tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prescott TA et al. | A yeast chemical genetics approach identifies the compound 3,4,5-trimethoxybenzyl isothiocyanate as a calcineurin inhibitor. | 2014 | FEBS Lett. | pmid:24374339 |
| Kamburova EG et al. | Longitudinal analysis of T and B cell phenotype and function in renal transplant recipients with or without rituximab induction therapy. | 2014 | PLoS ONE | pmid:25393622 |
| Filler G and Smith N | The need for tacrolimus assay standardization. | 2014 | Ther Drug Monit | pmid:25390282 |
| Jun H et al. | Experiences on conversion to once-daily Advagraf and sirolimus combination in stable kidney recipients. | 2014 | Transplant. Proc. | pmid:24655973 |
| Sachewsky N et al. | Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway. | 2014 | Dis Model Mech | pmid:25056698 |
| Masutani K et al. | Protocol biopsy findings in living donor kidney transplant patients treated with once-daily or twice-daily tacrolimus formulation. | 2014 | Transplant. Proc. | pmid:24655972 |
| Erdinest N and Solomon A | Topical immunomodulators in the management of allergic eye diseases. | 2014 | Curr Opin Allergy Clin Immunol | pmid:25054831 |
| Mo D et al. | In vitro interactions of calcineurin inhibitors with conventional antifungal agents against the yeast form of Penicillium marneffei. | 2014 | Mycopathologia | pmid:25052248 |
| Tian SY et al. | Immunosuppressive therapies for the induction treatment of proliferative lupus nephritis: a systematic review and network metaanalysis. | 2014 | J. Rheumatol. | pmid:25225281 |
| Qi R et al. | FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and Smads signal pathways. | 2014 | Ren Fail | pmid:24512120 |
| Klawitter J et al. | Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. | 2014 | PLoS ONE | pmid:24497939 |
| Thölking G et al. | The tacrolimus metabolism rate influences renal function after kidney transplantation. | 2014 | PLoS ONE | pmid:25340655 |
| Mori T et al. | Nephrotoxicity of concomitant use of tacrolimus and teicoplanin in allogeneic hematopoietic stem cell transplant recipients. | 2014 | Transpl Infect Dis | pmid:24494811 |
| Alloway RR et al. | Conversion from twice daily tacrolimus capsules to once daily extended-release tacrolimus (LCP-Tacro): phase 2 trial of stable liver transplant recipients. | 2014 | Liver Transpl. | pmid:24493215 |
| DU C et al. | [In vitro effects of tacrolimus on platelet function]. | 2014 | Zhonghua Xue Ye Xue Za Zhi | pmid:25339327 |
| Yin Z et al. | Topical pimecrolimus inhibits high-dose UVB irradiation-induced epidermal Langerhans cell migration, via regulation of TNF-α and E-cadherin. | 2014 | Drug Des Devel Ther | pmid:25336924 |
| Tsuchimoto A et al. | Urinary neutrophil gelatinase-associated lipocalin: a useful biomarker for tacrolimus-induced acute kidney injury in liver transplant patients. | 2014 | PLoS ONE | pmid:25329716 |
| Verma M et al. | Impact of single immunosuppressive drug withdrawal on lymphocyte immunoreactivity. | 2014 | J. Surg. Res. | pmid:24485875 |
| El-Sheikh AA et al. | Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus. | 2014 | Transl Res | pmid:24486136 |
| Carr L et al. | Calcineurin activity assay measurement by liquid chromatography-tandem mass spectrometry in the multiple reaction monitoring mode. | 2014 | Clin. Chem. | pmid:24281780 |
| Rehman S et al. | Effect of different tacrolimus levels on early outcomes after kidney transplantation. | 2014 | Ann. Transplant. | pmid:24509826 |
| Xie M et al. | Tacrolimus-related seizure after pediatric liver transplantation--a single-center experience. | 2014 | Pediatr Transplant | pmid:24283660 |
| Balato A et al. | Tacrolimus does not alter the production of several cytokines and antimicrobial peptide in Malassezia furfur-infected-keratinocytes. | 2014 | Mycoses | pmid:24512536 |
| Qin XL et al. | In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus. | 2014 | Drug Metab. Dispos. | pmid:24195812 |
| Li CJ et al. | Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR genetic polymorphisms on tacrolimus metabolism in Chinese renal transplant recipients. | 2014 | PLoS ONE | pmid:24465960 |
| Silva-Cunha A et al. | Evaluation of the pharmacokinetics and ocular tolerance of a microemulsion containing tacrolimus. | 2014 | J Ocul Pharmacol Ther | pmid:24199740 |
| Vavic N et al. | The influence of comedication on tacrolimus blood concentration in patients subjected to kidney transplantation: a retrospective study. | 2014 | Eur J Drug Metab Pharmacokinet | pmid:24356808 |
| Chen D et al. | Association of hemoglobin levels, CYP3A5, and NR1I3 gene polymorphisms with tacrolimus pharmacokinetics in liver transplant patients. | 2014 | Drug Metab. Pharmacokinet. | pmid:24351870 |
| Bruel A et al. | Early protocol biopsies in pediatric renal transplantation: interest for the adaptation of immunosuppression. | 2014 | Pediatr Transplant | pmid:24341571 |
| Sapir-Pichhadze R et al. | Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant failure. | 2014 | Kidney Int. | pmid:24336032 |
| Danby SG et al. | The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis. | 2014 | Br. J. Dermatol. | pmid:24328907 |
| Budde K et al. | Novel once-daily extended-release tacrolimus (LCPT) versus twice-daily tacrolimus in de novo kidney transplants: one-year results of Phase III, double-blind, randomized trial. | 2014 | Am. J. Transplant. | pmid:25278376 |
| Cho A et al. | Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. | 2014 | Neuron | pmid:24698271 |
| Teraki Y | [Atopic dermatitis in pregnancy]. | 2014 | Arerugi | pmid:24714179 |
| Casey MJ et al. | Prolonged immunosuppression preserves nonsensitization status after kidney transplant failure. | 2014 | Transplantation | pmid:24717218 |
| Stifft F et al. | Lower variability in 24-hour exposure during once-daily compared to twice-daily tacrolimus formulation in kidney transplantation. | 2014 | Transplantation | pmid:24686426 |
| Hirai F et al. | Impact of CYP3A5 genetic polymorphisms on the pharmacokinetics and short-term remission in patients with ulcerative colitis treated with tacrolimus. | 2014 | J. Gastroenterol. Hepatol. | pmid:24033383 |
| Shlivko IL et al. | Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus. | 2014 | Skin Res Technol | pmid:23808907 |
| Jalil MH et al. | Population pharmacokinetic and pharmacogenetic analysis of tacrolimus in paediatric liver transplant patients. | 2014 | Br J Clin Pharmacol | pmid:23738951 |
| Deng Z et al. | [Early diagnosis and comprehensive treatments of post-transplantation lymphoproliferative disorder after pediatric liver transplantation]. | 2014 | Zhonghua Er Ke Za Zhi | pmid:25224233 |
| Peloso LJ et al. | The serum concentration of tacrolimus after ingesting omeprazole: a pilot study. | 2014 | Transplantation | pmid:25221905 |
| Tanaka H et al. | Efficacy of mizoribine-tacrolimus-based induction therapy for pediatric lupus nephritis. | 2014 | Lupus | pmid:24651669 |
| Taber DJ et al. | Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients. | 2014 | Am. J. Nephrol. | pmid:24969370 |
| Jacobo-Cabral CO et al. | Limustin®, a non-innovator tacrolimus formulation, yields reduced drug exposure in pediatric renal transplant recipients. | 2014 | Pediatr Transplant | pmid:25156476 |
| Keniya MV et al. | Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. | 2014 | Mol. Pharm. | pmid:25115303 |
| Shah NP et al. | Treatment of a Crohn's disease-related cutaneous facial lesion with topical tacrolimus. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:25151593 |
| Werk AN et al. | Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. | 2014 | Clin. Pharmacol. Ther. | pmid:24126681 |
| Carcas-Sansuán AJ et al. | Conversion from Prograf to Advagraf in stable paediatric renal transplant patients and 1-year follow-up. | 2014 | Pediatr. Nephrol. | pmid:23907143 |
| Chatterjea A et al. | Suppression of the immune system as a critical step for bone formation from allogeneic osteoprogenitors implanted in rats. | 2014 | J. Cell. Mol. Med. | pmid:24237965 |
| Størset E et al. | Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling. | 2014 | Br J Clin Pharmacol | pmid:25279405 |
| Tolar J and McGrath JA | Augmentation of cutaneous wound healing by pharmacologic mobilization of endogenous bone marrow stem cells. | 2014 | J. Invest. Dermatol. | pmid:25120149 |
| Pichler R et al. | De novo renal cell carcinoma in a kidney allograft with focus on contrast-enhanced ultrasound. | 2014 | Urol. Int. | pmid:25115614 |
| ZivÄić-Ćosić S et al. | Immune reactivity of renal transplant recipients receiving interleukin-2 receptor antagonists during the early posttransplant period. | 2014 | Int Urol Nephrol | pmid:23515930 |
| Hadjipanagi D et al. | Genetic polymorphisms in warfarin and tacrolimus-related genes VKORC1, CYP2C9 and CYP3A5 in the Greek-Cypriot population. | 2014 | BMC Res Notes | pmid:24593903 |
| Yan YH et al. | Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization. | 2014 | Neurosci. Lett. | pmid:24607931 |
| Bogan JS | Endocytic cycling of glucose transporters and insulin resistance due to immunosuppressive agents. | 2014 | J. Clin. Endocrinol. Metab. | pmid:25279573 |
| Sethna CB and Gipson DS | Treatment of FSGS in Children. | 2014 | Adv Chronic Kidney Dis | pmid:24602468 |
| Demmers MW et al. | Substantial proliferation of human renal tubular epithelial cell-reactive CD4+CD28null memory T cells, which is resistant to tacrolimus and everolimus. | 2014 | Transplantation | pmid:24157471 |
| Tsuchida T et al. | The development of humanized liver with Rag1 knockout rats. | 2014 | Transplant. Proc. | pmid:24815157 |
| Li Q et al. | Proniosome-derived niosomes for tacrolimus topical ocular delivery: in vitro cornea permeation, ocular irritation, and in vivo anti-allograft rejection. | 2014 | Eur J Pharm Sci | pmid:24905830 |
| Kraus TS et al. | Angioimmunoblastic T cell lymphoma: an unusual presentation of posttransplant lymphoproliferative disorder in a pediatric patient. | 2014 | Acta Haematol. | pmid:24157860 |
| Hostettler KE et al. | Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation. | 2014 | Eur. Respir. J. | pmid:23645405 |
| Oda K and Yamano K | Effect of telaprevir on the metabolism and hepatic uptake of tacrolimus (FK506). | 2014 | Biopharm Drug Dispos | pmid:25059890 |
| Lapteva M et al. | Polymeric micelle nanocarriers for the cutaneous delivery of tacrolimus: a targeted approach for the treatment of psoriasis. | 2014 | Mol. Pharm. | pmid:25057896 |
| Levinger E et al. | Topical 0.03% tacrolimus for subepithelial infiltrates secondary to adenoviral keratoconjunctivitis. | 2014 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:24696044 |
| Nikitin AV | [Mechanisms of nephrotoxic action of immunodepressants, calcineurine inhibitors]. | 2014 | Antibiot. Khimioter. | pmid:25051716 |
| GoriaÄnov VA et al. | [Effect of tacrolimus on the results of living related kidney donor transplantation]. | 2014 | Ter. Arkh. | pmid:25095659 |
| Shilpa PS et al. | Topical tacrolimus in the management of oral lichen planus: literature review. | 2014 | J Calif Dent Assoc | pmid:25080722 |
| Carbajal R et al. | Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. | 2014 | Transplant. Proc. | pmid:24981811 |
| Kuramitsu S et al. | [Case report of introducing MMF and steroids as an immunosuppressive therapy after living-donor liver transplantation for a patient with the diabetic nephropathy]. | 2014 | Fukuoka Igaku Zasshi | pmid:25000660 |
| Kluk J et al. | Follicular mucinosis treated with topical 0.1% tacrolimus ointment. | 2014 | Clin. Exp. Dermatol. | pmid:24252117 |
| Ohe M et al. | Successful treatment with tacrolimus of refractory adult-onset Still's disease. | 2014 | Korean J. Intern. Med. | pmid:24648814 |
| Kassir N et al. | Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in paediatric liver transplant recipients. | 2014 | Br J Clin Pharmacol | pmid:24977292 |
| Matsumoto K et al. | [Perioperative agranulocytosis induced by immunosuppressants in a renal graft recipient : a case report]. | 2014 | Hinyokika Kiyo | pmid:25001642 |
| Friedrich RB et al. | Nanoencapsulation of tacrolimus in lipid-core nanocapsules showed similar immunosuppressive activity after oral and intraperitoneal administrations. | 2014 | J Biomed Nanotechnol | pmid:25016659 |
| Wu Q et al. | Heterogeneity of radiological spectrum in tacrolimus-associated encephalopathy after lung transplantation. | 2014 | Behav Neurol | pmid:24970980 |
| Nath PR et al. | Immunophilins control T lymphocyte adhesion and migration by regulating CrkII binding to C3G. | 2014 | J. Immunol. | pmid:25225668 |
| Toniutto P et al. | Biliary strictures after liver transplantation: role of interleukin 28B genotypes in cyclosporine treated. | 2014 | Int J Surg | pmid:25219480 |
| Buechter M et al. | Tacrolimus as a reasonable alternative in a patient with steroid-dependent and thiopurine-refractory autoimmune pancreatitis with IgG4-associated cholangitis. | 2014 | Z Gastroenterol | pmid:24905108 |
| Wohlfahrtova M and Viklicky O | Recent trials in immunosuppression and their consequences for current therapy. | 2014 | Curr Opin Organ Transplant | pmid:24905020 |
| Boonyapredee M et al. | Increased BK viremia and progression to BK-virus nephropathy following high-dose intravenous immunoglobulin for acute cellular rejection. | 2014 | Mil Med | pmid:24902140 |
| Savikko J et al. | Different effects of tacrolimus and cyclosporine on PDGF induction and chronic allograft injury: evidence for improved kidney graft outcome. | 2014 | Transpl. Immunol. | pmid:25158212 |
| Lebel MJ et al. | Increase in de novo food allergies after pediatric liver transplantation: tacrolimus vs. cyclosporine immunosuppression. | 2014 | Pediatr Transplant | pmid:25156571 |
| Lee KM and Eun SC | Experimental canine facial transplantation. | 2014 | Transplant. Proc. | pmid:24815162 |
| Kurbalija V et al. | Time-series analysis in the medical domain: a study of Tacrolimus administration and influence on kidney graft function. | 2014 | Comput. Biol. Med. | pmid:24813681 |
| Reitamo S and Remitz A | An update on current pharmacotherapy options in atopic dermatitis. | 2014 | Expert Opin Pharmacother | pmid:24811606 |
| Stifft F et al. | Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers. | 2014 | Br J Clin Pharmacol | pmid:24809233 |
| Korbel L et al. | Clinically relevant pharmacogenomic testing in pediatric practice. | 2014 | Clin Pediatr (Phila) | pmid:24803633 |
| Yamanaka M et al. | Development and evaluation of a tacrolimus cream formulation using a binary solvent system. | 2014 | Int J Pharm | pmid:24456671 |
| Levy G et al. | REFINE: a randomized trial comparing cyclosporine A and tacrolimus on fibrosis after liver transplantation for hepatitis C. | 2014 | Am. J. Transplant. | pmid:24456049 |
| Dipchand AI et al. | Myocyte growth, repair, and oxidative stress following pediatric heart transplantation. | 2014 | Pediatr Transplant | pmid:25118092 |
| Upadhyay V et al. | Rapid and sensitive UPLC-MS-MS determination of tacrolimus in Wistar rats and human blood. | 2014 | J Chromatogr Sci | pmid:23264321 |
| Hošková L et al. | Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system. | 2014 | Hypertens. Res. | pmid:24718302 |
| Lee SJ et al. | Functional interpretation of metabolomics data as a new method for predicting long-term side effects: treatment of atopic dermatitis in infants. | 2014 | Sci Rep | pmid:25491116 |
| Miller EC et al. | Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits. | 2014 | Eur. J. Neurosci. | pmid:24713000 |
| Fernandes MB et al. | Supplementation with omega-3 polyunsaturated fatty acids and experimental tacrolimus-induced nephrotoxicity. | 2014 | Exp Clin Transplant | pmid:25489802 |
| Supe-Markovina K et al. | Alemtuzumab with corticosteroid minimization for pediatric deceased donor renal transplantation: a seven-yr experience. | 2014 | Pediatr Transplant | pmid:24712738 |
| Chung BH et al. | Decrease of immature B cell and interleukin-10 during early-post-transplant period in renal transplant recipients under tacrolimus based immunosuppression. | 2014 | Transpl. Immunol. | pmid:24709525 |
| Al-Kadhimi Z et al. | High incidence of severe acute graft-versus-host disease with tacrolimus and mycophenolate mofetil in a large cohort of related and unrelated allogeneic transplantation patients. | 2014 | Biol. Blood Marrow Transplant. | pmid:24709007 |
| Larkins N and Matsell DG | Tacrolimus therapeutic drug monitoring and pediatric renal transplant graft outcomes. | 2014 | Pediatr Transplant | pmid:25284168 |