tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stienstra NA et al. | Development of a Simple and Rapid Method to Measure the Free Fraction of Tacrolimus in Plasma Using Ultrafiltration and LC-MS/MS. | 2016 | Ther Drug Monit | pmid:27805928 |
| Prytula A et al. | Tacrolimus Predose Concentration Is Associated With Hypertension in Pediatric Liver Transplant Recipients. | 2016 | J. Pediatr. Gastroenterol. Nutr. | pmid:26910645 |
| Muduma G et al. | Indirect treatment comparison of belatacept versus tacrolimus from a systematic review of immunosuppressive therapies for kidney transplant patients. | 2016 | Curr Med Res Opin | pmid:26907083 |
| Sato Y et al. | Acute encephalitis with refractory, repetitive partial seizures: Pathological findings and a new therapeutic approach using tacrolimus. | 2016 | Brain Dev. | pmid:26906012 |
| Ghareeb M and Akhlaghi F | Development and validation of a sensitive and selective LC-MS/MS method for determination of tacrolimus in oral fluids. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27771258 |
| Fu LF et al. | Improvement of FK506 production by synthetic biology approaches. | 2016 | Biotechnol. Lett. | pmid:27600954 |
| Rodrigo E et al. | Within-Patient Variability in Tacrolimus Blood Levels Predicts Kidney Graft Loss and Donor-Specific Antibody Development. | 2016 | Transplantation | pmid:26703349 |
| Zhang XS et al. | FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:27757551 |
| Coghill AE et al. | Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. | 2016 | Am. J. Transplant. | pmid:26824445 |
| Hellström VC et al. | Malignancies in transplanted patients: Multidisciplinary evaluation and switch to mTOR inhibitors after kidney transplantation - experiences from a prospective, clinical, observational study. | 2016 | Acta Oncol | pmid:26824275 |
| Gathogo E et al. | Impact of Tacrolimus Compared With Cyclosporin on the Incidence of Acute Allograft Rejection in Human Immunodeficiency Virus-Positive Kidney Transplant Recipients. | 2016 | Transplantation | pmid:26413990 |
| Sienkiewicz B et al. | The impact of CYP3A5 on the metabolism of cyclosporine A and tacrolimus in the evaluation of efficiency and safety of immunosuppressive treatment in patients after kidney transplantation. | 2016 | Pharmazie | pmid:29441922 |
| Snell GI et al. | ABO incompatible renal transplantation following lung transplantation. | 2016 | Transpl. Immunol. | pmid:27663090 |
| Juillerat A et al. | Design of chimeric antigen receptors with integrated controllable transient functions. | 2016 | Sci Rep | pmid:26750734 |
| Prakash A et al. | Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506. | 2016 | Protein Sci. | pmid:26749369 |
| Bae JM et al. | Repigmentation of poliosis in a patient with segmental vitiligo. | 2016 | J. Am. Acad. Dermatol. | pmid:27317537 |
| Yang Y et al. | STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. | 2016 | Neuroreport | pmid:26694943 |
| Ganetsky A et al. | Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation. | 2016 | Bone Marrow Transplant. | pmid:26691423 |
| El-Asmar J et al. | Clotrimazole troches induce supratherapeutic blood levels of sirolimus and tacrolimus in an allogeneic hematopoietic cell-transplant recipient resulting in acute kidney injury. | 2016 | Hematol Oncol Stem Cell Ther | pmid:26684920 |
| Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
| Gojowy D et al. | High Frequency of Arterial Hypertension in Patients After Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27496479 |
| Wilusz M et al. | Effects of Immunosuppressive Drugs on Serum Fatty Acids of Phospholipids Fraction in Renal Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27496457 |
| Mehraj V et al. | The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response. | 2016 | EBioMedicine | pmid:27397514 |
| Wu Q et al. | Repair of Neurological Function in Response to FK506 Through CaN/NFATc1 Pathway Following Traumatic Brain Injury in Rats. | 2016 | Neurochem. Res. | pmid:27386875 |
| O'Donnell JC et al. | Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. | 2016 | J. Neurosci. | pmid:27383588 |
| Mittal A et al. | Pilot Study to Evaluate the Efficacy and Safety of Oral Tacrolimus in Adult Patients With Refractory Severe Plaque Psoriasis. | 2016 | J Cutan Med Surg | pmid:26553734 |
| Roblin E et al. | Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients. | 2016 | Pediatr Transplant | pmid:26750745 |
| Zarrinpar A et al. | Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform. | 2016 | Sci Transl Med | pmid:27053773 |
| Oetting WS et al. | Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. | 2016 | Am. J. Transplant. | pmid:26485092 |
| Deininger KM et al. | CYP3A pharmacogenetics and tacrolimus disposition in adult heart transplant recipients. | 2016 | Clin Transplant | pmid:27314545 |
| de Mesquita Coutinho PR et al. | Effects of tacrolimus and erythropoietin in experimental spinal cord lesion in rats: functional and histological evaluation. | 2016 | Spinal Cord | pmid:26481712 |
| Sun W et al. | Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes. | 2016 | Pflugers Arch. | pmid:27318696 |
| M Kotowski M et al. | The influence of the tumor necrosis factor-alpa-308G>A polymorphism on the efficacy of immunosuppressive therapy in patients after kidney transplantation. | 2016 | J. Physiol. Pharmacol. | pmid:28195062 |
| Kyaw TH et al. | A 45-Year-Old Woman With 3 Weeks of Cough and Night Sweats. | 2016 | Chest | pmid:26965979 |
| Golubovic B et al. | Population Pharmacokinetic Approach of Immunosuppressive Therapy in Kidney Transplant Patients. | 2016 | Curr. Med. Chem. | pmid:26687831 |
| Hošková L et al. | Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation. | 2016 | Ann. Transplant. | pmid:27226081 |
| Yousef AM et al. | Effects of Genetic Polymorphism in CYP3A4 and CYP3A5 Genes on Tacrolimus Dose Among Kidney Transplant Recipients. | 2016 | Iran J Kidney Dis | pmid:27225724 |
| Fields JA et al. | Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. | 2016 | J Neuroinflammation | pmid:27220536 |
| Jia W et al. | The calcineruin inhibitor cyclosporine a synergistically enhances the susceptibility of Candida albicans biofilms to fluconazole by multiple mechanisms. | 2016 | BMC Microbiol. | pmid:27316338 |
| Azzi J et al. | Targeted Delivery of Immunomodulators to Lymph Nodes. | 2016 | Cell Rep | pmid:27134176 |
| SelimoÄŸlu MA et al. | Evaluation of renal functions in pediatric liver transplantation. | 2016 | Pediatr Transplant | pmid:26607307 |
| Giussani A et al. | Posterior reversible encephalopathy syndrome after kidney transplantation in pediatric recipients: Two cases. | 2016 | Pediatr Transplant | pmid:26607205 |
| Adler M et al. | A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. | 2016 | J. Am. Soc. Nephrol. | pmid:26260164 |
| Jung H and Oh ES | FK506 positively regulates the migratory potential of melanocyte-derived cells by enhancing syndecan-2 expression. | 2016 | Pigment Cell Melanoma Res | pmid:27060922 |
| Labroo P et al. | Controlled Delivery of FK506 to Improve Nerve Regeneration. | 2016 | Shock | pmid:27058050 |
| Wang YY et al. | Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network. | 2016 | Sci Rep | pmid:27052100 |
| Kawahara T et al. | Cyclosporine A and tacrolimus inhibit urothelial tumorigenesis. | 2016 | Mol. Carcinog. | pmid:25594762 |
| Brito-Costa A et al. | Factors Associated With Changes in Body Composition Shortly After Orthotopic Liver Transplantation: The Potential Influence of Immunosuppressive Agents. | 2016 | Transplantation | pmid:27136260 |
| Sinangil A et al. | New-Onset Diabetes After Kidney Transplantation and Pretransplant Hypomagnesemia. | 2016 | Prog Transplant | pmid:27136250 |
| Moiseev IS et al. | Graft-versus-Host Disease Prophylaxis in Unrelated Peripheral Blood Stem Cell Transplantation with Post-Transplantation Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil. | 2016 | Biol. Blood Marrow Transplant. | pmid:26970381 |