tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Armenti VT et al. | Breastfeeding and tacrolimus: is it a reasonable approach? | 2013 | Expert Rev Clin Immunol | pmid:23899232 |
| Gómez-Bravo MA et al. | Impact of donor and recipient CYP3A5 and ABCB1 genetic polymorphisms on tacrolimus dosage requirements and rejection in Caucasian Spanish liver transplant patients. | 2013 | J Clin Pharmacol | pmid:23900887 |
| Nakatani K | [Personalized medicine in transplantation therapy]. | 2013 | Rinsho Byori | pmid:23947183 |
| Vassal O et al. | [Bacterial parotitis in an immunocompromised patient in adult ICU]. | 2013 | Ann Fr Anesth Reanim | pmid:23948025 |
| Neto P et al. | De novo tacrolimus- associated hemolytic uremic syndrome after renal transplantation - case report. | 2013 | Nefrologia | pmid:23364650 |
| Yoshikawa Y et al. | [Pre-evening meal administration of tacrolimus improved refractory ocular symptoms in two young children with latent general myasthenia gravis]. | 2013 | No To Hattatsu | pmid:23951946 |
| Preidl RH et al. | Clopidogrel reduces post-transplant obliterative bronchiolitis. | 2013 | Transpl. Int. | pmid:23952051 |
| Rabie R et al. | Efficacy of antiviral therapy for hepatitis C after liver transplantation with cyclosporine and tacrolimus: a systematic review and meta-analysis. | 2013 | Liver Transpl. | pmid:22821730 |
| Mignogna MD et al. | Clinical behaviour and long-term therapeutic response in orofacial granulomatosis patients treated with intralesional triamcinolone acetonide injections alone or in combination with topical pimecrolimus 1%. | 2013 | J. Oral Pathol. Med. | pmid:22784292 |
| Nonaka K et al. | Intractable membranous lupus nephritis showing selective improvement of subepithelial deposits with tacrolimus therapy: a case report. | 2013 | Clin. Nephrol. | pmid:22541676 |
| Nobuoka Y et al. | Immune response following liver transplantation compared to kidney transplantation: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity and cytochrome P450 3A5 genotype assay. | 2013 | Clin. Dev. Immunol. | pmid:24454479 |
| Akelma AZ et al. | A diagnostic dilemma: inflammatory linear verrucous epidermal nevus versus linear psoriasis. | 2013 | J. Pediatr. | pmid:23149170 |
| Lemaitre F et al. | Monitoring of tacrolimus concentrations in peripheral blood mononuclear cells: application to cardiac transplant recipients. | 2013 | Clin. Biochem. | pmid:23454394 |
| Park JH et al. | The effectiveness of early treatment in segmental vitiligo: retrospective study according to disease duration. | 2013 | Photodermatol Photoimmunol Photomed | pmid:23458396 |
| Zuo XC et al. | Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: a population pharmacokinetic analysis. | 2013 | Pharmacogenet. Genomics | pmid:23459029 |
| Boivin AA et al. | Influence of SLCO1B3 genetic variations on tacrolimus pharmacokinetics in renal transplant recipients. | 2013 | Drug Metab. Pharmacokinet. | pmid:23149872 |
| van den Hoogen MW et al. | Effect of a single intraoperative high-dose ATG-Fresenius on delayed graft function in donation after cardiac-death donor renal allograft recipients: a randomized study. | 2013 | Exp Clin Transplant | pmid:23431996 |
| Brown RS et al. | Topical tacrolimus with custom trays in the treatment of severe oral chronic graft-versus-host disease refractory to a potent topical steroid therapy: a case report. | 2013 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:23102802 |
| van den Hoogen MW et al. | Insulin requirement after a renal transplant in patients with type 2 diabetes: the choice of calcineurin inhibitors. | 2013 | Exp Clin Transplant | pmid:23432070 |
| Westland T et al. | Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? | 2013 | J Eur Acad Dermatol Venereol | pmid:23106347 |
| Du J et al. | Long-term efficacy and safety of tacrolimus ointment in the treatment of vitiligo. | 2013 | J. Dermatol. | pmid:24111918 |
| Pan F et al. | [Protective effect of tacrolimus postconditioning on oxidative stress injury provoked by spinal cord ischemia-reperfusion in rats]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:24548402 |
| Verma S et al. | Preradial myxedema in a euthyroid male: A distinct rarity. | 2013 | Dermatol. Online J. | pmid:24021369 |
| Yosipovitch G et al. | A comparative study of clinical characteristics, work-up, treatment, and association to malignancy in dermatomyositis between two tertiary skin centers in the USA and Singapore. | 2013 | Int. J. Dermatol. | pmid:22835263 |
| Hirsch HH et al. | Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study. | 2013 | Am. J. Transplant. | pmid:23137180 |
| Uchino M et al. | Topical tacrolimus therapy for antibiotic-refractory pouchitis. | 2013 | Dis. Colon Rectum | pmid:24022534 |
| Lamoth F et al. | In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains. | 2013 | Antimicrob. Agents Chemother. | pmid:23165466 |
| de Jonge H et al. | Impact of CYP3A5 genotype on tacrolimus versus midazolam clearance in renal transplant recipients: new insights in CYP3A5-mediated drug metabolism. | 2013 | Pharmacogenomics | pmid:24024898 |
| Gijsen VM et al. | CYP3A4*22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients. | 2013 | Pharmacogenomics | pmid:23837477 |
| Mesar I et al. | Rescue therapy with sirolimus in a renal transplant recipient with tacrolimus-induced hepatotoxicity. | 2013 | Ren Fail | pmid:24028307 |
| Zhu Q et al. | Pluronic F127-modified liposome-containing tacrolimus-cyclodextrin inclusion complexes: improved solubility, cellular uptake and intestinal penetration. | 2013 | J. Pharm. Pharmacol. | pmid:23837579 |
| Shihab FS et al. | Effect of corticosteroid withdrawal on tacrolimus and mycophenolate mofetil exposure in a randomized multicenter study. | 2013 | Am. J. Transplant. | pmid:23167508 |
| Dong QE et al. | [Inhibitory effects of tacrolimus on effector T cells from patients with severe aplastic anemia]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:24028719 |
| Augusto JF et al. | Long-term maintenance immunosuppressive regimen with tacrolimus monotherapy. | 2013 | Ann. Transplant. | pmid:23872516 |
| Rojas LE et al. | Meta-analysis and systematic review of the effect of the donor and recipient CYP3A5 6986A>G genotype on tacrolimus dose requirements in liver transplantation. | 2013 | Pharmacogenet. Genomics | pmid:23873120 |
| Bourdeaux C et al. | Prope tolerance after pediatric liver transplantation. | 2013 | Pediatr Transplant | pmid:23171043 |
| Jones AC et al. | Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster. | 2013 | PLoS ONE | pmid:23874942 |
| Prucha H et al. | Pimecrolimus, a topical calcineurin inhibitor used in the treatment of atopic eczema. | 2013 | Expert Opin Drug Metab Toxicol | pmid:23876065 |
| Kim CH et al. | 850nm light-emitting-diode phototherapy plus low-dose tacrolimus (FK-506) as combination therapy in the treatment of Dermatophagoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice. | 2013 | J. Dermatol. Sci. | pmid:23810774 |
| Sapoznikov D et al. | Heart rate response to blood pressure variations: sympathetic activation versus baroreflex response in patients with end-stage renal disease. | 2013 | PLoS ONE | pmid:24124623 |
| Rickels MR et al. | Improvement in insulin sensitivity after human islet transplantation for type 1 diabetes. | 2013 | J. Clin. Endocrinol. Metab. | pmid:24085506 |
| Renner B et al. | Cyclosporine induces endothelial cell release of complement-activating microparticles. | 2013 | J. Am. Soc. Nephrol. | pmid:24092930 |
| RodrÃguez-Perálvarez M et al. | Early tacrolimus exposure after liver transplantation: relationship with moderate/severe acute rejection and long-term outcome. | 2013 | J. Hepatol. | pmid:23023010 |
| Tadano T et al. | [A case of calcineurin-inhibitor induced pain syndrome associated with tacrolimus therapy for ulcerative colitis]. | 2013 | Nihon Shokakibyo Gakkai Zasshi | pmid:24097149 |
| Faralli JA et al. | Dexamethasone increases αvβ3 integrin expression and affinity through a calcineurin/NFAT pathway. | 2013 | Biochim. Biophys. Acta | pmid:24100160 |
| Michel S et al. | Renal recovery after conversion to an everolimus-based immunosuppression in early and late heart transplant recipients: a 12-month analysis. | 2013 | Exp Clin Transplant | pmid:24128136 |
| Ciftci HS et al. | Effect of MDR1 polymorphisms on the blood concentrations of tacrolimus in Turkish renal transplant patients. | 2013 | Transplant. Proc. | pmid:23622581 |
| Kim Y et al. | Patients with persistent new-onset diabetes after transplantation have greater weight gain after kidney transplantation. | 2013 | J. Korean Med. Sci. | pmid:24133345 |
| Cotovio P et al. | New-onset diabetes after transplantation: assessment of risk factors and clinical outcomes. | 2013 | Transplant. Proc. | pmid:23622631 |
| Valente G et al. | Conversion from twice-daily to once-daily tacrolimus in stable liver transplant patients: effectiveness in a real-world setting. | 2013 | Transplant. Proc. | pmid:23622676 |
| Landy J et al. | Oral tacrolimus as maintenance therapy for refractory ulcerative colitis--an analysis of outcomes in two London tertiary centres. | 2013 | J Crohns Colitis | pmid:23623737 |
| Vichyanond P and Kosrirukvongs P | Use of cyclosporine A and tacrolimus in treatment of vernal keratoconjunctivitis. | 2013 | Curr Allergy Asthma Rep | pmid:23625179 |
| Wang Y et al. | Micelles of methoxy poly(ethylene glycol)-poly(epsilon-caprolactone) as a novel drug delivery vehicle for tacrolimus. | 2013 | J Biomed Nanotechnol | pmid:23627041 |
| Elens L et al. | Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus. | 2013 | Pharmacogenet. Genomics | pmid:24113216 |
| Magalhaes OA et al. | Topical 0.03% tacrolimus preventing rejection in high-risk corneal transplantation: a cohort study. | 2013 | Br J Ophthalmol | pmid:24008822 |
| Axelsson J et al. | Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability. | 2013 | Am. J. Physiol. Renal Physiol. | pmid:23657856 |
| Hung TC et al. | Investigation of SSEA-4 binding protein in breast cancer cells. | 2013 | J. Am. Chem. Soc. | pmid:23574147 |
| Quaglia M et al. | Severe acute nephrotoxicity in a kidney transplant patient despite low tacrolimus levels: a possible interaction between donor and recipient genetic polymorphisms. | 2013 | J Clin Pharm Ther | pmid:23574377 |
| Wang R et al. | Systemic lupus erythematosus associated with Moyamoya syndrome: a case report and literature review. | 2013 | Lupus | pmid:23574743 |
| Karapetyan YE et al. | Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23576755 |
| Miyoshi J et al. | Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients. | 2013 | J Crohns Colitis | pmid:23680174 |
| Selden NR et al. | Central nervous system stem cell transplantation for children with neuronal ceroid lipofuscinosis. | 2013 | J Neurosurg Pediatr | pmid:23581634 |
| Xia M et al. | Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis. | 2013 | Biotechnol. Bioeng. | pmid:23682004 |
| Hill JA et al. | Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations. | 2013 | PLoS Genet. | pmid:23593013 |
| Lee Sr et al. | Angiotensinogen polymorphisms and post-transplantation diabetes mellitus in Korean renal transplant subjects. | 2013 | Kidney Blood Press. Res. | pmid:23594830 |
| Israni AK et al. | Tacrolimus trough levels after month 3 as a predictor of acute rejection following kidney transplantation: a lesson learned from DeKAF Genomics. | 2013 | Transpl. Int. | pmid:23879408 |
| Cristelli MP et al. | Safety profile comparing azathioprine and mycophenolate in kidney transplant recipients receiving tacrolimus and corticosteroids. | 2013 | Transpl Infect Dis | pmid:23701592 |
| Casanova JR et al. | Rapid hippocampal network adaptation to recurring synchronous activity--a role for calcineurin. | 2013 | Eur. J. Neurosci. | pmid:23879713 |
| Siegfried EC et al. | Topical calcineurin inhibitors and lymphoma risk: evidence update with implications for daily practice. | 2013 | Am J Clin Dermatol | pmid:23703374 |
| Huang D et al. | Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement. | 2013 | Microb. Cell Fact. | pmid:23705993 |
| Ban YH et al. | Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration. | 2013 | J. Nat. Prod. | pmid:23706030 |
| Pamuk F et al. | Effects of tacrolimus and nifedipine, alone or in combination, on gingival tissues. | 2013 | J. Periodontol. | pmid:23289868 |
| Eguchi R et al. | FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway. | 2013 | Cell. Signal. | pmid:23707520 |
| Fitzgerald RT et al. | Isolated leptomeningeal enhancement in tacrolimus-associated posterior reversible encephalopathy syndrome. | 2013 | Pediatr. Neurol. | pmid:23290027 |
| van Maarseveen EM et al. | Pretransplantation pharmacokinetic curves of tacrolimus in HIV-infected patients on ritonavir-containing cART: a pilot study. | 2013 | Transplantation | pmid:23250333 |
| Han N et al. | Prediction of the tacrolimus population pharmacokinetic parameters according to CYP3A5 genotype and clinical factors using NONMEM in adult kidney transplant recipients. | 2013 | Eur. J. Clin. Pharmacol. | pmid:22660440 |
| Oteo I et al. | Tacrolimus pharmacokinetics in the early post-liver transplantation period and clinical applicability via Bayesian prediction. | 2013 | Eur. J. Clin. Pharmacol. | pmid:22660442 |
| Valdivieso N et al. | Tacrolimus dose individualization in "de novo" patients after 10 years of experience in liver transplantation: pharmacokinetic considerations and patient pathophysiology. | 2013 | Int J Clin Pharmacol Ther | pmid:23735178 |
| Zhou X et al. | A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe. | 2013 | PLoS ONE | pmid:23738021 |
| Bashratyan R et al. | Insulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice. | 2013 | Eur. J. Immunol. | pmid:23817982 |
| Hebert MF et al. | Interpreting tacrolimus concentrations during pregnancy and postpartum. | 2013 | Transplantation | pmid:23274970 |
| Chitnis SD et al. | Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. | 2013 | Xenobiotica | pmid:23278282 |
| Bunnapradist S et al. | Conversion from twice-daily tacrolimus to once-daily extended release tacrolimus (LCPT): the phase III randomized MELT trial. | 2013 | Am. J. Transplant. | pmid:23279614 |
| Zlatic SA et al. | Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis. | 2013 | Mol. Biol. Cell | pmid:23761069 |
| Ceschi A et al. | Acute calcineurin inhibitor overdose: analysis of cases reported to a national poison center between 1995 and 2011. | 2013 | Am. J. Transplant. | pmid:23279718 |
| Yin H et al. | Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin. | 2013 | PLoS ONE | pmid:23762423 |
| Böer TM et al. | Correlation of thermal analysis and pyrolysis coupled to GC-MS in the characterization of tacrolimus. | 2013 | J Pharm Biomed Anal | pmid:22361660 |
| López E et al. | FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells. | 2013 | Biochim. Biophys. Acta | pmid:23228564 |
| Tie X et al. | NFAT1 is highly expressed in, and regulates the invasion of, glioblastoma multiforme cells. | 2013 | PLoS ONE | pmid:23762456 |
| Bootun R | Effects of immunosuppressive therapy on wound healing. | 2013 | Int Wound J | pmid:22364410 |
| Fujita Y et al. | Analysis of cytochrome P450 gene polymorphism in a lupus nephritis patient in whom tacrolimus blood concentration was markedly elevated after administration of azole antifungal agents. | 2013 | J Clin Pharm Ther | pmid:22971159 |
| Sharma P and Barman P | Everolimus for liver transplant recipients: is it ready for prime time? | 2013 | Gastroenterology | pmid:23260492 |
| Sofue T et al. | Excess fluid distribution affects tacrolimus absorption in peritoneal dialysis patients. | 2013 | Clin. Exp. Nephrol. | pmid:23269423 |
| Inoue T et al. | The efficacy of oral tacrolimus in patients with moderate/severe ulcerative colitis not receiving concomitant corticosteroid therapy. | 2013 | Intern. Med. | pmid:23291669 |
| Tanaka Y et al. | [Effect of tacrolimus on the pharmacokinetics and glucuronidation of SN-38, an active metabolite of irinotecan]. | 2013 | Yakugaku Zasshi | pmid:23328499 |
| Wong R and Lin AN | Efficacy of topical calcineurin inhibitors in vitiligo. | 2013 | Int. J. Dermatol. | pmid:23331250 |
| Loar RW et al. | Posterior reversible encephalopathy syndrome and hemorrhage associated with tacrolimus in a pediatric heart transplantation recipient. | 2013 | Pediatr Transplant | pmid:23331314 |
| Mori T et al. | Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus. | 2013 | Brain Dev. | pmid:22840813 |
| Barbas AS et al. | Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation. | 2013 | Am. J. Transplant. | pmid:23331705 |
| Rice SA et al. | Topical tacrolimus 0.1% ointment for treatment of cutaneous Crohn's Disease. | 2013 | BMC Res Notes | pmid:23331739 |