tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Springer JE et al. | Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury. | 2000 | J. Neurosci. | pmid:11007881 |
| Lorf T et al. | The effect of pantoprazole on tacrolimus and cyclosporin A blood concentration in transplant recipients. | 2000 | Eur. J. Clin. Pharmacol. | pmid:11009056 |
| Bronster DJ et al. | Tacrolimus-associated mutism after orthotopic liver transplantation. | 2000 | Transplantation | pmid:11014653 |
| Kaufman DB et al. | Simultaneous pancreas-kidney transplantation in the mycophenolate mofetil/tacrolimus era: evolution from induction therapy with bladder drainage to noninduction therapy with enteric drainage. | 2000 | Surgery | pmid:11015108 |
| Miyake K et al. | [Tacrolimus administration to a patient with cyclosporine-induced encephalopathy after allogeneic bone marrow transplantation]. | 2000 | Rinsho Ketsueki | pmid:11020982 |
| Hayashi T and Miyamori I | [Cyclosporine- and tacrolimus-induced hypertension]. | 2000 | Nippon Rinsho | pmid:11028414 |
| Matsuura M et al. | Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats. | 2000 | Inflamm. Res. | pmid:11028757 |
| Marsen TA et al. | Differential transcriptional regulation of endothelin-1 by immunosuppressants FK506 and cyclosporin A. | 2000 Jul-Aug | Fundam Clin Pharmacol | pmid:11030448 |
| Toma H | [Neurologic disorders in renal transplantation]. | 2000 | Ryoikibetsu Shokogun Shirizu | pmid:11031921 |
| Davis DL and Soldin SJ | Identification of ubiquitin as an immunophilin. | 2000 | Biochem. Biophys. Res. Commun. | pmid:11032725 |
| Taylor PJ et al. | Simultaneous quantification of tacrolimus and sirolimus, in human blood, by high-performance liquid chromatography-tandem mass spectrometry. | 2000 | Ther Drug Monit | pmid:11034268 |
| van Gelder T et al. | Drug interaction between mycophenolate mofetil and tacrolimus detectable within therapeutic mycophenolic acid monitoring in renal transplant patients. | 2000 | Ther Drug Monit | pmid:11034275 |
| Mayer JM et al. | Single doses of FK506 and OKT3 reduce severity in early experimental acute pancreatitis. | 2000 | Eur J Surg | pmid:11034471 |
| Shimoyama M et al. | Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension. | 2000 | Circulation | pmid:11034951 |
| Shiraishi S et al. | Post-translational reduction of cell surface expression of insulin receptors by cyclosporin A, FK506 and rapamycin in bovine adrenal chromaffin cells. | 2000 | Neurosci. Lett. | pmid:11036198 |
| Shapiro R et al. | Simultaneous pancreas-kidney transplantation at the University of Pittsburgh. | 1999 | Clin Transpl | pmid:11038640 |
| Cronin DC et al. | Liver transplantation at the University of Chicago. | 1999 | Clin Transpl | pmid:11038642 |
| Nakahama H et al. | Co-administration of furosemide augments tacrolimus-induced impairment in kidney function in rats. | 2000 | Ren Fail | pmid:11041285 |
| Przepiorka D et al. | Tacrolimus clearance is age-dependent within the pediatric population. | 2000 | Bone Marrow Transplant. | pmid:11041564 |
| Kantrow SP et al. | Regulation of tumor necrosis factor cytotoxicity by calcineurin. | 2000 | FEBS Lett. | pmid:11042265 |
| Yano M et al. | Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure. | 2000 | Circulation | pmid:11044432 |
| Miyazawa N et al. | Protective effect of FK506 in the reperfusion model after short-term occlusion of middle cerebral artery in the rat: assessment by autoradiography using [125I]PK-11195. | 2000 | Neurol. Res. | pmid:11045029 |
| Jiang H et al. | Distinct patterns of cytokine gene suppression by the equivalent effective doses of cyclosporine and tacrolimus in rat heart allografts. | 2000 | Immunobiology | pmid:11045663 |
| Ciancio G et al. | Partial venous thrombosis of the pancreatic allografts after simultaneous pancreas-kidney transplantation. | 2000 | Clin Transplant | pmid:11048991 |
| Bechstein WO | Neurotoxicity of calcineurin inhibitors: impact and clinical management. | 2000 | Transpl. Int. | pmid:11052266 |
| Weimer R et al. | Switch from cyclosporine A to tacrolimus in renal transplant recipients: impact on Th1, Th2, and monokine responses. | 2000 | Hum. Immunol. | pmid:11053632 |
| Murayama T and Ogawa Y | Selectively suppressed Ca2+-induced Ca2+ release activity of alpha-ryanodine receptor (alpha-RyR) in frog skeletal muscle sarcoplasmic reticulum: potential distinct modes in Ca2+ release between alpha- and beta-RyR. | 2001 | J. Biol. Chem. | pmid:11054412 |
| Ono K et al. | Altered interaction of FKBP12.6 with ryanodine receptor as a cause of abnormal Ca(2+) release in heart failure. | 2000 | Cardiovasc. Res. | pmid:11054478 |
| Shitamukai A et al. | A positive screening for drugs that specifically inhibit the Ca2+-signaling activity on the basis of the growth promoting effect on a yeast mutant with a peculiar phenotype. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11055400 |
| Molkentin JD | Calcineurin and beyond: cardiac hypertrophic signaling. | 2000 | Circ. Res. | pmid:11055975 |
| Sakata Y et al. | Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats. | 2000 | Circulation | pmid:11056104 |
| Bornhövd EC et al. | [Immunosuppressive macrolides and their use in dermatology]. | 2000 | Hautarzt | pmid:11057390 |
| Paul C et al. | Ascomycins: promising agents for the treatment of inflammatory skin diseases. | 2000 | Expert Opin Investig Drugs | pmid:11060661 |
| Gold BG | Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders. | 2000 | Expert Opin Investig Drugs | pmid:11060810 |
| Kuinose M et al. | Calcineurin antagonists inhibit interferon-gamma production by downregulation of interleukin-18 in human mixed lymphocyte reactions. | 2000 | Acta Med. Okayama | pmid:11061569 |
| Bandyopadhyay A et al. | Calcineurin regulates ryanodine receptor/Ca(2+)-release channels in rat heart. | 2000 | Biochem. J. | pmid:11062058 |
| Mack-Shipman LR et al. | Reproductive hormones after pancreas transplantation. | 2000 | Transplantation | pmid:11063337 |
| Chisholm MA et al. | Renal transplant patient compliance with free immunosuppressive medications. | 2000 | Transplantation | pmid:11063348 |
| Dominguez J et al. | Conversion to rapamycin immunosuppression in renal transplant recipients: report of an initial experience. | 2000 | Transplantation | pmid:11063349 |
| Hernández G et al. | Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. | 2000 | J. Periodontol. | pmid:11063397 |
| Abramowicz D et al. | Immunosuppressive strategies in renal transplantation at the beginning of the third millennium. | 2000 | Adv. Nephrol. Necker Hosp. | pmid:11068631 |
| Bova D et al. | Delayed transient neurologic toxicity due to tacrolimus: CT and MRI. | 2000 | Neuroradiology | pmid:11071440 |
| Miyamoto S et al. | Signal transduction pathways that contribute to increased protein synthesis during T-cell activation. | 2000 | Biochim. Biophys. Acta | pmid:11072066 |
| Dale S and Shaw J | Clinical picture. Eosinophilic pustular folliculitis. | 2000 | Lancet | pmid:11072943 |
| Shimizu K et al. | Tacrolimus (FK506) treatment of CD34+ hematopoietic progenitor cells promote the development of dendritic cells that drive CD4+ T cells toward Th2 responses. | 2000 | J. Leukoc. Biol. | pmid:11073101 |
| Griffith EC et al. | Yeast three-hybrid system for detecting ligand-receptor interactions. | 2000 | Meth. Enzymol. | pmid:11075340 |
| Soncin F et al. | Role of calcium activated kinases and phosphatases in heat shock factor-1 activation. | 2000 | Int. J. Mol. Med. | pmid:11078832 |
| Guo WH et al. | Recipient FK506 pretreatment regimens in rat small bowel transplantation: allograft survival, function, and systemic infection. | 2000 | J. Pediatr. Surg. | pmid:11083432 |
| Bathgate AJ et al. | Pretransplantation tumor necrosis factor-alpha production predicts acute rejection after liver transplantation. | 2000 | Liver Transpl. | pmid:11084058 |
| Chang GJ et al. | Experience with the use of sirolimus in liver transplantation--use in patients for whom calcineurin inhibitors are contraindicated. | 2000 | Liver Transpl. | pmid:11084060 |