tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gökceoğlu AU et al. | Circulating endothelial cells in pediatric renal transplant recipients. | 2013 | Pediatr. Nephrol. | pmid:24018796 |
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| Carcas-Sansuán AJ et al. | Conversion from Prograf to Advagraf in adolescents with stable liver transplants: comparative pharmacokinetics and 1-year follow-up. | 2013 | Liver Transpl. | pmid:23894093 |
| Howell J et al. | Cyclosporine and tacrolimus have inhibitory effects on toll-like receptor signaling after liver transplantation. | 2013 | Liver Transpl. | pmid:23894100 |
| Zhang CW et al. | [Establishment of a real-time PCR assay for simultaneously detecting human BKV and CMV DNA and its application in renal transplantation recipients]. | 2013 | Bing Du Xue Bao | pmid:23895006 |
| Cardona M et al. | [Association of everolimus with tacrolimus during the first year after heart transplantation: initial experience]. | 2013 | Med Clin (Barc) | pmid:23384432 |
| Gray FL et al. | Predictive value of the Pediatric Ulcerative Colitis Activity Index in the surgical management of ulcerative colitis. | 2013 | J. Pediatr. Surg. | pmid:23895969 |
| Yildirim R et al. | Treatment of pure red-cell aplasia with cyclosporine in a renal transplant patient. | 2013 | Exp Clin Transplant | pmid:22891934 |
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| Foroncewicz B et al. | A comparison between two tacrolimus-based immunosuppression regimens in renal transplant recipients: 7-year follow-up. | 2013 | Ann. Transplant. | pmid:23896824 |
| Danby SG and Cork MJ | The effects of pimecrolimus on the innate immune response in atopic dermatitis. | 2013 | Br. J. Dermatol. | pmid:23362967 |
| Yoon SH et al. | CYP3A and ABCB1 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of tacrolimus and its metabolites (M-I and M-III). | 2013 | Transplantation | pmid:23364483 |
| Yu JJ et al. | Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway. | 2013 | Psychopharmacology (Berl.) | pmid:22875481 |
| Rosado-Rubio C et al. | Delayed introduction of tacrolimus in sub-optimal kidneys. A short-term follow-up study in the University Hospital of Salamanca. | 2013 | Nefrologia | pmid:23364645 |
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| Yuda S et al. | [Sodium-losing nephropathy caused by tacrolimus after allogeneic hematopoietic stem cell transplantation]. | 2013 | Rinsho Ketsueki | pmid:24452151 |
| Nakane S | [Calcineurin inhibitors and IVIg in the treatment of myasthenia gravis]. | 2013 | Rinsho Shinkeigaku | pmid:24291970 |
| Nobuoka Y et al. | Immune response following liver transplantation compared to kidney transplantation: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity and cytochrome P450 3A5 genotype assay. | 2013 | Clin. Dev. Immunol. | pmid:24454479 |
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| Kovacs D et al. | Follow up of lung transplant recipients using an electronic nose. | 2013 | J Breath Res | pmid:23445553 |
| Gijsen VM et al. | Prevalence of renal dysfunction in tacrolimus-treated pediatric transplant recipients: a systematic review. | 2013 | Pediatr Transplant | pmid:23448292 |
| Okamoto M et al. | Successful treatment with tacrolimus in a case of lung-dominant connective tissue disease. | 2013 | Intern. Med. | pmid:23448773 |
| Muili KA et al. | Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. | 2013 | J. Biol. Chem. | pmid:23148215 |
| Brzezińska B et al. | Factors associated with glucose metabolism disorders after kidney transplantation. | 2013 | Endokrynol Pol | pmid:23450443 |
| Akelma AZ et al. | A diagnostic dilemma: inflammatory linear verrucous epidermal nevus versus linear psoriasis. | 2013 | J. Pediatr. | pmid:23149170 |
| Lemaitre F et al. | Monitoring of tacrolimus concentrations in peripheral blood mononuclear cells: application to cardiac transplant recipients. | 2013 | Clin. Biochem. | pmid:23454394 |
| TruneÄka P | [Immunosuppression after liver transplant, now and in future]. | 2013 | Vnitr Lek | pmid:24007221 |
| Telkes G et al. | Kidney transplantation in hereditary coproporphyria using tacrolimus and mycophenolate mofetil: a case report. | 2013 | Transplant. Proc. | pmid:24315002 |
| Azzi JR et al. | Calcineurin inhibitors: 40 years later, can't live without ... | 2013 | J. Immunol. | pmid:24319282 |
| Praehauser C et al. | Risk factors and outcome of expanded-criteria donor kidney transplants in patients with low immunological risk. | 2013 | Swiss Med Wkly | pmid:24222631 |
| Matsuoka K and Hibi T | Treatment guidelines in inflammatory bowel disease: the Japanese perspectives. | 2013 | Dig Dis | pmid:24246989 |
| Kim CR and Lee DY | Combination of narrow-band ultraviolet B and topical tacrolimus is effective for segmental vitiligo. | 2013 | Int. J. Dermatol. | pmid:24073911 |
| Ali FR and Lyon CC | Tacrolimus toxicity following topical treatment of perianal Crohn's disease: an admonitory anecdote. | 2013 | J Crohns Colitis | pmid:24076430 |
| PalacÃn M et al. | FK506 affects mitochondrial protein synthesis and oxygen consumption in human cells. | 2013 | Cell Biol. Toxicol. | pmid:24077807 |
| Tsuchiya T et al. | Comparison of pharmacokinetics and pathology for low-dose tacrolimus once-daily and twice-daily in living kidney transplantation: prospective trial in once-daily versus twice-daily tacrolimus. | 2013 | Transplantation | pmid:23792649 |
| Hu AB et al. | Safety and efficacy of four steroid-minimization protocols in liver transplant recipients: 3-year follow-up in a single center. | 2013 | J Dig Dis | pmid:23134408 |
| Kosugi K et al. | A longitudinal study of the effect of experimental osteoporosis on bone trabecular structure in the rat mandibular condyle. | 2013 | Cranio | pmid:23795404 |
| Issa N et al. | Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence. | 2013 | Am. J. Nephrol. | pmid:23796509 |
| Durand P et al. | Tacrolimus dose requirement in pediatric liver transplantation: influence of CYP3A5 gene polymorphism. | 2013 | Pharmacogenomics | pmid:23837476 |
| Gijsen VM et al. | CYP3A4*22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients. | 2013 | Pharmacogenomics | pmid:23837477 |
| Honda A et al. | Omission of day-11 MTX, in combination with tacrolimus, is not associated with increased risk of acute graft-versus-host disease after allo-BMT. | 2013 | Bone Marrow Transplant. | pmid:22751000 |
| Pitarch G and Giner F | Periorbital necrobiosis lipoidica. | 2013 | Actas Dermosifiliogr | pmid:23871211 |
| Piram M et al. | Short- and long-term outcome of linear morphoea in children. | 2013 | Br. J. Dermatol. | pmid:24032480 |
| Mouzaki M et al. | Basiliximab with delayed introduction of calcineurin inhibitors as a renal-sparing protocol following liver transplantation in children with renal impairment. | 2013 | Pediatr Transplant | pmid:24118898 |
| Vannaprasaht S et al. | Personalized tacrolimus doses determined by CYP3A5 genotype for induction and maintenance phases of kidney transplantation. | 2013 | Clin Ther | pmid:24120259 |
| Hilbrands R et al. | Predictive factors of allosensitization after immunosuppressant withdrawal in recipients of long-term cultured islet cell grafts. | 2013 | Transplantation | pmid:23857001 |
| Zlotkowski K et al. | Small-molecule mechanism of action studies in Caenorhabditis elegans. | 2013 | Chembiochem | pmid:24123757 |
| Wang SE et al. | Hepatic veno-occlusive disease related to tacrolimus after pancreas transplantation. | 2013 | J Chin Med Assoc | pmid:23602212 |
| Sapoznikov D et al. | Heart rate response to blood pressure variations: sympathetic activation versus baroreflex response in patients with end-stage renal disease. | 2013 | PLoS ONE | pmid:24124623 |
| Fujii H et al. | Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. | 2013 | Cell Rep | pmid:23602566 |
| Hodge G et al. | Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome. | 2013 | Clin. Exp. Immunol. | pmid:23607447 |
| RodrÃguez-Perálvarez M et al. | Early tacrolimus exposure after liver transplantation: relationship with moderate/severe acute rejection and long-term outcome. | 2013 | J. Hepatol. | pmid:23023010 |
| Ben Fredj N et al. | Tacrolimus therapeutic drug monitoring in Tunisian renal transplant recipients: effect of post-transplantation period. | 2013 | Transpl. Immunol. | pmid:23608723 |
| Yin ZQ et al. | Effects of topical tacrolimus 0.03% on long-term suberythemal ultraviolet B-irradiated epidermal Langerhans cells in mice. | 2013 | J Eur Acad Dermatol Venereol | pmid:22471949 |
| De Bruyne R et al. | Post-transplant food allergy in children is associated with liver and not with renal transplantation: a monocentric comparative study. | 2013 | Eur. J. Pediatr. | pmid:23609525 |
| Ciftci HS et al. | Effect of MDR1 polymorphisms on the blood concentrations of tacrolimus in Turkish renal transplant patients. | 2013 | Transplant. Proc. | pmid:23622581 |
| Hammerstrom AE et al. | Tacrolimus-associated posterior reversible encephalopathy syndrome in hematopoietic allogeneic stem cell transplantation. | 2013 | Am. J. Hematol. | pmid:23460378 |
| Briem-Richter A et al. | Peripheral blood biomarkers for the characterization of alloimmune reactivity after pediatric liver transplantation. | 2013 | Pediatr Transplant | pmid:24164827 |
| Sheu JJ et al. | Innate immune response after acute myocardial infarction and pharmacomodulatory action of tacrolimus in reducing infarct size and preserving myocardial integrity. | 2013 | J. Biomed. Sci. | pmid:24165293 |
| McDiarmid SV | Adolescence: challenges and responses. | 2013 | Liver Transpl. | pmid:24166838 |
| Jensen JM et al. | Effects of pimecrolimus compared with triamcinolone acetonide cream on skin barrier structure in atopic dermatitis: a randomized, double-blind, right-left arm trial. | 2013 | Acta Derm. Venereol. | pmid:23571785 |
| Gorgan M et al. | Pulmonary hemorrhage with capillaritis secondary to mycophenolate mofetil in a heart-transplant patient. | 2013 | Arch. Pathol. Lab. Med. | pmid:24168511 |
| Vafadari R et al. | Tacrolimus inhibits NF-κB activation in peripheral human T cells. | 2013 | PLoS ONE | pmid:23573283 |
| Elens L et al. | Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus. | 2013 | Pharmacogenet. Genomics | pmid:24113216 |
| Dai Y et al. | Liposomes containing bile salts as novel ocular delivery systems for tacrolimus (FK506): in vitro characterization and improved corneal permeation. | 2013 | Int J Nanomedicine | pmid:23690687 |
| Sinha R and Marks SD | Tacrolimus toxicity secondary to diarrhoea in nephrotic syndrome. | 2013 | Acta Paediatr. | pmid:23573873 |
| Takada Y et al. | Randomized, multicenter trial comparing tacrolimus plus mycophenolate mofetil to tacrolimus plus steroids in hepatitis C virus-positive recipients of living donor liver transplantation. | 2013 | Liver Transpl. | pmid:23696054 |
| Hung TC et al. | Investigation of SSEA-4 binding protein in breast cancer cells. | 2013 | J. Am. Chem. Soc. | pmid:23574147 |
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| Trotter JF et al. | Early use of renal-sparing agents in liver transplantation: a closer look. | 2013 | Liver Transpl. | pmid:23696464 |
| Zheng S et al. | Tacrolimus placental transfer at delivery and neonatal exposure through breast milk. | 2013 | Br J Clin Pharmacol | pmid:23528073 |
| Ishii T et al. | Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506. | 2013 | FASEB J. | pmid:23241312 |
| Nwaba A et al. | Tacrolimus-induced thrombotic microangiopathy in orthotopic liver transplant patients: case series of four patients. | 2013 | Intern Med J | pmid:23441660 |
| Hofmann M et al. | Validation of Dermaphot(®) for the assessment of steroid-induced skin atrophy. | 2013 | Arch. Dermatol. Res. | pmid:23242470 |
| Koop DR et al. | Analysis of tacrolimus and creatinine from a single dried blood spot using liquid chromatography tandem mass spectrometry. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23548676 |
| Lewis RE et al. | Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis. | 2013 | J. Infect. Dis. | pmid:23242544 |
| Vafadari R et al. | Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus. | 2013 | Ther Drug Monit | pmid:23743668 |
| Pople PV and Singh KK | Development and evaluation of colloidal modified nanolipid carrier: application to topical delivery of tacrolimus, Part II--in vivo assessment, drug targeting, efficacy, and safety in treatment for atopic dermatitis. | 2013 | Eur J Pharm Biopharm | pmid:23246619 |
| Sevc J et al. | Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: effect on spinally grafted human neural precursor survival. | 2013 | Exp. Neurol. | pmid:23748136 |
| Nakagawa Y et al. | Induction of rapid apoptosis for class I MHC molecule-restricted CD8(+) HIV-1 gp160-specific murine activated CTLs by free antigenic peptide in vivo. | 2013 | Int. Immunol. | pmid:22945875 |
| Pinelli NR et al. | Coadministration of liraglutide with tacrolimus in kidney transplant recipients: a case series. | 2013 | Diabetes Care | pmid:24065848 |
| Ramser EM et al. | Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. | 2013 | Mol. Biol. Cell | pmid:23783030 |
| Niioka T et al. | Pharmaceutical and genetic determinants for interindividual differences of tacrolimus bioavailability in renal transplant recipients. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23733010 |
| Tanaka Y et al. | Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study. | 2013 | Mod Rheumatol | pmid:23271170 |
| Murase S | Signal transducer and activator of transcription 3 (STAT3) degradation by proteasome controls a developmental switch in neurotrophin dependence. | 2013 | J. Biol. Chem. | pmid:23733189 |
| Min SI et al. | Conversion of twice-daily tacrolimus to once-daily tacrolimus formulation in stable pediatric kidney transplant recipients: pharmacokinetics and efficacy. | 2013 | Am. J. Transplant. | pmid:23734831 |
| Valdivieso N et al. | Tacrolimus dose individualization in "de novo" patients after 10 years of experience in liver transplantation: pharmacokinetic considerations and patient pathophysiology. | 2013 | Int J Clin Pharmacol Ther | pmid:23735178 |
| Egli A et al. | Comparison of the effect of standard and novel immunosuppressive drugs on CMV-specific T-cell cytokine profiling. | 2013 | Transplantation | pmid:23274966 |
| Hebert MF et al. | Interpreting tacrolimus concentrations during pregnancy and postpartum. | 2013 | Transplantation | pmid:23274970 |
| Quigley MA et al. | Development of a reliable model of total abdominal wall transplantation. | 2013 | Plast. Reconstr. Surg. | pmid:24076687 |
| Sha T et al. | Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice. | 2013 | Int. Immunopharmacol. | pmid:23142502 |
| Bramham K et al. | Breastfeeding and tacrolimus: serial monitoring in breast-fed and bottle-fed infants. | 2013 | Clin J Am Soc Nephrol | pmid:23349333 |
| Khaled SK et al. | A phase II study of sirolimus, tacrolimus and rabbit anti-thymocyte globulin as GVHD prophylaxis after unrelated-donor PBSC transplant. | 2013 | Bone Marrow Transplant. | pmid:23000644 |
| Mei Y et al. | Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. | 2013 | PLoS ONE | pmid:23349825 |
| MartÃnez-Castro M et al. | Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'. | 2013 | Appl. Microbiol. Biotechnol. | pmid:22990582 |
| Gladstone DE et al. | Partially mismatched transplantation and human leukocyte antigen donor-specific antibodies. | 2013 | Biol. Blood Marrow Transplant. | pmid:23353119 |
| Sharma P and Barman P | Everolimus for liver transplant recipients: is it ready for prime time? | 2013 | Gastroenterology | pmid:23260492 |
| Nara M et al. | Effect of itraconazole on the concentrations of tacrolimus and cyclosporine in the blood of patients receiving allogeneic hematopoietic stem cell transplants. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23354810 |