Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Shapiro R et al. | Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report. | 1993 | Transplant. Proc. | pmid:7679836 |
Propper DJ et al. | Effects of the immunosuppressive macrolides rapamycin and FK 506 in high responder rats presensitized to major histocompatibility complex antigens. | 1993 | Transplant. Proc. | pmid:7679837 |
Stock PG et al. | Standard sequential immunosuppression with Minnesota antilymphoblast globulin and cyclosporine vs FK 506: a comparison of early nephrotoxicity. | 1993 | Transplant. Proc. | pmid:7679838 |
Tabasco-Minguillan J et al. | Long-term insulin requirement after liver transplantation with FK 506 in American veterans. | 1993 | Transplant. Proc. | pmid:7679839 |
Klintmalm GB et al. | Use of Prograf (FK 506) as rescue therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679840 |
Gunji Y et al. | Pathologic characteristics of vasculitis in renal transplant recipient dogs receiving immunosuppressive agents, FK 506, rapamycin, or RS-61443. | 1993 | Transplant. Proc. | pmid:7679841 |
Jayaraman T and Marks AR | Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line. | 1993 | J. Biol. Chem. | pmid:7503980 |
Saeki T et al. | Human P-glycoprotein transports cyclosporin A and FK506. | 1993 | J. Biol. Chem. | pmid:7681059 |
D'Ambrosio R et al. | Validation and quality assurance program for monitoring tacrolimus (FK 506) concentrations in plasma and whole blood. | 1993 | Ther Drug Monit | pmid:7504339 |
Dutz JP et al. | A role for calcineurin in degranulation of murine cytotoxic T lymphocytes. | 1993 | J. Immunol. | pmid:7681074 |
Takeguchi N et al. | Inhibition of the multidrug efflux pump in isolated hepatocyte couplets by immunosuppressants FK506 and cyclosporine. | 1993 | Transplantation | pmid:7681229 |
Valdivia LA et al. | Successful hamster-to-rat liver xenotransplantation under FK506 immunosuppression induces unresponsiveness to hamster heart and skin. | 1993 | Transplantation | pmid:7681230 |
Fujimura A et al. | Chronopharmacokinetic study of a new immunosuppressive agent, FK 506, in mice. | 1993 | Jpn. J. Pharmacol. | pmid:7681489 |
Peters DH et al. | Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. | 1993 | Drugs | pmid:7506654 |
Mühl H et al. | Cyclosporin derivatives inhibit interleukin 1 beta induction of nitric oxide synthase in renal mesangial cells. | 1993 | Eur. J. Pharmacol. | pmid:7506668 |
Nagata K et al. | Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in a canine two-hemorrhage model. | 1993 | J. Neurosurg. | pmid:7692019 |
Simek SL et al. | Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. | 1993 | Genomics | pmid:7507077 |
Lhoëst G et al. | Isolation and identification by FAB mass spectrometry and NMR spectroscopy of a demethylated metabolite of FK506 from erythromycin-induced rabbit liver microsomes. | 1993 | Pharm Acta Helv | pmid:7692454 |
Izumi S and Okuhara M | [FK506 and kifunensine, new immunomodulators of microbial origin]. | 1993 | Tanpakushitsu Kakusan Koso | pmid:7692469 |
Wakugami T et al. | Effect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporin. | 1993 | Tohoku J. Exp. Med. | pmid:7692621 |
Hill CC et al. | Penile prosthesis surgery in the immunosuppressed patient. | 1993 | Transplantation | pmid:7692633 |
Bierer BE et al. | Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. | 1993 | Curr. Opin. Immunol. | pmid:7694595 |
Sato M et al. | FK506 inhibits phytohemagglutinin-, but not interferon-gamma-, induced HLA-DR antigen expression and accessory cell function on primary cultured human thyroid cells. | 1993 | Acta Endocrinol. | pmid:7509103 |
White DJ | Immunosuppression for heart transplantation. | 1993 | Br. J. Biomed. Sci. | pmid:7694717 |
Blaehr H et al. | Acute effects of FK506 and cyclosporine A on cultured human proximal tubular cells. | 1993 | Eur. J. Pharmacol. | pmid:7683267 |
Kadmon M et al. | Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. | 1993 | Gastroenterology | pmid:7683296 |
Denesyuk AI et al. | Structural similarity of the binding sites of cyclophilin A-cyclosporin A and FKBP-FK506 systems. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7683466 |
Suzuki S et al. | Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. | 1993 | Transplantation | pmid:7685932 |
McDiarmid SV et al. | Differences in oral FK506 dose requirements between adult and pediatric liver transplant patients. | 1993 | Transplantation | pmid:7685933 |
Moutabarrik A et al. | Use of FK 506 in kidney transplantation. | 1993 | Transplant. Proc. | pmid:7685946 |
Moutabarrik A et al. | Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. | 1993 | Transplant. Proc. | pmid:7685949 |
Takaya S et al. | Use of prostaglandin E1 in crossmatch-negative liver transplant recipients treated with FK 506. | 1993 | Transplant. Proc. | pmid:7685953 |
Lyson T et al. | Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. | 1993 | Circ. Res. | pmid:7688670 |
Morkawa K et al. | Immunosuppressive property of bromocriptine on human B lymphocyte function in vitro. | 1993 | Clin. Exp. Immunol. | pmid:7688676 |
Yamaoka K et al. | Cyclosporin A and FK506 block the negative signaling mediated by surface IgM cross-linking in normal human mature B cells. | 1993 | Immunol. Lett. | pmid:7688712 |
Smith DF et al. | Two FKBP-related proteins are associated with progesterone receptor complexes. | 1993 | J. Biol. Chem. | pmid:7688746 |
Jacobs JC et al. | Pyoderma gangrenosum in infancy. | 1993 | J. Am. Acad. Dermatol. | pmid:7688775 |
Clardy J | Structural studies of complexed FK-506 binding protein. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689808 |
Starzl TE et al. | Allograft and xenograft acceptance under FK-506 and other immunosuppressant treatment. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689809 |
Reem GH et al. | FK-506 inhibits the IL-2-independent induction of the activation antigen CD 69. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689811 |
Mollison KW et al. | Comparison of FK-506, rapamycin, ascomycin, and cyclosporine in mouse models of host-versus-graft disease and heterotopic heart transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689812 |
Tai PK et al. | P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. | 1993 | Biochemistry | pmid:7689858 |
Lieberman R | FK506, artificial intelligence and pharmacoeconomics. | 1993 | J Clin Pharmacol | pmid:7690045 |
Barthelmess IB and Tropschug M | FK506-binding protein of Neurospora crassa (NcFKBP) mediates sensitivity to the immunosuppressant FK506; resistant mutants identify two loci. | 1993 | Curr. Genet. | pmid:7679056 |
Fingar DC et al. | Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. | 1993 | J. Biol. Chem. | pmid:7679106 |
Griffiths EJ and Halestrap AP | Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. | 1993 | J. Mol. Cell. Cardiol. | pmid:7512654 |
McCaffrey PG et al. | NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. | 1993 | J. Biol. Chem. | pmid:7679116 |
Armitage JM et al. | Pediatric lung transplantation. The years 1985 to 1992 and the clinical trial of FK 506. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7679172 |
Ito K and Komatsu Y | [Drug induced hemolytic uremic syndrome]. | 1993 | Nippon Rinsho | pmid:7679450 |
Langrehr JM et al. | Clinical course, morphology, and treatment of chronically rejecting small bowel allografts. | 1993 | Transplantation | pmid:7679526 |