tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guy S et al. | Immunosuppression conversion for relief of side effects. | 1994 | Transplant. Proc. | pmid:7527956 |
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| Scheel AK et al. | Severe neurotoxicity of tacrolimus (FK506) after renal transplantation: two case reports. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750573 |
| Siekierka JJ et al. | Potential roles of other FK 506-binding proteins in mediating the effects of FK 506. | 1991 | Transplant. Proc. | pmid:1721256 |
| Satomura K et al. | Pharmacokinetics of FK 506 in living-related liver transplantation. | 1996 | Transplant. Proc. | pmid:8623209 |
| Morris-Stiff G et al. | Prospective randomized study comparing FK 506 (Prograft) and cyclosporine A (Neoral) as primary immunosuppression in cadaveric renal transplants at a single institution: interim report of the first 80 cases. | 1998 | Transplant. Proc. | pmid:9636525 |
| Wang XH et al. | Tacrolimus vs CyA Neoral in combination with MMF and steroids after cadaveric renal transplantation. | 2000 | Transplant. Proc. | pmid:11119899 |
| Burke GW et al. | Cholesterol control: long-term benefit of pancreas-kidney transplantation with FK 506 immunosuppression. | 1998 | Transplant. Proc. | pmid:9532153 |
| Aravot D et al. | A new immunosuppressive protocol for lung transplantation: early promising results. | 2003 | Transplant. Proc. | pmid:12644072 |
| Gallego-Valcarce E et al. | Conversion to tacrolimus extended-release formulation: short-term clinical results. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715909 |
| Mollevà DG et al. | Late xenograft rejection: comparison between liver and heart xenografts under low-dose tacrolimus. | 2002 | Transplant. Proc. | pmid:11959212 |
| Cimsit B et al. | Successful treatment of fibrosing cholestatic hepatitis after liver transplantation. | 2011 | Transplant. Proc. | pmid:21486625 |
| Zhao Y et al. | Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808586 |
| Lee KK et al. | Successful orthotopic small bowel transplantation with short-term FK 506 immunosuppressive therapy. | 1990 | Transplant. Proc. | pmid:1689908 |
| Chan KL et al. | Porcine small bowel transplantation with FK506 as a single immunosuppressant. | 2001 | Transplant. Proc. | pmid:11406260 |
| Charpentier B | An induction versus no-induction protocol in anticalcineurin-based immunosuppression using very low-dose steroids. | 2001 | Transplant. Proc. | pmid:11406262 |
| Rilo HR et al. | Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts. | 1993 | Transplant. Proc. | pmid:7680172 |
| Fukuzaki T et al. | Induction of unresponsiveness to islet allograft by preoperative donor spleen cell injection and FK 506 treatment. | 1993 | Transplant. Proc. | pmid:7680173 |
| Blanc P et al. | Antiproliferative effect of FK 506 and cyclosporine on adult human hepatocytes in culture. | 1991 | Transplant. Proc. | pmid:1721288 |
| Ueno M et al. | Immunosuppressive effect in combination therapy of cyclosporine A, FK 506, and 15-deoxyspergualin on pancreatic islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1373546 |
| Loréal O et al. | FK 506 is less cytotoxic than cyclosporine to human and rat hepatocytes in vitro. | 1991 | Transplant. Proc. | pmid:1721289 |
| Matsuzaki T et al. | Liver transplantation for diethylnitrosamine-induced hepatocellular carcinoma in rats. | 1992 | Transplant. Proc. | pmid:1373547 |
| D'Silva M et al. | Immunosuppressive effect of RS-61443 on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623467 |
| Platz KP et al. | Indications for mycophenolate mofetil therapy in hepatitis C-patients undergoing liver transplantation. | 1998 | Transplant. Proc. | pmid:9636596 |
| Moriuchi H et al. | Mechanisms of immunosuppressive effects of FK 506 in light of apoptosis of hepatocytes and infiltrating lymphocytes in rat allografted livers. | 2000 | Transplant. Proc. | pmid:11120182 |
| Ghobrial RM et al. | Retransplantation for recurrent hepatitis C following tacrolimus or cyclosporine immunosuppression. | 1998 | Transplant. Proc. | pmid:9636597 |
| Oliveira DB and Chang R | Report of the first 118 tacrolimus-treated patients at St George's Hospital, London. | 1999 | Transplant. Proc. | pmid:10576047 |
| Tian JH et al. | Induction with and without antithymocyte globulin combined with cyclosporine/tacrolimus-based immunosuppression in renal transplantation: a meta-analysis of randomized controlled trials. | 2009 | Transplant. Proc. | pmid:19917365 |
| Hatori M et al. | Clinicopathologic examination of no-episode biopsies in well-functioning renal allografts. | 1998 | Transplant. Proc. | pmid:9474971 |
| San Segundo D et al. | Study of B-cell subpopulations in lung transplant recipients with posttransplant infection. | 2012 | Transplant. Proc. | pmid:23146491 |
| Egawa H et al. | Lymphoproliferative disorders in patients undergoing living-related liver transplantation. | 1998 | Transplant. Proc. | pmid:9474982 |
| Tanabe K et al. | Excellent outcome of ABO-incompatible living kidney transplantation under pretransplantation immunosuppression with tacrolimus, mycophenolate mofetil, and steroid. | 2004 | Transplant. Proc. | pmid:15518791 |
| Metcalfe S et al. | FK 506 and cyclosporine A: early effects on activation and gene induction in mouse spleen cells. | 1990 | Transplant. Proc. | pmid:1697107 |
| Demetris AJ et al. | Hematolymphoid cell trafficking, microchimerism, and GVH reactions after liver, bone marrow, and heart transplantation. | 1993 | Transplant. Proc. | pmid:7505503 |
| Todo S et al. | Intestinal transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7518136 |
| Woodle ES et al. | FK 506 rescue therapy: the rapidity of rejection reversal is related to the subsequent development of CMV disease. | 1993 | Transplant. Proc. | pmid:7682360 |
| Lang T et al. | Distinct patterns of Th2 cytokine production during immune activation in pediatric liver allograft recipients. | 1995 | Transplant. Proc. | pmid:7533367 |
| Chen-Woan M et al. | Diminished lymphocyte growth from endomyocardial biopsies from cardiac transplant patients on FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721320 |
| Ziolkowski J et al. | Renal function after liver transplantation: calcineurin inhibitor nephrotoxicity. | 2003 | Transplant. Proc. | pmid:14529923 |
| Ushigome H et al. | Pediatric living-related renal transplantation under tacrolimus as the primary immunosuppressive agent. | 2003 | Transplant. Proc. | pmid:12591350 |
| Nakamura Y et al. | Evaluation of appropriate blood level in continuous intravenous infusion from trough concentrations after oral administration based on area under trough level in tacrolimus and cyclosporine therapy. | 2005 | Transplant. Proc. | pmid:15919445 |
| Furukawa H and Todo S | Evolution of immunosuppression in liver transplantation: contribution of cyclosporine. | 2004 | Transplant. Proc. | pmid:15041353 |
| Ogino S et al. | Conversion from tacrolimus to cyclosporine microemulsion therapy in liver transplant recipients. | 2004 | Transplant. Proc. | pmid:15041357 |
| Junge G et al. | Microchimerism in patients after orthotopic liver transplantation: a prognostic indicator? | 2002 | Transplant. Proc. | pmid:12176475 |
| Kumano K et al. | Role of endothelin in FK 506-induced renal hypoperfusion in rats. | 1995 | Transplant. Proc. | pmid:7533423 |
| Orlandi V et al. | Tacrolimus-associated myositis: a case report in a renal transplant patient. | 2004 | Transplant. Proc. | pmid:15110639 |
| Kilian K et al. | FK-506 (tacrolimus) therapy for an unusual SLE-like disease. | 1998 | Transplant. Proc. | pmid:9865322 |
| Green M et al. | Infectious complications of pediatric liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721352 |
| de Oliveira Clark RM et al. | Evaluation of hemodynamic, metabolic, and electrolytic changes after graft reperfusion in a porcine model of intestinal transplantation. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172287 |
| Fischereder M et al. | Gynaecomastia following solid organ transplantation. | 2002 | Transplant. Proc. | pmid:12270376 |
| Hohage H et al. | Switching immunosuppression from cyclosporine to tacrolimus improves long-term kidney function: a 6-year study. | 2005 | Transplant. Proc. | pmid:15919497 |
| Perego C et al. | Orthotopic liver-small bowel transplantation in pigs: study of immunologic parameters during therapy with FK 506-based immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907908 |
| Budde K et al. | Five year outcome of tacrolimus rescue therapy in late rejection after renal transplantation. | 2002 | Transplant. Proc. | pmid:12176499 |
| Malaise J et al. | Corticosteroid withdrawal in simultaneous pancreas-kidney transplantation: a 3-year report. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182832 |
| Soylu H et al. | Survival of renal transplant patients: data from a tertiary care center in Turkey. | 2015 | Transplant. Proc. | pmid:25769571 |
| Karakulska-Prystupiuk E et al. | Pericarditis in Patients With Chronic Graft-vs-Host Disease. | 2018 | Transplant. Proc. | pmid:30177139 |
| Hara Y et al. | Heterotopic rat heart transplantation to the iliac vessels. | 1994 | Transplant. Proc. | pmid:7520632 |
| Nishimura Y et al. | A trial to obtain donor-specific immunotolerance using a vascularized thymus allograft. | 1998 | Transplant. Proc. | pmid:9838684 |
| McCauley J et al. | Changes in renal function after liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721385 |
| Damotte D et al. | Morphologic features of large bowel biopsies in combined small and large bowel transplantations could predict clinical rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083252 |
| Ota H et al. | Intrathymic microchimerism predicts rejection response in allograft recipients. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123279 |
| Tashiro H et al. | Correlation of high-level microchimerism with graft acceptance in rat liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123287 |
| Paul LC | Overview of side effects of immunosuppressive therapy. | 2001 | Transplant. Proc. | pmid:11377462 |
| Kiuchi T et al. | Experience of tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampicin and side effects. | 1996 | Transplant. Proc. | pmid:8962229 |
| Rodrigo E et al. | Histopathological findings according to Banff-97 classification system comparing tacrolimus versus cyclosporine. | 2002 | Transplant. Proc. | pmid:12176550 |
| Ierardi E et al. | Long-term tacrolimus: a promising therapeutic approach for Crohn's disease. | 2001 | Transplant. Proc. | pmid:11377467 |
| Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
| Hatakeyama S et al. | A switch from conventional twice-daily tacrolimus to once-daily extended-release tacrolimus in stable kidney transplant recipients. | 2012 | Transplant. Proc. | pmid:22310594 |
| Mori T et al. | Tacrolimus and methotrexate for the prophylaxis of graft-versus-host disease after unrelated donor cord blood transplantation for adult patients with hematologic malignancies. | 2007 | Transplant. Proc. | pmid:17580201 |
| Ishibashi M et al. | Experimental study of tacrolimus immunosuppression on the mode of administration: efficacy of constant intravenous infusion avoiding C(max). | 2001 Feb-Mar | Transplant. Proc. | pmid:11266958 |
| Fukuzaki T et al. | Induction of tolerance to islet allografts with preoperative donor spleen cell injection and a short course of FK 506 treatment. | 1991 | Transplant. Proc. | pmid:1721415 |
| Degawa H et al. | Blocking of ICAM-1 and LFA-1 in rat liver transplantation. | 1996 | Transplant. Proc. | pmid:8658695 |
| Braun N et al. | Impairment of renal function following liver transplantation. | 2003 | Transplant. Proc. | pmid:12826191 |
| Van Buren D et al. | Impact of Sandimmune, Neoral, and Prograf on rejection incidence and renal function in primary liver transplant recipients. | 1998 | Transplant. Proc. | pmid:9723299 |
| Taber DJ et al. | Drug-drug interaction between chloramphenicol and tacrolimus in a liver transplant recipient. | 2000 | Transplant. Proc. | pmid:10812156 |
| El-Sabrout R et al. | Sirolimus in combination with tacrolimus or mycophenolate mofetil for minimizing acute rejection risk in renal transplant recipients--a single center experience. | 2003 | Transplant. Proc. | pmid:12742474 |
| Testillano M et al. | Survival and hepatitis C virus recurrence after liver transplantation in HIV- and hepatitis C virus-coinfected patients: experience in a single center. | 2009 | Transplant. Proc. | pmid:19376421 |
| Jiménez-Pérez M et al. | Everolimus plus mycophenolate mofetil as initial immunosuppression in liver transplantation. | Transplant. Proc. | pmid:25645779 | |
| Polanco N et al. | Everolimus-based immunosuppression therapy for BK virus nephropathy. | Transplant. Proc. | pmid:25645770 | |
| Filler G et al. | One-year glomerular filtration rate predicts graft survival in pediatric renal recipients: a randomized trial of tacrolimus vs cyclosporine microemulsion. | 2002 | Transplant. Proc. | pmid:12176634 |
| Tinti F et al. | Improvement of graft function after conversion to once daily tacrolimus of stable kidney transplant patients. | 2010 | Transplant. Proc. | pmid:21168623 |
| Shaffer D et al. | Calcineurin inhibitor avoidance versus steroid avoidance following kidney transplantation: Postoperative complications. | 2006 | Transplant. Proc. | pmid:17175304 |
| Staak A et al. | Immunoglobulin induction therapy in renal transplant recipients: Effects on immunoglobulin and regulatory antibody levels. | 2006 | Transplant. Proc. | pmid:17175311 |
| Neff GW et al. | Sirolimus therapy in orthotopic liver transplant recipients with calcineurin inhibitor related chronic renal insufficiency. | 2003 | Transplant. Proc. | pmid:14697970 |
| MartÃn-Fernández M et al. | Effects of Cyclosporine, Tacrolimus, and Rapamycin on Osteoblasts. | 2017 | Transplant. Proc. | pmid:29149986 |
| Fabrega AJ et al. | FK 506 enhances the beneficial effects of donor-specific blood transfusion on allograft survival in rats. | 1991 | Transplant. Proc. | pmid:1721447 |
| Winkler M et al. | Plasma level-guided low-dose FK 506 therapy in patients with early liver dysfunction after liver transplantation. | 1993 | Transplant. Proc. | pmid:7689277 |
| Moreno M et al. | Clinical management of tacrolimus drug interactions in renal transplant patients. | 1999 | Transplant. Proc. | pmid:10500564 |
| Viebahn R et al. | Simulation of hypoxic and preservation injury in human hepatocyte cultures: influence of FK 506 and cyclosporine. | 1993 | Transplant. Proc. | pmid:7689278 |
| Tur MD et al. | Apolipoprotein CIII is upregulated by anticalcineurins and rapamycin: implications in transplantation-induced dyslipidemia. | 2000 | Transplant. Proc. | pmid:11134804 |
| Dé P et al. | Early steroid-resistant rejection following orthotopic liver transplantation: new aspects of treatment with FK 506 instead of OKT3? | 1993 | Transplant. Proc. | pmid:7689279 |
| Kanbay M et al. | Influence of cyclosporine and tacrolimus on serum uric acid levels in stable kidney transplant recipients. | 2005 | Transplant. Proc. | pmid:16213325 |
| Mita A et al. | Optimal initial dose of orally administered once-daily extended-release tacrolimus following intravenous tacrolimus therapy after liver transplantation. | 2014 | Transplant. Proc. | pmid:24767351 |
| Wojarski J et al. | Immunosuppressive Treatment and Its Effect on the Occurrence of Pneumocystis jiroveci, Mycoplasma pneumoniae, Chlamydophila pnemoniae, and Legionella pneumophila Infections/Colonizations Among Lung Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30177108 |
| Preston R et al. | FK 506 as primary immunosuppressive therapy in renal transplantation. | 1998 | Transplant. Proc. | pmid:9636493 |
| Tamura S et al. | Conversion to cyclosporine provides valuable rescue therapy for living donor adult liver transplant patients intolerant to tacrolimus: A single-center experience at the University of Tokyo. | 2004 | Transplant. Proc. | pmid:15686738 |
| Kanatani T et al. | Experimental limb transplantation, part III: induction of tolerance in the rigorous strain combination of Brown Norway donor to Lewis recipient. | 2004 | Transplant. Proc. | pmid:15686745 |
| Dallos G et al. | Results and complications after living related kidney transplantation in Hungary: 30 years' experience. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692470 |
| Szabó L et al. | Effect of tacrolimus on the excitatory synaptic transmission between the parallel fibers and pyramidal cells in the rat dorsal cochlear nucleus. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692476 |