Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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de Mattos AM et al. | Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future. | 2000 | Am. J. Kidney Dis. | pmid:10676738 |
Kooman JP et al. | A comparison between office and ambulatory blood pressure measurements in renal transplant patients with chronic transplant nephropathy. | 2001 | Am. J. Kidney Dis. | pmid:11382685 |
Birdwell KA et al. | Decreased antibody response to influenza vaccination in kidney transplant recipients: a prospective cohort study. | 2009 | Am. J. Kidney Dis. | pmid:19185404 |
Rostaing L et al. | Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial. | 2016 | Am. J. Kidney Dis. | pmid:26717860 |
Revelo MP et al. | A 14-year-old boy with kidney allograft failure in the first month after transplantation. | 2000 | Am. J. Kidney Dis. | pmid:11007695 |
Böhmig GA et al. | Role of humoral immune reactions as target for antirejection therapy in recipients of a spousal-donor kidney graft. | 2000 | Am. J. Kidney Dis. | pmid:10739788 |
Neylan JF et al. | Assessment of the frequency and costs of posttransplantation hospitalizations in patients receiving tacrolimus versus cyclosporine. | 1998 | Am. J. Kidney Dis. | pmid:9820446 |
First MR | Renal transplantation for the nephrologist: new immunosuppressive drugs. | 1992 | Am. J. Kidney Dis. | pmid:1371201 |
Paoletti E et al. | ACE inhibitors and persistent left ventricular hypertrophy after renal transplantation: a randomized clinical trial. | 2007 | Am. J. Kidney Dis. | pmid:17591533 |
Mertz D et al. | Drug-drug interaction in a kidney transplant recipient receiving HIV salvage therapy and tacrolimus. | 2009 | Am. J. Kidney Dis. | pmid:19346040 |
Israni A et al. | Conversion to tacrolimus for the treatment of cyclosporine-associated nephrotoxicity in heart transplant recipients. | 2002 | Am. J. Kidney Dis. | pmid:11877596 |
Reese PP et al. | Automated Reminders and Physician Notification to Promote Immunosuppression Adherence Among Kidney Transplant Recipients: A Randomized Trial. | 2017 | Am. J. Kidney Dis. | pmid:27940063 |
Lien YH | Top 10 Things Primary Care Physicians Should Know About Maintenance Immunosuppression for Transplant Recipients. | 2016 | Am. J. Med. | pmid:26714210 |
Bar J et al. | Is immunosuppression therapy in renal allograft recipients teratogenic? A single-center experience. | 2003 | Am. J. Med. Genet. A | pmid:12476448 |
Perez-Aytes A et al. | In utero exposure to mycophenolate mofetil: a characteristic phenotype? | 2008 | Am. J. Med. Genet. A | pmid:18074358 |
Chen W et al. | Outcomes of tacrolimus therapy in adults with refractory membranous nephrotic syndrome: a prospective, multicenter clinical trial. | 2013 | Am. J. Med. Sci. | pmid:22627258 |
Hsu MS et al. | Clinical features and outcome of tuberculosis in solid organ transplant recipients. | 2007 | Am. J. Med. Sci. | pmid:17700199 |
Ocampo-Garza J et al. | Acquired Hyperpigmentation and Cicatricial Alopecia. | 2016 | Am. J. Med. Sci. | pmid:27524226 |
Chen M et al. | Tacrolimus combined with corticosteroids in treatment of nephrotic idiopathic membranous nephropathy: a multicenter randomized controlled trial. | 2010 | Am. J. Med. Sci. | pmid:20220333 |
Esposito C et al. | Sirolimus prevents short-term renal changes induced by ischemia-reperfusion injury in rats. | 2011 | Am. J. Nephrol. | pmid:21358177 |