tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gaweco AS et al. | Distinct intragraft cytokine gene expression patterns during acute hepatic rejection under cyclosporine versus FK 506 primary immunosuppression. | 1994 | Transplant. Proc. | pmid:7527948 |
| Burke GW et al. | The use of FK506 in simultaneous pancreas/kidney transplantation: rescue, induction, and maintenance immunosuppression. | 1995 | Transplant. Proc. | pmid:8539874 |
| Ueki M et al. | Peritoneal-omental pouch as a site for islet allotransplantation. | 1994 | Transplant. Proc. | pmid:7513462 |
| Valdivia LA et al. | Hamster-to-rat liver xenografts protect extrahepatic organs from rejection. | 1993 | Transplant. Proc. | pmid:7679816 |
| Yasunami Y et al. | Acceptance of donor-specific islet allografts in rat by intraportal preimmunization with islets and FK 506. | 1994 | Transplant. Proc. | pmid:7513467 |
| Alejandro R et al. | Combined liver-islet allotransplantation in man under FK 506. | 1991 | Transplant. Proc. | pmid:1703712 |
| Zeevi A et al. | Functional differentiation of human cytotoxic T lymphocytes in the presence of FK 506 and CyA. | 1990 | Transplant. Proc. | pmid:1689884 |
| Pascual J and Ortuño J | Simple tacrolimus-based immunosuppressive regimens following renal transplantation: a large multicenter comparison between double and triple therapy. | 2002 | Transplant. Proc. | pmid:11959198 |
| Gamboa O et al. | Cost-effectiveness analysis of the early conversion of tacrolimus to mammalian target of rapamycin inhibitors in patients with renal transplantation. | 2011 | Transplant. Proc. | pmid:22099798 |
| Fougeray S et al. | Increased body mass index after kidney transplantation in activating transcription factor 6 single polymorphism gene carriers. | 2011 | Transplant. Proc. | pmid:22099811 |
| Grewal HP et al. | Corticosteroid cessation 1 week following renal transplantation using tacrolimus/mycophenolate mofetil based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636558 |
| Fernández A et al. | Complete switch to everolimus in long-term kidney transplants: evolution of the renal function. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715915 |
| Marcén R et al. | Evolution of rejection rates and kidney graft survival: a historical analysis. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715918 |
| Chueh SC et al. | Drug fever caused by mycophenolate mofetil in a renal transplant recipient--a case report. | 2000 | Transplant. Proc. | pmid:11120003 |
| Vathsala A et al. | Inhibition of apoptosis in anti-CD3-treated peripheral blood lymphocytes by immunosuppressive drugs. | 2000 | Transplant. Proc. | pmid:11120034 |
| Shibata T et al. | Does FK 506 accelerate the development of coronary artery disease in the transplanted heart as well as the native heart? | 1993 | Transplant. Proc. | pmid:7680147 |
| Todo S et al. | Intestinal transplantation in humans under FK 506. | 1993 | Transplant. Proc. | pmid:7680148 |
| Cofan F et al. | Effect of calcineurin inhibitors on low-density lipoprotein oxidation. | 2005 | Transplant. Proc. | pmid:16386540 |
| Wu YM et al. | Interaction between FK 506 and cyclosporine in dogs. | 1991 | Transplant. Proc. | pmid:1721281 |
| Habucky K et al. | The pharmacodynamics of pentobarbital following FK 506 therapy. | 1991 | Transplant. Proc. | pmid:1721282 |
| Horimoto H et al. | Hepatocyte xenotransplantation for Nagase's analbuminemic rats: the effect of FK506. | 1996 | Transplant. Proc. | pmid:8623421 |
| Sung RS et al. | Survival of human islet xenografts irradiated with ultraviolet B in diabetic rats. | 1996 | Transplant. Proc. | pmid:8623427 |
| DÃaz-Molina B et al. | Effect of CYP3A5, CYP3A4, and ABCB1 genotypes as determinants of tacrolimus dose and clinical outcomes after heart transplantation. | 2012 | Transplant. Proc. | pmid:23146479 |
| San Segundo D et al. | Study of B-cell subpopulations in lung transplant recipients with posttransplant infection. | 2012 | Transplant. Proc. | pmid:23146491 |
| Tekgündüz E et al. | Electrolyte free water clearance could be an early sign of renal dysfunction in renal transplant patients. | 2009 | Transplant. Proc. | pmid:19917375 |
| Lipson DA et al. | Conversion to tacrolimus (FK506) from cyclosporine after orthotopic lung transplantation. | 1998 | Transplant. Proc. | pmid:9636612 |
| Zawiasa A et al. | Effect of oral fructose load on serum uric acid and lipids in kidney transplant recipients treated with cyclosporine or tacrolimus. | 2009 Jan-Feb | Transplant. Proc. | pmid:19249511 |
| Hohage H et al. | Cyclosporine and tacrolimus: influence on cardiovascular risk factors. | 2005 | Transplant. Proc. | pmid:15848615 |
| Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
| Schuller S et al. | Daclizumab induction therapy associated with tacrolimus-MMF has better outcome compared with tacrolimus-MMF alone in pediatric living donor liver transplantation. | 2005 | Transplant. Proc. | pmid:15848653 |
| Mueller AR et al. | The superior immunosuppressant according to diagnosis: FK 506 or cyclosporine A. | 1995 | Transplant. Proc. | pmid:7533359 |
| Kita J et al. | Effects of tacrolimus on small and large bowel anastomoses in the rat. | 1999 | Transplant. Proc. | pmid:10578292 |
| Woo J et al. | Kinetics of early T-cell repopulation in the mouse following syngeneic bone marrow transplantation: FK 506 causes a maturational defect of CD4+ CD8- T cells. | 1991 | Transplant. Proc. | pmid:1721313 |
| Azuma T et al. | Study of graft-infiltrating cells in the rat small bowel allograft using low-dose FK 506. | 1999 | Transplant. Proc. | pmid:10578293 |
| Telkes G et al. | Kidney transplantation in hereditary coproporphyria using tacrolimus and mycophenolate mofetil: a case report. | 2013 | Transplant. Proc. | pmid:24315002 |
| Ebbs A et al. | Tacrolimus treats ongoing allograft rejection by inhibiting interleukin-10 mediated functional cytotoxic cell infiltration. | 2002 | Transplant. Proc. | pmid:12176404 |
| Savikko J et al. | Tacrolimus inhibits platelet-derived growth factor ligand and receptor induction as well as rejection changes in rat renal allografts during long-term follow-up. | 2002 | Transplant. Proc. | pmid:12176405 |
| Ã…berg F et al. | Asymptomatic De Novo Inflammatory Bowel Disease Late After Liver Transplantation for Primary Sclerosing Cholangitis: A Case Report. | 2015 | Transplant. Proc. | pmid:26680092 |
| Heilman RL et al. | Steroid avoidance immunosuppression in low-risk kidney transplant recipients. | 2005 | Transplant. Proc. | pmid:15919466 |
| Akita K and Mandel TE | Effect of FK 506 and anti-CD4 monoclonal antibody treatment on xenografts of organ-cultured fetal pig pancreas and host lymphoid populations. | 1993 | Transplant. Proc. | pmid:7692650 |
| Tanabe M et al. | Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation. | 1995 | Transplant. Proc. | pmid:7533411 |
| Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
| Mieles LA et al. | Liver transplantation of American veterans under FK 506 immunosuppression: a preliminary report. | 1991 | Transplant. Proc. | pmid:1721344 |
| Nakazato P et al. | Early experience with FK 506 induction immunosuppression--suggestion for using oral FK 506. | 1991 | Transplant. Proc. | pmid:1721345 |
| Bortman GV et al. | South American Heart Transplantation Registry of patients receiving everolimus in their immunosuppressive regimens. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172342 |
| Parada MT et al. | Everolimus in lung transplantation in Chile. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172343 |
| Reis A et al. | Mycophenolate mofetil and FK506: two novel immunosuppressants in murine corneal transplantation. | 1998 | Transplant. Proc. | pmid:9865380 |
| Malaise J et al. | Tacrolimus compared with cyclosporine microemulsion in primary simultaneous pancreas-kidney transplantation: the EURO-SPK 3-year results. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182828 |
| Naraghi RM et al. | Long-term follow-up of tacrolimus rescue therapy for renal allograft rejection. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123013 |
| Meçule A et al. | Interleukin-2 profiles shortly after tacrolimus conversion from a twice-daily to once-daily regimen. | 2011 | Transplant. Proc. | pmid:21620040 |
| Calia R et al. | Effects of switching from twice-daily to once-daily tacrolimus formulation on quality of life, anxiety, and transplant benefit perception after kidney transplantation. | 2011 | Transplant. Proc. | pmid:21620041 |
| Velio P et al. | Rejection and survival after total orthotopic liver-small bowel allotransplantation in pigs immunosuppressed with FK 506. | 1996 | Transplant. Proc. | pmid:8907936 |
| Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
| Watanabe T et al. | Effects of the endothelin-1 receptor antagonist TAK-044 on pulmonary injury in discordant xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936270 |
| Boots JM et al. | Pretransplant pharmacokinetics: does it predict the dose of tacrolimus after renal transplantation? | 2002 | Transplant. Proc. | pmid:12493409 |
| Ueda D et al. | Influence of FK 506 on renal blood flow. | 1991 | Transplant. Proc. | pmid:1721377 |
| Peraira JR et al. | High incidence of severe infections in heart transplant recipients receiving tacrolimus. | 2003 | Transplant. Proc. | pmid:12962875 |
| Pisitkun T et al. | The roles of C4 and AUC0-4 in monitoring of tacrolimus in stable kidney transplant patients. | 2002 | Transplant. Proc. | pmid:12493410 |
| Thomson AW et al. | The influence of FK 506 on the thymus: implications of drug-induced injury to thymic epithelial cells. | 1991 | Transplant. Proc. | pmid:1703361 |
| Perico N et al. | FK 506 does not affect the glomerular filtration rate and renal plasma flow in the rat. | 1991 | Transplant. Proc. | pmid:1721378 |
| Zegarska J et al. | Evaluation of the Relationship Between Concentrations of Tacrolimus Metabolites, 13-O-Demethyl Tacrolimus and 15-O-Demethyl Tacrolimus, and Clinical and Biochemical Parameters in Kidney Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30177142 |
| Mieles L et al. | Glycemia and insulin need following FK 506 rescue therapy in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1703362 |
| Okamoto M et al. | Tacrolimus-based immunosuppression in renal transplantation: 78 experiences in a single Japanese center. | 2002 | Transplant. Proc. | pmid:12176527 |
| Tanabe K et al. | Improved outcome of minor-mismatched living renal allografts under tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176528 |
| Rastellini C et al. | Prolonged survival of islet allografts following combined therapy with tacrolimus and leflunomide. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083278 |
| Tsuchiya T et al. | Effect of conversion from twice-daily to once-daily tacrolimus on glucose intolerance in stable kidney transplant recipients. | 2012 | Transplant. Proc. | pmid:22310593 |
| Hatakeyama S et al. | A switch from conventional twice-daily tacrolimus to once-daily extended-release tacrolimus in stable kidney transplant recipients. | 2012 | Transplant. Proc. | pmid:22310594 |
| Millis JM et al. | Tacrolimus treatment of steroid-resistant rejection provides economic advantages compared with OKT3 therapy. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123421 |
| Mollison KW et al. | Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat. | 1996 | Transplant. Proc. | pmid:8962236 |
| Pelekanou V et al. | FK 506 and rapamycin do not affect platelet aggregation or mitochondrial function. | 1991 | Transplant. Proc. | pmid:1721408 |
| Taki J et al. | DNA analysis of peripheral blood mononuclear cells for early detection of hepatic graft rejection. | 1992 | Transplant. Proc. | pmid:1379760 |
| Nagashima N et al. | Immunocompetence assay for net effect of combined immunosuppression. | 2001 | Transplant. Proc. | pmid:11377556 |
| Baran DA et al. | Tacrolimus and cardiac transplantation: a comparison of monotherapy and steroid-dependent patients. | 2002 | Transplant. Proc. | pmid:12176599 |
| Chan MC et al. | Conversion of cyclosporine to tacrolimus for refractory or persistent myocardial rejection. | 2002 | Transplant. Proc. | pmid:12176601 |
| Calconi G and Vianello A | One-year follow-up of a large European trial comparing dual versus triple tacrolimus-based immunosuppressive regimens following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267173 |
| Pretagostini R et al. | Conversion from cyclosporin to tacrolimus in chronic allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267174 |
| Lang M et al. | Combined liver-kidney transplantation: long-term follow-up in 18 patients. | 1998 | Transplant. Proc. | pmid:9723313 |
| Behr TM et al. | Incidence of humoral rejection in heart transplant recipients treated with tacrolimus or cyclosporine A. | 1998 | Transplant. Proc. | pmid:9723333 |
| Ji SM et al. | Rescue therapy by immunoadsorption in combination with tacrolimus and mycophenolate mofetil for C4d-positive acute humoral renal allograft rejection. | 2006 | Transplant. Proc. | pmid:17175303 |
| Ersoy A et al. | Diabetic ketoacidosis following development of de novo diabetes in renal transplant recipient associated with tacrolimus. | 2004 | Transplant. Proc. | pmid:15251345 |
| López-Vilella R et al. | Incidence of development of obesity after heart transplantation according to the calcineurin inhibitor. | Transplant. Proc. | pmid:25645789 | |
| Jiang H et al. | Prolonged cardiac allograft survival in sensitized rats by low-dose FK 506 in combination with splenectomy. | 1991 | Transplant. Proc. | pmid:1721439 |
| Sato K et al. | Comparative study of FK 506, cyclosporine, and triple regimen immunosuppression with FK 506, cyclosporine, and mizoribine. | 1991 | Transplant. Proc. | pmid:1721440 |
| Makowka L et al. | The effect of FK-506 on hyperacute rejection in presensitized rats. | 1987 | Transplant. Proc. | pmid:2445082 |
| Katayama Y et al. | Immunosuppressive effects of FK 506 in rat lung transplantation. | 1991 | Transplant. Proc. | pmid:1721441 |
| Odocha O et al. | Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689268 |
| Ochiai T et al. | Effects of FK-506 on xenotransplantation of the heart and skin in a mouse-rat combination. | 1987 | Transplant. Proc. | pmid:2445083 |
| Odocha O et al. | Serum cholesterol levels in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689269 |
| Nalesnik MA et al. | Toxicology of FK-506 in the Lewis rat. | 1987 | Transplant. Proc. | pmid:2445084 |
| MartÃn-Fernández M et al. | Effects of Cyclosporine, Tacrolimus, and Rapamycin on Osteoblasts. | 2017 | Transplant. Proc. | pmid:29149986 |
| Langrehr JM et al. | IL-2 receptor antibody induction increases the risk for chronic rejection after liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267360 |
| González-Pinto I et al. | Usefulness of the switch to tacrolimus in liver transplantation. | 1999 | Transplant. Proc. | pmid:10500653 |
| Mita A et al. | Optimal initial dose of orally administered once-daily extended-release tacrolimus following intravenous tacrolimus therapy after liver transplantation. | 2014 | Transplant. Proc. | pmid:24767351 |
| Haba T et al. | Pathological and immunohistochemical examination in the rat treated with FK 506. | 1991 | Transplant. Proc. | pmid:1714649 |
| Morris-Stiff G et al. | Preoperative induction with tacrolimus does not have a detrimental effect on primary graft function in adult cadaveric renal transplantation. | 1998 | Transplant. Proc. | pmid:9636499 |
| Eghtesad B et al. | Use of tacrolimus as the primary immunosuppression after renal transplant in Native Americans and Hispanics. | 1998 | Transplant. Proc. | pmid:9636500 |
| Scholler G et al. | Comparison of cyclosporine A and FK506 with regard to complaints and psychosocial characteristics before and after liver transplantation. | 1997 | Transplant. Proc. | pmid:9270822 |
| Pichlmayr R et al. | Three-year follow-up of the European Multicenter Tacrolimus (FK506) Liver Study. | 1997 | Transplant. Proc. | pmid:9270825 |
| Pillet A et al. | Monitoring HCMV infection with quantitative real-time PCR in HCMV-positive orthotopic liver transplant recipients, and predictive factors for treatment of the first episode of HCMV viremia. | 2006 | Transplant. Proc. | pmid:16980083 |
| Fisher A et al. | Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. | 1994 | Transplant. Proc. | pmid:7527947 |