tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Woodle ES et al. | Tacrolimus therapy for refractory acute renal allograft rejection: a prospective multicenter trial. Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplant. Proc. | pmid:8962225 |
| Schumacher G et al. | Neurologic symptoms improve in patients with Wilson's disease despite immunosuppression. | 1996 | Transplant. Proc. | pmid:8962200 |
| Golbaekdal K et al. | The acute effects of FK-506 on renal haemodynamics, water and sodium excretion and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide and vasopressin in pigs. | 1996 | J. Pharm. Pharmacol. | pmid:8961168 |
| Antoniou E et al. | Effect of RS61443 in combination with leflunomide or FK506 on rat heart allograft survival. | 1996 | Transpl. Int. | pmid:8959858 |
| Fändrich F et al. | Circumvention of natural killer cell and T-cell mediated allogeneic target killing with tacrolimus (FK506) in small bowel transplantation related graft-vs-host disease. | 1996 | Transpl. Int. | pmid:8959843 |
| Gruessner RW et al. | Use of FK 506 in pancreas transplantation. | 1996 | Transpl. Int. | pmid:8959841 |
| Jonas S et al. | Indications for tacrolimus anti-rejection therapy in liver allograft recipients. | 1996 | Transpl. Int. | pmid:8959817 |
| Williams R et al. | Two-year data from the European multicentre tacrolimus (FK506) liver study. | 1996 | Transpl. Int. | pmid:8959812 |
| Chambraud B et al. | FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. | 1996 | J. Biol. Chem. | pmid:8955134 |
| Ueda S et al. | In-vitro metabolic studies of tacrolimus using precision-cut rat and human liver slices. | 1996 | J Pharm Biomed Anal | pmid:8951695 |
| Benelli U et al. | FK-506 delays corneal graft rejection in a model of corneal xenotransplantation. | 1996 | J Ocul Pharmacol Ther | pmid:8951679 |
| Iwata M et al. | Regulation of T cell apoptosis via T cell receptors and steroid receptors. | 1996 | Stem Cells | pmid:8948021 |
| Brunet M et al. | Comparative analysis of tacrolimus (FK506) in whole blood liver transplant recipients by PRO-TRAC enzyme-linked immunosorbent assay and microparticle enzyme immunoassay IMX methods. | 1996 | Ther Drug Monit | pmid:8946669 |
| MacFarlane G et al. | A simplified whole blood enzyme-linked immunosorbent assay (ProTrac II) for tacrolimus (FK506) using proteolytic extraction in place of organic solvents. | 1996 | Ther Drug Monit | pmid:8946668 |
| Winkler M et al. | Evaluation of the Pro-Trac tacrolimus monoclonal whole-blood enzyme-linked immunosorbent assay for monitoring of tacrolimus levels in patients after kidney, heart, and liver transplantation. | 1996 | Ther Drug Monit | pmid:8946659 |
| McCall E et al. | Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. | 1996 | Circ. Res. | pmid:8943949 |
| Przepiorka D et al. | Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after matched unrelated donor marrow transplantation. | 1996 | Blood | pmid:8943876 |
| Adachi M et al. | Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain. | 1996 | Blood | pmid:8943845 |
| Rokaw MD et al. | Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells. | 1996 | J. Biol. Chem. | pmid:8943313 |
| Poon M et al. | Rapamycin inhibits vascular smooth muscle cell migration. | 1996 | J. Clin. Invest. | pmid:8941644 |
| Freiberg RA et al. | Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. | 1996 | J. Biol. Chem. | pmid:8940187 |
| Cai W et al. | Transcription-modulating drugs: mechanism and selectivity. | 1996 | Curr. Opin. Biotechnol. | pmid:8939643 |
| Ide T et al. | An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the mongolian gerbil. | 1996 | Neurosci. Lett. | pmid:8938254 |
| Budde K et al. | Clinical pharmacokinetics of tacrolimus in rescue therapy after renal transplantation. | 1996 | Int J Clin Pharmacol Ther | pmid:8937932 |
| Andrews PA et al. | Racial variation in dosage requirements of tacrolimus. | 1996 | Lancet | pmid:8937292 |
| Soin AS and Jamieson NV | Lessons learnt from the multicentre randomized trials of tacrolimus in liver transplantation. | 1996 Sep-Oct | Natl Med J India | pmid:8937063 |
| Galat A | A large-scale processing of kinetic data files with derivation of the inhibitory constant Ki: an application to proline isomerases. | 1996 | Comput. Chem. | pmid:8936426 |
| Bader A et al. | Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8935714 |
| Curran CF et al. | Acute overdoses of tacrolimus. | 1996 | Transplantation | pmid:8932293 |
| Devlin J and Williams R | Transplantation for fulminant hepatic failure: comparing tacrolimus versus cyclosporine for immunosuppression and the outcome in elective transplants. European FK506 Liver Study Group. | 1996 | Transplantation | pmid:8932266 |
| Shapiro R et al. | "Suboptimal" kidney donors: the experience with tacrolimus-based immunosuppression. | 1996 | Transplantation | pmid:8932264 |
| Shuker SB et al. | Discovering high-affinity ligands for proteins: SAR by NMR. | 1996 | Science | pmid:8929414 |
| Yamamoto S et al. | Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment. | 1995 | Jpn. J. Ophthalmol. | pmid:8926639 |
| Cumming DV et al. | Pharmacological preconditioning of primary rat cardiac myocytes by FK506. | 1996 Sep-Oct | Basic Res. Cardiol. | pmid:8922254 |
| Licitra EJ and Liu JO | A three-hybrid system for detecting small ligand-protein receptor interactions. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8917502 |
| Wang X et al. | Rapamycin inhibits aldolase A expression during human lymphocyte activation. | 1996 | J. Cell. Biochem. | pmid:8913875 |
| Yagita Y et al. | Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils. | 1996 | Life Sci. | pmid:8913329 |
| Weigao C | [Limb allograft in rats: studies on optimal maintenance dose of FK506 and development of graft-versus-host-disease (GVHD)]. | 1996 | Fukuoka Igaku Zasshi | pmid:8913057 |
| Bell A et al. | The antiparasite effects of cyclosporin A: possible drug targets and clinical applications. | 1996 | Gen. Pharmacol. | pmid:8909976 |
| Rozen TD et al. | Treatment-refractory cyclosporine-associated headache: relief with conversion to FK-506. | 1996 | Neurology | pmid:8909459 |
| Namieno T and Uchino J | Comparative study of the effects of cyclosporine and FK 506 on rat hepatocytes cocultured with nonparenchymal liver cells. | 1996 | Transplant. Proc. | pmid:8908147 |
| Alper G and Small SL | Cerebrospinal fluid after organ transplantation. | 1996 | Transplant. Proc. | pmid:8908142 |
| Rao AS et al. | Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients. | 1996 | Transplant. Proc. | pmid:8908140 |
| Reyes J et al. | Intestinal transplantation in children: five-year experience. | 1996 | Transplant. Proc. | pmid:8908042 |
| Asfar S et al. | Small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8908039 |
| Alessiani M et al. | Intestinal transplantation with and without the colon in FK 506 immunosuppressed pigs. | 1996 | Transplant. Proc. | pmid:8908021 |
| Spada M et al. | Bacterial translocation is enhanced in pig intestinal transplantation when the colon is included in the graft. | 1996 | Transplant. Proc. | pmid:8907997 |
| Reggiani P et al. | Oral administration of FK 506 in a swine model of liver-small bowel allotransplantation. | 1996 | Transplant. Proc. | pmid:8907965 |
| Cicalese L et al. | Effect of FK506 on the mucosal perfusion of the rat intestinal allograft. | 1996 | Transplant. Proc. | pmid:8907959 |
| Costa A et al. | Stimulatory effect of FK506 and erythromycin on pig intestinal motility. | 1996 | Transplant. Proc. | pmid:8907957 |