tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ruzicka T et al. | Tacrolimus: the drug for the turn of the millennium? | 1999 | Arch Dermatol | pmid:10328199 |
| Qureshi AA and Fischer MA | Topical calcineurin inhibitors for atopic dermatitis: balancing clinical benefit and possible risks. | 2006 | Arch Dermatol | pmid:16702502 |
| Van Leent EJ et al. | Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis. | 1998 | Arch Dermatol | pmid:9681343 |
| Mandelin J et al. | Effect of oral acetylsalicylic acid on burning caused by tacrolimus ointment in patients with atopic dermatitis. | 2010 | Arch Dermatol | pmid:20956662 |
| Passeron T et al. | Topical tacrolimus and the 308-nm excimer laser: a synergistic combination for the treatment of vitiligo. | 2004 | Arch Dermatol | pmid:15381545 |
| Bunker CB et al. | Topical tacrolimus, genital lichen sclerosus, and risk of squamous cell carcinoma. | 2004 | Arch Dermatol | pmid:15381566 |
| Byrd JA et al. | Response of oral lichen planus to topical tacrolimus in 37 patients. | 2004 | Arch Dermatol | pmid:15611431 |
| Santos-Juanes J et al. | Topical tacrolimus: an effective therapy for Zoon balanitis. | 2004 | Arch Dermatol | pmid:15611442 |
| Milingou M et al. | Alcohol intolerance and facial flushing in patients treated with topical tacrolimus. | 2004 | Arch Dermatol | pmid:15611445 |
| Carroll PB et al. | Effect of tacrolimus (FK506) in dystrophic epidermolysis bullosa: rationale and preliminary results. | 1994 | Arch Dermatol | pmid:7526802 |
| Allen DM and Esterly NB | Significant systemic absorption of tacrolimus after topical application in a patient with lamellar ichthyosis. | 2002 | Arch Dermatol | pmid:12225004 |
| Yeh C et al. | Effect of FK506 on functional recovery after facial nerve injury in the rat. | 2007 Sep-Oct | Arch Facial Plast Surg | pmid:17875826 |
| Geramizadeh B et al. | Post-transplantation lymphoproliferative disorder after liver transplantation: report of 5 cases among more than 550 liver transplants in Iran. | 2010 | Arch Iran Med | pmid:20804309 |
| Dehghani SM et al. | Tacrolimus related hypertrophic cardiomyopathy in liver transplant recipients. | 2010 | Arch Iran Med | pmid:20187665 |
| Rybojad M | [Atopic dermatitis]. | 2012 | Arch Pediatr | pmid:22796288 |
| Monchaud C et al. | [Long lasting side effects of immunosuppressants in children]. | 2007 | Arch Pediatr | pmid:17442546 |
| Sánchez Ferreiro AV and Muñoz Bellido L | [Tacrolimus in the treatment of atopic kerato-conjunctivitis]. | 2013 | Arch Soc Esp Oftalmol | pmid:23886369 |
| RodrÃguez-AusÃn P et al. | Topical tacrolimus 0.03% for the treatment of ocular psoriasis. | 2016 | Arch Soc Esp Oftalmol | pmid:27130870 |
| Fryer JP et al. | Bacterial translocation in a large-animal model of small-bowel transplantation. Portal vs systemic venous drainage and the effect of tacrolimus immunosuppression. | 1996 | Arch Surg | pmid:8546583 |
| Harmon JV et al. | Experimental short-term immunosuppression after bowel transplantation and donor-specific bone marrow infusion. | 2001 | Arch Surg | pmid:11448397 |
| Echigo Y et al. | Effects of cyclosporine and tacrolimus (FK 506) on acute pancreatitis in mice. | 1995 | Arch Surg | pmid:7528496 |
| Freise CE et al. | Excellent short-term results with steroid-free maintenance immunosuppression in low-risk simultaneous pancreas-kidney transplantation. | 2003 | Arch Surg | pmid:14557130 |
| Johnson MW et al. | Hepatitis C viral infection in liver transplantation. | 1996 | Arch Surg | pmid:8611094 |
| Stötter H and Lotze MT | Human lymphokine-activated killer cell activity. Role of IL-2, IL-4, and IL-7. | 1991 | Arch Surg | pmid:1726819 |
| Wen H et al. | Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. | 2012 | Arch. Biochem. Biophys. | pmid:22100703 |
| Vincent SH et al. | In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. | 1992 | Arch. Biochem. Biophys. | pmid:1373595 |
| Yin M and Ochs RS | Mechanism for the paradoxical inhibition and stimulation of calcineurin by the immunosuppresive drug tacrolimus (FK506). | 2003 | Arch. Biochem. Biophys. | pmid:14592464 |
| Salowe SP and Hermes JD | Competitive and slow-binding inhibition of calcineurin by drug x immunophilin complexes. | 1998 | Arch. Biochem. Biophys. | pmid:9675023 |
| Tomono M et al. | Inhibitors of calcineurin block expression of cyclins A and E induced by fibroblast growth factor in Swiss 3T3 fibroblasts. | 1998 | Arch. Biochem. Biophys. | pmid:9606972 |
| Kakegawa T et al. | Rapamycin induces binding activity to the terminal oligopyrimidine tract of ribosomal protein mRNA in rats. | 2002 | Arch. Biochem. Biophys. | pmid:12051685 |
| Mukerjee N et al. | Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells. | 2000 | Arch. Biochem. Biophys. | pmid:10898953 |
| Borro JM et al. | Long-term success of combined kidney-lung transplantation in a patient with cystic fibrosis. | 2013 | Arch. Bronconeumol. | pmid:23427867 |
| Reig Mezquida JP et al. | Thrombotic microangiopathy associated with tacrolimus in lung transplantation. | 2015 | Arch. Bronconeumol. | pmid:25138798 |
| Zurbano F et al. | Maternity and lung transplantation: cases in Spain. | 2012 | Arch. Bronconeumol. | pmid:22771003 |
| Nishimuta K and Ito Y | Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice. | 2003 | Arch. Dermatol. Res. | pmid:12624780 |
| Ito F et al. | FK506 and cyclosporin A inhibit stem cell factor-dependent cell proliferation/survival, while inducing upregulation of c-kit expression in cells of the mast cell line MC/9. | 1999 | Arch. Dermatol. Res. | pmid:10367710 |
| Lubaki LJ et al. | Time-kinetic study of repigmentation in vitiligo patients by tacrolimus or pimecrolimus. | 2010 | Arch. Dermatol. Res. | pmid:19547993 |
| Eberlein-König B et al. | Modulation of histamine release in vitro by FK506 and interleukin-3 is determined by sequence of incubation. | 1997 | Arch. Dermatol. Res. | pmid:9373722 |
| Hultsch T et al. | Direct evidence that FK506 inhibition of FcepsilonRI-mediated exocytosis from RBL mast cells involves calcineurin. | 1998 | Arch. Dermatol. Res. | pmid:9681677 |
| GarcÃa-GarcÃa B et al. | Frosch' surface microscopy score for the assessment of steroid-induced atrophy. | 2014 | Arch. Dermatol. Res. | pmid:24402286 |
| Paus R et al. | Hair growth control by immunosuppression. | 1996 | Arch. Dermatol. Res. | pmid:8818191 |
| Furukawa F et al. | FK506: therapeutic effects on lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr mice. | 1995 | Arch. Dermatol. Res. | pmid:7487142 |
| Ockenfels HM et al. | Cyclosporin A, FK506 and dithranol after tyrosine-specific protein phosphorylation in HaCaT keratinocytes. | 1995 | Arch. Dermatol. Res. | pmid:7541191 |
| Yoon NY et al. | Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model. | 2015 | Arch. Dermatol. Res. | pmid:25786383 |
| Hofmann M et al. | Validation of Dermaphot(®) for the assessment of steroid-induced skin atrophy. | 2013 | Arch. Dermatol. Res. | pmid:23242470 |
| Toyota N et al. | Effects of FK506 and cyclosporin A on proliferation, histamine release and phenotype of murine mast cells. | 1996 | Arch. Dermatol. Res. | pmid:8844128 |
| Engelhart K et al. | In vitro reproduction of clinical hallmarks of eczematous dermatitis in organotypic skin models. | 2005 | Arch. Dermatol. Res. | pmid:15952007 |
| Hultsch T et al. | Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner. | 1998 | Arch. Dermatol. Res. | pmid:9808344 |
| Lauerma AI et al. | Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig. | 1994 | Arch. Dermatol. Res. | pmid:7526805 |
| Lancia P et al. | Choosing the right dose of tacrolimus. | 2015 | Arch. Dis. Child. | pmid:25416736 |