tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Abnormalities, Multiple D000015 13 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Adenocarcinoma D000230 166 associated lipids
Adrenal Insufficiency D000309 3 associated lipids
Akinetic Mutism D000405 1 associated lipids
Albuminuria D000419 18 associated lipids
Alopecia D000505 14 associated lipids
Alopecia Areata D000506 6 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amenorrhea D000568 4 associated lipids
Amputation, Traumatic D000673 2 associated lipids
Anemia D000740 21 associated lipids
Anemia, Aplastic D000741 6 associated lipids
Anemia, Hemolytic D000743 4 associated lipids
Anemia, Hemolytic, Autoimmune D000744 5 associated lipids
Anemia, Refractory D000753 3 associated lipids
Anemia, Refractory, with Excess of Blasts D000754 2 associated lipids
Aneurysm, Dissecting D000784 2 associated lipids
Angiolymphoid Hyperplasia with Eosinophilia D000796 1 associated lipids
Angioedema D000799 6 associated lipids
Anus Diseases D001004 3 associated lipids
Apraxias D001072 1 associated lipids
Arm Injuries D001134 1 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Arthritis, Infectious D001170 8 associated lipids
Arthritis, Juvenile D001171 8 associated lipids
Ascites D001201 25 associated lipids
Ataxia D001259 20 associated lipids
Ataxia Telangiectasia D001260 6 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Autonomic Nervous System Diseases D001342 4 associated lipids
Bacterial Infections D001424 21 associated lipids
Balanitis D001446 4 associated lipids
Beckwith-Wiedemann Syndrome D001506 1 associated lipids
Behcet Syndrome D001528 7 associated lipids
Biliary Fistula D001658 13 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Blepharitis D001762 4 associated lipids
Blindness D001766 6 associated lipids
Body Weight D001835 333 associated lipids
Bone Diseases D001847 4 associated lipids
Bradycardia D001919 13 associated lipids
Brain Diseases D001927 27 associated lipids
Brain Edema D001929 20 associated lipids
Bronchiolitis D001988 6 associated lipids
Bronchiolitis Obliterans D001989 8 associated lipids
Burkitt Lymphoma D002051 15 associated lipids
Burns D002056 34 associated lipids
Candidiasis, Oral D002180 11 associated lipids
Candidiasis, Vulvovaginal D002181 8 associated lipids
Carcinoma, Squamous Cell D002294 14 associated lipids
Cardiomyopathy, Hypertrophic D002312 6 associated lipids
Cardiomyopathy, Restrictive D002313 1 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Carpal Tunnel Syndrome D002349 3 associated lipids
Catalepsy D002375 30 associated lipids
Cataract D002386 34 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Myoclonic Cerebellar Dyssynergia D002527 1 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Uterine Cervical Dysplasia D002578 2 associated lipids
Cheilitis D002613 2 associated lipids
Cholelithiasis D002769 16 associated lipids
Cholestasis D002779 23 associated lipids
Choline Deficiency D002796 16 associated lipids
Hemophilia B D002836 3 associated lipids
Chronic Disease D002908 7 associated lipids
Cicatrix D002921 9 associated lipids
Coccidioidomycosis D003047 2 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Collagen Diseases D003095 2 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Confusion D003221 4 associated lipids
Connective Tissue Diseases D003240 2 associated lipids
Corneal Diseases D003316 13 associated lipids
Cough D003371 19 associated lipids
Crigler-Najjar Syndrome D003414 1 associated lipids
Crohn Disease D003424 12 associated lipids
Cryptococcosis D003453 3 associated lipids
Cutis Laxa D003483 1 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cystitis D003556 23 associated lipids
Phyllodes Tumor D003557 1 associated lipids
Hearing Loss, Sudden D003639 1 associated lipids
Deglutition Disorders D003680 2 associated lipids
Dehydration D003681 11 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Dental Enamel Hypoplasia D003744 2 associated lipids
Dental Pulp Calcification D003784 2 associated lipids
Dermatitis D003872 30 associated lipids
Drug Eruptions D003875 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Dermatitis, Contact D003877 59 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Zhu ZJ et al. [Diagnosis and treatment of de novo malignancy after liver transplantation]. 2007 Zhonghua Zhong Liu Za Zhi pmid:17649647
Dong J et al. [Osteoblastic differentiation and in vivo osteogenic activity of marrow-derived mesenchymal stem cells stimulated by Tacrolimus: experiment with rats]. 2007 Zhonghua Yi Xue Za Zhi pmid:17425851
Liang TB et al. [Graft versus host disease after liver transplantation: a report of 3 cases]. 2004 Zhonghua Yi Xue Za Zhi pmid:15200885
Wang W et al. [Relationship between MDR1 gene polymorphism and blood concentration of tacrolimus in renal transplant patients]. 2005 Zhonghua Yi Xue Za Zhi pmid:16409819
Chen YH et al. [Nephrotoxicity of tacrolimus and preventive effect of diltiazem: experiment with rats]. 2009 Zhonghua Yi Xue Za Zhi pmid:19595068
Lu AW et al. [Dual, triple, and quadruple oral tacrolimus-based immunosuppression regimens after orthotopic liver transplantation: a randomised comparative study of regimens]. 2006 Zhonghua Yi Xue Za Zhi pmid:17313848
Huang G et al. [Analysis on BK virus associated nephropathy related risk factors in renal transplant recipients]. 2015 Zhonghua Yi Xue Za Zhi pmid:26814103
Pan F et al. [Protective effect of tacrolimus postconditioning on oxidative stress injury provoked by spinal cord ischemia-reperfusion in rats]. 2013 Zhonghua Yi Xue Za Zhi pmid:24548402
Dong QE et al. [Inhibitory effects of tacrolimus on effector T cells from patients with severe aplastic anemia]. 2013 Zhonghua Yi Xue Za Zhi pmid:24028719
Li YX et al. [Preliminary experience with partial tolerance protocol in small bowel transplantation]. 2009 Zhonghua Yi Xue Za Zhi pmid:20137270
Feng HY et al. [Therapeutic efficacy and safety of tacrolimus for intractable myasthenia gravis: a report of 36 patients]. 2011 Zhonghua Yi Xue Za Zhi pmid:22333101
Huang HF et al. [Conversion from calcineurin inhibitors to sirolimus in chronic allograft nephropathy: a 4-year prospective study]. 2011 Zhonghua Yi Xue Za Zhi pmid:22333250
Chen H et al. [Mycophenolate mofetil in treatment of graft-versus-host disease after allogeneic hematopoietic cell transplantation: analysis of 44 cases]. 2008 Zhonghua Yi Xue Za Zhi pmid:19080474
Zhao SM et al. [Promotion of in vitro long term expansion of primitive multipotential hematopoietic cells by transduced JAK2 gene]. 2004 Zhonghua Yi Xue Za Zhi pmid:15329285
Chen YH et al. [Prevention of diltiazem in tacrolimus-induced nephrotoxicity: experiment with rats]. 2007 Zhonghua Yi Xue Za Zhi pmid:18001539
Li YL et al. [Measurement of tacrolimus in blood with the method of high performance liquid chromatography-mass spectrometry]. 2008 Zhonghua Yi Xue Za Zhi pmid:19087682
Cai JQ et al. [Study of the effects of immunosuppressive agents on human islet cells in vitro]. 2005 Zhonghua Yi Xue Za Zhi pmid:15932724
Wang J and Fan H [Assessment of P70S6 kinase phosphorylation after liver transplantation by phospho-flow cytometry]. 2014 Zhonghua Yi Xue Za Zhi pmid:25623311
Xia WL et al. [Effects of ciclosporin and tacrolimus on replication of hepatitis B virus in vitro: a comparative study]. 2006 Zhonghua Yi Xue Za Zhi pmid:16620716
Lü DC et al. [Effect of FK506 on axonal regeneration of rat sciatic nerve in regeneration chamber: an experimental study]. 2005 Zhonghua Yi Xue Za Zhi pmid:16313776
Zhang WG et al. [Favorable effect of chitosan sustained-release FK506 incorporated conduits on axonal regeneration in rat sciatic nerve]. 2006 Zhonghua Yi Xue Za Zhi pmid:16784713
Jin J et al. Impact of multidrug resistance 1 gene polymorphism on tacrolimus dose and concentration-to-dose ratio in Chinese liver transplantation recipients. 2005 Zhonghua Yi Xue Yi Chuan Xue Za Zhi pmid:16331555
Xie H et al. [Effect of FK506 eye-drop combined with keratoplasty on recurrent Mooren's ulcer]. 2002 Zhonghua Yan Ke Za Zhi pmid:11955293
Chen J et al. [The study of FK506 eye drops preventing and treating immune rejection on limbal allograft transplantation]. 2003 Zhonghua Yan Ke Za Zhi pmid:14766087
Xiang DM et al. [The observation of tacrolimus eye drops preventing the early immunological rejection after penetrating keratoplasty for fungal keratitis]. 2017 Zhonghua Yan Ke Za Zhi pmid:28412805
Sun YJ et al. [Systematic review of penetrating keratoplasty rejection treated by immunosuppressants]. 2010 Zhonghua Yan Ke Za Zhi pmid:21211228
Shi WY et al. [Implantation of FK506 drug delivery system into the anterior chamber for inhibiting corneal rejection in high risk rabbit corneal allograft]. 2006 Zhonghua Yan Ke Za Zhi pmid:16762204
Fei WL et al. [The pharmacokinetics of FK506 and its nanoparticles in aqueous humor of rabbits]. 2006 Zhonghua Yan Ke Za Zhi pmid:16762205
Lü L et al. [Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats]. 1999 Zhonghua Yan Ke Za Zhi pmid:11835769
Lü L and Zhang W [Immunopathologic studies on the effects of immunosuppressant FK 506 on penetrating keratoplasty rejection model in rat]. 1998 Zhonghua Yan Ke Za Zhi pmid:11877144
DU C et al. [In vitro effects of tacrolimus on platelet function]. 2014 Zhonghua Xue Ye Xue Za Zhi pmid:25339327
Zhao SM et al. [Long term regulated expansion and committed differentiation of JAK2 gene transfected hematopoietic stem/progenitor cells in vitro]. 2004 Zhonghua Xue Ye Xue Za Zhi pmid:14990041
Chen F et al. [Outcomes of allogeneic hematopoietic stem cell transplantation for 18 patients with paroxysmal nocturnal haemoglobinuria]. 2015 Zhonghua Xue Ye Xue Za Zhi pmid:26759101
Sun J et al. [A preliminary study on the biological characteristics and function of tolerogenic dendritic cells induced by tacrolimus]. 2014 Zhonghua Xue Ye Xue Za Zhi pmid:24985179
Cao KJ et al. [Immunosuppressive therapy after human lung transplantation]. 2007 Zhonghua Wai Ke Za Zhi pmid:17845780
Li YX et al. [Preliminary experience with Campath 1H induction combined with low-dose monotherapy of tacrolimus in small bowel transplantation]. 2009 Zhonghua Wai Ke Za Zhi pmid:19961008
Pan F et al. [Effect of tacrolimus on apoptosis and expression of heat shock protein 70 after acute spinal cord injury in rats]. 2006 Zhonghua Wai Ke Za Zhi pmid:17359722
Lü DC et al. [An experimental study of the neuroprotective effect of FK506 on acute spinal cord injury in dogs]. 2005 Zhonghua Wai Ke Za Zhi pmid:16194341
Zhao X et al. [A retrospective cohort study regarding the effect of sirolimus-based immunosuppression protocol on the long-term survival of hepatocellular carcinoma patients after liver transplantation]. 2014 Zhonghua Wai Ke Za Zhi pmid:24924566
Ju WQ et al. [Two-dose steroid combined with two-dose daclizumab and tacrolimus regimen in liver transplant recipients]. 2009 Zhonghua Wai Ke Za Zhi pmid:19781270
Hu AB et al. [Evaluation of efficacy and safety on steroid withdraw at the seventh day after liver transplantation]. 2008 Zhonghua Wai Ke Za Zhi pmid:19094670
Yang FC et al. [Influence of combined cyclosporine A and tacrolimus with 5-fluorouracil on hepatocellular carcinoma rats]. 2003 Zhonghua Wai Ke Za Zhi pmid:12895356
Chen YP et al. [The clinical efficacy and safety of tacrolimus in patients with myasthenia gravis]. 2013 Zhonghua Nei Ke Za Zhi pmid:24266997
Sun L et al. [Effect of FK506 on the cavernous nerve regeneration after injury]. 2005 Zhonghua Nan Ke Xue pmid:15755036
Cao ZG et al. [Effects of different immunodepressants on the sperm parameters of kidney transplant recipients]. 2006 Zhonghua Nan Ke Xue pmid:16755867
Zhao S et al. [Effects of tacrolimus (FK506) on heat-shock proteins 70, Bcl-2 and Bax expression in nervous tissue of acrylamide-induced rat]. 2010 Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi pmid:20465949
Sun YJ and Sun Z [Treatment of erosive oral lichen planus with topical tacrolimus]. 2010 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:20450689
Zhang J et al. [Effects of sirolimus on the growth of transplanted hepatocellular carcinoma]. 2009 Zhonghua Gan Zang Bing Za Zhi pmid:19567017
Qian SK et al. [The prevention and management of cerebrovascular complications in nine cases after orthotopic liver transplantation]. 2005 Zhonghua Gan Zang Bing Za Zhi pmid:16313741
Wang ZL et al. [Management of pediatric patients who underwent liver transplantation]. 2007 Zhonghua Er Ke Za Zhi pmid:17880788