tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Piekoszewski W et al. | Pharmacokinetic and pharmacodynamic effects of coadministration of methylprednisolone and tacrolimus in rabbits. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7513355 |
| Ueki M et al. | Peritoneal-omental pouch as a site for islet allotransplantation. | 1994 | Transplant. Proc. | pmid:7513462 |
| Yasunami Y et al. | Acceptance of donor-specific islet allografts in rat by intraportal preimmunization with islets and FK 506. | 1994 | Transplant. Proc. | pmid:7513467 |
| Ueki M et al. | Functional and morphologic characterization of renal subcapsular islet isografts in rats treated with FK 506. | 1994 | Transplant. Proc. | pmid:7513469 |
| Tze WJ et al. | Immunohistochemical studies of pig islet xenograft in rats immunosuppressed with FK 506. | 1994 | Transplant. Proc. | pmid:7513470 |
| Reggiani P et al. | Conversion to rescue therapy with FK 506: data from eight liver transplant patients. | 1994 | Transplant. Proc. | pmid:7527982 |
| Lemmens HP et al. | Outcome following orthotopic liver transplantation in HBsAg-positive patients using short- or long-term immunoprophylaxis. | 1994 | Transplant. Proc. | pmid:7527983 |
| Mueller AR et al. | Increased rejection after liver transplantation in FK 506-treated patients is associated with viral hepatitis C disease. | 1994 | Transplant. Proc. | pmid:7527984 |
| Tanabe M et al. | The influence of donor and recipient strains in isolated small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7527986 |
| Yamamoto S and Kato R | Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants. | 1994 | J. Dermatol. Sci. | pmid:7528050 |
| Sekigawa I et al. | FK506 can inhibit apoptotic cell death induced by the HIV-1 envelope glycoprotein gp120. | 1994 | AIDS | pmid:7531458 |
| Mazariegos GV et al. | Rubella infection after orthotopic liver transplantation. | 1994 | Pediatr. Infect. Dis. J. | pmid:7514783 |
| Mañez R et al. | Fluconazole therapy in transplant recipients receiving FK506. | 1994 | Transplantation | pmid:7515201 |
| Foster CA et al. | Pharmacological modulation of endothelial cell-associated adhesion molecule expression: implications for future treatment of dermatological diseases. | 1994 | J. Dermatol. | pmid:7531725 |
| Eng WK et al. | The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth. | 1994 | Gene | pmid:7530227 |
| Petros AM and Fesik SW | Nuclear magnetic resonance methods for studying protein-ligand complexes. | 1994 | Meth. Enzymol. | pmid:7530321 |
| Dawson TM et al. | The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. | 1994 | Neuroscience | pmid:7530348 |
| Ohtsuka S et al. | Effect of splenectomy on hamster-to-rat pancreas xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518109 |
| Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
| Miyazawa H et al. | Mechanisms of hamster kidney graft rejection in the rat. | 1994 | Transplant. Proc. | pmid:7518111 |
| Nardo B et al. | Pretransplant xenogeneic blood transfusion combined with FK 506 prolongs hamster-to-rat liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7518112 |
| Singh N et al. | Decreased incidence of viral infections in liver transplant recipients. Possible effects of FK506? | 1994 | Dig. Dis. Sci. | pmid:7506641 |
| D'Ambrosio R et al. | Improved procedures for enzyme immunoassay of tacrolimus (FK506) in whole blood. | 1994 | Clin. Chem. | pmid:7507007 |
| Wang T et al. | Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. | 1994 | Science | pmid:7518616 |
| Tanabe M et al. | Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation. | 1994 | Transplantation | pmid:7518619 |
| Tamura K et al. | Interaction of tacrolimus(FK506) and its metabolites with FKBP and calcineurin. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7518678 |
| Hooks MA | Tacrolimus, a new immunosuppressant--a review of the literature. | 1994 | Ann Pharmacother | pmid:7518710 |
| Frizell E et al. | FK506 enhances fibrogenesis in in vitro and in vivo models of liver fibrosis in rats. | 1994 | Gastroenterology | pmid:7518783 |
| Yamamoto S et al. | Stimulation of hair growth by topical application of FK506, a potent immunosuppressive agent. | 1994 | J. Invest. Dermatol. | pmid:7508960 |
| Logan TM et al. | Structural characterization of the FK506 binding protein unfolded in urea and guanidine hydrochloride. | 1994 | J. Mol. Biol. | pmid:7508991 |
| Cooper MH et al. | Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors. | 1994 | Transplantation | pmid:7509089 |
| Rosh JR et al. | Therapy with FK 506 in pediatric liver recipients. | 1994 | Transplant. Proc. | pmid:7509091 |
| Scantlebury VP et al. | Pediatric kidney transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7509095 |
| Imanishi M et al. | Induction of tolerance by intrathymic injection of donor bone marrow cells in the rat: simultaneous heart and skin allograft model. | 1994 | Transplant. Proc. | pmid:7520615 |
| Charters AR et al. | Immunochemical analysis of FK506 binding proteins in neuronal cell lines and rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535258 |
| Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
| Charters AR et al. | The subcellular distribution of FK506 binding proteins in rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535259 |
| Ota K | Living donor kidney transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520622 |
| Hirose M and Kuroda Y | Reinforcement of cyclosporin A-induced red cell destruction by superoxide. | 1994 | Tokushima J. Exp. Med. | pmid:7535479 |
| Takahara S et al. | Monitoring of FK 506 blood levels in kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7520623 |
| Woo J et al. | FK506 inhibits the differentiation of developing thymocytes but not negative selection of T cell receptor V beta 5+ and V beta 11+ T lymphocytes in vivo. | 1994 | Transpl. Immunol. | pmid:7521743 |
| Kasiske BL | The effects of immunosuppressive agents on plasma lipoproteins after organ transplantation. | 1994 | J. Lab. Clin. Med. | pmid:7521894 |
| Hiromura K et al. | FK506 inhibits renal glomerular thrombosis induced in rats by nephrotoxic serum and lipopolysaccharide. | 1994 | Kidney Int. | pmid:7523750 |
| Ohtomo Y et al. | Coexisting NPY and NE synergistically regulate renal tubular Na+, K(+)-ATPase activity. | 1994 | Kidney Int. | pmid:7523751 |
| Siekierka JJ | Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin. | 1994 | Immunol. Res. | pmid:7539823 |
| Moore R and Lord R | Tacrolimus (FK506) versus cyclosporin in prevention of liver allograft rejection. | 1994 | Lancet | pmid:7523805 |
| Krentz AJ et al. | Tacrolimus (FK506) versus cyclosporin in prevention of liver allograft rejection. | 1994 | Lancet | pmid:7523806 |
| Collins RH | Tacrolimus (FK506) versus cyclosporin in prevention of liver allograft rejection. | 1994 | Lancet | pmid:7523807 |
| Tacrolimus introduced for use in liver transplantation. | 1994 | Am J Hosp Pharm | pmid:7524317 | |
| Przepiorka D et al. | Blood tacrolimus concentration unchanged by plasmapheresis. | 1994 | Am J Hosp Pharm | pmid:7524318 |
| Burnett D et al. | Inhibition by FK506 of formyl peptide-induced neutrophil activation and associated protein synthesis. | 1994 | Biochem. Pharmacol. | pmid:7524504 |
| Bierer BE | Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action. | 1994 | Chem. Immunol. | pmid:7524531 |
| Lepre CA et al. | Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12. | 1994 | Biochemistry | pmid:7524662 |
| Matsunami H et al. | New technique for measuring tacrolimus concentrations in blood. | 1994 | Am J Hosp Pharm | pmid:7510929 |
| Lewis HM | Therapeutic progress. II: Treatment of psoriasis. | 1994 | J Clin Pharm Ther | pmid:7527403 |
| Chen SR et al. | Asymmetrical blockade of the Ca2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7527548 |
| Calmus Y | [Rejection of a liver allograft. Diagnosis and treatment]. | 1994 | Ann Radiol (Paris) | pmid:7527621 |
| Jiang H et al. | The superior effect of the combination of FK 506 and deoxyspergualin on rat cardiac allograft survival. | 1994 | Transpl. Int. | pmid:7527637 |
| Lhoëst G et al. | Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. | 1993 Sep-Oct | Drug Metab. Dispos. | pmid:7694828 |
| Iwasaki K et al. | Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. | 1993 Nov-Dec | Drug Metab. Dispos. | pmid:7507815 |
| Fukuse T et al. | Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508750 |
| Morris RE | New small molecule immunosuppressants for transplantation: review of essential concepts. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508752 |
| Schreier MH | Immunophilins and immunosuppression. | 1993 Mar-Apr | Clin. Exp. Rheumatol. | pmid:7686830 |
| Piekoszewski W et al. | Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. | 1993 Jul-Aug | Drug Metab. Dispos. | pmid:7690698 |
| Kobayashi J et al. | A new rat infection-heart transplant model: effect of infection on graft survival studies. | 1993 Jul-Aug | J. Heart Lung Transplant. | pmid:7690253 |
| Kahan BD | Cyclosporine: the base for immunosuppressive therapy--present and future. | 1993 | Transplant. Proc. | pmid:7679819 |
| Starzl TE | FK 506 versus cyclosporine. | 1993 | Transplant. Proc. | pmid:7679820 |
| Nakajima K et al. | Effects of triple therapy of cyclosporine, FK 506, and RS-61443 on allogeneic small bowel transplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679821 |
| Abu-Elmagd KM et al. | Monitoring and treatment of intestinal allograft rejection in humans. | 1993 | Transplant. Proc. | pmid:7680150 |
| McCauley J et al. | FK 506 in the management of nephrotic syndrome after renal transplantation. | 1993 | Transplant. Proc. | pmid:7680154 |
| Mañez R et al. | Association between donor-recipient HLA-DR compatibility and cytomegalovirus hepatitis and chronic rejection in liver transplantation. | 1993 | Transplant. Proc. | pmid:7680170 |
| McCauley J | The nephrotoxicity of FK506 as compared with cyclosporine. | 1993 | Curr. Opin. Nephrol. Hypertens. | pmid:7532089 |
| Woan MC et al. | Characterization of the biopsy growth assay in monitoring cardiac transplant patients for rejection. | 1993 | Transplant. Proc. | pmid:7680171 |
| Reese JC et al. | The effect of FK506 on canine bile flow. | 1993 | Transplantation | pmid:7504342 |
| Woodle ES et al. | FK506--reversal of humorally mediated cardiac allograft rejection in the presence of preformed anti-class I antibody. | 1993 | Transplantation | pmid:7504346 |
| Jindal RM et al. | Effect of deoxyspergualin on the endocrine function of the rat pancreas. | 1993 | Transplantation | pmid:7504347 |
| Frank B et al. | Neurotoxicity of FK 506 in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7682355 |
| Klintmalm GB et al. | Rejection: FK 506 for rescue or maintenance. | 1993 | Transplant. Proc. | pmid:7682356 |
| Woodle ES et al. | Recurrent rejection following FK 506 rescue therapy for acute hepatic allograft rejection. | 1993 | Transplant. Proc. | pmid:7682358 |
| Woodle ES et al. | FK 506 rescue therapy: early conversion improves efficacy. | 1993 | Transplant. Proc. | pmid:7682359 |
| Simek SL et al. | Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. | 1993 | Genomics | pmid:7507077 |
| Quesniaux VF | Immunosuppressants: tools to investigate the physiological role of cytokines. | 1993 | Bioessays | pmid:7507316 |
| Nakamura T et al. | Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. | 1993 | EMBO J. | pmid:7693452 |
| Higa A et al. | Attenuation of epithelial injury in acute experimental colitis by immunomodulators. | 1993 | Eur. J. Pharmacol. | pmid:7693488 |
| Schmitt J et al. | Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor. | 1993 | Gene | pmid:7693550 |
| Sato M et al. | FK506 inhibits phytohemagglutinin-, but not interferon-gamma-, induced HLA-DR antigen expression and accessory cell function on primary cultured human thyroid cells. | 1993 | Acta Endocrinol. | pmid:7509103 |
| Clipstone NA and Crabtree GR | Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509131 |
| Takahara S | Efficacy of FK506 in renal transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509132 |
| Francavilla A et al. | Hepatic regeneration and growth factors. | 1993 | J Surg Oncol Suppl | pmid:7684910 |
| Connelly PR et al. | Probing hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and rapamycin binding to FK506 binding protein in D2O and H2O. | 1993 | Biochemistry | pmid:7684925 |
| Wallemacq PE et al. | Improvement and assessment of enzyme-linked immunosorbent assay to detect low FK506 concentrations in plasma or whole blood within 6 hours. | 1993 | Clin. Chem. | pmid:7684956 |
| Mochizuki M et al. | A clinical trial of FK506 in refractory uveitis. | 1993 | Am. J. Ophthalmol. | pmid:7685147 |
| Koga T et al. | Pulmonary infiltrates recovered by FK506 in a patient with Behçet's disease. | 1993 | Chest | pmid:7686837 |
| Nishi M et al. | Effects of the immunosuppressant FK506 on a penetrating keratoplasty rejection model in the rat. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:7686893 |
| Nishizawa S et al. | Therapeutic effect of a new immunosuppressant, FK-506, on vasospasm after subarachnoid hemorrhage. | 1993 | Neurosurgery | pmid:7687044 |
| Warty V et al. | FK506 measurement: comparison of different analytical methods. | 1993 | Ther Drug Monit | pmid:7687389 |
| Groth CG et al. | New immunosuppressive drugs in transplantation. | 1993 | Transplant. Proc. | pmid:7689274 |
| McMaster P and Buist L | FK 506 in transplantation. | 1993 | Transplant. Proc. | pmid:7689275 |
| Jost U et al. | FK 506 treatment of intractable rejection after liver transplantation. | 1993 | Transplant. Proc. | pmid:7689276 |
| Takahashi H and Iizuka H | Neither cyclosporin A nor FK506 affects adenylate cyclase responses of fetal rat keratinizing epidermal cells (FRSK cells) at concentrations that inhibit thymidine incorporation. | 1993 | J. Dermatol. Sci. | pmid:7511000 |