Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Weichert G and Sauder DN | Efficacy of tacrolimus (FK 506) in idiopathic treatment-resistant pyoderma gangrenosum. | 1998 | J. Am. Acad. Dermatol. | pmid:9777778 |
Chelmicka-Schorr E et al. | Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats. | 1998 | J. Autoimmun. | pmid:9776710 |
Fellermann K et al. | Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). | 1998 | Am. J. Gastroenterol. | pmid:9772045 |
Gómez J et al. | The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT. | 1998 | Oncogene | pmid:9771966 |
Luo Z et al. | Calcineurin inhibitors and cardiac hypertrophy. | 1998 | Nat. Med. | pmid:9771723 |
Bennett WM | The nephrotoxicity of new and old immunosuppressive drugs. | 1998 | Ren Fail | pmid:9768435 |
Lamb ML and Jorgensen WL | Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations. | 1998 | J. Med. Chem. | pmid:9767630 |
Hauser IA et al. | Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells. | 1998 | Kidney Int. | pmid:9767529 |
Wang JD et al. | Lymphotactin: a key regulator of lymphocyte trafficking during acute graft rejection. | 1998 | Immunology | pmid:9767457 |
Billaud EM et al. | Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients. | 1998 | Br J Clin Pharmacol | pmid:9764970 |