tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wiederrecht GJ et al. | Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. | 1995 | Prog Cell Cycle Res | pmid:9552353 |
| Ku YM et al. | Compatibility of tacrolimus injection with cimetidine hydrochloride injection in 0.9% sodium chloride injection. | 1995 | Am J Health Syst Pharm | pmid:8528874 |
| Arreaza G et al. | Expression of intercellular adhesion molecule-1 on human thyroid cells from patients with autoimmune thyroid disease: study of thyroid xenografts in nude and severe combined immunodeficient mice and treatment with FK-506. | 1995 | J. Clin. Endocrinol. Metab. | pmid:8530625 |
| Fruman DA et al. | The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells. | 1995 | J. Immunol. | pmid:7530743 |
| Neuhaus P et al. | Comparison of FK506- and cyclosporine-based immunosuppression in primary orthotopic liver transplantation. A single center experience. | 1995 | Transplantation | pmid:7530868 |
| Hamasaki Y et al. | Inhibition of leukotriene production by FK506 in rat basophilic leukemia-1 cells. | 1995 | Pharmacology | pmid:7538218 |
| Zarnt T et al. | Time-dependent inhibition of peptidylprolyl cis-trans-isomerases by FK506 is probably due to cis-trans isomerization of the inhibitor's imide bond. | 1995 | Biochem. J. | pmid:7529995 |
| Wera S et al. | Rapamycin, FK506 and cyclosporin A inhibit human prolactin gene expression. | 1995 | FEBS Lett. | pmid:7530217 |
| Van Thiel DH et al. | Tacrolimus (FK 506), a treatment for primary sclerosing cholangitis: results of an open-label preliminary trial. | 1995 | Am. J. Gastroenterol. | pmid:7532912 |
| Ning YM and Sanchez ER | Stabilization in vitro of the untransformed glucocorticoid receptor complex of S49 lymphocytes by the immunophilin ligand FK506. | 1995 | J. Steroid Biochem. Mol. Biol. | pmid:7532989 |
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| Cameron AM et al. | Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7533300 |
| Zeevi A et al. | Serial evaluation of immune profiles of simultaneous bone marrow and whole organ transplant recipients. | 1995 | Transplant. Proc. | pmid:7533388 |
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| Hirakata Y et al. | Influence of various immunosuppressive agents on the occurrence of endogenous bacteraemia in mice. | 1995 | J. Med. Microbiol. | pmid:7533840 |
| Gregory CR et al. | Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement. | 1995 | Transplantation | pmid:7533955 |
| Egawa H et al. | Isolated alkaline phosphatemia following pediatric liver transplantation in the FK506 ERA. | 1995 | Transplantation | pmid:7533958 |
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| Thomson AW and Bonham CA | Inhibition of T lymphocyte activation and apoptotic cell death by cyclosporin A and tacrolimus (FK506). Its relevance to therapy of HIV infection. | 1995 | Adv. Exp. Med. Biol. | pmid:7572394 |
| Paterson JM et al. | Control of a novel adenylyl cyclase by calcineurin. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575502 |
| Bang H et al. | Activation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7536932 |
| Cunningham EB | The human erythrocyte membrane contains a novel 12-kDa inositolphosphate-binding protein that is an immunophilin. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575593 |
| Masaki Y et al. | Cellular basis of acquired immunologic tolerance following total bowel transplantation in rats. I. Relation between donor lymphocyte chimerism and host-cell-mediated immunity. | 1995 | Transplant. Proc. | pmid:7536971 |
| Masaki Y et al. | Cellular basis of immunologic tolerance following total bowel transplantation in rats. II. Dominant role of suppressor T cells in adoptive transfer of acquired tolerance to vascularized allografts. | 1995 | Transplant. Proc. | pmid:7536972 |
| Suzuki H et al. | Spleen grafting might induce transplantation tolerance in rats. | 1995 | Transplant. Proc. | pmid:7536973 |
| Dix SP et al. | Re: Severe interaction between methotrexate and a macrolide-like antibiotic. | 1995 | J. Natl. Cancer Inst. | pmid:7563209 |
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| Warty V et al. | Tacrolimus analysis: a comparison of different methods and matrices. | 1995 | Ther Drug Monit | pmid:7542809 |
| Freeman DJ et al. | Stability of FK 506 in whole blood samples. | 1995 | Ther Drug Monit | pmid:7542810 |
| Strumph P et al. | The effect of FK506 on glycemic response as assessed by the hyperglycemic clamp technique. | 1995 | Transplantation | pmid:7542815 |
| Sihra TS et al. | A role for calcineurin (protein phosphatase-2B) in the regulation of glutamate release. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7542882 |
| Theopold U et al. | FKBP39, a Drosophila member of a family of proteins that bind the immunosuppressive drug FK506. | 1995 | Gene | pmid:7538962 |
| Dumont FJ et al. | Increased LFA-1-mediated homotypic cell adhesion is associated with the G1 growth arrest induced by rapamycin in a T cell lymphoma. | 1995 | Exp. Cell Res. | pmid:7543051 |
| Zhao Y et al. | Calcineurin activation protects T cells from glucocorticoid-induced apoptosis. | 1995 | J. Immunol. | pmid:7539018 |
| Bronsther O et al. | Liver transplantation for HBV-related disease under immunosuppression with tacrolimus: an experience with 78 consecutive cases. | 1995 | J Okla State Med Assoc | pmid:7539077 |
| Chen J et al. | Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7539137 |
| Renoir JM et al. | Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7539138 |
| Ingels SC et al. | Stability of FK506 (tacrolimus) in whole-blood specimens. | 1995 | Clin. Chem. | pmid:7544707 |
| Takizawa H et al. | Activated immunocompetent cells in rat colitis mucosa induced by dextran sulfate sodium and not complete but partial suppression of colitis by FK506. | 1995 | Digestion | pmid:7544748 |
| Sher LS and Makowka L | Immunosuppression: now we have choices. | 1995 | Hepatology | pmid:7544759 |
| Perrot-Applanat M et al. | The 59 kDa FK506-binding protein, a 90 kDa heat shock protein binding immunophilin (FKBP59-HBI), is associated with the nucleus, the cytoskeleton and mitotic apparatus. | 1995 | J. Cell. Sci. | pmid:7544801 |
| Yang WM et al. | Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity. | 1995 | J. Biol. Chem. | pmid:7541038 |
| Hibi S et al. | Severe rhabdomyolysis associated with tacrolimus. | 1995 | Lancet | pmid:7544861 |
| Kawamura A and Su MS | Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain. | 1995 | J. Biol. Chem. | pmid:7541044 |
| Rao PN et al. | Reduction of FK-506 requirements by combination with polyethylene glycol superoxide dismutase in orthotopic rat liver transplantation. | 1995 | J. Allergy Clin. Immunol. | pmid:7541060 |
| Gold BG et al. | The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. | 1995 | J. Neurosci. | pmid:7472502 |
| Takahara S and Okuyama A | [Blood level monitoring of immunosuppressive agent]. | 1995 | Rinsho Byori | pmid:7474422 |
| Zhu D et al. | Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. | 1995 | J. Biol. Chem. | pmid:7559604 |
| Stoller G et al. | A ribosome-associated peptidyl-prolyl cis/trans isomerase identified as the trigger factor. | 1995 | EMBO J. | pmid:7588623 |
| Farcasanu IC et al. | Protein phosphatase 2B of Saccharomyces cerevisiae is required for tolerance to manganese, in blocking the entry of ions into the cells. | 1995 | Eur. J. Biochem. | pmid:7588708 |
| Stemmer PM et al. | Factors responsible for the Ca(2+)-dependent inactivation of calcineurin in brain. | 1995 | FEBS Lett. | pmid:7589543 |
| Kaplan A et al. | The effects of cyclosporin A and FK506 on proliferation and IL-8 production of cultured human keratinocytes. | 1995 | J. Dermatol. Sci. | pmid:8534611 |
| Hadad SJ et al. | FK 506: effects on glomerular hemodynamics and on mesangial cells in culture. | 1995 | Kidney Int. | pmid:7564092 |
| Zhu X et al. | Enhancing and suppressive effects of immunosuppressants cyclosporin A, FK506, and KM2210 on the colony formation of murine bone marrow cells. | 1995 | Ann. Hematol. | pmid:8534762 |
| Mazur P et al. | Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. | 1995 | Mol. Cell. Biol. | pmid:7565718 |
| Ockenfels HM et al. | Tyrosine phosphorylation in psoriatic T cells is modulated by drugs that induce or improve psoriasis. | 1995 | Dermatology (Basel) | pmid:8534940 |
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| Vilquin JT et al. | FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. | 1995 | Hum. Gene Ther. | pmid:8573612 |
| Sano T et al. | FK506 and cyclosporin A inhibit granulocyte/macrophage colony-stimulating factor production by mononuclear cells in asthma. | 1995 | Eur. Respir. J. | pmid:8575571 |
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| Su Q et al. | Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase. | 1995 May-Jun | Ren. Physiol. Biochem. | pmid:7542793 |
| Hayashi S et al. | Evidence that donor pretreatment with FK506 has a synergistic effect on graft prolongation in hamster-to-rat heart xenotransplantation. | 1995 May-Jun | J. Heart Lung Transplant. | pmid:7544621 |
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| Tanaka M et al. | Tacrolimus (FK 506)-dependent tolerance after liver and heart xenotransplantation: inhibition of humoral response and acceptance of donor organs. | 1996 | Transplant. Proc. | pmid:8623341 |
| Ye Q et al. | Functional analysis of hamster kidney xenografts in the rat: possible functional incompatibility and adaptation of hamster kidney grafts in a xenogenic rat environment. | 1996 | Transplant. Proc. | pmid:8623350 |
| Fehr T et al. | Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain. | 1996 | J. Antibiot. | pmid:8626235 |
| Zhang BW et al. | T cell responses in calcineurin A alpha-deficient mice. | 1996 | J. Exp. Med. | pmid:8627154 |
| Singh N et al. | Pulmonary infections in liver transplant recipients receiving tacrolimus. Changing pattern of microbial etiologies. | 1996 | Transplantation | pmid:8610349 |
| Yanchar NL et al. | Tacrolimus (FK506)--its effects on intestinal glucose transport. | 1996 | Transplantation | pmid:8610392 |
| Kawashima M et al. | Tacrolimus concentrations in blood during topical treatment of atopic dermatitis. | 1996 | Lancet | pmid:8898050 |
| Michel G et al. | FK506 in the treatment of inflammatory skin disease: promises and perspectives. | 1996 | Immunol. Today | pmid:8820265 |
| Boeve BF et al. | Dysarthria and apraxia of speech associated with FK-506 (tacrolimus). | 1996 | Mayo Clin. Proc. | pmid:8820772 |
| Asfar S et al. | Small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8908039 |
| Reyes J et al. | Intestinal transplantation in children: five-year experience. | 1996 | Transplant. Proc. | pmid:8908042 |
| Ikebe S et al. | Immunosuppressive effect of tacrolimus (FK-506). Bone xenografts in rabbits. | 1996 | Acta Orthop Scand | pmid:8792745 |
| Taler SJ et al. | Role of steroid dose in hypertension early after liver transplantation with tacrolimus (FK506) and cyclosporine. | 1996 | Transplantation | pmid:8970613 |
| Ishikawa M et al. | Acetaminophen absorption test as a useful indicator of small intestinal rejection in rats. | 1996 | Transplant. Proc. | pmid:8658911 |
| Kawano K et al. | FK506 reduces oxidative hepatic injury following cold ischemic preservation and transplantation. | 1996 | Transplant. Proc. | pmid:8658938 |
| McCall E et al. | Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. | 1996 | Circ. Res. | pmid:8943949 |
| Nichterlein T et al. | Effects of FK-506 on the course of murine salmonellosis. | 1996 | J Chemother | pmid:8981186 |
| Tyedmers J et al. | Efficient folding of firefly luciferase after transport into mammalian microsomes in the absence of luminal chaperones and folding catalysts. | 1996 | J. Biol. Chem. | pmid:8702642 |
| Raufman JP et al. | Calcineurin mediates calcium-induced potentiation of adenylyl cyclase activity in dispersed chief cells from guinea pig stomach. Further evidence for cross-talk between signal transduction pathways that regulate pepsinogen secretion. | 1996 | J. Biol. Chem. | pmid:8702699 |
| Barkholt LM et al. | Epstein-Barr virus DNA in serum after liver transplantation--surveillance of viral activity during treatment with different immunosuppressive agents. | 1996 | Transpl. Int. | pmid:8875785 |
| Shapiro R et al. | Tacrolimus in pediatric renal transplantation. | 1996 | Transplantation | pmid:8990356 |
| Morris-Stiff G et al. | Haemolytic uraemic syndrome associated with OKT3. | 1996 | Transpl. Int. | pmid:8875800 |
| Przepiorka D et al. | Allogeneic transplantation for advanced leukemia: improved short-term outcome with blood stem cell grafts and tacrolimus. | 1996 | Transplantation | pmid:8990368 |
| Eckert B et al. | Calcium-mobilizing insulin secretagogues stimulate transcription that is directed by the cyclic adenosine 3',5'-monophosphate/calcium response element in a pancreatic islet beta-cell line. | 1996 | Endocrinology | pmid:8536617 |