tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Scorpion Stings D065008 1 associated lipids
Drug-Related Side Effects and Adverse Reactions D064420 3 associated lipids
Retrognathia D063173 1 associated lipids
End Stage Liver Disease D058625 1 associated lipids
Candidiasis, Invasive D058365 2 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Thrombotic Microangiopathies D057049 1 associated lipids
Central Serous Chorioretinopathy D056833 1 associated lipids
Leukoencephalopathies D056784 3 associated lipids
Netherton Syndrome D056770 1 associated lipids
Latent Tuberculosis D055985 1 associated lipids
Invasive Pulmonary Aspergillosis D055744 1 associated lipids
Keratosis, Actinic D055623 3 associated lipids
Multiple Pulmonary Nodules D055613 2 associated lipids
Pancreatitis, Graft D055589 1 associated lipids
Failed Back Surgery Syndrome D055111 3 associated lipids
Primary Graft Dysfunction D055031 1 associated lipids
Idiopathic Interstitial Pneumonias D054988 1 associated lipids
Dendritic Cell Sarcoma, Interdigitating D054739 1 associated lipids
Precursor Cell Lymphoblastic Leukemia-Lymphoma D054198 10 associated lipids
Posterior Leukoencephalopathy Syndrome D054038 1 associated lipids
Dysuria D053159 1 associated lipids
Nocturia D053158 1 associated lipids
Delayed Graft Function D051799 2 associated lipids
Renal Insufficiency D051437 8 associated lipids
Lymphohistiocytosis, Hemophagocytic D051359 1 associated lipids
Granulomatosis, Orofacial D051261 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Dyslipidemias D050171 7 associated lipids
Diabetes Complications D048909 4 associated lipids
Hepatic Insufficiency D048550 1 associated lipids
Colitis, Collagenous D046729 1 associated lipids
Protoporphyria, Erythropoietic D046351 1 associated lipids
Coproporphyria, Hereditary D046349 1 associated lipids
Ileus D045823 3 associated lipids
Intestinal Volvulus D045822 1 associated lipids
Cholecystolithiasis D041761 2 associated lipids
Mastocytosis, Cutaneous D034701 1 associated lipids
Hypoalbuminemia D034141 1 associated lipids
Hyperuricemia D033461 4 associated lipids
Papillomavirus Infections D030361 4 associated lipids
Denys-Drash Syndrome D030321 1 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Polyomavirus Infections D027601 1 associated lipids
Coronary Stenosis D023921 6 associated lipids
Lacerations D022125 1 associated lipids
Brachial Plexus Neuritis D020968 2 associated lipids
Neuroaspergillosis D020953 2 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Central Nervous System Viral Diseases D020805 1 associated lipids
Intracranial Thrombosis D020767 2 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Nervous System Autoimmune Disease, Experimental D020721 3 associated lipids
Stroke D020521 32 associated lipids
Brain Infarction D020520 17 associated lipids
Peroneal Neuropathies D020427 1 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Paraneoplastic Syndromes, Nervous System D020361 1 associated lipids
Hypertensive Encephalopathy D020343 1 associated lipids
Migraine with Aura D020325 1 associated lipids
Autoimmune Diseases of the Nervous System D020274 1 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Facial Nerve Injuries D020220 1 associated lipids
Trauma, Nervous System D020196 2 associated lipids
Nocturnal Myoclonus Syndrome D020189 1 associated lipids
Sleep Apnea, Central D020182 1 associated lipids
Citrullinemia D020159 1 associated lipids
Hepatopulmonary Syndrome D020065 1 associated lipids
Epstein-Barr Virus Infections D020031 3 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Miller Fisher Syndrome D019846 1 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Hepatitis, Autoimmune D019693 1 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Intracranial Hypertension D019586 4 associated lipids
Dermatitis, Perioral D019557 4 associated lipids
Pouchitis D019449 3 associated lipids
Endotoxemia D019446 27 associated lipids
Oral Ulcer D019226 1 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Fasciitis, Necrotizing D019115 1 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Multiple Endocrine Neoplasia Type 2a D018813 1 associated lipids
Anemia, Iron-Deficiency D018798 6 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Hypoplastic Left Heart Syndrome D018636 1 associated lipids
Cryptogenic Organizing Pneumonia D018549 3 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Lichen Sclerosus et Atrophicus D018459 2 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Hutchinson's Melanotic Freckle D018327 2 associated lipids
Angiofibroma D018322 2 associated lipids
Cervical Intraepithelial Neoplasia D018290 1 associated lipids
Seminoma D018239 2 associated lipids
Smooth Muscle Tumor D018235 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Lanford RE et al. Comparison of tamarins and marmosets as hosts for GBV-B infections and the effect of immunosuppression on duration of viremia. 2003 Virology pmid:12832204
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Goldfeld AE et al. Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin. 1995 Virology pmid:7538254
Zhao W et al. Role of cellular FKBP52 protein in intracellular trafficking of recombinant adeno-associated virus 2 vectors. 2006 Virology pmid:16828834
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Gambarino S et al. Human Cytomegalovirus Impact on mir-146a Expression Levels in Kidney Transplant Patients. 2016 Viral Immunol. pmid:27077822
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Mortola E et al. The use of two immunosuppressive drugs, cyclosporin A and tacrolimus, to inhibit virus replication and apoptosis in cells infected with feline immunodeficiency virus. 1998 Vet. Res. Commun. pmid:10066129
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Kano R et al. Treatment of sterile panniculitis in a dog. 2004 Vet. Rec. pmid:15134169
Ofri R et al. Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: a comparison with cyclosporine A. 2009 Vet. J. pmid:17950639
Sestak K et al. Tacrolimus-FK506 induced immunosuppression in gnotobiotic piglets. 2000 Vet. Immunol. Immunopathol. pmid:11137126
Marsella R et al. Investigation on the clinical efficacy and safety of 0.1% tacrolimus ointment (Protopic) in canine atopic dermatitis: a randomized, double-blinded, placebo-controlled, cross-over study. 2004 Vet. Dermatol. pmid:15500481
Mauldin EA et al. Proliferative and necrotizing otitis externa in four cats. 2007 Vet. Dermatol. pmid:17845627
Banovic F et al. Tacrolimus therapy for dermal arteritis of the nasal philtrum refractory to surgery and anti-inflammatory therapy (doxycycline/niacinamide and topical fluocinolone) in a dog. 2018 Vet. Dermatol. pmid:28990239
Hilton H et al. Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse. 2008 Vet. Dermatol. pmid:19055613
Marsella R and Nicklin CF Investigation on the use of 0.3% tacrolimus lotion for canine atopic dermatitis: a pilot study. 2002 Vet. Dermatol. pmid:12174182
Banovic F et al. Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus. 2017 Vet. Dermatol. pmid:28439997
Rosenkrantz WS Pemphigus: current therapy. 2004 Vet. Dermatol. pmid:15030557
Olivry T et al. Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis. 2010 Vet. Dermatol. pmid:20456716
Marsella R et al. Investigation on the effects of topical therapy with 0.1% tacrolimus ointment (Protopic) on intradermal skin test reactivity in atopic dogs. 2004 Vet. Dermatol. pmid:15305928
Lehner GM and Linek M A case of vesicular cutaneous lupus erythematosus in a Border collie successfully treated with topical tacrolimus and nicotinamide-tetracycline. 2013 Vet. Dermatol. pmid:24118370
Kelley LS et al. Safety and tolerability of 0.1% tacrolimus solution applied to the external ear canals of atopic beagle dogs without otitis. 2010 Vet. Dermatol. pmid:20609208
Bensignor E and Olivry T Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded randomized controlled trial. 2005 Vet. Dermatol. pmid:15725106
Scholz FM et al. Focal metatarsal fistulae syndrome affecting a greyhound dog successfully treated with topical 0.1% tacrolimus ointment. 2015 Vet. Dermatol. pmid:26216245
Nell B et al. The effect of topical pimecrolimus on keratoconjunctivitis sicca and chronic superficial keratitis in dogs: results from an exploratory study. 2005 Jan-Feb Vet Ophthalmol pmid:15644099
Berdoulay A et al. Effect of topical 0.02% tacrolimus aqueous suspension on tear production in dogs with keratoconjunctivitis sicca. 2005 Jul-Aug Vet Ophthalmol pmid:16008701
Hafizi S et al. Differential effects of rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling. 2004 May-Jun Vascul. Pharmacol. pmid:15607500
Dissemond J et al. Successful treatment of stasis dermatitis with topical tacrolimus. 2004 VASA pmid:15623206
Woodward RS et al. The long-term outcomes and costs of diabetes mellitus among renal transplant recipients: tacrolimus versus cyclosporine. 2011 Value Health pmid:21315636
Christ B et al. Interactions of sildenafil and tacrolimus in men with erectile dysfunction after kidney transplantation. 2001 Urology pmid:11597545
Harmon JD et al. Stuttering priapism in a liver transplant patient with toxic levels of fk506. 1999 Urology pmid:10754131
Chkhotua AB et al. Kidney transplantation from living-unrelated donors: comparison of outcome with living-related and cadaveric transplants under current immunosuppressive protocols. 2003 Urology pmid:14665344
Ebert AK et al. [Topical therapy of balanitis xerotica obliterans in childhood. Long-term clinical results and an overview]. 2007 Urologe A pmid:17994212
[Tacrolimus--a new perspective in kidney transplantation]. 1996 Urologe A pmid:9022401
Nomura T et al. Enhancement by cyclosporin A of taxol-induced apoptosis of human urinary bladder cancer cells. 2002 Urol. Res. pmid:12086014
Hwang MT and Goldfarb DS Uric acid stones following hepatic transplantation. 2004 Urol. Res. pmid:15565437
Veroux P et al. Severe neurotoxicity in tacrolimus-treated living kidney transplantation in two cases. 2003 Urol. Int. pmid:14646448
Pichler R et al. De novo renal cell carcinoma in a kidney allograft with focus on contrast-enhanced ultrasound. 2014 Urol. Int. pmid:25115614
Naderi GH et al. Tacrolimus rescue therapy for corticosteroid-resistant and polyclonal antibody-resistant kidney allograft rejections. 2009 Urol J pmid:19241339
Freire A et al. Comparison of blood tacrolimus concentrations in liver and kidney transplant recipients using ACMIA and MEIA immunoassays. 2008 Ups. J. Med. Sci. pmid:18521804
Präst I et al. Nerve cells in transplanted pancreatic islets: no effects of cyclosporin or tacrolimus on immediate neuronal survival. 2001 Ups. J. Med. Sci. pmid:11888070
Valesky EM et al. [Postoperative pyoderma gangrenosum of Cullen]. 2007 Unfallchirurg pmid:17786400
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Mørtz CG and Deleuran MS [A case of childhood granulomatous perioral dermatitis (CGPD) in a three year old boy from Madagascar]. 2008 Ugeskr. Laeg. pmid:18252166
Tümgör G et al. Fatty liver due to high levels of serum tacrolimus after liver transplantation. 2007 Apr-Jun Turk. J. Pediatr. pmid:17907528
Ismailoglu O et al. Topical application of tacrolimus prevents epidural fibrosis in a rat postlaminectomy model: histopathological and ultrastructural analysis. 2011 Turk Neurosurg pmid:22194127
Tümgör G et al. A case of uneventful ABO-incompatible liver transplantation from a deceased donor managed with routine immunosuppressive treatment. 2014 Turk J Gastroenterol pmid:25599790
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Bajetta E et al. Merkel cell carcinoma after liver transplantation: a case report. 2007 May-Jun Tumori pmid:17679476
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Sommerer C et al. Design and rationale of the ATHENA study--A 12-month, multicentre, prospective study evaluating the outcomes of a de novo everolimus-based regimen in combination with reduced cyclosporine or tacrolimus versus a standard regimen in kidney transplant patients: study protocol for a randomised controlled trial. 2016 Trials pmid:26888217
Nashan B et al. Evaluating the efficacy, safety and evolution of renal function with early initiation of everolimus-facilitated tacrolimus reduction in de novo liver transplant recipients: Study protocol for a randomized controlled trial. 2015 Trials pmid:25873064
Snyder SH et al. Neural actions of immunophilin ligands. 1998 Trends Pharmacol. Sci. pmid:9509898
Liu J FK506 and ciclosporin: molecular probes for studying intracellular signal transduction. 1993 Trends Pharmacol. Sci. pmid:7692652
Chang JY et al. FK506 and rapamycin: novel pharmacological probes of the immune response. 1991 Trends Pharmacol. Sci. pmid:1710854
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Report from the 4th International Workshop on Clinical Pharmacology of HIV Therapy. Drug levels in PHAs who receive liver transplants. 2003 Apr-May TreatmentUpdate pmid:17216847
Dumont FJ et al. A tacrolimus-related immunosuppressant with reduced toxicity. 1998 Transplantation pmid:9448138
Hernández D et al. Randomized controlled study comparing reduced calcineurin inhibitors exposure versus standard cyclosporine-based immunosuppression. 2007 Transplantation pmid:17893603
Mieles L et al. Interaction between FK506 and clotrimazole in a liver transplant recipient. 1991 Transplantation pmid:1721250
Roth D et al. A prospective study of hepatitis C virus infection in renal allograft recipients. 1996 Transplantation pmid:8623154
Khanafer A et al. Increased nitric oxide production during acute rejection in kidney transplantation: a useful marker to aid in the diagnosis of rejection. 2007 Transplantation pmid:17876269
Zoppo A et al. Trimetazidine counteracts tacrolimus nephrotoxicity in a hypertensive liver transplant patient. 1999 Transplantation pmid:10551656
Takahara S et al. The in vitro immunosuppressive effect of deoxymethylspergualin in man as compared with FK506 and cyclosporine. 1992 Transplantation pmid:1373537
Kim CD et al. Metabonomic analysis of serum metabolites in kidney transplant recipients with cyclosporine A- or tacrolimus-based immunosuppression. 2010 Transplantation pmid:20842074
Timmermann W et al. Videomicroscopic imaging of graft mucosa for monitoring immunosuppressive therapy after small intestinal transplantation in rats. 1999 Transplantation pmid:10401762
Demmers MW et al. Limited efficacy of immunosuppressive drugs on CD8+ T cell-mediated and natural killer cell-mediated lysis of human renal tubular epithelial cells. 2014 Transplantation pmid:24704664
Manitpisitkul W et al. Maintenance immunosuppressive agents as risk factors for BK virus nephropathy: a case-control study. 2009 Transplantation pmid:19584685
Fujimura Y and Owen RL Tacrolimus (FK506) and cyclosporine reduce the uptake and transport of particles into rabbit Peyer's patches. 2002 Transplantation pmid:11965030
Kaufman DB et al. Mycophenolate mofetil and tacrolimus as primary maintenance immunosuppression in simultaneous pancreas-kidney transplantation: initial experience in 50 consecutive cases. 1999 Transplantation pmid:10071032
Bozorgzadeh A et al. Impact of hepatitis C viral infection in primary cadaveric liver allograft versus primary living-donor allograft in 100 consecutive liver transplant recipients receiving tacrolimus. 2004 Transplantation pmid:15087773
Benigni A et al. The acute effect of FK506 and cyclosporine on endothelial cell function and renal vascular resistance. 1992 Transplantation pmid:1279848
Barraclough KA et al. NR1I2 polymorphisms are related to tacrolimus dose-adjusted exposure and BK viremia in adult kidney transplantation. 2012 Transplantation pmid:23095803
Diem HV et al. Pediatric liver transplantation for biliary atresia: results of primary grafts in 328 recipients. 2003 Transplantation pmid:12777858
Smets F et al. Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease. 2002 Transplantation pmid:12042647
Heidt S et al. Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin. 2008 Transplantation pmid:19005412
Serón D et al. Immunophenotype of infiltrating cells in protocol renal allograft biopsies from tacrolimus-versus cyclosporine-treated patients. 2007 Transplantation pmid:17353788
Andoh TF et al. Enhancement of FK506 nephrotoxicity by sodium depletion in an experimental rat model. 1994 Transplantation pmid:7509514
Imado T et al. Effect of FK506 on donor T-cell functions that are responsible for graft-versus-host disease and graft-versus-leukemia effect. 2004 Transplantation pmid:14966413
Wallia A et al. Posttransplant hyperglycemia is associated with increased risk of liver allograft rejection. 2010 Transplantation pmid:20098286
Woodle ES et al. A multicenter trial of FK506 (tacrolimus) therapy in refractory acute renal allograft rejection. A report of the Tacrolimus Kidney Transplantation Rescue Study Group. 1996 Transplantation pmid:8830821
Hayashi S et al. Effect of adenovirus-mediated transfer of the CTLA4IG gene in hamster-to-rat xenotransplantation. 2005 Transplantation pmid:16123724
Mañez R et al. Anomalous pattern of IgG antibody response to primary cytomegalovirus infection after solid organ retransplantation. 1995 Transplantation pmid:7537400
Pacifico L et al. Tacrolimus and food allergy. 2003 Transplantation pmid:14688538
Gullestad L et al. Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: a multicenter, randomized trial. 2010 Transplantation pmid:20061999
Ciancio G et al. Review of major clinical trials with mycophenolate mofetil in renal transplantation. 2005 Transplantation pmid:16251852
Vyas S et al. Outcome of twin pregnancy in a renal transplant recipient treated with tacrolimus. 1999 Transplantation pmid:10030303
Muthukkumar S et al. Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells. 1995 Transplantation pmid:7544036
Boots JM et al. Early steroid withdrawal in renal transplantation with tacrolimus dual therapy: a pilot study. 2002 Transplantation pmid:12499885
Molmenti EP et al. Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection. 2001 Transplantation pmid:11213072
Jain AB et al. Capillary blood versus arterial or venous blood for tacrolimus monitoring in liver transplantation. 1995 Transplantation pmid:7545836
Vincenti F et al. One-year follow-up of an open-label trial of FK506 for primary kidney transplantation. A report of the U.S. Multicenter FK506 Kidney Transplant Group. 1996 Transplantation pmid:8669100
de Jonge H et al. Reduced C0 concentrations and increased dose requirements in renal allograft recipients converted to the novel once-daily tacrolimus formulation. 2010 Transplantation pmid:20592652
Shibasaki S et al. Immunosuppressive effects of DTCM-G, a novel inhibitor of the mTOR downstream signaling pathway. 2013 Transplantation pmid:23269193
Bolley R et al. Tacrolimus-induced nephrotoxicity unmasked by induction of the CYP3A4 system with St John's wort. 2002 Transplantation pmid:11923712