tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Russell JJ | Topical tacrolimus: a new therapy for atopic dermatitis. | 2002 | Am Fam Physician | pmid:12469964 |
| Tamada S et al. | Inhibition of nuclear factor-kappaB activation by pyrrolidine dithiocarbamate prevents chronic FK506 nephropathy. | 2003 | Kidney Int. | pmid:12472797 |
| Hsiao CC et al. | Evaluation for synergistic suppression of T cell responses to minor histocompatibility antigens by chloroquine in combination with tacrolimus and a rapamycin derivative, SDZ-RAD. | 2002 | Bone Marrow Transplant. | pmid:12476284 |
| Bar J et al. | Is immunosuppression therapy in renal allograft recipients teratogenic? A single-center experience. | 2003 | Am. J. Med. Genet. A | pmid:12476448 |
| Fellermann K et al. | Response of refractory colitis to intravenous or oral tacrolimus (FK506). | 2002 | Inflamm. Bowel Dis. | pmid:12479646 |
| Blanchet B et al. | Determination of serine/threonine protein phosphatase type 2B PP2B in lymphocytes by HPLC. | 2003 | Anal. Biochem. | pmid:12479828 |
| Staatz CE and Tett SE | Comparison of two population pharmacokinetic programs, NONMEM and P-PHARM, for tacrolimus. | 2002 | Eur. J. Clin. Pharmacol. | pmid:12483452 |
| Maes BD et al. | Differential effect of diarrhea on FK506 versus cyclosporine A trough levels and resultant prevention of allograft rejection in renal transplant recipients. | 2002 | Am. J. Transplant. | pmid:12484345 |
| Polastri L et al. | Secretory defects induced by immunosuppressive agents on human pancreatic beta-cells. | 2002 | Acta Diabetol | pmid:12486498 |
| Lake DB and Poole TR | Tacrolimus. | 2003 | Br J Ophthalmol | pmid:12488279 |
| Su Z et al. | Effects of FK506 on [Ca2+]i differ in mouse and rabbit ventricular myocytes. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12490609 |
| Hodur DM and Mandelbrot D | Immunosuppression and BKV Nephropathy. | 2002 | N. Engl. J. Med. | pmid:12490694 |
| Macphee IA et al. | Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement. | 2002 | Transplantation | pmid:12490779 |
| Shapiro AM et al. | Defining optimal immunosuppression for islet transplantation based on reduced diabetogenicity in canine islet autografts. | 2002 | Transplantation | pmid:12490784 |
| Mehra MR et al. | Ethnic disparity in clinical outcome after heart transplantation is abrogated using tacrolimus and mycophenolate mofetil-based immunosuppression. | 2002 | Transplantation | pmid:12490790 |
| Espà A et al. | Influence of hepatic ischemia-reperfusion injury on tacrolimus acute renal toxicity in pigs. | 2002 | Transplant. Proc. | pmid:12493373 |
| Mange KC and Bloom RD | Rates of acute rejection by recipient race and type of calcineurin inhibitor with mycophenolate mofetil. | 2002 | Transplant. Proc. | pmid:12493393 |
| Boots JM et al. | Pretransplant pharmacokinetics: does it predict the dose of tacrolimus after renal transplantation? | 2002 | Transplant. Proc. | pmid:12493409 |
| Pisitkun T et al. | The roles of C4 and AUC0-4 in monitoring of tacrolimus in stable kidney transplant patients. | 2002 | Transplant. Proc. | pmid:12493410 |
| Veroux P et al. | Tacrolimus-induced neurotoxicity in kidney transplant recipients. | 2002 | Transplant. Proc. | pmid:12493415 |
| Izbicki G et al. | Improved survival after lung transplantation in patients treated with tacrolimus/mycophenolate mofetil as compared with cyclosporine/azathioprine. | 2002 | Transplant. Proc. | pmid:12493439 |
| Witzigmann H et al. | Immunosuppression with sirolimus/tacrolimus combination in pancreas transplantation: 1-year results. | 2002 | Transplant. Proc. | pmid:12493472 |
| Barat C and Tremblay MJ | Treatment of human T cells with bisperoxovanadium phosphotyrosyl phosphatase inhibitors leads to activation of cyclooxygenase-2 gene. | 2003 | J. Biol. Chem. | pmid:12493747 |
| Staatz CE et al. | Population pharmacokinetics of tacrolimus in adult kidney transplant recipients. | 2002 | Clin. Pharmacol. Ther. | pmid:12496747 |
| Cofán F et al. | [Interaction between sildenafil and calcineurin inhibitors in renal transplant recipients with erectile dysfunction]. | 2002 | Nefrologia | pmid:12497749 |
| Gewirtz AT and Sitaraman SV | Tacrolimus Fujisawa. | 2002 | Curr Opin Investig Drugs | pmid:12498005 |
| Li P et al. | Structure of the N-terminal domain of human FKBP52. | 2003 | Acta Crystallogr. D Biol. Crystallogr. | pmid:12499534 |
| Boots JM et al. | Early steroid withdrawal in renal transplantation with tacrolimus dual therapy: a pilot study. | 2002 | Transplantation | pmid:12499885 |
| Fridell JA et al. | Causes of mortality beyond 1 year after primary pediatric liver transplant under tacrolimus. | 2002 | Transplantation | pmid:12499888 |
| Kano Y et al. | Immunosuppressant FK506 induces sustained activation of MAP kinase and promotes neurite outgrowth in PC12 mutant cells incapable of differentiating. | 2002 | Cell Struct. Funct. | pmid:12502894 |
| Shoker AS et al. | Cytokine gene expression by alloactivated cells in SCID mice. | 2002 | Transpl. Immunol. | pmid:12507403 |
| Tsuchida H et al. | Engineered allogeneic mesenchymal stem cells repair femoral segmental defect in rats. | 2003 | J. Orthop. Res. | pmid:12507579 |
| Keswani SC et al. | FK506 is neuroprotective in a model of antiretroviral toxic neuropathy. | 2003 | Ann. Neurol. | pmid:12509848 |
| Morioka D et al. | Prostaglandin E1 improved the function of transplanted fatty liver in a rat reduced-size-liver transplantation model under conditions of permissible cold preservation. | 2003 | Liver Transpl. | pmid:12514777 |
| Kano Y et al. | Immunosuppressant FK506 induces neurite outgrowth in PC12 mutant cells with impaired NGF-promoted neuritogenesis via a novel MAP kinase signaling pathway. | 2002 | Neurochem. Res. | pmid:12515319 |
| Gómez E et al. | [Remission of severe disease induced by CMV and lymphoproliferative post-transplant disease after changing the immunosuppressive regime]. | 2002 | Nefrologia | pmid:12516292 |
| Sarkodee-Adoo C et al. | Thrombotic microangiopathy in blood and marrow transplant patients receiving tacrolimus or cyclosporine A. | 2003 | Transfusion | pmid:12519434 |
| Gjersvik PJ | [A new therapeutic era for atopic eczema?]. | 2002 | Tidsskr. Nor. Laegeforen. | pmid:12523140 |
| Richard RE and Blau CA | Small-molecule-directed mpl signaling can complement growth factors to selectively expand genetically modified cord blood cells. | 2003 | Stem Cells | pmid:12529553 |
| Cairn J et al. | Time-related changes in pulmonary function after conversion to tacrolimus in bronchiolitis obliterans syndrome. | 2003 | J. Heart Lung Transplant. | pmid:12531413 |
| [Selective calcineurin inhibitor. Neurodermatitis patients need fewer corticoids]. | 2002 | MMW Fortschr Med | pmid:12534090 | |
| Ohkawa Y et al. | Calcineurin-mediated pathway involved in the differentiated phenotype of smooth muscle cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12535643 |
| Li S et al. | Intrathymic inoculation of donor bone marrow induces long-term acceptance of lung allografts. | 2003 | Ann. Thorac. Surg. | pmid:12537225 |
| Asano M et al. | Baboons undergoing orthotopic concordant cardiac xenotransplantation surviving more than 300 days: effect of immunosuppressive regimen. | 2003 | J. Thorac. Cardiovasc. Surg. | pmid:12538986 |
| Simon N et al. | Tacrolimus and sirolimus decrease oxidative phosphorylation of isolated rat kidney mitochondria. | 2003 | Br. J. Pharmacol. | pmid:12540528 |
| Takano H et al. | Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization. | 2003 | Brain Res. | pmid:12543454 |
| Yang CW et al. | Preconditioning with cyclosporine A or FK506 differentially regulates mitogen-activated protein kinase expression in rat kidneys with ischemia/reperfusion injury. | 2003 | Transplantation | pmid:12544865 |
| Lykavieris P et al. | Angioedema in pediatric liver transplant recipients under tacrolimus immunosuppression. | 2003 | Transplantation | pmid:12544888 |
| Lawsin L and Light JA | Severe acute renal failure after exposure to sirolimus-tacrolimus in two living donor kidney recipients. | 2003 | Transplantation | pmid:12544890 |
| Zabawski E | Treatment of cutaneous lupus with Elidel. | 2002 | Dermatol. Online J. | pmid:12546779 |
| Sonoda T et al. | Outcome of 3 years of immunosuppression with tacrolimus in more than 1,000 renal transplant recipients in japan. | 2003 | Transplantation | pmid:12548123 |
| St Peter SD et al. | Effects of tacrolimus on ischemia-reperfusion injury. | 2003 | Liver Transpl. | pmid:12548502 |
| Staatz CE et al. | Toward better outcomes with tacrolimus therapy: population pharmacokinetics and individualized dosage prediction in adult liver transplantation. | 2003 | Liver Transpl. | pmid:12548506 |
| St Peter SD et al. | Tacrolimus as a liver flush solution to ameliorate the effects of ischemia/reperfusion injury following liver transplantation. | 2003 | Liver Transpl. | pmid:12548508 |
| Utsugisawa K et al. | Effects of FK506 on myasthenia gravis patients with high interleukin-2 productivity in peripheral blood mononuclear cells. | 2003 | Muscle Nerve | pmid:12548534 |
| Yano M et al. | FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure. | 2003 | Circulation | pmid:12551874 |
| Chang DW and Yang X | Activation of procaspases by FK506 binding protein-mediated oligomerization. | 2003 | Sci. STKE | pmid:12554853 |
| Nagata H et al. | Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation. | 2003 | Gastroenterology | pmid:12557148 |
| Mukherjee S | The TMC study. | 2003 | Lancet | pmid:12559885 |
| Davies MH et al. | The TMC study. | 2003 | Lancet | pmid:12559886 |
| Johnston A and Levy GA | The TMC study. | 2003 | Lancet | pmid:12559887 |
| Kontoyiannis DP et al. | Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species. | 2003 | J. Antimicrob. Chemother. | pmid:12562696 |
| Román ID et al. | Cyclosporin A induced internalization of the bile salt export pump in isolated rat hepatocyte couplets. | 2003 | Toxicol. Sci. | pmid:12563113 |
| Mascarell L and Truffa-Bachi P | New aspects of cyclosporin a mode of action: from gene silencing to gene up-regulation. | 2003 | Mini Rev Med Chem | pmid:12570836 |
| Sato M | [Effects of FK506 on neuroendocrine system--special reference to the effects on growth hormone secretory systems]. | 2001 | Jpn J Antibiot | pmid:12575414 |
| Chunasuwankul R et al. | Low dose discontinued FK506 treatment enhances peripheral nerve regeneration. | 2002 Oct-Dec | Int Surg | pmid:12575814 |
| Pistorius A et al. | Effects of selected immunouppressive drugs on prostaglandin release, protein synthesis and cell proliferation in human gingival fibroblasts and on the growth of plaque bacteria. | 2003 | Eur. J. Med. Res. | pmid:12578751 |
| Stickle DF et al. | Effects of sterilizing gamma irradiation on bloodspot newborn screening tests and whole blood cyclosporine and tacrolimus measurements. | 2003 | Am. J. Clin. Pathol. | pmid:12580001 |
| Keate RF et al. | Lichen planus esophagitis: report of three patients treated with oral tacrolimus or intraesophageal corticosteroid injections or both. | 2003 | Dis. Esophagus | pmid:12581256 |
| Satterwhite T et al. | Increased expression of cytotoxic effector molecules: different interpretations for steroid-based and steroid-free immunosuppression. | 2003 | Pediatr Transplant | pmid:12581329 |
| Nowak P et al. | Follow-up of antiretroviral treatment in liver transplant recipients with primary and chronic HIV type 1 infection. | 2003 | AIDS Res. Hum. Retroviruses | pmid:12581512 |
| Nishimura M et al. | Tacrolimus-induced life-threatening arrhythmia in a pediatric liver-transplant patient. | 2002 | Intensive Care Med | pmid:12583382 |
| Ginestà MM et al. | Acute xenograft rejection, late xenograft rejection and long term survival xenografts in the hamster-to-rat heart transplantation model: histological characterisation under low-dose of FK506. | 2002 | APMIS | pmid:12583441 |
| Nielsen FT et al. | Kidney function and morphology after short-term combination therapy with cyclosporine A, tacrolimus and sirolimus in the rat. | 2003 | Nephrol. Dial. Transplant. | pmid:12584269 |
| Ho VC et al. | Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infants. | 2003 | J. Pediatr. | pmid:12584537 |
| Bernard LA et al. | A rosacea-like granulomatous eruption in a patient using tacrolimus ointment for atopic dermatitis. | 2003 | Arch Dermatol | pmid:12588240 |
| Segal E et al. | Predominant factors associated with bone loss in liver transplant patients - after prolonged post-transplantation period. | 2003 | Clin Transplant | pmid:12588316 |
| Kanekura T et al. | Efficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosus. | 2003 | Br. J. Dermatol. | pmid:12588393 |
| Jørgensen KA et al. | Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus. | 2003 | Scand. J. Immunol. | pmid:12588654 |
| Yang Z et al. | Long-term liver allograft survival induced by combined treatment with rAAV-hCTLA4Ig gene transfer and low-dose FK506. | 2003 | Transplantation | pmid:12589149 |
| Furuichi Y et al. | Neuroprotective action of tacrolimus (FK506) in focal and global cerebral ischemia in rodents: dose dependency, therapeutic time window and long-term efficacy. | 2003 | Brain Res. | pmid:12591130 |
| Kato T et al. | FK506 may suppress liver injury during the early period following living-related liver transplantation. | 2003 | Transplant. Proc. | pmid:12591316 |
| Takai K et al. | Delayed graft function after renal transplantation from a non-heart-beating donors. | 2003 | Transplant. Proc. | pmid:12591320 |
| Ushigome H et al. | Pediatric living-related renal transplantation under tacrolimus as the primary immunosuppressive agent. | 2003 | Transplant. Proc. | pmid:12591350 |
| Kim SW et al. | Decreased formation of nitric oxide in rats treated with FK506. | 2003 | Transplant. Proc. | pmid:12591357 |
| Kim HC et al. | Primary immunosuppression with tacrolimus in renal transplantation: a single center experience. | 2003 | Transplant. Proc. | pmid:12591370 |
| Chiang Y et al. | Posttransplantation Kaposi sarcoma-experience in a patient receiving FK-506 and MMF. | 2003 | Transplant. Proc. | pmid:12591389 |
| Suga A et al. | Diabetes mellitus after renal transplantation under tacrolimus-based immunosuppression. | 2003 | Transplant. Proc. | pmid:12591391 |
| Liu B et al. | Single-center experience: tacrolimus and mycophenolate mofetil in early stage of kidney transplantation with liver dysfunction. | 2003 | Transplant. Proc. | pmid:12591396 |
| Nakamura K et al. | Renal transplant recipient experiencing pneumatosis cystoides intestinalis: a case report. | 2003 | Transplant. Proc. | pmid:12591410 |
| Akioka K et al. | Abdominal pain is a critical complication of mycophenolate mofetil in renal transplant recipients. | 2003 | Transplant. Proc. | pmid:12591411 |
| Kitamura T et al. | Severe hemolytic anemia related to production of cold agglutinins following living donor liver transplantation: a case report. | 2003 | Transplant. Proc. | pmid:12591458 |
| Mizuta K et al. | Increase of bile acid production by tacrolimus in the rat liver. | 2003 | Transplant. Proc. | pmid:12591477 |
| Mitsuoka N et al. | Cytokinic character of graft infiltrate versus peripheral blood lymphocytes during calcineurin inhibitor-resistant small bowel transplantation in rats. | 2003 | Transplant. Proc. | pmid:12591532 |
| Izuishi K et al. | Effect of an immunosuppressive agent, tacroliums (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems of rat liver microsomes. | 2003 | Transplant. Proc. | pmid:12591538 |
| Furukawa T et al. | Small bowel allografts maintained by administration of bombesin while under immunosuppression. | 2003 | J. Pediatr. Surg. | pmid:12592625 |
| Zhang X et al. | Graft expression of p38 and tumor necrosis factor-alpha in heart transplantation in rats. | 2002 | Prog Transplant | pmid:12593072 |
| Golli L et al. | [Mucosa-associated lyphoid tissue hepatic lymphoma with low-grade malignancy associated with primary biliary cirrhosis]. | 2003 | Gastroenterol. Clin. Biol. | pmid:12594380 |
| Kondo E et al. | NF-ATc2 induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor. | 2003 | Eur. J. Immunol. | pmid:12594826 |
| van den Ham EC et al. | The influence of early steroid withdrawal on body composition and bone mineral density in renal transplantation patients. | 2003 | Transpl. Int. | pmid:12595969 |