tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gaweco AS et al. | Distinct intragraft cytokine gene expression patterns during acute hepatic rejection under cyclosporine versus FK 506 primary immunosuppression. | 1994 | Transplant. Proc. | pmid:7527948 |
| Klintmalm GB et al. | Use of FK 506 for the prevention of recurrent allograft rejection after successful conversion from cyclosporine for refractory rejection. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679826 |
| Fukuzawa M and Okada A | Analysis of mouse xenogeneic T-cell responses and the effect of FK 506 on these responses and on xeno-skin graft rejection. | 1994 | Transplant. Proc. | pmid:7513483 |
| Jordan ML et al. | FK 506 salvage of renal allografts with ongoing rejection failing cyclosporine immunosuppression. | 1993 | Transplant. Proc. | pmid:7679827 |
| Warty VS et al. | Practical aspects of FK 506 analysis (Pittsburgh experience). | 1991 | Transplant. Proc. | pmid:1721259 |
| Van Thiel DH et al. | Gastrointestinal and metabolic problems associated with immunosuppression with either CyA or FK 506 in liver transplantation. | 1990 | Transplant. Proc. | pmid:1689893 |
| Jusko WJ and D'Ambrosio R | Monitoring FK 506 concentrations in plasma and whole blood. | 1991 | Transplant. Proc. | pmid:1721260 |
| Sher LS et al. | Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation. | 1996 | Transplant. Proc. | pmid:8623212 |
| Millis JM et al. | Treatment of steroid-resistant rejection with tacrolimus prior to OKT3 in liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8623213 |
| Grewal HP et al. | Corticosteroid cessation 1 week following renal transplantation using tacrolimus/mycophenolate mofetil based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636558 |
| Tanabe K et al. | Malabsorption of tacrolimus in kidney transplant recipients: a Japanese single center experience. | 2000 | Transplant. Proc. | pmid:11119906 |
| Rossi G et al. | Three-year follow-up of low dose tacrolimus oral therapy after liver transplantation: a single-centre experience. | 1998 | Transplant. Proc. | pmid:9636562 |
| Wong KM et al. | Tacrolimus versus cyclosporine as primary prophylactic therapy after cadaveric renal transplant: two-year survival study. | 2000 | Transplant. Proc. | pmid:11119907 |
| Yao B et al. | The incidence of posttransplantation diabetes mellitus during follow-up in kidney transplant recipients and relationship to Fok1 vitamin D receptor polymorphism. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375298 |
| Vilalta R et al. | Rapamycin use and rapid withdrawal of calcineurin inhibitors in pediatric renal transplantation. | 2003 | Transplant. Proc. | pmid:12644102 |
| Ciancio G et al. | Efficacy and safety of daclizumab induction for primary kidney transplant recipients in combination with tacrolimus, mycophenolate mofetil, and steroids as maintenance immunosuppression. | 2003 | Transplant. Proc. | pmid:12644172 |
| Rath T and Küpper M | Comparison of inosine-monophosphate-dehydrogenase activity in patients with enteric-coated mycophenolate sodium or mycophenolate mofetil after renal transplantation. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715967 |
| Morell Ginestà M et al. | Histology and immunopathology of heart and liver xenografts under low-dose tacrolimus. | 2002 | Transplant. Proc. | pmid:11959305 |
| Cofan F et al. | Oxidation of low-density lipoproteins in renal transplant recipients treated with tacrolimus. | 2002 | Transplant. Proc. | pmid:11959335 |
| McLachlan G et al. | Growth inhibition of the MOLT-4 human T-leukemia cell line. A comparison of cyclosporine and FK 506. | 1991 | Transplant. Proc. | pmid:1721291 |
| D'Silva M et al. | Immunosuppressive effect of brequinar on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623476 |
| Thomas FT et al. | Comparative efficacy of immunosuppressive drugs in xenografting. | 1990 | Transplant. Proc. | pmid:1693452 |
| Lipson DA et al. | Conversion to tacrolimus (FK506) from cyclosporine after orthotopic lung transplantation. | 1998 | Transplant. Proc. | pmid:9636612 |
| Braun F et al. | An ex vivo model to study the intestinal biotransformation of immunosuppressives. | 2000 | Transplant. Proc. | pmid:11120282 |
| Vanrenterghem Y | Vascular rejection with tacrolimus and potential long-term graft outcome. | 1999 | Transplant. Proc. | pmid:10576054 |
| Iaria G et al. | Prospective study of switch from cyclosporine to tacrolimus for fibroadenomas of the breast in kidney transplantation. | 2010 | Transplant. Proc. | pmid:20534252 |
| Woodle ES | A prospective, randomized, multicenter, double-blind study of early corticosteroid cessation versus long-term maintenance of corticosteroid therapy with tacrolimus and mycophenolate mofetil in primary renal transplant recipients: one year report. | 2005 | Transplant. Proc. | pmid:15848538 |
| Akiyama T et al. | Mizoribine in combination therapy with tacrolimus for living donor renal transplantation: analysis of a nationwide study in Japan. | 2005 | Transplant. Proc. | pmid:15848551 |
| López-Montenegro Soria MA et al. | Genetic polymorphisms and individualized tacrolimus dosing. | 2010 | Transplant. Proc. | pmid:20970601 |
| Andrés A et al. | Extended-release tacrolimus therapy in de novo kidney transplant recipients: single-center experience. | 2010 | Transplant. Proc. | pmid:20970602 |
| Nowacka-Cieciura E et al. | Late conversion to everolimus complicated with necrotizing glomerulonephritis in a renal allograft recipient: case report. | 2009 Jan-Feb | Transplant. Proc. | pmid:19249576 |
| Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
| Takada Y et al. | Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist. | 1998 | Transplant. Proc. | pmid:9838621 |
| Tze WJ et al. | FK 506--an effective immunosuppressant in achieving long-term functional islet allograft survival in diabetic rats. | 1992 | Transplant. Proc. | pmid:1376509 |
| Rao PN et al. | Prediction of early graft function by effluent levels of hyaluronic acid in clinical liver transplantation. | 1993 | Transplant. Proc. | pmid:7682366 |
| Armstrong VW et al. | Metabolic liver function and lipoprotein metabolism after orthotopic liver transplantation in patients on immunosuppressive therapy with FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533371 |
| Ebbs A et al. | Tacrolimus treats ongoing allograft rejection by inhibiting interleukin-10 mediated functional cytotoxic cell infiltration. | 2002 | Transplant. Proc. | pmid:12176404 |
| Jordan ML et al. | Inhibition of T-cell function by FK 506 and cyclosporine is not accompanied by alterations in intracellular calcium. | 1991 | Transplant. Proc. | pmid:1721323 |
| Akioka K et al. | Abdominal pain is a critical complication of mycophenolate mofetil in renal transplant recipients. | 2003 | Transplant. Proc. | pmid:12591411 |
| Hohage H et al. | Differential effects of cyclosporine and tacrolimus on mycophenolate pharmacokinetics in patients with impaired kidney function. | 2005 | Transplant. Proc. | pmid:15919453 |
| Borda B et al. | Early histopathological changes in new-onset diabetes after kidney transplantation. | Transplant. Proc. | pmid:25131129 | |
| Laskow DA et al. | Phase II FK 506 multicenter concentration control study: one-year follow-up. | 1995 | Transplant. Proc. | pmid:7533431 |
| Shapiro R et al. | A prospective, randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone in renal transplant patients. | 1995 | Transplant. Proc. | pmid:7533432 |
| Reyes J et al. | Posttransplant lymphoproliferative disorders occurring under primary FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721355 |
| Whiteside TL et al. | Serial monitoring of immunologic function and phenotype of lymphocytes in the blood of transplanted patients randomized to cyclosporine or FK 506. | 1991 | Transplant. Proc. | pmid:1721356 |
| Reis A et al. | Mycophenolate mofetil and FK506: two novel immunosuppressants in murine corneal transplantation. | 1998 | Transplant. Proc. | pmid:9865380 |
| Emiroglu R et al. | Tacrolimus-related neurologic and renal complications in liver transplantation: A single-center experience. | 2006 | Transplant. Proc. | pmid:16549190 |
| Prates LC et al. | Pain syndrome induced by calcineurin inhibitor and resolved by conversion to sirolimus in a child after kidney transplantation: a case report. | 2012 | Transplant. Proc. | pmid:23026634 |
| Martin Garcia D et al. | Tacrolimus-Basiliximab versus Cyclosporine-Basiliximab in renal transplantation "de novo": acute rejection and complications. | 2003 | Transplant. Proc. | pmid:12962761 |
| Solà R et al. | Tacrolimus in induction immunosuppressive treatment in renal transplantation: comparison with cyclosporine. | 2003 | Transplant. Proc. | pmid:12962763 |
| Naraghi RM et al. | Long-term follow-up of tacrolimus rescue therapy for renal allograft rejection. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123013 |
| Nishi K et al. | The colon displays an absorptive capacity of tacrolimus. | 2004 | Transplant. Proc. | pmid:15050160 |
| Velio P et al. | Rejection and survival after total orthotopic liver-small bowel allotransplantation in pigs immunosuppressed with FK 506. | 1996 | Transplant. Proc. | pmid:8907936 |
| Sonnenday CJ et al. | Preemptive therapy with plasmapheresis/intravenous immunoglobulin allows successful live donor renal transplantation in patients with a positive cross-match. | 2002 | Transplant. Proc. | pmid:12176507 |
| Bardella MT et al. | FK 506 and cyclosporine: effect on D-xylose absorption in pigs with orthotopic liver-small bowel allotransplants. | 1996 | Transplant. Proc. | pmid:8907937 |
| Ciancio G et al. | Effect of daclizumab, tacrolimus and mycophenolate mofetil in racial minority first renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176508 |
| Di Benedetto F et al. | University of Modena experience in HIV-positive patients undergoing liver transplantation. | 2011 | Transplant. Proc. | pmid:21620066 |
| Gringeri E et al. | Neoadjuvant therapy protocol and liver transplantation in combination with pancreatoduodenectomy for the treatment of hilar cholangiocarcinoma occurring in a case of primary sclerosing cholangitis: case report with a more than 8-year disease-free survival. | 2011 | Transplant. Proc. | pmid:21620084 |
| Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
| Ota K | Living donor kidney transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520622 |
| Thomson AW et al. | Immunosuppressive activity, T-cell subset analysis, and acute toxicity of FK-506 in rats. | 1989 | Transplant. Proc. | pmid:2468203 |
| Hossein-Nia M et al. | Urinary proteins as a marker of drug-induced renal damage following treatment with cyclosporine or FK 506. | 1991 | Transplant. Proc. | pmid:1721388 |
| Rastellini C et al. | Prolonged survival of islet allografts following combined therapy with tacrolimus and leflunomide. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083278 |
| Millis JM et al. | Tacrolimus treatment of steroid-resistant rejection provides economic advantages compared with OKT3 therapy. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123421 |
| Klupp J et al. | New approach in drug development: whole blood pharmacodynamic assays reflect biological activities of tacrolimus. | 2001 | Transplant. Proc. | pmid:11377491 |
| Mollison KW et al. | Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat. | 1996 | Transplant. Proc. | pmid:8962236 |
| Pozzetto U et al. | Effects of immunosuppressive regimens on plasma levels of transforming growth factor-beta 1 in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176558 |
| Mao PC et al. | Trends in the use of immunosuppressive agents by outpatients after renal transplantation at a medical center in southern Taiwan. | 2012 | Transplant. Proc. | pmid:22310611 |
| Tsai SF et al. | Trends in maintenance immunosuppressive drugs used in taiwanese kidney transplant recipients: an analysis of the national health insurance research database. | 2012 | Transplant. Proc. | pmid:22310612 |
| Markus PM et al. | The effect of cyclosporine, rapamycin and FK 506 the survival following allogeneic bone marrow transplantation. | 1991 | Transplant. Proc. | pmid:1721418 |
| Yuzawa K et al. | Topical immunosuppression in skin grafting with FK 506 ointment. | 1996 | Transplant. Proc. | pmid:8658707 |
| Yagura K et al. | Pharmacokinetic characteristics of two types of liposomal FK 506. | 1996 | Transplant. Proc. | pmid:8658708 |
| Calconi G and Vianello A | One-year follow-up of a large European trial comparing dual versus triple tacrolimus-based immunosuppressive regimens following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267173 |
| Pretagostini R et al. | Conversion from cyclosporin to tacrolimus in chronic allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267174 |
| Dresske B et al. | Synergistic impact of "WOFIE" on the immunosuppressive potency of FK 506 in a heterotopic heart transplantation model in the rat. | 1999 | Transplant. Proc. | pmid:10331001 |
| Nayeri A et al. | Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report. | Transplant. Proc. | pmid:28104136 | |
| Sicilia-Castro D et al. | Reconstruction of a severe facial defect by allotransplantation in neurofibromatosis type 1: a case report. | 2011 | Transplant. Proc. | pmid:21911174 |
| Dedhia P et al. | Eculizumab and Belatacept for De Novo Atypical Hemolytic Uremic Syndrome Associated With CFHR3-CFHR1 Deletion in a Kidney Transplant Recipient: A Case Report. | Transplant. Proc. | pmid:28104134 | |
| Kanatani T et al. | Donor leukocytes combine with immunosuppressive drug therapy to prolong limb allograft survival. | 2005 | Transplant. Proc. | pmid:15964421 |
| Lang M et al. | Combined liver-kidney transplantation: long-term follow-up in 18 patients. | 1998 | Transplant. Proc. | pmid:9723313 |
| Gnatta D et al. | Use of tacrolimus and the development of posttransplant diabetes mellitus: a Brazilian single-center, observational study. | 2010 | Transplant. Proc. | pmid:20304169 |
| Behr TM et al. | Incidence of humoral rejection in heart transplant recipients treated with tacrolimus or cyclosporine A. | 1998 | Transplant. Proc. | pmid:9723333 |
| Trotter JF | Sirolimus in liver transplantation. | 2003 | Transplant. Proc. | pmid:12742496 |
| Ventura E et al. | Calcineurin Inhibitor Determination in Whole Blood With the RXL Dimension Analyzer: A Useful Tool for Immunosuppressive Drug Monitoring. | 2009 | Transplant. Proc. | pmid:19328963 |
| Ojogho ON et al. | Mycophenolate mofetil without antibody induction in pediatric renal transplantation. | 2002 | Transplant. Proc. | pmid:12176641 |
| van der Laan LJ et al. | Results of a two-center study comparing hepatic fibrosis progression in HCV-positive liver transplant patients receiving cyclosporine or tacrolimus. | 2010 | Transplant. Proc. | pmid:21168740 |
| Gruttadauria S et al. | A safe immunosuppressive protocol in adult-to-adult living related liver transplantation. | 2006 | Transplant. Proc. | pmid:16757278 |
| Nanmoku K et al. | Steroid Withdrawal Using Everolimus in ABO-Incompatible Kidney Transplant Recipients With Post-Transplant Diabetes Mellitus. | 2018 | Transplant. Proc. | pmid:29631750 |
| Yumiba T et al. | Immunosuppressive and diabetogenic effect of FK 506 on pancreatic islet xenotransplantation. | 1995 | Transplant. Proc. | pmid:7540780 |
| Langrehr JM et al. | IL-2 receptor antibody induction increases the risk for chronic rejection after liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267360 |
| Nikolaidis NL et al. | Metabolic effects of FK 506 in patients with severe psoriasis: short-term follow-up of seven cases. | 1991 | Transplant. Proc. | pmid:1721450 |
| Ochiai T et al. | Studies on FK506 in experimental organ transplantation. | 1988 | Transplant. Proc. | pmid:2450414 |
| Immunosuppression: FK506. | 1988 | Transplant. Proc. | pmid:2450415 | |
| Chang HK et al. | Ten-Year Experience With Bowel Transplantation at Seoul St. Mary's Hospital. | 2016 | Transplant. Proc. | pmid:27109981 |
| González-Pinto I et al. | Usefulness of the switch to tacrolimus in liver transplantation. | 1999 | Transplant. Proc. | pmid:10500653 |
| Garcia CD et al. | Pediatric renal transplantation under tacrolimus or cyclosporine immunosuppression and basiliximab induction. | 2002 | Transplant. Proc. | pmid:12431513 |
| Wang M et al. | Acute influence of FK506 on T-lymphocyte populations of peripheral blood and spleen in rats. | 2007 Jan-Feb | Transplant. Proc. | pmid:17275526 |
| Fung JJ et al. | Conversion of liver allograft recipients from cyclosporine to FK 506-based immunosuppression: benefits and pitfalls. | 1991 | Transplant. Proc. | pmid:1703682 |
| Eghtesad B et al. | Use of tacrolimus as the primary immunosuppression after renal transplant in Native Americans and Hispanics. | 1998 | Transplant. Proc. | pmid:9636500 |
| Pichlmayr R et al. | Three-year follow-up of the European Multicenter Tacrolimus (FK506) Liver Study. | 1997 | Transplant. Proc. | pmid:9270825 |