tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Delaney CP et al. | Allogeneic hematolymphoid microchimerism and prevention of autoimmune disease in the rat. A relationship between allo- and autoimmunity. | 1996 | J. Clin. Invest. | pmid:8550837 |
| Tomikawa S et al. | Immunosuppressive effects of bactobolamine in vitro and in vivo. | 1996 | Transplant. Proc. | pmid:8623223 |
| Nakajima H and Oka T | The inhibition of T-cell-receptor-induced Fas ligand upregulation by cyclosporine and FK 506. | 1996 | Transplant. Proc. | pmid:8623224 |
| Ko S et al. | Different immunosuppressive effects of liposomal FK506 in liver and kidney transplantation. | 1996 | Transplant. Proc. | pmid:8623229 |
| Morozumi K et al. | A comparative study of morphological characteristics of renal injuries of tacrolimus (FK506) and cyclosporin (CyA) in renal allografts: are the morphologic characteristics of FK506 and CyA nephrotoxicity similar? | 1996 | Transplant. Proc. | pmid:8623232 |
| Takada S et al. | HGF prevents tacrolimus (FK 506)-induced nephrotoxicity in SHR rats. | 1996 | Transplant. Proc. | pmid:8623236 |
| Nakai T et al. | Immunosuppressive mechanism and immune tolerance of FK 506 in rat small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8623237 |
| Jin MB et al. | Protective effect of FK 506 on hepatic energy metabolism in warm ischemic canine livers induced by total hepatic vascular exclusion. | 1996 | Transplant. Proc. | pmid:8623243 |
| Smit JA et al. | Induction of primate TH2 lymphokines to suppress TH1 cells. | 1996 | Transplant. Proc. | pmid:8623334 |
| Elmer DS et al. | Use of FK506 immunosuppressive therapy in pancreas transplantation. | 1996 | J Transpl Coord | pmid:9188369 |
| Troppmann C et al. | Perioperative immunosuppression as a critical determinant of early outcome after discordant xenoislet transplantation: a comparative study. | 1996 | Transplant. Proc. | pmid:8623487 |
| McKenna BA et al. | Tacrolimus (FK 506): a whole blood assay as measured on the Abbott IMx analyzer. | 1996 | Transplant. Proc. | pmid:8623491 |
| Stratta RJ et al. | FK 506 induction and rescue therapy in pancreas transplant recipients. | 1996 | Transplant. Proc. | pmid:8623492 |
| Birk PE et al. | Preliminary experience with FK 506 in pediatric renal transplant recipients: a single-center report. | 1996 | Transplant. Proc. | pmid:8623493 |
| Alloway RR et al. | Conversion from cyclosporine to tacrolimus in kidney, kidney/pancreas, and pancreas alone transplant recipients: the Memphis experience. | 1996 | Transplant. Proc. | pmid:8623494 |
| Woodle ES et al. | Role of protocol biopsies in the treatment of refractory renal allograft rejection with FK 506. | 1996 | Transplant. Proc. | pmid:8623495 |
| Appignani BA et al. | Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity. | 1996 | AJR Am J Roentgenol | pmid:8623651 |
| Chudek J et al. | [The role of endothelin in the physiology and pathophysiology of the circulatory system and kidneys]. | 1996 | Pol. Arch. Med. Wewn. | pmid:9139279 |
| Murao K et al. | Immunosuppressant agent FK506 stimulates growth hormone (GH) secretion and gene expression of hypothalamic GH-releasing hormone in the rat. | 1996 | Endocrinology | pmid:8603582 |
| Fay JW et al. | FK506 (Tacrolimus) monotherapy for prevention of graft-versus-host disease after histocompatible sibling allogenic bone marrow transplantation. | 1996 | Blood | pmid:8605372 |
| Greeno EW et al. | Exchange transfusion the hard way: massive hemolysis following transplantation of bone marrow with minor ABO incompatibility. | 1996 | Transfusion | pmid:8607158 |
| Suzuki S et al. | Pure red cell aplasia induced by FK506. | 1996 | Transplantation | pmid:8607191 |
| Busuttil RW et al. | General guidelines for the use of tacrolimus in adult liver transplant patients. | 1996 | Transplantation | pmid:8607197 |
| Esquivel CO et al. | Suggested guidelines for the use of tacrolimus in pediatric liver transplant patients. | 1996 | Transplantation | pmid:8607198 |
| Peters KP et al. | The automatic search for ligand binding sites in proteins of known three-dimensional structure using only geometric criteria. | 1996 | J. Mol. Biol. | pmid:8609611 |
| Corrigan CJ et al. | Glucocorticoid resistant asthma: T-lymphocyte steroid metabolism and sensitivity to glucocorticoids and immunosuppressive agents. | 1996 | Eur. Respir. J. | pmid:8902470 |
| Sakane T and Miura K | [Research for basic and clinical aspects of Behcet's disease--recent advance and future--]. | 1996 | Nippon Rinsho | pmid:8904250 |
| Weinzweig N et al. | Peripheral-nerve allotransplantation in rats immunosuppressed with transient or long-term FK-506. | 1996 | J Reconstr Microsurg | pmid:8905545 |
| Nagai H et al. | The role of interleukin-5 (IL-5) in allergic airway hyperresponsiveness in mice. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906215 |
| Tsunoda SM and Aweeka FT | The use of therapeutic drug monitoring to optimise immunosuppressive therapy. | 1996 | Clin Pharmacokinet | pmid:8906895 |
| Yocum DE | Cyclosporine, FK-506, rapamycin, and other immunomodulators. | 1996 | Rheum. Dis. Clin. North Am. | pmid:8907069 |
| Lu YF et al. | FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus. | 1996 | Neurosci. Lett. | pmid:8907327 |
| Sperr WR et al. | Effects of cyclosporin A and FK-506 on stem cell factor-induced histamine secretion and growth of human mast cells. | 1996 | J. Allergy Clin. Immunol. | pmid:8757216 |
| Ye Q et al. | Persistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation. | 1996 | Transplant. Proc. | pmid:8907895 |
| Venkataraman L et al. | Differential regulation of c-Rel translocation in activated B and T cells. | 1996 | J. Immunol. | pmid:8757620 |
| Brunner T et al. | Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506. | 1996 | Int. Immunol. | pmid:8757947 |
| Gusev AI et al. | A quantitative study of in vitro hepatic metabolism of tacrolimus (FK506) using secondary ion and matrix-assisted laser desorption/ionization mass spectrometry. | 1996 | Rapid Commun. Mass Spectrom. | pmid:8759330 |
| Rokaw MD et al. | FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells. | 1996 | Am. J. Physiol. | pmid:8760046 |
| Tomono M et al. | Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts. | 1996 | Biochem. J. | pmid:8760349 |
| Becker G et al. | Diltiazem minimizes tubular damage due to FK506-mediated nephrotoxicity following ischemia and reperfusion in rats. | 1996 | Transpl. Immunol. | pmid:8762016 |
| Paus R et al. | Hair growth control by immunosuppression. | 1996 | Arch. Dermatol. Res. | pmid:8818191 |
| Hisanaga Y et al. | Implication of nitric oxide synthase activity in the genesis of water immersion stress-induced gastric lesions in rats: the protective effects of FK506. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971291 |
| Corey HE et al. | Improved renal allograft survival in children treated with FK 506 (tacrolimus) rescue therapy. | 1996 | Pediatr. Nephrol. | pmid:8971888 |
| Williams R et al. | Two-year data from the European multicentre tacrolimus (FK506) liver study. | 1996 | Transpl. Int. | pmid:8959812 |
| Jonas S et al. | Indications for tacrolimus anti-rejection therapy in liver allograft recipients. | 1996 | Transpl. Int. | pmid:8959817 |
| James DG | A new immunosuppressant: tacrolimus. | 1996 | Postgrad Med J | pmid:8977938 |
| Gruessner RW et al. | Use of FK 506 in pancreas transplantation. | 1996 | Transpl. Int. | pmid:8959841 |
| Weppler D et al. | Status of liver and gastrointestinal transplantation at the University of Miami. | 1996 | Clin Transpl | pmid:9286568 |
| Fändrich F et al. | Circumvention of natural killer cell and T-cell mediated allogeneic target killing with tacrolimus (FK506) in small bowel transplantation related graft-vs-host disease. | 1996 | Transpl. Int. | pmid:8959843 |
| Antoniou E et al. | Effect of RS61443 in combination with leflunomide or FK506 on rat heart allograft survival. | 1996 | Transpl. Int. | pmid:8959858 |
| Golbaekdal K et al. | The acute effects of FK-506 on renal haemodynamics, water and sodium excretion and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide and vasopressin in pigs. | 1996 | J. Pharm. Pharmacol. | pmid:8961168 |
| Schumacher G et al. | Neurologic symptoms improve in patients with Wilson's disease despite immunosuppression. | 1996 | Transplant. Proc. | pmid:8962200 |
| Sunyecz JA et al. | Lymphoproliferative disorder involving the cervix in a patient being treated with FK-506. | 1996 | Gynecol. Oncol. | pmid:8751565 |
| Woodle ES et al. | Tacrolimus therapy for refractory acute renal allograft rejection: a prospective multicenter trial. Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplant. Proc. | pmid:8962225 |
| Ho SN et al. | Dimeric ligands define a role for transcriptional activation domains in reinitiation. | 1996 | Nature | pmid:8752278 |
| Motamedi H et al. | Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. | 1996 | J. Bacteriol. | pmid:8752344 |
| Yamashita M et al. | Non-T cell-derived IL-4 plays an important role in IgE production induced by antigen resensitization and is resistant to FK506. | 1996 | J. Immunol. | pmid:8752921 |
| Silva ND and Prendergast FG | Tryptophan dynamics of the FK506 binding protein: time-resolved fluorescence and simulations. | 1996 | Biophys. J. | pmid:8785272 |
| Wagenknecht T et al. | Cryoelectron microscopy resolves FK506-binding protein sites on the skeletal muscle ryanodine receptor. | 1996 | Biophys. J. | pmid:8785329 |
| Dumont FJ et al. | Mixed agonist/antagonist activity of an FK-506-related immunosuppressant: biological and biochemical characterization. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8786538 |
| Michel G et al. | Antioncogene P53 and mitogenic cytokine interleukin-8 aberrantly expressed in psoriatic skin are inversely regulated by the antipsoriatic drug tacrolimus (FK506). | 1996 | Biochem. Pharmacol. | pmid:8787547 |
| Kershner RP and Fitzsimmons WE | Relationship of FK506 whole blood concentrations and efficacy and toxicity after liver and kidney transplantation. | 1996 | Transplantation | pmid:8878385 |
| Nolan TJ and Schad GA | Tacrolimus allows autoinfective development of the parasitic nematode Strongyloides stercoralis. | 1996 | Transplantation | pmid:8878405 |
| Devine SM et al. | Tacrolimus (FK506)-induced cerebral blindness following bone marrow transplantation. | 1996 | Bone Marrow Transplant. | pmid:8879619 |
| Taylor P et al. | Conformational polymorphism in peptidic and nonpeptidic drug molecules. | 1996 | Biopolymers | pmid:9101762 |
| Ikegami S et al. | A facilitatory effect on the induction of long-term potentiation in vivo by chronic administration of antisense oligodeoxynucleotides against catalytic subunits of calcineurin. | 1996 | Brain Res. Mol. Brain Res. | pmid:8883951 |
| Soldin SJ | Receptor assays in the clinical laboratory. | 1996 | Clin. Biochem. | pmid:8884064 |
| Woodle ES et al. | FK 506 therapy for refractory renal allograft rejection: lessons from liver transplantation. | 1996 | Clin Transplant | pmid:8884103 |
| Karashima T et al. | FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0/G1 phases of the cell cycle. | 1996 | J. Dermatol. Sci. | pmid:8884530 |
| Sakimoto H et al. | Administration of tacrolimus (FK506) in hamster-to-rat pancreas xenotransplantation. | 1996 | Transplant. Proc. | pmid:8658727 |
| Monfar M and Blenis J | Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone. | 1996 | Mol. Endocrinol. | pmid:8885245 |
| Takeda M et al. | Pretreatment with splenectomy and FK506 in xeno-lung transplantation. | 1996 | Transplant. Proc. | pmid:8658728 |
| Zou XM et al. | Immunosuppressive effect of FK506 on orthotopic liver and small bowel xenotransplantation (xenoOLTx and SBTx). | 1996 | Transplant. Proc. | pmid:8658729 |
| Kokado Y et al. | Hypertension in renal transplant recipients and its effect on long-term renal allograft survival. | 1996 | Transplant. Proc. | pmid:8658802 |
| Park KM et al. | Bone loss after orthotopic liver transplantation: FK 506 versus cyclosporine. | 1996 | Transplant. Proc. | pmid:8658863 |
| Kakefuda T et al. | Detection of nitrosylhemoglobin in liver allograft in rats by using near-infrared spectroscopy. | 1996 | Transplant. Proc. | pmid:8658885 |
| Kawabe A et al. | Anti-adhesion (anti-ICAM-1 and anti-LFA-1) therapy in a rat pancreas transplantation model. | 1996 | Transplant. Proc. | pmid:8658893 |
| Hayakawa K et al. | Maintenance of unresponsiveness by short-term pulse therapy with FK 506 in rat transplantation. | 1996 | Transplant. Proc. | pmid:8658904 |
| Holt DW et al. | Quality assessment issues of new immunosuppressive drugs and experimental experience. | 1996 | Ther Drug Monit | pmid:8857551 |
| McMichael J et al. | Computer-guided randomized concentration-controlled trials of tacrolimus in autoimmunity: multiple sclerosis and primary biliary cirrhosis. | 1996 | Ther Drug Monit | pmid:8857564 |
| Bartlett ST et al. | Equivalent success of simultaneous pancreas kidney and solitary pancreas transplantation. A prospective trial of tacrolimus immunosuppression with percutaneous biopsy. | 1996 | Ann. Surg. | pmid:8857849 |
| Takuma T et al. | Dephosphorylation of cofilin in parotid acinar cells. | 1996 | J. Biochem. | pmid:8864841 |
| Yamada A et al. | Long-term acceptance of major histocompatibility complex-mismatched cardiac allograft induced by a low dose of CTLA4IgM plus FK506. | 1996 | Microbiol. Immunol. | pmid:8865157 |
| Christians U et al. | Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. | 1996 | Br J Clin Pharmacol | pmid:8866917 |
| [Tacrolimus--a new perspective in kidney transplantation]. | 1996 | Urologe A | pmid:9022401 | |
| Cox KL and Freese DK | Tacrolimus (FK506): the pros and cons of its use as an immunosuppressant in pediatric liver transplantation. | 1996 | Clin Invest Med | pmid:8889279 |
| Bashuda H et al. | Induction of persistent allograft tolerance in the rat by combined treatment with anti-leukocyte function-associated antigen-1 and anti-intercellular adhesion molecule-1 monoclonal antibodies, donor-specific transfusion, and FK506. | 1996 | Transplantation | pmid:8693525 |
| Fung JJ et al. | The Pittsburgh randomized trial of tacrolimus compared to cyclosporine for hepatic transplantation. | 1996 | J. Am. Coll. Surg. | pmid:8696542 |
| Shaw LM et al. | Toxic effects of immunosuppressive drugs: mechanisms and strategies for controlling them. | 1996 | Clin. Chem. | pmid:8697605 |
| Bousvaros A et al. | Treatment of pediatric autoimmune enteropathy with tacrolimus (FK506). | 1996 | Gastroenterology | pmid:8698205 |
| Mach-Pascual S et al. | Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy. | 1996 | Am. J. Hematol. | pmid:8701950 |
| Hemenway CS and Heitman J | Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. | 1996 | J. Biol. Chem. | pmid:8702500 |
| Chambraud B et al. | FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. | 1996 | J. Biol. Chem. | pmid:8955134 |
| Sano Y et al. | Effect of a single injection of high-dose FK506 on lung transplantation in rats. | 1996 | Surg. Today | pmid:9017963 |
| Villalba L and Adams EM | Update on therapy for refractory dermatomyositis and polymyositis. | 1996 | Curr Opin Rheumatol | pmid:9018458 |
| Schuetz EG et al. | Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. | 1996 | Mol. Pharmacol. | pmid:8632764 |
| Sun S et al. | Effect of tacrolimus on hemodynamics and absorption of experimental small intestinal transplants. | 1996 | Transplantation | pmid:8633368 |
| Kashu Y et al. | The effect of combination splenectomy and low-dose FK506 therapy on graft survival after liver allograft transplantation in rats. | 1996 | Transplantation | pmid:8633382 |
| Yoshimura N et al. | A case report of pregnancy in renal transplant recipient treated with FK506 (tacrolimus). | 1996 | Transplantation | pmid:8633388 |
| Ohtomo Y et al. | C-peptide stimulates rat renal tubular Na+, K(+)-ATPase activity in synergism with neuropeptide Y. | 1996 | Diabetologia | pmid:8635672 |