tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guy S et al. | Immunosuppression conversion for relief of side effects. | 1994 | Transplant. Proc. | pmid:7527956 |
| Knoop C et al. | FK 506 rescue therapy for irreversible airway rejection in heart-lung transplant recipients: report on five cases. | 1994 | Transplant. Proc. | pmid:7527957 |
| Gołębiewska J et al. | Tako-tsubo cardiomyopathy on the first day after renal transplantation - case report and literature review. | 2014 | Transplant. Proc. | pmid:25380951 |
| Nomoto S et al. | Cardiotoxicity of long-term intravenous administration of FK506 in rabbits: dose relationship and recovery after discontinuance. | 1994 | Transplant. Proc. | pmid:7513477 |
| Yuan QS et al. | Rescue therapy with tacrolimus in renal graft patients with cyclosporine A-induced hepatotoxicity: a preliminary study. | 2000 | Transplant. Proc. | pmid:11119896 |
| Kato H et al. | Spontaneous proliferation of peripheral blood mononuclear cells as an indicator for insufficient plasma levels of FK 506 in the early phase after liver transplantation. | 1994 | Transplant. Proc. | pmid:7513481 |
| TuÄŸcu M et al. | Tacrolimus-Induced Diabetic Ketoacidosis and Effect of Switching to Everolimus: A Case Report. | 2015 | Transplant. Proc. | pmid:26093759 |
| Asensio M et al. | Experience with tacrolimus as primary immunosuppressor in pediatric liver transplant. | 2002 | Transplant. Proc. | pmid:11959208 |
| Porayko MK et al. | Nephrotoxicity of FK 506 and cyclosporine when used as primary immunosuppression in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7679835 |
| Iwasaki K et al. | Pharmacokinetic study of FK 506 in the rat. | 1991 | Transplant. Proc. | pmid:1721268 |
| Andersson J et al. | FK 506 and cyclosporine inhibit antigen- or mitogen-induced monokine and lymphokine production in vitro. | 1992 | Transplant. Proc. | pmid:1371621 |
| Kay JE et al. | Uptake of FK 506 by lymphocytes and erythrocytes. | 1991 | Transplant. Proc. | pmid:1721269 |
| Takada S et al. | HGF prevents tacrolimus (FK 506)-induced nephrotoxicity in SHR rats. | 1996 | Transplant. Proc. | pmid:8623236 |
| Monden M et al. | A potent immunosuppressive effect of FK 506 in orthotopic liver transplantation in primates. | 1990 | Transplant. Proc. | pmid:1689904 |
| Ericzon BG et al. | Pancreaticoduodenal allotransplantation with FK 506 in the cynomolgus monkey. | 1990 | Transplant. Proc. | pmid:1689905 |
| Millis JM et al. | Successful use of tacrolimus for initial rejection episodes after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636569 |
| Videla CO | Two-year experience with tacrolimus in renal transplantation after late conversion from cyclosporine therapy. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715995 |
| Santos T et al. | New Recipes With Known Ingredients: Combined Therapy of Everolimus and Low-dose Tacrolimus in De Novo Renal Allograft Recipients. | 2015 | Transplant. Proc. | pmid:26036483 |
| Higuchi K et al. | FK506 induces the atrophy of enteric ganglia in small bowel transplantation, which can be prevented by the neuropeptide bombesin. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908293 |
| Koyamada N et al. | Strategy for chronic rejection in recipient of living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120102 |
| Harihara Y et al. | Correlation between graft size and necessary tacrolimus dose after living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120116 |
| MartÃn-Mateos RM et al. | Initial immunosuppression with or without basiliximab: a comparative study. | 2012 | Transplant. Proc. | pmid:23146457 |
| Kohnle M et al. | Conversion from cyclosporine to tacrolimus in renal transplant recipients with gum hyperplasia. | 1999 | Transplant. Proc. | pmid:10576043 |
| van Hooff JP et al. | Tacrolimus and glucose metabolism. | 1999 | Transplant. Proc. | pmid:10576044 |
| Nakamuta M et al. | Cyclosporine suppresses cell growth and collagen production in hepatic stellate cells. | 2005 | Transplant. Proc. | pmid:16387179 |
| Kim HC et al. | Primary immunosuppression with tacrolimus in kidney transplantation: three-year follow-up in a single center. | 2004 | Transplant. Proc. | pmid:15518753 |
| Woodle ES et al. | Role of protocol biopsies in the treatment of refractory renal allograft rejection with FK 506. | 1996 | Transplant. Proc. | pmid:8623495 |
| Rao P et al. | Effect of FK 506 on FK-binding protein and transforming growth factor beta gene expression. | 1991 | Transplant. Proc. | pmid:1721301 |
| Comuzzi C et al. | Safety of conversion from twice-daily tacrolimus (Prograf) to once-daily prolonged-release tacrolimus (Advagraf) in stable liver transplant recipients. | 2010 | Transplant. Proc. | pmid:20534291 |
| Burke GW et al. | Use of tacrolimus and mycophenolate mofetil for pancreas-kidney transplantation with or without OKT3 induction. | 1998 | Transplant. Proc. | pmid:9636627 |
| Gruessner RW | Antibody induction therapy in pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9636632 |
| Marchewka Z et al. | Kidney graft function in long-term cyclosporine and tacrolimus treatment: comparative study with nephrotoxicity markers. | 2009 | Transplant. Proc. | pmid:19545703 |
| Herrero MJ et al. | Clinical interest of pharmacogenetic polymorphisms in the immunosuppressive treatment after heart transplantation. | 2010 | Transplant. Proc. | pmid:20970643 |
| Platz KP et al. | FK 506 and mycofenolate mofetil rescue for acute steroid-resistant and chronic rejection after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365598 |
| Villamil F et al. | Long-term outcomes in liver transplant patients with hepatic C infection receiving tacrolimus or cyclosporine. | 2006 | Transplant. Proc. | pmid:17112875 |
| Platz KP et al. | Indications for mycofenolate mofetil therapy after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365601 |
| Reyes J et al. | Lymphoproliferative disease after intestinal transplantation under primary FK 506 immunosuppression. | 1994 | Transplant. Proc. | pmid:7518137 |
| Falkiewicz K et al. | Tacrolimus decreases tubular phosphate wasting in renal allograft recipients. | 2003 | Transplant. Proc. | pmid:14529892 |
| Li J et al. | Regulatory effect of FK506 on CD152 and PD-1 in the liver allorecipients. | 2008 | Transplant. Proc. | pmid:18589137 |
| Ennaifer R et al. | Nodular hyperplasia of the gastrointestinal tract after liver transplantation: role of immunosuppressive therapy? A case report. | 2015 | Transplant. Proc. | pmid:25891739 |
| Yang YJ et al. | Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency. | 2008 | Transplant. Proc. | pmid:18589147 |
| Stockmann M et al. | Influence of immunosuppressive drugs on intestinal epithelial transport function. | 2002 | Transplant. Proc. | pmid:12176434 |
| Jain A et al. | Intravenous, oral pharmacokinetics, and oral dosing of FK 506 in small bowel transplant patients. | 1992 | Transplant. Proc. | pmid:1376518 |
| Watanabe K et al. | Factors influencing long-term operational tolerance in dogs treated with fractionated lymphoid irradiation, donor bone marrow cell infusion and FK506. | 1995 | Transplant. Proc. | pmid:7533389 |
| Masutani H et al. | Suppression of the histologic changes of GVHD by FK 506 in rat small bowel transplantation. | 1992 | Transplant. Proc. | pmid:1376519 |
| Wennberg L et al. | Efficacy of various immunosuppressive drugs in preventing pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:7533391 |
| Borg AJ and Kumagai M | FK 506 and xenogeneic human anti-porcine cellular reactivity. | 1991 | Transplant. Proc. | pmid:1721332 |
| Fung J et al. | A randomized trial of primary liver transplantation under immunosuppression with FK 506 vs cyclosporine. | 1991 | Transplant. Proc. | pmid:1721333 |
| Signorell J et al. | Recurrent non-melanoma skin cancer: remission of field cancerization after conversion from calcineurin inhibitor- to proliferation signal inhibitor-based immunosuppression in a cardiac transplant recipient. | 2010 | Transplant. Proc. | pmid:21094874 |
| Hayes D et al. | Aerosolized tacrolimus: a case report in a lung transplant recipient. | 2010 | Transplant. Proc. | pmid:21094875 |
| Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
| Numakura K et al. | Incidence and risk factors of clinical characteristics, tacrolimus pharmacokinetics, and related genomic polymorphisms for posttransplant diabetes mellitus in the early stage of renal transplant recipients. | 2005 | Transplant. Proc. | pmid:15919487 |
| Colak T et al. | Effect of conversion from cyclosporine to tacrolimus on lipid profiles in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12270321 |
| Waller JR et al. | Primary immunosuppression with tacrolimus is associated with a reduction in renal allograft fibrosis compared with neoral therapy. | 2002 | Transplant. Proc. | pmid:12176496 |
| De Ruvo N et al. | Preliminary results of immunosuppression with thymoglobuline pretreatment and hepatitis C virus recurrence in liver transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182760 |
| Tze WJ et al. | FK 506: an effective immunosuppressant for islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1281577 |
| Jordan ML et al. | FK 506 conversion of renal allografts failing cyclosporine immunosuppression. | 1991 | Transplant. Proc. | pmid:1721365 |
| Alessiani M et al. | Infections in adult liver transplant patients under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1703345 |
| Sasaki K et al. | Effect of FK 506 and splenectomy on orthotopic small bowel xenotransplantation in the hamster-to-rat animal models. | 1998 | Transplant. Proc. | pmid:9838521 |
| Marino IR et al. | Preoperative assessment of risk in liver transplantation: a multivariate analysis in 2376 cases of the UW era. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123079 |
| Alessiani M et al. | Intestinal transplantation with and without the colon in FK 506 immunosuppressed pigs. | 1996 | Transplant. Proc. | pmid:8908021 |
| Nozaki S et al. | Effect of brequinar sodium on accelerated cardiac allograft rejection in presensitized recipients. | 1994 | Transplant. Proc. | pmid:7520633 |
| Takayama K et al. | Nonmuscle myosin heavy chain and nuclear factor-kappa B expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936372 |
| Goller AL et al. | Loss of serum bicarbonate after discordant liver xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936383 |
| Boots JM et al. | Risk of adrenal insufficiency with steroid maintenance therapy in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176541 |
| Boots JM et al. | Early steroid withdrawal in renal transplantation with tacrolimus dual therapy: a pilot study. | 2002 | Transplant. Proc. | pmid:12176542 |
| Klupp J et al. | Mycophenolate mofetil in combination with tacrolimus versus Neoral after liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083497 |
| Watanabe K et al. | Prolongation effect of a small dose of FK506, cyclosporine, or azathioprine on renal allografts in dogs treated with fractionated lymphoid irradiation and donor bone marrow cell infusion. | 1989 | Transplant. Proc. | pmid:2468213 |
| Eidelman BH et al. | Neurologic complications of FK 506. | 1991 | Transplant. Proc. | pmid:1721398 |
| Yang HC et al. | Tacrolimus/"low-dose" mycophenolate mofetil versus microemulsion cyclosporine/"low-dose" mycophenolate mofetil after kidney transplantation--1-year follow-up of a prospective, randomized clinical trial. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083501 |
| Hsu KH et al. | Combined sirolimus-calcineurin inhibitor immunosuppressive therapy in simultaneous heart and kidney transplantation: a retrospective analysis of a single hospital's experience. | 2010 | Transplant. Proc. | pmid:20430208 |
| Alessiani M et al. | Morphological and functional changes in small-bowel allografts of pigs under combined tacrolimus and mycophenolate mofetil immunosuppression. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123483 |
| Galvao FH et al. | Experimental animal model of graft-versus-host disease (GVHD) after small-bowel transplantation: characteristics of the model and application to developing treatment strategies. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123488 |
| Tatekawa Y et al. | Intragraft expression of p38 in rat small bowel transplantation. | 2000 | Transplant. Proc. | pmid:10995948 |
| Karamperis N et al. | Comparison of the pharmacokinetics of tacrolimus and cyclosporine at equivalent molecular doses. | 2003 | Transplant. Proc. | pmid:12826146 |
| Land W et al. | Tacrolimus versus cyclosporine in primary simultaneous pancreas-kidney transplantation: preliminary results at 1 year of a large multicenter trial. | 2002 | Transplant. Proc. | pmid:12176625 |
| Navaneethan SD et al. | Tacrolimus-associated hypomagnesemia in renal transplant recipients. | 2006 | Transplant. Proc. | pmid:16797291 |
| Lorenzini S et al. | Posttransplant lymphoproliferative disorders in liver transplanted patients: a report of four cases. | 2006 | Transplant. Proc. | pmid:16797338 |
| Fukuzawa M et al. | Effect of donor-specific transfusion and FK 506 on small intestine allotransplantation. | 1991 | Transplant. Proc. | pmid:1721427 |
| Park KM et al. | Bone loss after orthotopic liver transplantation: FK 506 versus cyclosporine. | 1996 | Transplant. Proc. | pmid:8658863 |
| Zamauskaite A et al. | FK506 and CsA differ in their effect on intracellular cytokine expression following kidney transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267184 |
| Ogasa N et al. | Effect of FK 506 on growth of transplanted newborn rat intestine. | 1991 | Transplant. Proc. | pmid:1721428 |
| Kakefuda T et al. | Detection of nitrosylhemoglobin in liver allograft in rats by using near-infrared spectroscopy. | 1996 | Transplant. Proc. | pmid:8658885 |
| Venkataramanan R et al. | Biopharmaceutical aspects of FK-506. | 1987 | Transplant. Proc. | pmid:2445070 |
| Kino T et al. | Effect of FK-506 on human mixed lymphocyte reaction in vitro. | 1987 | Transplant. Proc. | pmid:2445071 |
| Donadio C et al. | Tubular damage and impairment of renal function in transplanted kidneys. | 1998 | Transplant. Proc. | pmid:9723381 |
| Aidong W et al. | Therapeutic drug monitoring of tacrolimus in early stage after heart transplantation. | 2004 | Transplant. Proc. | pmid:15561258 |
| Rabkin JM et al. | Pharmacoeconomic study of tacrolimus-based versus cyclosporine-based immunosuppressive therapy following liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267411 |
| Uber PA et al. | Ethnic disparities in the pharmacologic characteristics of tacrolimus in heart transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267428 |
| Carrieri G et al. | Effect of FK 506 in the prophylaxis of autoimmune glomerulonephritis in NZB/WF1 mice. | 1991 | Transplant. Proc. | pmid:1721460 |
| Isobe M et al. | Downregulation of endothelin expression in allograft coronary arteries after gene therapy targeting Cdk2 kinase. | 1998 | Transplant. Proc. | pmid:9636407 |
| Ciancio G et al. | Randomized trial of thymoglobulin versus alemtuzumab (with lower dose maintenance immunosuppression) versus daclizumab in living donor renal transplantation. | 2010 | Transplant. Proc. | pmid:21094804 |
| Malinowski K et al. | Effect of different anti-rejection regimens on the expression of differentiation and activation markers on the surface of host lymphocytes. | 2000 | Transplant. Proc. | pmid:10856579 |
| Soh KS et al. | Simultaneous liver and kidney transplantation from different living donors. | 2012 | Transplant. Proc. | pmid:22410057 |
| Ericzon BG et al. | Effect of FK 506 on glucose metabolism in the cynomolgus monkey: studies in pancreatic transplant recipients and nontransplanted animals. | 1991 | Transplant. Proc. | pmid:1703695 |
| Blume C et al. | Conversion from cyclosporine to tacrolimus prevents transplant function loss due to acute steroid-resistant or chronic rejection in renal allograft recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750357 |
| Kumano K et al. | FK 506-induced nephrotoxicity in rats. | 1991 | Transplant. Proc. | pmid:1703696 |
| Jørgensen KA et al. | Optimal time for determination of blood tacrolimus level. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750358 |
| Busque S et al. | Conversion from Neoral (cyclosporine) to tacrolimus of kidney transplant recipients for gingival hyperplasia or hypertrichosis. | 1998 | Transplant. Proc. | pmid:9636507 |
| Loss GE et al. | Reversal of delayed hyperacute renal allograft rejection with a tacrolimus-based therapeutic regimen. | 1998 | Transplant. Proc. | pmid:9636508 |