tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qin J et al. | Radiological and clinical findings of 25 patients with invasive pulmonary aspergillosis: retrospective analysis of 2150 liver transplantation cases. | 2012 | Br J Radiol | pmid:22496071 |
| Anoopkumar-Dukie S et al. | Mitochondrial modulation of oxygen-dependent radiosensitivity in some human tumour cell lines. | 2009 | Br J Radiol | pmid:19366737 |
| Murphy GJ et al. | Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. | 2003 | Br J Surg | pmid:12808614 |
| Middleton SJ et al. | Adult small intestinal transplantation in England and Wales. | 2003 | Br J Surg | pmid:12808622 |
| Morris-Stiff GJ et al. | Sequential changes in plasma selenium concentration after cadaveric renal transplantation. | 2004 | Br J Surg | pmid:14991636 |
| Wilson CH et al. | Randomized clinical trial of daclizumab induction and delayed introduction of tacrolimus for recipients of non-heart-beating kidney transplants. | 2005 | Br J Surg | pmid:15856479 |
| Waller JR et al. | Effects of the combination of rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia. | 2002 | Br J Surg | pmid:12390379 |
| Brook NR et al. | Fibrosis-associated gene expression in renal transplant glomeruli after acute renal allograft rejection. | 2003 | Br J Surg | pmid:12905557 |
| Jain S et al. | Tacrolimus has less fibrogenic potential than cyclosporin A in a model of renal ischaemia-reperfusion injury. | 2000 | Br J Surg | pmid:11091246 |
| Bicknell GR et al. | Differential effects of cyclosporin and tacrolimus on the expression of fibrosis-associated genes in isolated glomeruli from renal transplants. | 2000 | Br J Surg | pmid:11091247 |
| White DJ | Immunosuppression for heart transplantation. | 1993 | Br. J. Biomed. Sci. | pmid:7694717 |
| Reichert TE et al. | The role of endogenous interleukin-2 in proliferation of human carcinoma cell lines. | 1999 | Br. J. Cancer | pmid:10555752 |
| Andersson Y et al. | Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo. | 2009 | Br. J. Cancer | pmid:19773757 |
| Chambers CA | Topical tacrolimus for cutaneous lupus erythematosus. | 2003 | Br. J. Dermatol. | pmid:12752154 |
| Ludwig E et al. | New treatment modalities for granuloma faciale. | 2003 | Br. J. Dermatol. | pmid:14511001 |
| Vecchietti G et al. | Topical tacrolimus (FK506) for relapsing erosive stomatitis in paraneoplastic pemphigus. | 2003 | Br. J. Dermatol. | pmid:12752158 |
| Patel NP et al. | Treatment of eosinophilic pustulosis of infancy with topical tacrolimus. | 2012 | Br. J. Dermatol. | pmid:22563626 |
| Aoyama H et al. | Successful treatment of resistant facial lesions of atopic dermatitis with 0.1% FK506 ointment. | 1995 | Br. J. Dermatol. | pmid:8547017 |
| Meingassner JG et al. | Pimecrolimus does not affect Langerhans cells in murine epidermis. | 2003 | Br. J. Dermatol. | pmid:14616380 |
| Wilsmann-Theis D et al. | Successful treatment of acrodermatitis continua suppurativa with topical tacrolimus 0.1% ointment. | 2004 | Br. J. Dermatol. | pmid:15214910 |
| Lerbaek A and Agner T | Facial eruption of molluscum contagiosum during topical treatment of atopic dermatitis with tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15214914 |
| Edmonds EV et al. | Nodular prurigo responding to topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15214918 |
| Murrell DF et al. | A randomized controlled trial of pimecrolimus cream 1% in adolescents and adults with head and neck atopic dermatitis and intolerant of, or dependent on, topical corticosteroids. | 2007 | Br. J. Dermatol. | pmid:17935515 |
| Liao YH et al. | Comparison of cutaneous tolerance and efficacy of calcitriol 3 microg g(-1) ointment and tacrolimus 0.3 mg g(-1) ointment in chronic plaque psoriasis involving facial or genitofemoral areas: a double-blind, randomized controlled trial. | 2007 | Br. J. Dermatol. | pmid:17935517 |
| Sugiura H et al. | An open study of a lotion formulation to improve tolerance of tacrolimus in facial atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11736904 |
| Wu CS et al. | FK506 inhibits the enhancing effects of transforming growth factor (TGF)-β1 on collagen expression and TGF-β/Smad signalling in keloid fibroblasts: implication for new therapeutic approach. | 2012 | Br. J. Dermatol. | pmid:22540338 |
| Tennis P et al. | Evaluation of cancer risk related to atopic dermatitis and use of topical calcineurin inhibitors. | 2011 | Br. J. Dermatol. | pmid:21466537 |
| Afshar M et al. | The effect of pimecrolimus on innate immunity in subjects with atopic dermatitis: a double-blind, randomized, vehicle-controlled study. | 2013 | Br. J. Dermatol. | pmid:22577776 |
| Calza AM and Lübbe J | Tacrolimus ointment-associated alcohol intolerance in infants receiving ethanol-containing medication. | 2005 | Br. J. Dermatol. | pmid:15787832 |
| Rigopoulos D et al. | Pimecrolimus cream 1% vs. betamethasone 17-valerate 0.1% cream in the treatment of seborrhoeic dermatitis. A randomized open-label clinical trial. | 2004 | Br. J. Dermatol. | pmid:15541087 |
| Clayton TH and Harrison PV | Successful treatment of chronic ulcerated necrobiosis lipoidica with 0.1% topical tacrolimus ointment. | 2005 | Br. J. Dermatol. | pmid:15787840 |
| RodrÃguez GarcÃa F et al. | Generalized pustular psoriasis successfully treated with topical tacrolimus. | 2005 | Br. J. Dermatol. | pmid:15787845 |
| Danby SG et al. | The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis. | 2014 | Br. J. Dermatol. | pmid:24328907 |
| Weidinger S et al. | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal. | 2017 | Br. J. Dermatol. | pmid:28868633 |
| Charman C | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - comment. | 2017 | Br. J. Dermatol. | pmid:28858382 |
| Carroll CL et al. | Better medication adherence results in greater improvement in severity of psoriasis. | 2004 | Br. J. Dermatol. | pmid:15491434 |
| Wenzel J et al. | Successful treatment of recalcitrant Wegener's granulomatosis of the skin with tacrolimus (Prograf). | 2004 | Br. J. Dermatol. | pmid:15491443 |
| Chung BY et al. | The proactive treatment of atopic dermatitis with tacrolimus ointment in Korean patients: a comparative study between once-weekly and thrice-weekly applications. | 2013 | Br. J. Dermatol. | pmid:23110605 |
| Kabashima K et al. | Treatment of eosinophilic pustular folliculitis (Ofuji's disease) with tacrolimus ointment. | 2004 | Br. J. Dermatol. | pmid:15491457 |
| Esquivel-Pedraza L et al. | Treatment of oral lichen planus with topical pimecrolimus 1% cream. | 2004 | Br. J. Dermatol. | pmid:15099380 |
| Aguilar-Bernier M et al. | Successful treatment of pruritus with topical tacrolimus in a patient with primary biliary cirrhosis. | 2005 | Br. J. Dermatol. | pmid:15840123 |
| Sorgentini C et al. | Lichen striatus in an adult: successful treatment with tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15099383 |
| Dissemond J et al. | Pimecrolimus in an adhesive ointment as a new treatment option for oral lichen planus. | 2004 | Br. J. Dermatol. | pmid:15099387 |
| Harth W and Linse R | Topical tacrolimus in granuloma annulare and necrobiosis lipoidica. | 2004 | Br. J. Dermatol. | pmid:15099394 |
| Higgins E and Collins P | Recurrent bullous erythema multiforme treated with topical tacrolimus 0·1% ointment. | 2011 | Br. J. Dermatol. | pmid:21114481 |
| Pitt M et al. | A cost-utility analysis of pimecrolimus vs. topical corticosteroids and emollients for the treatment of mild and moderate atopic eczema. | 2006 | Br. J. Dermatol. | pmid:16704646 |
| Hashizume H et al. | Comparable risk of herpes simplex virus infection between topical treatments with tacrolimus and corticosteroids in adults with atopic dermatitis. | 2006 | Br. J. Dermatol. | pmid:16704659 |
| Simon D et al. | Successful treatment of pityriasis lichenoides with topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15149526 |
| Mrowietz U et al. | The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion. | 1998 | Br. J. Dermatol. | pmid:9990361 |
| Jain S and Stephens CJ | Successful treatment of disseminated granuloma annulare with topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15149532 |
| Koguchi-Yoshioka H et al. | Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules. | 2017 | Br. J. Dermatol. | pmid:28346662 |
| Ghislain PD et al. | Efficacy and systemic absorption of topical tacrolimus used in pyoderma gangrenosum. | 2004 | Br. J. Dermatol. | pmid:15149540 |
| Hoeger PH et al. | The treatment of facial atopic dermatitis in children who are intolerant of, or dependent on, topical corticosteroids: a randomized, controlled clinical trial. | 2009 | Br. J. Dermatol. | pmid:19067708 |
| Griffiths CE | Ascomycin: an advance in the management of atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298524 |
| Fujimoto N et al. | Facial lichen striatus: successful treatment with tacrolimus ointment. | 2003 | Br. J. Dermatol. | pmid:12653755 |
| Ueda M et al. | Successful treatment of amyopathic dermatomyositis with topical tacrolimus. | 2003 | Br. J. Dermatol. | pmid:12653761 |
| Fricain JC et al. | Long-term efficacy of topical tacrolimus on oral lesions of chronic graft-versus-host disease. | 2007 | Br. J. Dermatol. | pmid:17300261 |
| Vissers WH et al. | Topical treatment of mild to moderate plaque psoriasis with 0.3% tacrolimus gel and 0.5% tacrolimus cream: the effect on SUM score, epidermal proliferation, keratinization, T-cell subsets and HLA-DR expression. | 2008 | Br. J. Dermatol. | pmid:18284400 |
| Ormerod AD | Topical tacrolimus and pimecrolimus and the risk of cancer: how much cause for concern? | 2005 | Br. J. Dermatol. | pmid:16181449 |
| Lan CC et al. | FK506 inhibits tumour necrosis factor-alpha secretion in human keratinocytes via regulation of nuclear factor-kappaB. | 2005 | Br. J. Dermatol. | pmid:16181452 |
| Vukmanovic-Stejic M et al. | Relative impact of CD4+CD25+ regulatory T cells and tacrolimus on inhibition of T-cell proliferation in patients with atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:16181456 |
| Martin-Munoz MF et al. | Topical treatment tacrolimus and food allergy. | 2005 | Br. J. Dermatol. | pmid:16181473 |
| Nissi R et al. | Altered p53 and Bcl-2 expression in keratinocytes of vulvar lichen sclerosus during pimecrolimus treatment. | 2009 | Br. J. Dermatol. | pmid:19659469 |
| Lan CC et al. | FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo. | 2005 | Br. J. Dermatol. | pmid:16120133 |
| Alomar A et al. | The role of topical calcineurin inhibitors in atopic dermatitis. | 2004 | Br. J. Dermatol. | pmid:15548171 |
| Ständer S et al. | Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin. | 2007 | Br. J. Dermatol. | pmid:17388925 |
| Mashayekhi S et al. | The treatment of vulval lichen sclerosus in prepubertal girls: a critically appraised topic. | 2017 | Br. J. Dermatol. | pmid:28244087 |
| Reitamo S et al. | A 4-year follow-up study of atopic dermatitis therapy with 0.1% tacrolimus ointment in children and adult patients. | 2008 | Br. J. Dermatol. | pmid:18637898 |
| Barbier N et al. | Validation of the Eczema Area and Severity Index for atopic dermatitis in a cohort of 1550 patients from the pimecrolimus cream 1% randomized controlled clinical trials programme. | 2004 | Br. J. Dermatol. | pmid:14746622 |
| Rubegni P et al. | A case of reticular erythematous mucinosis treated with topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:14746650 |
| Abe R et al. | Severe refractory chronic actinic dermatitis successfully treated with tacrolimus ointment. | 2002 | Br. J. Dermatol. | pmid:12452891 |
| Taher ZA et al. | Analysis of interleukin-10 levels in lesions of vitiligo following treatment with topical tacrolimus. | 2009 | Br. J. Dermatol. | pmid:19438859 |
| Lonsdale-Eccles AA and Velangi S | Topical pimecrolimus in the treatment of genital lichen planus: a prospective case series. | 2005 | Br. J. Dermatol. | pmid:16086755 |
| Undre NA et al. | Skin and systemic pharmacokinetics of tacrolimus following topical application of tacrolimus ointment in adults with moderate to severe atopic dermatitis. | 2009 | Br. J. Dermatol. | pmid:19076975 |
| Bäumer W et al. | Cilomilast, tacrolimus and rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis. | 2005 | Br. J. Dermatol. | pmid:16029339 |
| Caproni M et al. | The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study. | 2007 | Br. J. Dermatol. | pmid:17223872 |
| Bilenchi R et al. | Human papillomavirus reactivation following topical tacrolimus therapy of anogenital lichen sclerosus. | 2007 | Br. J. Dermatol. | pmid:17223903 |
| Mashiko M et al. | A case of angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment. | 2006 | Br. J. Dermatol. | pmid:16536847 |
| Wollenberg A et al. | Economic evaluation of maintenance treatment with tacrolimus 0.1% ointment in adults with moderate to severe atopic dermatitis. | 2008 | Br. J. Dermatol. | pmid:18782316 |
| Doss N et al. | Superiority of tacrolimus 0.1% ointment compared with fluticasone 0.005% in adults with moderate to severe atopic dermatitis of the face: results from a randomized, double-blind trial. | 2009 | Br. J. Dermatol. | pmid:19416227 |
| Thaçi D et al. | Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: results of a randomized, multicentre, comparative study. | 2008 | Br. J. Dermatol. | pmid:18782319 |
| Leung DY et al. | Effects of pimecrolimus cream 1% in the treatment of patients with atopic dermatitis who demonstrate a clinical insensitivity to topical corticosteroids: a randomized, multicentre vehicle-controlled trial. | 2009 | Br. J. Dermatol. | pmid:19416245 |
| Hickey JR et al. | Does topical tacrolimus induce lentigines in children with atopic dermatitis? A report of three cases. | 2005 | Br. J. Dermatol. | pmid:15656817 |
| Mancuso G and Berdondini RM | Localized scleroderma: response to occlusive treatment with tacrolimus ointment. | 2005 | Br. J. Dermatol. | pmid:15656828 |
| Neckermann G et al. | Atopic dermatitis-like symptoms in hypomagnesaemic hairless rats are prevented and inhibited by systemic or topical SDZ ASM 981. | 2000 | Br. J. Dermatol. | pmid:10792216 |
| Queille-Roussel C et al. | The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. | 2001 | Br. J. Dermatol. | pmid:11260007 |
| Ramsay HM and Harden PN | Cyclosporin-induced flushing in a renal transplant recipient resolving after substitution with tacrolimus. | 2000 | Br. J. Dermatol. | pmid:10792253 |
| Rao A and Bunker C | Efficacy and safety of tacrolimus ointment 0.1% vs. betamethasone 17-valerate 0.1% in the treatment of chronic paronychia: an unblinded randomized study. | 2010 | Br. J. Dermatol. | pmid:20353455 |
| Ellis C et al. | International Consensus Conference on Atopic Dermatitis II (ICCAD II): clinical update and current treatment strategies. | 2003 | Br. J. Dermatol. | pmid:12694268 |
| Oji V et al. | Topical pimecrolimus: a novel therapeutic option for Netherton syndrome. | 2005 | Br. J. Dermatol. | pmid:16225628 |
| Clayton TH et al. | Topical tacrolimus for facial psoriasis. | 2003 | Br. J. Dermatol. | pmid:12932257 |
| Burkhart CG and Burkhart CN | Tacrolimus and topical steroids: which is more effective? | 2004 | Br. J. Dermatol. | pmid:15606537 |
| Lee DH et al. | Pimecrolimus 1% cream for the treatment of steroid-induced rosacea: an 8-week split-face clinical trial. | 2008 | Br. J. Dermatol. | pmid:18363758 |
| Moreno-Arias GA et al. | Plasma cell balanitis treated with tacrolimus 0.1%. | 2005 | Br. J. Dermatol. | pmid:16307659 |
| Tzung TY and Wu JC | Topical calcineurin inhibitors in treating Jessner's lymphocytic infiltration of the skin: report of a case. | 2005 | Br. J. Dermatol. | pmid:15727667 |
| Poole CD et al. | Health-related utility among adults with atopic dermatitis treated with 0.1% tacrolimus ointment as maintenance therapy over the long term: findings from the Protopic CONTROL study. | 2009 | Br. J. Dermatol. | pmid:19754867 |
| Chu CY | The use of 1% pimecrolimus cream for the treatment of steroid-induced rosacea. | 2005 | Br. J. Dermatol. | pmid:15727676 |
| Park CW et al. | Tacrolimus decreases the expression of eotaxin, CCR3, RANTES and interleukin-5 in atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:15948978 |
| Grassberger M et al. | A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology. | 1999 | Br. J. Dermatol. | pmid:10468798 |
| Takeuchi S et al. | Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web-based questionnaire survey. | 2015 | Br. J. Dermatol. | pmid:25421804 |