tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Mediastinal Diseases D008477 1 associated lipids
Hypophosphatemia D017674 1 associated lipids
Leukemia, Myeloid, Chronic-Phase D015466 1 associated lipids
Myelinolysis, Central Pontine D017590 1 associated lipids
Protoporphyria, Erythropoietic D046351 1 associated lipids
Smooth Muscle Tumor D018235 1 associated lipids
Coproporphyria, Hereditary D046349 1 associated lipids
Ichthyosiform Erythroderma, Congenital D016113 1 associated lipids
Panniculitis, Lupus Erythematosus D015435 1 associated lipids
Retrognathia D063173 1 associated lipids
Lacerations D022125 1 associated lipids
Megacolon, Toxic D008532 1 associated lipids
Tinea Capitis D014006 1 associated lipids
Digestive System Fistula D016154 1 associated lipids
Crigler-Najjar Syndrome D003414 1 associated lipids
Leukoplakia, Oral D007972 1 associated lipids
Peroneal Neuropathies D020427 1 associated lipids
Poxviridae Infections D011213 1 associated lipids
Kaposi Varicelliform Eruption D007617 1 associated lipids
Lymphohistiocytosis, Hemophagocytic D051359 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
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Authors Title Published Journal PubMed Link
Picard N The pharmacokinetic interaction between mycophenolic acid and cyclosporine revisited: a commentary on "Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus". 2013 Xenobiotica pmid:23339626
Jeong H and Chiou WL Role of P-glycoprotein in the hepatic metabolism of tacrolimus. 2006 Xenobiotica pmid:16507509
Gupta AS et al. Pyoderma Gangrenosum of the Scalp: A Rare Clinical Variant. 2018 Wounds pmid:29481333
Kiyama T et al. Tacrolimus enhances colon anastomotic healing in rats. 2002 Sep-Oct Wound Repair Regen pmid:12406167
Yang J et al. Zinc finger protein A20 protects rats against chronic liver allograft dysfunction. 2012 World J. Gastroenterol. pmid:22826618
Chen ZS et al. Early steroid withdrawal after liver transplantation for hepatocellular carcinoma. 2007 World J. Gastroenterol. pmid:17876900
Zhou J et al. Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma: Report of an initial experience. 2006 World J. Gastroenterol. pmid:16718799
Li DW et al. Risk factors for new onset diabetes mellitus after liver transplantation: A meta-analysis. 2015 World J. Gastroenterol. pmid:26034369
Guo YW et al. Successful treatment of ileal ulcers caused by immunosuppressants in two organ transplant recipients. 2016 World J. Gastroenterol. pmid:27350740
Liu F et al. Tacrolimus dosage requirements in living donor liver transplant recipients with small-for-size grafts. 2009 World J. Gastroenterol. pmid:19701975
Takeichi T et al. Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver. 2009 World J. Gastroenterol. pmid:19960569
Hilgard P et al. Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation: effects on virus replication and recurrent hepatitis. 2006 World J. Gastroenterol. pmid:16521181
Jiang JW et al. Optimal immunosuppressor induces stable gut microbiota after liver transplantation. 2018 World J. Gastroenterol. pmid:30228781
Liu C et al. Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl]rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro. 2005 World J. Gastroenterol. pmid:16437685
Meier J and Sturm A Current treatment of ulcerative colitis. 2011 World J. Gastroenterol. pmid:21912469
Larsen FS et al. Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis. 2007 World J. Gastroenterol. pmid:17589903
Higashi H et al. First successful perinatal management of pregnancy after ABO-incompatible liver transplantation. 2017 World J. Gastroenterol. pmid:28210092
Shao ZY et al. Prophylaxis of chronic kidney disease after liver transplantation--experience from west China. 2012 World J. Gastroenterol. pmid:22408361
Indriolo A and Ravelli P Clinical management of inflammatory bowel disease in the organ recipient. 2014 World J. Gastroenterol. pmid:24707135
Shen T et al. Reversible sinusoidal obstruction syndrome associated with tacrolimus following liver transplantation. 2015 World J. Gastroenterol. pmid:26034381