Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ren H et al. | Tacrolimus versus cyclophosphamide in steroid-dependent or steroid-resistant focal segmental glomerulosclerosis: a randomized controlled trial. | 2013 | Am. J. Nephrol. | pmid:23343906 |
Araujo LP et al. | Interaction of the anti-inflammatory annexin A1 protein and tacrolimus immunosuppressant in the renal function of rats. | 2010 | Am. J. Nephrol. | pmid:20484890 |
Fourtounas C et al. | Different immunosuppressive combinations on T-cell regulation in renal transplant recipients. | 2010 | Am. J. Nephrol. | pmid:20484893 |
Bhimma R et al. | Management of steroid-resistant focal segmental glomerulosclerosis in children using tacrolimus. | 2006 | Am. J. Nephrol. | pmid:17159342 |
Ferreira A et al. | Donor-Specific Anti-Human Leukocyte Antigens Antibodies, Acute Rejection, Renal Function, and Histology in Kidney Transplant Recipients Receiving Tacrolimus and Everolimus. | 2017 | Am. J. Nephrol. | pmid:28511172 |
Tsipotis E et al. | Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis. | 2016 | Am. J. Nephrol. | pmid:27576318 |
Issa N et al. | Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence. | 2013 | Am. J. Nephrol. | pmid:23796509 |
Taber DJ et al. | Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients. | 2014 | Am. J. Nephrol. | pmid:24969370 |
Vural A et al. | Assessment of oxidative stress in the early posttransplant period: comparison of cyclosporine A and tacrolimus-based regimens. | 2005 May-Jun | Am. J. Nephrol. | pmid:15925859 |
Zhang Q et al. | Tacrolimus improves the proteinuria remission in patients with refractory IgA nephropathy. | 2012 | Am. J. Nephrol. | pmid:22456060 |
Li J et al. | Evaluation of mycophenolic acid exposure using a limited sampling strategy in renal transplant recipients. | 2013 | Am. J. Nephrol. | pmid:23689735 |
Lee CT et al. | Effects of cyclosporine, tacrolimus and rapamycin on renal calcium transport and vitamin D metabolism. | 2011 | Am. J. Nephrol. | pmid:21691056 |
Soubhia RM et al. | Tacrolimus and nonsteroidal anti-inflammatory drugs: an association to be avoided. | 2005 Jul-Aug | Am. J. Nephrol. | pmid:15976495 |
Dai DS et al. | Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury. | 2015 | Am. J. Nephrol. | pmid:26439819 |
El-Dahshan KF et al. | Ketoconazole-tacrolimus coadministration in kidney transplant recipients: two-year results of a prospective randomized study. | 2006 | Am. J. Nephrol. | pmid:16804292 |
Jin J et al. | Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway. | 2016 | Am. J. Nephrol. | pmid:27174564 |
Weir MR et al. | Late calcineurin inhibitor withdrawal as a strategy to prevent graft loss in patients with suboptimal kidney transplant function. | 2004 Jul-Aug | Am. J. Nephrol. | pmid:15237243 |
Bagnis C et al. | Comparative acute nephrotoxicity of FK-506 and ciclosporin in an isolated in situ autoperfused rat kidney model. | 1997 | Am. J. Nephrol. | pmid:9057948 |
von Felbert V et al. | Squamous cell carcinoma arising from a localized vulval lesion of Hailey-Hailey disease after tacrolimus therapy. | 2010 | Am. J. Obstet. Gynecol. | pmid:20816142 |
Kauppila S et al. | The effect of topical pimecrolimus on inflammatory infiltrate in vulvar lichen sclerosus. | 2010 | Am. J. Obstet. Gynecol. | pmid:19889396 |