK 506. | 1998 | Transplant. Proc. | pmid:9636413 |
Kacar S et al. | Low-dose calcineurin inhibitor regimen combined with mammalian target of rapamycin inhibitors preserves kidney functions in renal transplant recipients without allograft nephropathy. | 2010 | Transplant. Proc. | pmid:21094806 |
McLaughlin GE et al. | Effect of aminophylline on urine flow in children with tacrolimus-induced renal insufficiency. | 2000 | Transplant. Proc. | pmid:10856596 |
Soh KS et al. | Simultaneous liver and kidney transplantation from different living donors. | 2012 | Transplant. Proc. | pmid:22410057 |
Wojciechowski D et al. | Mycophenolate Mofetil Withdrawal With Conversion to Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923623 |
Ott R et al. | Conversion from tacrolimus to Neoral in liver and kidney transplant recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750359 |
Kliem V et al. | Tacrolimus for steroid- and OKT3-resistant rejection in kidney recipients. | 1998 | Transplant. Proc. | pmid:9636509 |