tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gauthier C et al. | Functional similarities and differences between Candida albicans Cdr1p and Cdr2p transporters. | 2003 | Antimicrob. Agents Chemother. | pmid:12709320 |
| Del Poeta M et al. | Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. | 2000 | Antimicrob. Agents Chemother. | pmid:10681348 |
| Lamoth F et al. | In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains. | 2013 | Antimicrob. Agents Chemother. | pmid:23165466 |
| Reedy JL et al. | Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients. | 2006 | Antimicrob. Agents Chemother. | pmid:16569889 |
| Kontoyiannis DP et al. | Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis. | 2008 | Antimicrob. Agents Chemother. | pmid:18070977 |
| Aoki Y and Kao PN | Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells. | 1999 | Antimicrob. Agents Chemother. | pmid:10543746 |
| Rivosecchi RM et al. | Effects of Isavuconazole on the Plasma Concentrations of Tacrolimus among Solid-Organ Transplant Patients. | 2017 | Antimicrob. Agents Chemother. | pmid:28674051 |
| Venkataramanan R et al. | Voriconazole inhibition of the metabolism of tacrolimus in a liver transplant recipient and in human liver microsomes. | 2002 | Antimicrob. Agents Chemother. | pmid:12183280 |
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| Kuo WW et al. | Cardiomyoblast apoptosis induced by insulin-like growth factor (IGF)-I resistance is IGF-II dependent and synergistically enhanced by angiotensin II. | 2006 | Apoptosis | pmid:16699953 |
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| Chen D et al. | Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems. | 2012 | Appl. Environ. Microbiol. | pmid:22582065 |
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| Mo S et al. | Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23053074 |
| Wang J et al. | Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28175948 |
| Ordóñez-Robles M et al. | Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27357227 |
| Salehi-Najafabadi Z et al. | Characterisation of a γ-butyrolactone receptor of Streptomyces tacrolimicus: effect on sporulation and tacrolimus biosynthesis. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21792593 |
| Ma D et al. | Manipulating the expression of SARP family regulator BulZ and its target gene product to increase tacrolimus production. | 2018 | Appl. Microbiol. Biotechnol. | pmid:29666890 |
| Ordóñez-Robles M et al. | Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28983826 |
| Kim DH et al. | Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23392766 |
| MartÃnez-Castro M et al. | Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'. | 2013 | Appl. Microbiol. Biotechnol. | pmid:22990582 |
| Pavan M et al. | Polyomavirus associated nephropathy presenting five years after kidney transplantation. | 2011 | Arab J Nephrol Transplant | pmid:21999857 |
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| Kreuter A et al. | 1% pimecrolimus, 0.005% calcipotriol, and 0.1% betamethasone in the treatment of intertriginous psoriasis: a double-blind, randomized controlled study. | 2006 | Arch Dermatol | pmid:16983001 |
| Stern RS | Topical calcineurin inhibitors labeling: putting the "box" in perspective. | 2006 | Arch Dermatol | pmid:16983018 |
| Travis LB et al. | Successful treatment of vitiligo with 0.1% tacrolimus ointment. | 2003 | Arch Dermatol | pmid:12756092 |
| Lepe V et al. | A double-blind randomized trial of 0.1% tacrolimus vs 0.05% clobetasol for the treatment of childhood vitiligo. | 2003 | Arch Dermatol | pmid:12756094 |
| Plettenberg H et al. | Childhood vitiligo and tacrolimus: immunomodulating treatment for an autoimmune disease. | 2003 | Arch Dermatol | pmid:12756103 |
| Lübbe J et al. | Adults with atopic dermatitis and herpes simplex and topical therapy with tacrolimus: what kind of prevention? | 2003 | Arch Dermatol | pmid:12756112 |
| Bakos L and Bakos RM | Focal acne during topical tacrolimus therapy for vitiligo. | 2007 | Arch Dermatol | pmid:17875902 |
| Laffitte E et al. | Erosive pustular dermatosis of the scalp: treatment with topical tacrolimus. | 2003 | Arch Dermatol | pmid:12810500 |
| Chu J et al. | Topical tacrolimus is a useful adjunctive therapy for bullous pemphigoid. | 2003 | Arch Dermatol | pmid:12810523 |
| Allen A et al. | Significant absorption of topical tacrolimus in 3 patients with Netherton syndrome. | 2001 | Arch Dermatol | pmid:11405764 |
| Eichenfield LF et al. | 1% pimecrolimus cream for atopic dermatitis. | 2003 | Arch Dermatol | pmid:14568846 |
| Thiers BH | Topical tacrolimus: treatment failure in a patient with alopecia areata. | 2000 | Arch Dermatol | pmid:10632221 |
| Rotunda AM et al. | Hyperkeratotic plaques on the palms and soles. Palmoplantar lichen planus, hyperkeratotic variant. | 2004 | Arch Dermatol | pmid:15492196 |
| Laffitte E and Panizzon RG | Is topical tacrolimus really an effective therapy for Hailey-Hailey disease? | 2004 | Arch Dermatol | pmid:15492199 |
| Systemic tacrolimus (FK 506) is effective for the treatment of psoriasis in a double-blind, placebo-controlled study. The European FK 506 Multicentre Psoriasis Study Group. | 1996 | Arch Dermatol | pmid:8629845 | |
| Firooz A et al. | Pimecrolimus cream, 1%, vs hydrocortisone acetate cream, 1%, in the treatment of facial seborrheic dermatitis: a randomized, investigator-blind, clinical trial. | 2006 | Arch Dermatol | pmid:16924062 |
| Bigby M | A thorough systematic review of treatments for atopic eczema. | 2001 | Arch Dermatol | pmid:11735714 |
| Bernard LA et al. | A rosacea-like granulomatous eruption in a patient using tacrolimus ointment for atopic dermatitis. | 2003 | Arch Dermatol | pmid:12588240 |
| Zonneveld IM et al. | Topical tacrolimus is not effective in chronic plaque psoriasis. A pilot study. | 1998 | Arch Dermatol | pmid:9762021 |
| Jegasothy BV et al. | Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis. | 1992 | Arch Dermatol | pmid:1376102 |
| Choi CJ and Nghiem P | Tacrolimus ointment in the treatment of chronic cutaneous graft-vs-host disease: a case series of 18 patients. | 2001 | Arch Dermatol | pmid:11559218 |
| Lener EV et al. | Successful treatment of erosive lichen planus with topical tacrolimus. | 2001 | Arch Dermatol | pmid:11295919 |
| Mehrabi D and Pandya AG | A randomized, placebo-controlled, double-blind trial comparing narrowband UV-B Plus 0.1% tacrolimus ointment with narrowband UV-B plus placebo in the treatment of generalized vitiligo. | 2006 | Arch Dermatol | pmid:16847214 |
| Colebunders R et al. | HIV eosinophilic folliculitis in Uganda. | 2006 | Arch Dermatol | pmid:16847219 |
| Lebwohl M et al. | Proven efficacy of tacrolimus for facial and intertriginous psoriasis. | 2005 | Arch Dermatol | pmid:16172314 |
| Neill SM and Lewis FM | Vulvovaginal lichen planus: a disease in need of a unified approach. | 2008 | Arch Dermatol | pmid:19015426 |
| Gorman CR and White SW | Rosaceiform dermatitis as a complication of treatment of facial seborrheic dermatitis with 1% pimecrolimus cream. | 2005 | Arch Dermatol | pmid:16172323 |
| Cooper SM et al. | Vulvovaginal lichen planus treatment: a survey of current practices. | 2008 | Arch Dermatol | pmid:19015433 |
| Heffernan MP et al. | 0.1% tacrolimus ointment in the treatment of discoid lupus erythematosus. | 2005 | Arch Dermatol | pmid:16172325 |
| Lally A et al. | Penile pyoderma gangrenosum treated with topical tacrolimus. | 2005 | Arch Dermatol | pmid:16172330 |
| Le Cleach L et al. | Is topical monotherapy effective for localized pyoderma gangrenosum? | 2011 | Arch Dermatol | pmid:21242400 |
| Pomerantz RG et al. | Posttransplant cutaneous T-cell lymphoma: case reports and review of the association of calcineurin inhibitor use with posttransplant lymphoproliferative disease risk. | 2010 | Arch Dermatol | pmid:20479299 |
| Ehst BD and Warshaw EM | Alcohol-induced application site erythema after topical immunomodulator use and its inhibition by aspirin. | 2004 | Arch Dermatol | pmid:15313828 |
| Sand C and Thomsen HK | Topical tacrolimus ointment is an effective therapy for Hailey-Hailey disease. | 2003 | Arch Dermatol | pmid:14623698 |
| Sagransky MJ et al. | A randomized controlled pilot study of the effects of an extra office visit on adherence and outcomes in atopic dermatitis. | 2010 | Arch Dermatol | pmid:21173330 |
| Laino L and DiCarlo A | Palmoplantar pustular psoriasis: clinical and video thermographic evaluation before and after topical tacrolimus treatment. | 2011 | Arch Dermatol | pmid:21690553 |
| Eiling E et al. | Pimecrolimus: a novel treatment for cetuximab-induced papulopustular eruption. | 2008 | Arch Dermatol | pmid:18794482 |
| Byrd JA et al. | Response of oral lichen planus to topical tacrolimus in 37 patients. | 2004 | Arch Dermatol | pmid:15611431 |
| Guenova E et al. | Interleukin 23 expression in pyoderma gangrenosum and targeted therapy with ustekinumab. | 2011 | Arch Dermatol | pmid:21680759 |
| Singh MN et al. | Solitary cutaneous nodule in an immunocompromised patient. | 2007 | Arch Dermatol | pmid:18087016 |
| Ng W and Ikeda S | Mount Tsukuba and the origin of tacrolimus. | 2009 | Arch Dermatol | pmid:19289758 |
| Sardana K et al. | Effect of tacrolimus on vitiligo in absence of UV radiation exposure. | 2007 | Arch Dermatol | pmid:17224558 |
| Carroll CL et al. | Topical tacrolimus ointment combined with 6% salicylic acid gel for plaque psoriasis treatment. | 2005 | Arch Dermatol | pmid:15655140 |
| Patel RR et al. | The safety and efficacy of tacrolimus therapy in patients younger than 2 years with atopic dermatitis. | 2003 | Arch Dermatol | pmid:12975161 |
| Nagao K et al. | A case of generalized pustular psoriasis treated with topical tacrolimus. | 2003 | Arch Dermatol | pmid:12975175 |
| Yan AC et al. | The safety and efficacy of pimecrolimus, 1%, cream for the treatment of Netherton syndrome: results from an exploratory study. | 2010 | Arch Dermatol | pmid:20083693 |
| Ciurea AM et al. | Complete and durable clinical response of malignant pyoderma to tacrolimus in combination with dapsone and prednisone. | 2010 | Arch Dermatol | pmid:20083712 |
| Castelo-Soccio L et al. | Induced lentiginosis with use of topical calcineurin inhibitors. | 2012 | Arch Dermatol | pmid:22710469 |
| Ward KM et al. | Eyelash trichomegaly associated with systemic tacrolimus. | 2006 | Arch Dermatol | pmid:16490862 |
| Ostovari N et al. | Lack of efficacy of tacrolimus in the treatment of vitiligo in the absence of UV-B exposure. | 2006 | Arch Dermatol | pmid:16490866 |
| Mikhail M et al. | Rapid enlargement of a malignant melanoma in a child with vitiligo vulgaris after application of topical tacrolimus. | 2008 | Arch Dermatol | pmid:18427063 |
| Chapman MS et al. | 0.1% tacrolimus ointment for the treatment of intertrigo. | 2005 | Arch Dermatol | pmid:15967933 |
| Olivier V et al. | Treatment of chronic erosive oral lichen planus with low concentrations of topical tacrolimus: an open prospective study. | 2002 | Arch Dermatol | pmid:12374539 |
| Toutous-Trellu L et al. | Topical tacrolimus for effective treatment of eosinophilic folliculitis associated with human immunodeficiency virus infection. | 2005 | Arch Dermatol | pmid:16230556 |
| Kunstfeld R et al. | Successful treatment of vulvar lichen sclerosus with topical tacrolimus. | 2003 | Arch Dermatol | pmid:12873877 |
| Böhm M et al. | Successful treatment of anogenital lichen sclerosus with topical tacrolimus. | 2003 | Arch Dermatol | pmid:12873890 |
| Sugiura H et al. | Long-term efficacy of tacrolimus ointment for recalcitrant facial erythema resistant to topical corticosteroids in adult patients with atopic dermatitis. | 2000 | Arch Dermatol | pmid:10926750 |
| Byrd JA et al. | Recalcitrant symptomatic vulvar lichen planus: response to topical tacrolimus. | 2004 | Arch Dermatol | pmid:15210463 |
| Shah KN and Yan AC | Low but detectable serum levels of tacrolimus seen with the use of very dilute, extemporaneously compounded formulations of tacrolimus ointment in the treatment of patients with netherton syndrome. | 2006 | Arch Dermatol | pmid:17043199 |
| Antille C et al. | Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment. | 2004 | Arch Dermatol | pmid:15096374 |
| Banky JP et al. | Successful treatment of epidermolysis bullosa pruriginosa with topical tacrolimus. | 2004 | Arch Dermatol | pmid:15262686 |
| Passeron T et al. | Treatment of oral erosive lichen planus with 1% pimecrolimus cream: a double-blind, randomized, prospective trial with measurement of pimecrolimus levels in the blood. | 2007 | Arch Dermatol | pmid:17438179 |
| Bruce A and Rogers RS | New and old therapeutics for oral ulcerations. | 2007 | Arch Dermatol | pmid:17438186 |
| Qureshi A and Fischer MA | Topical calcineurin inhibitors revisited. | 2007 | Arch Dermatol | pmid:17438195 |
| Rapaport MJ | Topical tacrolimus. | 2005 | Arch Dermatol | pmid:16301404 |
| Cheng A and Mann C | Oral erosive lichen planus treated with efalizumab. | 2006 | Arch Dermatol | pmid:16785369 |
| Mackelfresh J et al. | Combination therapy of doxycycline and topical tacrolimus for venous ulcers. | 2005 | Arch Dermatol | pmid:16301410 |
| Sniezek PJ et al. | Annular atrophic plaques on the arms of a 57-year-old woman. | 2006 | Arch Dermatol | pmid:16785386 |
| Hall VC et al. | Ocular mucous membrane pemphigoid and ocular pemphigus vulgaris treated topically with tacrolimus ointment. | 2003 | Arch Dermatol | pmid:12925404 |