tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Haagsma EB et al. | Inflammatory bowel disease after liver transplantation: the effect of different immunosuppressive regimens. | 2003 | Aliment. Pharmacol. Ther. | pmid:12848624 |
| Weinberg JM et al. | Atopic dermatitis: a new treatment paradigm using pimecrolimus. | 2003 | J Drugs Dermatol | pmid:12852364 |
| Kalia N et al. | Mucosal villus microcirculatory disturbances associated with rat intestinal ischaemia-reperfusion injury are not prevented by tacrolimus. | 2003 | Digestion | pmid:12853727 |
| Tocci MJ and Sigal NH | Recent advances in the mechanism of action of cyclosporine and FK506. | 1992 | Curr. Opin. Nephrol. Hypertens. | pmid:1285380 |
| Bavandi A et al. | Diet-induced dermatitis response of hairless rats to systemic treatment with cyclosporin A (Sandimmun), cyclosporin H and FK506. | 1992 | Exp. Dermatol. | pmid:1285411 |
| High KP and Handschumacher RE | Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks? | 1992 | Infect Agents Dis | pmid:1285413 |
| Mijal J et al. | Formation of synapses between dendritic cells and lymphocytes in skin lymph in an allogeneic reaction. | 2002 | Ann. Transplant. | pmid:12854345 |
| Kyles AE et al. | Pharmacokinetics of tacrolimus after multidose oral administration and efficacy in the prevention of allograft rejection in cats with renal transplants. | 2003 | Am. J. Vet. Res. | pmid:12856780 |
| Cosio FG and Larson TS | Cardiovascular disease after transplantation: do we know all of the variables? | 2003 | Am. J. Transplant. | pmid:12859523 |
| Krämer BK et al. | Cardiovascular risk factors and estimated risk for CAD in a randomized trial comparing calcineurin inhibitors in renal transplantation. | 2003 | Am. J. Transplant. | pmid:12859533 |
| Ciancio G et al. | The use of daclizumab, tacrolimus and mycophenolate mofetil in african-american and Hispanic first renal transplant recipients. | 2003 | Am. J. Transplant. | pmid:12859538 |
| Bunnapradist S et al. | Graft survival following living-donor renal transplantation: a comparison of tacrolimus and cyclosporine microemulsion with mycophenolate mofetil and steroids. | 2003 | Transplantation | pmid:12865780 |
| Pfitzmann R et al. | Mycophenolatemofetil for immunosuppression after liver transplantation: a follow-up study of 191 patients. | 2003 | Transplantation | pmid:12865798 |
| Katsura K et al. | Effects of FK506 on the translocation of protein kinase C and CaM kinase II in the gerbil hippocampal CA1 neurons. | 2003 | Neurol. Res. | pmid:12866202 |
| Matsuda S and Koyasu S | Regulation of MAPK signaling pathways through immunophilin-ligand complex. | 2003 | Curr Top Med Chem | pmid:12871167 |
| Gold BG and Villafranca JE | Neuroimmunophilin ligands: the development of novel neuroregenerative/ neuroprotective compounds. | 2003 | Curr Top Med Chem | pmid:12871168 |
| Avramut M and Achim CL | Immunophilins in nervous system degeneration and regeneration. | 2003 | Curr Top Med Chem | pmid:12871169 |
| Arya M et al. | Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. | 2003 | J. Thromb. Haemost. | pmid:12871313 |
| Muramoto M et al. | Detailed in vitro pharmacological analysis of FK506-induced neuroprotection. | 2003 | Neuropharmacology | pmid:12871656 |
| Lan CC et al. | Tacrolimus ointment for the treatment of atopic dermatitis: report of first clinical experience in Taiwan. | 2003 | Kaohsiung J. Med. Sci. | pmid:12873038 |
| Cantin B et al. | Post-operative conversion from cyclosporine to tacrolimus in heart transplantation: a single-center experience. | 2003 | J. Heart Lung Transplant. | pmid:12873539 |
| Kunstfeld R et al. | Successful treatment of vulvar lichen sclerosus with topical tacrolimus. | 2003 | Arch Dermatol | pmid:12873877 |
| Böhm M et al. | Successful treatment of anogenital lichen sclerosus with topical tacrolimus. | 2003 | Arch Dermatol | pmid:12873890 |
| Mignen O et al. | Calcineurin directs the reciprocal regulation of calcium entry pathways in nonexcitable cells. | 2003 | J. Biol. Chem. | pmid:12874277 |
| Kiemeneij IM et al. | Acute headache as a presenting symptom of tacrolimus encephalopathy. | 2003 | J. Neurol. Neurosurg. Psychiatr. | pmid:12876250 |
| Balogh A et al. | Can xipamide or tacrolimus inhibit the glucuronidation of mycophenolic acid in rat liver slices? | 2003 | Exp. Toxicol. Pathol. | pmid:12877348 |
| Lupp A et al. | Cyclosporine A and tacrolimus: in vitro investigations on the differential interactions with the cytochrome P450 system in rat and human liver. | 2003 | Exp. Toxicol. Pathol. | pmid:12877359 |
| Ciecierski R and Paczek L | [Regulatory mechanisms and the influence of immunosuppressive drugs on liver regeneration after partial hepatectomy]. | 2003 | Pol. Arch. Med. Wewn. | pmid:12879782 |
| Nakazato T et al. | Reversible posterior leukoencephalopathy syndrome associated with tacrolimus therapy. | 2003 | Intern. Med. | pmid:12879959 |
| Butani L et al. | Amelioration of tacrolimus-induced nephrotoxicity in rats using juniper oil. | 2003 | Transplantation | pmid:12883183 |
| Schmidt LE et al. | Relationship between postoperative erythromycin breath test and early morbidity in liver transplant recipients. | 2003 | Transplantation | pmid:12883193 |
| Troppmann C et al. | Higher surgical wound complication rates with sirolimus immunosuppression after kidney transplantation: a matched-pair pilot study. | 2003 | Transplantation | pmid:12883205 |
| Therapondos G et al. | Cardiac hypertrophy in liver transplant recipients: tacrolimus, cyclosporine or both? | 2003 | Transplantation | pmid:12883220 |
| Ogunseinde BA et al. | A case of tacrolimus (FK506)-induced pancreatitis and fatality 2 years postcadaveric renal transplant. | 2003 | Transplantation | pmid:12883222 |
| Kuypers DR et al. | Long-term pharmacokinetic study of the novel combination of tacrolimus and sirolimus in de novo renal allograft recipients. | 2003 | Ther Drug Monit | pmid:12883227 |
| Cervelli MJ and Russ GR | Itraconazole-tacrolimus drug interaction. | 2003 | Ther Drug Monit | pmid:12883234 |
| Rao NG and Pariser RJ | Annular erythema responding to tacrolimus ointment. | 2003 | J Drugs Dermatol | pmid:12884468 |
| Tanabe K | Calcineurin inhibitors in renal transplantation: what is the best option? | 2003 | Drugs | pmid:12887261 |
| Santos JB and Schauwecker PE | Protection provided by cyclosporin A against excitotoxic neuronal death is genotype dependent. | 2003 | Epilepsia | pmid:12887430 |
| Ciardella AP et al. | Cytomegalovirus retinitis and FK 506. | 2003 | Am. J. Ophthalmol. | pmid:12888078 |
| Al-Uzri A et al. | Anemia in children after transplantation: etiology and the effect of immunosuppressive therapy on erythropoiesis. | 2003 | Pediatr Transplant | pmid:12890002 |
| Bens G et al. | Topical treatment of Netherton's syndrome with tacrolimus ointment without significant systemic absorption. | 2003 | Br. J. Dermatol. | pmid:12890237 |
| Sandborn WJ et al. | Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial. | 2003 | Gastroenterology | pmid:12891539 |
| Crenesse D et al. | Rat liver ischemia-reperfusion-induced apoptosis and necrosis are decreased by FK506 pretreatment. | 2003 | Eur. J. Pharmacol. | pmid:12892836 |
| Coelho FF et al. | Use of tacrolimus in rescue therapy of acute and chronic rejection in liver transplantation. | 2003 May-Jun | Rev Hosp Clin Fac Med Sao Paulo | pmid:12894310 |
| Renders L et al. | Tacrolimus and cerivastatin pharmacokinetics and adverse effects after single and multiple dosing with cerivastatin in renal transplant recipients. | 2003 | Br J Clin Pharmacol | pmid:12895195 |
| Yang FC et al. | [Influence of combined cyclosporine A and tacrolimus with 5-fluorouracil on hepatocellular carcinoma rats]. | 2003 | Zhonghua Wai Ke Za Zhi | pmid:12895356 |
| Stammberger U et al. | Strong additive effect of 1,25-dihydroxycholecalciferol and cyclosporine A but not tacrolimus in rat lung allotransplantation. | 2003 | Eur J Cardiothorac Surg | pmid:12895607 |
| Vallet-Pichard A et al. | Veno-occlusive disease of the liver in renal transplant patients. | 2003 | Nephrol. Dial. Transplant. | pmid:12897112 |
| Nelson M et al. | Tacrolimus and mycophenolate mofetil provide effective immunosuppression in rat laryngeal transplantation. | 2003 | Laryngoscope | pmid:12897551 |
| Verma PS and Gallagher CM | Dyspnea on exertion, fatigue, and pallor in a 50-year-old active duty soldier. | 2003 | Mil Med | pmid:12901473 |
| Vennarecci G et al. | [Acute liver toxicity of antiretroviral therapy (HAART) after liver transplantation in a patient with HIV-HCV coinfection and associated hepatocarcinoma (HCC)]. | 2003 Jul-Aug | Tumori | pmid:12903579 |
| Udina E et al. | Comparative dose-dependence study of FK506 on transected mouse sciatic nerve repaired by allograft or xenograft. | 2003 | J. Peripher. Nerv. Syst. | pmid:12904235 |
| Perez-Abadia G et al. | Low-dose immunosuppression in a rat hind-limb transplantation model. | 2003 | Transpl. Int. | pmid:12904844 |
| Brook NR et al. | Fibrosis-associated gene expression in renal transplant glomeruli after acute renal allograft rejection. | 2003 | Br J Surg | pmid:12905557 |
| Tuñón MJ et al. | Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes. | 2003 | Biochem. Pharmacol. | pmid:12907243 |
| Meykadeh N and Hengge UR | [Topical immunomodulators in dermatology]. | 2003 | Hautarzt | pmid:12908453 |
| Verleden GM et al. | Effect of switching from cyclosporine to tacrolimus on exhaled nitric oxide and pulmonary function in patients with chronic rejection after lung transplantation. | 2003 | J. Heart Lung Transplant. | pmid:12909472 |
| Pandher BS et al. | Treatment of balanitis xerotica obliterans with topical tacrolimus. | 2003 | J. Urol. | pmid:12913735 |
| Koprak S et al. | Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin. | 2003 | Cell. Immunol. | pmid:12914753 |
| Artik S and Ruzicka T | Complementary therapy for atopic eczema and other allergic skin diseases. | 2003 | Dermatol Ther | pmid:12919117 |
| Hesselink DA et al. | Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroids. | 2003 | Br J Clin Pharmacol | pmid:12919182 |
| Lübbe J et al. | Rosaceiform dermatitis with follicular Demodex after treatment of facial atopic dermatitis with 1% pimecrolimus cream. | 2003 | Dermatology (Basel) | pmid:12920379 |
| Cherikh WS et al. | A comparison of discharge immunosuppressive drug regimens in primary cadaveric kidney transplantation. | 2003 | Transplantation | pmid:12923430 |
| Zieliński A et al. | Simultaneous pancreas-kidney transplant from living related donor: a single-center experience. | 2003 | Transplantation | pmid:12923442 |
| Erickson LM et al. | Microarray-based gene expression profiles of allograft rejection and immunosuppression in the rat heart transplantation model. | 2003 | Transplantation | pmid:12923448 |
| Maluccio M et al. | Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression. | 2003 | Transplantation | pmid:12923450 |
| Pascher A et al. | Successful infliximab treatment of steroid and OKT3 refractory acute cellular rejection in two patients after intestinal transplantation. | 2003 | Transplantation | pmid:12923454 |
| Tischmeyer W et al. | Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory. | 2003 | Eur. J. Neurosci. | pmid:12925020 |
| Hall VC et al. | Ocular mucous membrane pemphigoid and ocular pemphigus vulgaris treated topically with tacrolimus ointment. | 2003 | Arch Dermatol | pmid:12925404 |
| Luchowska E et al. | FK506 attenuates 1-methyl-4-phenylpyridinium- and 3-nitropropionic acid-evoked inhibition of kynurenic acid synthesis in rat cortical slices. | 2003 | Acta Neurobiol Exp (Wars) | pmid:12926536 |
| Masuda K et al. | Increased levels of serum interleukin-16 in adult type atopic dermatitis. | 2003 | Acta Derm. Venereol. | pmid:12926794 |
| Yamamoto T and Nishioka K | Deep dermatophytosis during topical tacrolimus therapy for psoriasis. | 2003 | Acta Derm. Venereol. | pmid:12926803 |
| Sand C | Topical tacrolimus ointment may induce skin tags in treated patients. | 2003 | Acta Derm. Venereol. | pmid:12926817 |
| Brecht S et al. | Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain. | 2003 | Neuroscience | pmid:12927209 |
| Kalthoff FS et al. | Pimecrolimus does not affect the differentiation, maturation and function of human monocyte-derived dendritic cells, in contrast to corticosteroids. | 2003 | Clin. Exp. Immunol. | pmid:12930360 |
| Clayton TH et al. | Topical tacrolimus for facial psoriasis. | 2003 | Br. J. Dermatol. | pmid:12932257 |
| Madhavan R et al. | The involvement of calcineurin in acetylcholine receptor redistribution in muscle. | 2003 | Mol. Cell. Neurosci. | pmid:12932439 |
| Kinoshita T et al. | Diffusion-weighted MR imaging of posterior reversible leukoencephalopathy syndrome: a pictorial essay. | 2003 Sep-Oct | Clin Imaging | pmid:12932680 |
| Gebert B et al. | Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. | 2003 | Science | pmid:12934009 |
| Gomez-Cambronero J | Rapamycin inhibits GM-CSF-induced neutrophil migration. | 2003 | FEBS Lett. | pmid:12935893 |
| Mootz HD et al. | Conditional protein splicing: a new tool to control protein structure and function in vitro and in vivo. | 2003 | J. Am. Chem. Soc. | pmid:12940738 |
| Högenauer C et al. | Effect of oral tacrolimus (FK 506) on steroid-refractory moderate/severe ulcerative colitis. | 2003 | Aliment. Pharmacol. Ther. | pmid:12940927 |
| Gupta AK and Chow M | Pimecrolimus: a review. | 2003 | J Eur Acad Dermatol Venereol | pmid:12941081 |
| Yoshida Y et al. | FK506-associated limbic injury following umbilical cord blood transplantation. | 2003 | Bone Marrow Transplant. | pmid:12942100 |
| Hamawy MM | Molecular actions of calcineurin inhibitors. | 2003 | Drug News Perspect. | pmid:12942158 |
| Jain AB et al. | Effect of coadministered lopinavir and ritonavir (Kaletra) on tacrolimus blood concentration in liver transplantation patients. | 2003 | Liver Transpl. | pmid:12942457 |
| Frühauf NR et al. | Late onset of tacrolimus-related posterior leukoencephalopathy after living donor liver transplantation. | 2003 | Liver Transpl. | pmid:12942462 |
| Shainhouse T and Eichenfield LF | Long-term safety of tacrolimus ointment in children treated for atopic dermatitis. | 2003 | Expert Opin Drug Saf | pmid:12946246 |
| Croxtall JD et al. | Differential modulation of glucocorticoid action by FK506 in A549 cells. | 2003 | Biochem. J. | pmid:12948397 |
| Ruzicka T et al. | Potential future dermatological indications for tacrolimus ointment. | 2003 Jul-Aug | Eur J Dermatol | pmid:12948911 |
| Yang W et al. | Regulation of gene expression by synthetic dimerizers with novel specificity. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12951089 |
| Brownell I et al. | Topical pimecrolimus in the treatment of seborrheic dermatitis. | 2003 | Dermatol. Online J. | pmid:12952760 |
| Alphey MS et al. | The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active site. | 2003 | J. Biol. Chem. | pmid:12952945 |
| Meyrier A | Treatment of idiopathic nephrosis by immunophillin modulation. | 2003 | Nephrol. Dial. Transplant. | pmid:12953048 |
| Tada H et al. | Chronopharmacokinetics of tacrolimus in kidney transplant recipients: occurrence of acute rejection. | 2003 | J Clin Pharmacol | pmid:12953343 |
| Kuypers DR et al. | Long-term changes in mycophenolic acid exposure in combination with tacrolimus and corticosteroids are dose dependent and not reflected by trough plasma concentration: a prospective study in 100 de novo renal allograft recipients. | 2003 | J Clin Pharmacol | pmid:12953344 |
| Pabby A et al. | Combination therapy of tetracycline and tacrolimus resulting in rapid resolution of steroid-induced periocular rosacea. | 2003 | Cutis | pmid:12953939 |
| Torok HM et al. | Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis. | 2003 | Cutis | pmid:12953943 |
| Patel N et al. | The use of oral tacrolimus in a case of short bowel syndrome. | 2004 | Transpl. Int. | pmid:12955349 |