| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Discoid | D008179 | 1 associated lipids |
| Lymphocytic Choriomeningitis | D008216 | 1 associated lipids |
| Erythroplasia | D004919 | 1 associated lipids |
| Hepatic Veno-Occlusive Disease | D006504 | 1 associated lipids |
| West Nile Fever | D014901 | 1 associated lipids |
| Hypoalbuminemia | D034141 | 1 associated lipids |
| Arm Injuries | D001134 | 1 associated lipids |
| Intussusception | D007443 | 1 associated lipids |
| Thrombotic Microangiopathies | D057049 | 1 associated lipids |
| Autoimmune Diseases of the Nervous System | D020274 | 1 associated lipids |
| Central Serous Chorioretinopathy | D056833 | 1 associated lipids |
| Feline Acquired Immunodeficiency Syndrome | D016181 | 1 associated lipids |
| Budd-Chiari Syndrome | D006502 | 1 associated lipids |
| AIDS-Associated Nephropathy | D016263 | 1 associated lipids |
| Oral Ulcer | D019226 | 1 associated lipids |
| Epidermolysis Bullosa Dystrophica | D016108 | 1 associated lipids |
| Primary Graft Dysfunction | D055031 | 1 associated lipids |
| Esophageal Perforation | D004939 | 1 associated lipids |
| Epididymitis | D004823 | 1 associated lipids |
| Pruritus Vulvae | D011539 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ludwig E et al. | New treatment modalities for granuloma faciale. | 2003 | Br. J. Dermatol. | pmid:14511001 |
| Bens G et al. | Topical treatment of Netherton's syndrome with tacrolimus ointment without significant systemic absorption. | 2003 | Br. J. Dermatol. | pmid:12890237 |
| Reich K et al. | Topical tacrolimus for pyoderma gangrenosum. | 1998 | Br. J. Dermatol. | pmid:9892935 |
| Danby SG and Cork MJ | The effects of pimecrolimus on the innate immune response in atopic dermatitis. | 2013 | Br. J. Dermatol. | pmid:23362967 |
| Schmitt J et al. | Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of randomized controlled trials. | 2011 | Br. J. Dermatol. | pmid:20819086 |
| Remitz A et al. | Tacrolimus ointment improves psoriasis in a microplaque assay. | 1999 | Br. J. Dermatol. | pmid:10417522 |
| Braza TJ et al. | Tacrolimus 0.1% ointment for seborrhoeic dermatitis: an open-label pilot study. | 2003 | Br. J. Dermatol. | pmid:12828755 |
| Danby SG et al. | The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis. | 2014 | Br. J. Dermatol. | pmid:24328907 |
| Charman C | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - comment. | 2017 | Br. J. Dermatol. | pmid:28858382 |
| Lan CC et al. | FK506 (tacrolimus) and endothelin combined treatment induces mobility of melanoblasts: new insights into follicular vitiligo repigmentation induced by topical tacrolimus on sun-exposed skin. | 2011 | Br. J. Dermatol. | pmid:21039414 |
| Sorgentini C et al. | Lichen striatus in an adult: successful treatment with tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15099383 |
| Dissemond J et al. | Pimecrolimus in an adhesive ointment as a new treatment option for oral lichen planus. | 2004 | Br. J. Dermatol. | pmid:15099387 |
| Harth W and Linse R | Topical tacrolimus in granuloma annulare and necrobiosis lipoidica. | 2004 | Br. J. Dermatol. | pmid:15099394 |
| Kanekura T et al. | Efficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosus. | 2003 | Br. J. Dermatol. | pmid:12588393 |
| Vente C et al. | Erosive mucosal lichen planus: response to topical treatment with tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233234 |
| Lyon CC et al. | Recalcitrant pyoderma gangrenosum treated with systemic tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233300 |
| Jolles S et al. | Combination oral and topical tacrolimus in therapy-resistant pyoderma gangrenosum. | 1999 | Br. J. Dermatol. | pmid:10233301 |
| Anstey A | Therapeutic advances and shift in disease paradigm for atopic dermatitis. | 2008 | Br. J. Dermatol. | pmid:19036027 |
| Koguchi-Yoshioka H et al. | Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules. | 2017 | Br. J. Dermatol. | pmid:28346662 |
| Griffiths CE | Ascomycin: an advance in the management of atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298524 |
| Harper J et al. | First experience of topical SDZ ASM 981 in children with atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298537 |
| Luger T et al. | SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis. | 2001 | Br. J. Dermatol. | pmid:11298538 |
| Lan CC et al. | FK506 independently upregulates transforming growth factor beta and downregulates inducible nitric oxide synthase in cultured human keratinocytes: possible mechanisms of how tacrolimus ointment interacts with atopic skin. | 2004 | Br. J. Dermatol. | pmid:15377358 |
| Reitamo S et al. | 0.03% Tacrolimus ointment applied once or twice daily is more efficacious than 1% hydrocortisone acetate in children with moderate to severe atopic dermatitis: results of a randomized double-blind controlled trial. | 2004 | Br. J. Dermatol. | pmid:15030341 |
| Chuh AA | The application of topical tacrolimus in vesicular pemphigoid. | 2004 | Br. J. Dermatol. | pmid:15030368 |
| Ormerod AD | Topical tacrolimus and pimecrolimus and the risk of cancer: how much cause for concern? | 2005 | Br. J. Dermatol. | pmid:16181449 |
| Lan CC et al. | FK506 inhibits tumour necrosis factor-alpha secretion in human keratinocytes via regulation of nuclear factor-kappaB. | 2005 | Br. J. Dermatol. | pmid:16181452 |
| Vukmanovic-Stejic M et al. | Relative impact of CD4+CD25+ regulatory T cells and tacrolimus on inhibition of T-cell proliferation in patients with atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:16181456 |
| Martin-Munoz MF et al. | Topical treatment tacrolimus and food allergy. | 2005 | Br. J. Dermatol. | pmid:16181473 |
| Gollnick H et al. | Pimecrolimus cream 1% in the long-term management of adult atopic dermatitis: prevention of flare progression. A randomized controlled trial. | 2008 | Br. J. Dermatol. | pmid:18341665 |
| Hjelmgren J et al. | Cost-effectiveness of tacrolimus ointment vs. standard treatment in patients with moderate and severe atopic dermatitis: a health-economic model simulation based on a patient survey and clinical trial data. | 2007 | Br. J. Dermatol. | pmid:17263826 |
| Rigopoulos D et al. | Efficacy and safety of tacrolimus ointment 0.1% vs. betamethasone 17-valerate 0.1% in the treatment of chronic paronychia: an unblinded randomized study. | 2009 | Br. J. Dermatol. | pmid:19120329 |
| Oranje AP et al. | Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis. | 2009 | Br. J. Dermatol. | pmid:18795918 |
| Wataya-Kaneda M et al. | A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients with TSC of different disease severity. | 2011 | Br. J. Dermatol. | pmid:21692771 |
| Spergel JM et al. | Addition of topical pimecrolimus to once-daily mid-potent steroid confers no short-term therapeutic benefit in the treatment of severe atopic dermatitis; a randomized controlled trial. | 2007 | Br. J. Dermatol. | pmid:17573885 |
| Niwa Y et al. | Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin. | 2003 | Br. J. Dermatol. | pmid:14632799 |
| Ko MJ and Chu CY | Topical tacrolimus therapy for localized bullous pemphigoid. | 2003 | Br. J. Dermatol. | pmid:14632824 |
| Doss N et al. | Superiority of tacrolimus 0.1% ointment compared with fluticasone 0.005% in adults with moderate to severe atopic dermatitis of the face: results from a randomized, double-blind trial. | 2009 | Br. J. Dermatol. | pmid:19416227 |
| Böhm M et al. | Resolution of lichen aureus in a 10-year-old child after topical pimecrolimus. | 2004 | Br. J. Dermatol. | pmid:15327576 |
| Leung DY et al. | Effects of pimecrolimus cream 1% in the treatment of patients with atopic dermatitis who demonstrate a clinical insensitivity to topical corticosteroids: a randomized, multicentre vehicle-controlled trial. | 2009 | Br. J. Dermatol. | pmid:19416245 |
| Hickey JR et al. | Does topical tacrolimus induce lentigines in children with atopic dermatitis? A report of three cases. | 2005 | Br. J. Dermatol. | pmid:15656817 |
| Mancuso G and Berdondini RM | Localized scleroderma: response to occlusive treatment with tacrolimus ointment. | 2005 | Br. J. Dermatol. | pmid:15656828 |
| Langeland T and Engh V | Topical use of tacrolimus and squamous cell carcinoma on the penis. | 2005 | Br. J. Dermatol. | pmid:15656830 |
| Kreuter A et al. | Pimecrolimus 1% cream for perianal atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:15656832 |
| Fiorentino DF et al. | The direct cellular target of topically applied pimecrolimus may not be infiltrating lymphocytes. | 2011 | Br. J. Dermatol. | pmid:21166661 |
| Lewis FM and Neill SM | Safety of calcineurin inhibitors in the management of lichen sclerosis. | 2007 | Br. J. Dermatol. | pmid:17535239 |
| Queille-Roussel C et al. | The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. | 2001 | Br. J. Dermatol. | pmid:11260007 |
| Oji V et al. | Topical pimecrolimus: a novel therapeutic option for Netherton syndrome. | 2005 | Br. J. Dermatol. | pmid:16225628 |
| Connolly M and Kennedy C | Exfoliative cheilitis successfully treated with topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15270904 |
| Healy E et al. | Cost-effectiveness of tacrolimus ointment in adults and children with moderate and severe atopic dermatitis: twice-weekly maintenance treatment vs. standard twice-daily reactive treatment of exacerbations from a third party payer (U.K. National Health Service) perspective. | 2011 | Br. J. Dermatol. | pmid:21083544 |
| Park CW et al. | Tacrolimus decreases the expression of eotaxin, CCR3, RANTES and interleukin-5 in atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:15948978 |
| Gottlieb AB et al. | Oral pimecrolimus in the treatment of moderate to severe chronic plaque-type psoriasis: a double-blind, multicentre, randomized, dose-finding trial. | 2005 | Br. J. Dermatol. | pmid:15948985 |
| Bhol KC and Schechter PJ | Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis. | 2005 | Br. J. Dermatol. | pmid:15948987 |
| Reitamo S et al. | A multicentre, randomized, double-blind, controlled study of long-term treatment with 0.1% tacrolimus ointment in adults with moderate to severe atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:15948994 |
| Bos JD | Topical tacrolimus and pimecrolimus are not associated with skin atrophy. | 2002 | Br. J. Dermatol. | pmid:11903264 |
| Wolff K et al. | Efficacy and tolerability of three different doses of oral pimecrolimus in the treatment of moderate to severe atopic dermatitis: a randomized controlled trial. | 2005 | Br. J. Dermatol. | pmid:15948996 |
| Rigopoulos D et al. | Pimecrolimus 1% cream in the treatment of disseminated granuloma annulare. | 2005 | Br. J. Dermatol. | pmid:15949015 |
| Kirtschig G et al. | Successful treatment of erosive vulvovaginal lichen planus with topical tacrolimus. | 2002 | Br. J. Dermatol. | pmid:12207624 |
| Feldmann KA et al. | Is topical tacrolimus effective in alopecia areata universalis? | 2002 | Br. J. Dermatol. | pmid:12410729 |
| Sigurgeirsson B and Luger T | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - author response. | 2017 | Br. J. Dermatol. | pmid:28940181 |
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| Rigopoulos D et al. | Tacrolimus ointment 0.1% in pityriasis alba: an open-label, randomized, placebo-controlled study. | 2006 | Br. J. Dermatol. | pmid:16792767 |
| Weissenbacher S et al. | Pimecrolimus cream 1% for papulopustular rosacea: a randomized vehicle-controlled double-blind trial. | 2007 | Br. J. Dermatol. | pmid:17493072 |
| Chohan R et al. | Long-term outcomes of allogeneic stem cell transplant recipients after calcineurin inhibitor-induced neurotoxicity. | 2003 | Br. J. Haematol. | pmid:14510951 |
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| Pulsipher MA et al. | A phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft versus host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL). | 2009 | Br. J. Haematol. | pmid:19744131 |
| Murata M et al. | A new preconditioning regimen with melphalan, busulphan and total body irradiation followed by low-dose immunosuppressant in allogeneic haemopoietic stem cell transplantation. | 1999 | Br. J. Haematol. | pmid:10354150 |
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| Mollee P et al. | Combination therapy with tacrolimus and anti-thymocyte globulin for the treatment of steroid-resistant acute graft-versus-host disease developing during cyclosporine prophylaxis. | 2001 | Br. J. Haematol. | pmid:11328304 |
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| Dusting GJ et al. | Cyclosporin A and tacrolimus (FK506) suppress expression of inducible nitric oxide synthase in vitro by different mechanisms. | 1999 | Br. J. Pharmacol. | pmid:10510443 |
| Quintá HR and Galigniana MD | The neuroregenerative mechanism mediated by the Hsp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation. | 2012 | Br. J. Pharmacol. | pmid:22091865 |
| Gil V et al. | Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility. | 2011 | Br. J. Pharmacol. | pmid:21486289 |
| Klettner A and Herdegen T | The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response. | 2003 | Br. J. Pharmacol. | pmid:12642403 |
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| Simon N et al. | Tacrolimus and sirolimus decrease oxidative phosphorylation of isolated rat kidney mitochondria. | 2003 | Br. J. Pharmacol. | pmid:12540528 |
| Øzbay LA et al. | Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells. | 2011 | Br. J. Pharmacol. | pmid:20825407 |
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| Price RD et al. | FK506 potentiates NGF-induced neurite outgrowth via the Ras/Raf/MAP kinase pathway. | 2003 | Br. J. Pharmacol. | pmid:14559856 |
| Hortelano S et al. | Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. | 1999 | Br. J. Pharmacol. | pmid:10205001 |
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| Yasutsune T et al. | Vasorelaxation and inhibition of the voltage-operated Ca2+ channels by FK506 in the porcine coronary artery. | 1999 | Br. J. Pharmacol. | pmid:10188984 |
| Deters M et al. | Sirolimus/cyclosporine/tacrolimus interactions on bile flow and biliary excretion of immunosuppressants in a subchronic bile fistula rat model. | 2002 | Br. J. Pharmacol. | pmid:12055139 |
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| Gardiner SM et al. | Regional haemodynamic effects of cyclosporine A, tacrolimus and sirolimus in conscious rats. | 2004 | Br. J. Pharmacol. | pmid:14744807 |
| Pahl A et al. | Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. | 2002 | Br. J. Pharmacol. | pmid:11959794 |
| Sakuma S et al. | FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells. | 2000 | Br. J. Pharmacol. | pmid:10928971 |
| Seidel ER and Ragan VL | Inhibition by rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC-6 cells in culture. | 1997 | Br. J. Pharmacol. | pmid:9051292 |
| Harrison CA et al. | Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506. | 2007 | Br. J. Pharmacol. | pmid:17200674 |
| Zuany-Amorim C et al. | Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice. | 1993 | Br. J. Pharmacol. | pmid:7694762 |
| Lampen A et al. | Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. | 1996 | Br. J. Pharmacol. | pmid:8732283 |
| Li J et al. | Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II. | 2005 | Br. J. Pharmacol. | pmid:15821752 |
| Macfarlane SR et al. | The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes. | 2005 | Br. J. Pharmacol. | pmid:15821758 |
| Oetjen E et al. | The immunosuppressive drugs cyclosporin A and tacrolimus inhibit membrane depolarization-induced CREB transcriptional activity at the coactivator level. | 2005 | Br. J. Pharmacol. | pmid:15711594 |