Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Rudi J et al. | Prevalence of serum antibodies to Helicobacter pylori and to CagA protein in liver transplant recipients. | 1997 | Am. J. Gastroenterol. | pmid:9317070 |
Baumgart DC et al. | Tacrolimus is safe and effective in patients with severe steroid-refractory or steroid-dependent inflammatory bowel disease--a long-term follow-up. | 2006 | Am. J. Gastroenterol. | pmid:16573777 |
Nara M et al. | Effect of oral itraconazole on the pharmacokinetics of tacrolimus in a hematopoietic stem cell transplant recipient with CYP3A5*3/*3. | 2010 | Am. J. Hematol. | pmid:20568249 |
Lekakis LJ et al. | BK virus nephropathy after allogeneic stem cell transplantation: a case report and literature review. | 2009 | Am. J. Hematol. | pmid:19208419 |
Hammerstrom AE et al. | Tacrolimus-associated posterior reversible encephalopathy syndrome in hematopoietic allogeneic stem cell transplantation. | 2013 | Am. J. Hematol. | pmid:23460378 |
Abdel-Azim H et al. | Unrelated donor hematopoietic stem cell transplantation for the treatment of non-malignant genetic diseases: An alemtuzumab based regimen is associated with cure of clinical disease; earlier clearance of alemtuzumab may be associated with graft rejection. | 2015 | Am. J. Hematol. | pmid:26242764 |
Uehara T et al. | Successful control of Epstein-Barr virus (EBV)-infected cells by allogeneic nonmyeloablative stem cell transplantation in a patient with the lethal form of chronic active EBV infection. | 2004 | Am. J. Hematol. | pmid:15282671 |
Nakamae H et al. | Risk factor analysis for thrombotic microangiopathy after reduced-intensity or myeloablative allogeneic hematopoietic stem cell transplantation. | 2006 | Am. J. Hematol. | pmid:16755559 |
Bolaños-Meade J et al. | Lymphocytic pneumonitis as the manifestation of acute graft-versus-host disease of the lung. | 2005 | Am. J. Hematol. | pmid:15929116 |
Ninan MJ and Datta YH | Post-transplant lymphoproliferative disorder presenting as multiple myeloma. | 2010 | Am. J. Hematol. | pmid:20578201 |
Mach-Pascual S et al. | Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy. | 1996 | Am. J. Hematol. | pmid:8701950 |
Uehara T et al. | A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT. | 2002 | Am. J. Hematol. | pmid:12221672 |
Cohen DL et al. | Pulse wave analysis to assess vascular compliance changes in stable renal transplant recipients. | 2004 | Am. J. Hypertens. | pmid:15001192 |
Zhang W and Victor RG | Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension. | 2000 | Am. J. Hypertens. | pmid:10981550 |
Taler SJ et al. | Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy. | 1995 | Am. J. Hypertens. | pmid:7544983 |
de Mattos AM et al. | Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future. | 2000 | Am. J. Kidney Dis. | pmid:10676738 |
Kooman JP et al. | A comparison between office and ambulatory blood pressure measurements in renal transplant patients with chronic transplant nephropathy. | 2001 | Am. J. Kidney Dis. | pmid:11382685 |
Paoletti E et al. | ACE inhibitors and persistent left ventricular hypertrophy after renal transplantation: a randomized clinical trial. | 2007 | Am. J. Kidney Dis. | pmid:17591533 |
Israni A et al. | Conversion to tacrolimus for the treatment of cyclosporine-associated nephrotoxicity in heart transplant recipients. | 2002 | Am. J. Kidney Dis. | pmid:11877596 |
Soi V et al. | Altered mental status in a kidney transplant recipient receiving tacrolimus. | 2008 | Am. J. Kidney Dis. | pmid:18155524 |