tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Milićević NM and Milićević Z | Stereological study of splenic tissue compartments in FK506-treated rats. | 1997 | Histol. Histopathol. | pmid:9302561 |
| Wingard JR et al. | Lack of interaction between tacrolimus (FK506) and methotrexate in bone marrow transplant recipients. | 1997 | Bone Marrow Transplant. | pmid:9232256 |
| Yamagami S et al. | Mechanism of concordant corneal xenograft rejection in mice: synergistic effects of anti-leukocyte function-associated antigen-1 monoclonal antibody and FK506. | 1997 | Transplantation | pmid:9233699 |
| Wijnen RM and Ericzon BG | Update of tacrolimus in pancreas transplantation. | 1997 | Diabet. Med. | pmid:9400914 |
| Sawabe T et al. | Sinus arrest during tacrolimus (FK506) and digitalis treatment in a bone marrow transplant recipient. | 1997 | Transplantation | pmid:9233725 |
| Misao T et al. | Efficacy of combining donor-specific presensitization with a simultaneous single injection of tacrolimus on pulmonary allografts. | 1997 | J. Heart Lung Transplant. | pmid:9402508 |
| Suzuki J et al. | Inhibition of accelerated coronary atherosclerosis with short-term blockade of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in a heterotopic murine model of heart transplantation. | 1997 | J. Heart Lung Transplant. | pmid:9402514 |
| Cohen SB et al. | Autocrine and paracrine regulation of human T cell IL-10 production. | 1997 | J. Immunol. | pmid:9190906 |
| Zucker K et al. | Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mycophenolate mofetil in combination therapy, and analogous in vitro findings. | 1997 | Transpl. Immunol. | pmid:9402690 |
| Miyata Y et al. | Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9405642 |
| Taylor DO | The use of tacrolimus and mycophenolate mofetil after cardiac transplantation. | 1997 | Curr. Opin. Cardiol. | pmid:9192485 |
| Harihara Y and Makuuchi M | [Partial liver transplantation]. | 1997 | Nippon Naika Gakkai Zasshi | pmid:9340350 |
| Hayashi S et al. | Adenovirus-mediated gene transfer to the xenogeneic liver in liver xenotransplantation: the transduction of complement regulatory factor genes (DAF and HRF20). | 1997 | Transplant. Proc. | pmid:9193595 |
| Wallemacq PE et al. | IMx tacrolimus II vs IMx tacrolimus microparticle enzyme immunoassay evaluated in renal and hepatic transplant patients. | 1997 | Clin. Chem. | pmid:9342026 |
| Hohage H et al. | Effects of cyclosporin A and FK 506 on lipid metabolism and fibrinogen in kidney transplant recipients. | 1997 | Clin Transplant | pmid:9193847 |
| Gold BG et al. | A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration. | 1997 | Exp. Neurol. | pmid:9344552 |
| Mrvos R et al. | Tacrolimus (FK 506) overdose: a report of five cases. | 1997 | J. Toxicol. Clin. Toxicol. | pmid:9204100 |
| Stegall MD et al. | Mycophenolate mofetil decreases rejection in simultaneous pancreas-kidney transplantation when combined with tacrolimus or cyclosporine. | 1997 | Transplantation | pmid:9422404 |
| Sikorski R and Peters R | A cell growth switch. | 1997 | Science | pmid:9206844 |
| Shield CF et al. | Assessment of health-related quality of life in kidney transplant patients receiving tacrolimus (FK506)-based versus cyclosporine-based immunosuppression. FK506 Kidney Transplant Study Group. | 1997 | Transplantation | pmid:9422413 |
| Shafiee A et al. | Chemical and biological characterization of two FK506 analogs produced by targeted gene disruption in Streptomyces sp. MA6548. | 1997 | J. Antibiot. | pmid:9207912 |
| Stegall MD et al. | Prednisone withdrawal 14 days after liver transplantation with mycophenolate: a prospective trial of cyclosporine and tacrolimus. | 1997 | Transplantation | pmid:9422416 |
| Uberti JP et al. | Tacrolimus and methotrexate for the prophylaxis of acute graft-versus-host disease in allogeneic bone marrow transplantation in patients with hematologic malignancies. | 1997 | Bone Marrow Transplant. | pmid:9208118 |
| Shihab FS et al. | Mechanism of fibrosis in experimental tacrolimus nephrotoxicity. | 1997 | Transplantation | pmid:9422427 |
| Ohashi Y et al. | Successful treatment of steroid-resistant severe acute GVHD with 24-h continuous infusion of FK506. | 1997 | Bone Marrow Transplant. | pmid:9085743 |
| Vu MD et al. | Tacrolimus (FK506) and sirolimus (rapamycin) in combination are not antagonistic but produce extended graft survival in cardiac transplantation in the rat. | 1997 | Transplantation | pmid:9422432 |
| Oz HS and Hughes WT | Novel anti-Pneumocystis carinii effects of the immunosuppressant mycophenolate mofetil in contrast to provocative effects of tacrolimus, sirolimus, and dexamethasone. | 1997 | J. Infect. Dis. | pmid:9086147 |
| Wagner K et al. | New-onset diabetes mellitus in pediatric thoracic organ recipients receiving tacrolimus-based immunosuppression. | 1997 | J. Heart Lung Transplant. | pmid:9087870 |
| Yasutomi M et al. | Evaluation of tetrahydropyranyladriamycin as an immunosuppressant in concordant xenotransplantation. | 1997 | J. Heart Lung Transplant. | pmid:9087871 |
| Kitagaki K et al. | Facilitation of apoptosis by cyclosporins A and H, but not FK506 in mouse bronchial eosinophils. | 1997 | Eur. J. Pharmacol. | pmid:9430427 |
| Midtvedt K et al. | Successful pregnancies in a combined pancreas and renal allograft recipient and in a renal graft recipient on tacrolimus treatment. | 1997 | Nephrol. Dial. Transplant. | pmid:9430893 |
| Rudant E et al. | Study of the correlation between MEIA and ELISA methods for FK 506 determination in liver transplant recipients. | 1997 | J Clin Pharm Ther | pmid:9373812 |
| Cetinkale O et al. | Involvement of neutrophils in ischemic injury. I. Biochemical and histopathological investigation of the effect of FK506 on dorsal skin flaps in rats. | 1997 | Ann Plast Surg | pmid:9374148 |
| Kuromitsu S et al. | 3-(13-Hydroxytridecyl)-1-[13-(3-pyridyl)tridecyl]pyridinium chloride (YM-53792), a novel inhibitor of NF-AT activation. | 1997 | Biochem. Pharmacol. | pmid:9374420 |
| Steffen R et al. | Autoimmune enteropathy in a pediatric patient: partial response to tacrolimus therapy. | 1997 | Clin Pediatr (Phila) | pmid:9152557 |
| Canzanello VJ et al. | Evolution of cardiovascular risk after liver transplantation: a comparison of cyclosporine A and tacrolimus (FK506). | 1997 | Liver Transpl Surg | pmid:9377752 |
| Chow FS et al. | Effect of hematocrit and albumin concentration on hepatic clearance of tacrolimus (FK506) during rabbit liver perfusion. | 1997 | Drug Metab. Dispos. | pmid:9152601 |
| De Gasperi A and Rohrer RJ | Scenario number two: sepsis and multiorgan failure after liver transplantation. | 1997 | Liver Transpl Surg | pmid:9377761 |
| Woo M et al. | Toxicities of tacrolimus and cyclosporin A after allogeneic blood stem cell transplantation. | 1997 | Bone Marrow Transplant. | pmid:9466284 |
| Araki T et al. | Effects of vinconate on age-related alterations in [3H]MK-801, [3H]glycine, sodium-dependent D-[3H]aspartate, [3H]FK-506 and [3H]PN200-110 binding in rats. | 1997 | Mech. Ageing Dev. | pmid:9152958 |
| Lang P and Baron C | Molecular mechanisms of immunosuppressive chemical agents recently introduced in clinical transplantation protocols. | 1997 | Nephrol. Dial. Transplant. | pmid:9351062 |
| Banholzer R et al. | Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region. | 1997 | Mol. Cell. Biol. | pmid:9154824 |
| Waer M | New immunosuppressive agents for organ transplantation. | 1997 | Acta Clin Belg | pmid:9351290 |
| Delehanty LL et al. | Apoptosis in a Fas-resistant, T-cell receptor-sensitive human leukaemic T-cell clone. | 1997 | Immunology | pmid:9155645 |
| Sheiner PA et al. | Increased risk of early rejection correlates with recovery of CD3 cell count after liver transplant in patients receiving OKT3 induction. | 1997 | Transplantation | pmid:9355846 |
| Newell KA et al. | Treatment with either anti-CD4 or anti-CD8 monoclonal antibodies blocks alphabeta T cell-mediated rejection of intestinal allografts in mice. | 1997 | Transplantation | pmid:9381541 |
| Iyengar AR et al. | Striking augmentation of hematopoietic cell chimerism in noncytoablated allogeneic bone marrow recipients by FLT3 ligand and tacrolimus. | 1997 | Transplantation | pmid:9158008 |
| Karlsson H and Nässberger L | FK506 suppresses the mitogen-induced increase in lymphocyte adhesiveness to endothelial cells, but does not affect endothelial cell activation in response to inflammatory stimuli. | 1997 | Transplantation | pmid:9355847 |
| van Hooff JP | Pneumocystis carinii pneumonia after renal transplantation. | 1997 | Transplantation | pmid:9158038 |
| Siddiqui MA et al. | Lymphomatoid papulosis and FK 506. | 1997 | Int. J. Dermatol. | pmid:9159004 |
| Okudaira H et al. | Control of allergic diseases by regulation of cytokine gene transcription. | 1997 | Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M | pmid:9383912 |
| Lee JW et al. | Tacrolimus (FK506): validation of a sensitive enzyme-linked immunosorbent assay kit for and application to a clinical pharmacokinetic study. | 1997 | Ther Drug Monit | pmid:9108651 |
| Thyagarajan GK et al. | FK506-induced fulminant leukoencephalopathy after single-lung transplantation. | 1997 | Ann. Thorac. Surg. | pmid:9386723 |
| Tomás ML | [Immunosuppressive agents: side effects]. | 1997 | An R Acad Nac Med (Madr) | pmid:9616947 |
| Graef IA et al. | Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. | 1997 | EMBO J. | pmid:9312021 |
| Wong BR et al. | TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. | 1997 | J. Biol. Chem. | pmid:9312132 |
| Hansen LJ et al. | Early pharmacokinetic profiles of enteral tacrolimus after multivisceral transplantation. | 1997 | Transplant. Proc. | pmid:9142303 |
| Durham HD et al. | The immunosuppressant FK506 prolongs transgene expression in brain following adenovirus-mediated gene transfer. | 1997 | Neuroreport | pmid:9243594 |
| Tanaka K et al. | Calcineurin inhibitor, FK506, prevents reduction in the binding capacity of cyclic AMP-dependent protein kinase in ischemic gerbil brain. | 1997 | J. Cereb. Blood Flow Metab. | pmid:9143223 |
| Yu C et al. | Glucocorticoids fail to enhance the effect of FK506 and methotrexate in prevention of graft-versus-host disease after DLA-nonidentical, unrelated marrow transplantation. | 1997 | Bone Marrow Transplant. | pmid:9244417 |
| Galley Y et al. | Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9144200 |
| Floren LC et al. | Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. | 1997 | Clin. Pharmacol. Ther. | pmid:9246018 |
| Soman KV et al. | Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling. | 1997 | Protein Sci. | pmid:9144770 |
| Cao S et al. | Potential effect of cyclosporin A in formation of cholesterol gallstones in pediatric liver transplant recipients. | 1997 | Dig. Dis. Sci. | pmid:9246038 |
| Wong PW and Pessah IN | Noncoplanar PCB 95 alters microsomal calcium transport by an immunophilin FKBP12-dependent mechanism. | 1997 | Mol. Pharmacol. | pmid:9145907 |
| McKee M et al. | Steroid withdrawal in tacrolimus (FK506)-treated pediatric liver transplant recipients. | 1997 | J. Pediatr. Surg. | pmid:9247215 |
| Marienfeld R et al. | Cyclosporin A interferes with the inducible degradation of NF-kappa B inhibitors, but not with the processing of p105/NF-kappa B1 in T cells. | 1997 | Eur. J. Immunol. | pmid:9247567 |
| Talbot D et al. | Alopecia as a consequence of tacrolimus therapy in renal transplantation? | 1997 | Transplantation | pmid:9415574 |
| Mignat C | Clinically significant drug interactions with new immunosuppressive agents. | 1997 | Drug Saf | pmid:9113494 |
| Gruessner RW and Sharp HL | Living-related intestinal transplantation: first report of a standardized surgical technique. | 1997 | Transplantation | pmid:9415566 |
| Meiser BM et al. | Tacrolimus: a superior agent to OKT3 for treating cases of persistent rejection after intrathoracic transplantation. | 1997 | J. Heart Lung Transplant. | pmid:9286771 |
| Morris-Stiff G et al. | Conversion from cyclosporin to tacrolimus in a patient with prolonged acute tubular necrosis. | 1997 | Transpl. Int. | pmid:9287408 |
| Gerlach J et al. | Systemic liberation of interleukin-8 in the perioperative phase of liver transplantation. | 1997 | Transpl. Int. | pmid:9287409 |
| Michel MC et al. | Comparison of old and new IMX assays for monitoring of tacrolimus levels. | 1997 | Transpl. Int. | pmid:9287412 |
| Brunet M | [Tacrolimus (FK506): clinical, pharmacological and analytical aspects]. | 1997 | Med Clin (Barc) | pmid:9289523 |
| Yagi M et al. | Effect of a glutamine-enriched diet on small bowel allograft during immunosuppressive therapy. | 1997 | Nutrition | pmid:9290090 |
| Kramer MR et al. | Dose adjustment and cost of itraconazole prophylaxis in lung transplant recipients receiving cyclosporine and tacrolimus (FK 506). | 1997 | Transplant. Proc. | pmid:9290780 |
| Ilan Y et al. | Transient immunosuppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviruses in the rat. | 1997 | Hepatology | pmid:9328318 |
| Vella JP and Sayegh MH | Maintenance pharmacological immunosuppressive strategies in renal transplantation. | 1997 | Postgrad Med J | pmid:9338020 |
| Atkison P et al. | Small bowel transplantation in children. | 1997 | Pediatr Transplant | pmid:10084770 |
| Webber SA | 15 years of pediatric heart transplantation at the University of Pittsburgh: lessons learned and future prospects. | 1997 | Pediatr Transplant | pmid:10084782 |
| Mori A et al. | IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506. | 1997 | J. Immunol. | pmid:9103428 |
| Hess DA et al. | The hydroxylamine of sulfamethoxazole synergizes with FK506 and cyclosporin A, inhibiting T-cell proliferation. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9103542 |
| Kawamura N et al. | Extremely high serum level of IgE during immunosuppressive therapy: paradoxical effect of cyclosporine A and tacrolimus. | 1997 | Int. Arch. Allergy Immunol. | pmid:9104801 |
| Beals CR et al. | Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. | 1997 | Genes Dev. | pmid:9106655 |
| Aiko S et al. | Effects of cyclosporine or FK506 in chronic colitis. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023326 |
| Budde K et al. | Differing proteinuria control with cyclosporin and tacrolimus. | 1997 | Lancet | pmid:9024386 |
| Alak AM et al. | A highly sensitive enzyme-linked immunosorbent assay for the determination of tacrolimus in atopic dermatitis patients. | 1997 | Ther Drug Monit | pmid:9029754 |
| Padhi ID et al. | Interaction between tacrolimus and erythromycin. | 1997 | Ther Drug Monit | pmid:9029762 |
| Tsuchida Y et al. | Limb allografts in rats treated with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies. | 1997 | J Reconstr Microsurg | pmid:9044184 |
| Wang W et al. | c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation. | 1997 | Immunity | pmid:9047238 |
| Steiner JP et al. | Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9050897 |
| Tsamandas AC et al. | Adult heart transplantation under tacrolimus (FK506) immunosuppression: histopathologic observations and comparison to a cyclosporine-based regimen with lympholytic (ATG) induction. | 1997 | J. Heart Lung Transplant. | pmid:9257254 |
| Trede NS et al. | Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation. | 1997 | Bone Marrow Transplant. | pmid:9257897 |
| Freiberg RA et al. | Transcriptional control in keratinocytes and fibroblasts using synthetic ligands. | 1997 | J. Clin. Invest. | pmid:9169490 |
| Wang JH and Kelly PT | Postsynaptic calcineurin activity downregulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons. | 1997 | J. Neurosci. | pmid:9169521 |
| Dodd DA | Rapid resolution of gingival hyperplasia after switching from cyclosporine A to tacrolimus. | 1997 | J. Heart Lung Transplant. | pmid:9171281 |
| Savoldi E et al. | [Dental and oral aspects in pediatric liver transplant patients. A comparison between the effects of cyclosporine A and FK 506]. | 1997 | Minerva Stomatol | pmid:9173223 |
| Rezeig MA et al. | Kaposi's sarcoma in liver transplant recipients on FK506: two case reports. | 1997 | Transplantation | pmid:9175820 |
| Rühlmann A and Nordheim A | Effects of the immunosuppressive drugs CsA and FK506 on intracellular signalling and gene regulation. | 1997 | Immunobiology | pmid:9442391 |