| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adrenal Insufficiency | D000309 | 3 associated lipids |
| Akinetic Mutism | D000405 | 1 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Alopecia Areata | D000506 | 6 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amenorrhea | D000568 | 4 associated lipids |
| Amputation, Traumatic | D000673 | 2 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Anemia, Hemolytic | D000743 | 4 associated lipids |
| Anemia, Hemolytic, Autoimmune | D000744 | 5 associated lipids |
| Anemia, Refractory | D000753 | 3 associated lipids |
| Anemia, Refractory, with Excess of Blasts | D000754 | 2 associated lipids |
| Aneurysm, Dissecting | D000784 | 2 associated lipids |
| Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hanawa H et al. | An immunosuppressant compound, FK-506, prevents the progression of autoimmune myocarditis in rats. | 1992 | Clin. Immunol. Immunopathol. | pmid:1371730 |
| Hiraoka Y et al. | The effects of FK-506, a novel and potent immunosuppressant, upon murine Coxsackievirus B3 myocarditis. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1372051 |
| Ichihashi T et al. | Haemolytic uraemic syndrome during FK506 therapy. | 1992 | Lancet | pmid:1376852 |
| Sawada M et al. | Down regulation of CD4 expression in cultured microglia by immunosuppressants and lipopolysaccharide. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1282000 |
| Yamada K et al. | FK 506-induced juxtaglomerular apparatus hyperplasia and tubular damage in rat kidney--morphologic and biologic analysis. | 1992 | Transplant. Proc. | pmid:1379756 |
| Yatscoff RW and Shaw LM | Therapeutic monitoring of cyclosporine, FK-506, and rapamycin. | 1992 | Ther Drug Monit | pmid:1381530 |
| Mizuno K et al. | Modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, FK506 and mizoribine. | 1992 Jan-Feb | Anticancer Res. | pmid:1373592 |
| Arai S et al. | The impact of FK506 on graft coronary disease of rat cardiac allograft--a comparison with cyclosporine. | 1992 Jul-Aug | J. Heart Lung Transplant. | pmid:1379829 |
| Fagiuoli S et al. | FK 506: a new immunosuppressive agent for organ transplantation. Pharmacology, mechanism of action and clinical applications. | 1992 Jul-Aug | Ital J Gastroenterol | pmid:1381245 |
| Tong J et al. | Effect of FK-506 and cyclosporin A on in vitro CFU-GM growth in severe aplastic anemia patients. | 1992 Jul-Aug | Haematologica | pmid:1385279 |
| Nazer H et al. | FK 506 associated disorders in liver transplantation. | 1992 May-Jun | J. Gastroenterol. Hepatol. | pmid:1377038 |
| Bowman H and Lennard TW | Immunosuppressive drugs. | 1992 Nov 4-17 | Br J Hosp Med | pmid:1282440 |
| Sattler M et al. | Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. | 1992 Sep-Oct | Drug Metab. Dispos. | pmid:1385058 |
| Cavaillé-Coll M and Mielach FA | Choice of cyclophosphamide dose in baboon-to-human liver transplantation. | 1993 | Lancet | pmid:7679768 |
| Kobayashi M et al. | HLA-DR matching effect in orthotopic liver transplantation under FK 506. | 1993 | Transplant. Proc. | pmid:7679812 |
| Watanabe K et al. | Fate of long-surviving allografts in tolerant recipients induced by fractionated lymphoid irradiation, donor bone marrow cell infusion, and FK 506 after retransplantation in dogs. | 1993 | Transplant. Proc. | pmid:7679813 |
| Stephens J et al. | Effects of orthotopic liver transplantation and immunosuppression on inflammatory bowel disease in primary sclerosing cholangitis patients. | 1993 | Transplant. Proc. | pmid:7680144 |
| Bonet H et al. | Survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. | 1993 | Transplant. Proc. | pmid:7680145 |
| Fung J et al. | Randomized trial in primary liver transplantation under immunosuppression with FK 506 or cyclosporine. | 1993 | Transplant. Proc. | pmid:7680146 |
| Yem AW et al. | An active FK506-binding domain of 17,000 daltons is isolated following limited proteolysis of chicken thymus hsp56. | 1993 | Biochemistry | pmid:7504525 |
| Manev H et al. | Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate. | 1993 | Brain Res. | pmid:7504570 |
| Takahara S et al. | [Blood level monitoring of FK506 on kidney transplant recipients]. | 1993 | Nippon Hinyokika Gakkai Zasshi | pmid:7504758 |
| Lieberman I et al. | Synergy between tetrandrine and FK506 in prevention of diabetes in BB rats. | 1993 | Life Sci. | pmid:7504774 |
| Xu RX et al. | 1H, 13C, and 15N assignments and secondary structure of the FK506 binding protein when bound to ascomycin. | 1993 | Biopolymers | pmid:7682113 |
| Tanaka N et al. | Regulation of liver regeneration by interleukin-2 and its inhibitors: cyclosporine A and FK 506. | 1993 | Int. J. Immunopharmacol. | pmid:7682200 |
| Bruserud O and Pawelec G | Cyclosporine A and FK506 show similar immunosuppressive effects on long-term in vitro T-cell proliferation. | 1993 | Int. J. Immunopharmacol. | pmid:7682202 |
| Winkler M et al. | Anaemia associated with FK 506 immunosuppression. | 1993 | Lancet | pmid:7682273 |
| Fernandes JB et al. | Comparative investigation of the effects of the immunosuppressants cyclosporine A, cyclosporine G, and FK-506 on platelet activation. | 1993 | Cell. Mol. Biol. Res. | pmid:7507391 |
| Tabasco-Minguillan J et al. | Insulin requirements after liver transplantation and FK-506 immunosuppression. | 1993 | Transplantation | pmid:7692637 |
| Wang SC et al. | A dual mechanism of immunosuppression by FK-506. Differential suppression of IL-4 and IL-10 levels in T helper 2 cells. | 1993 | Transplantation | pmid:7692640 |
| Akita K and Mandel TE | Effect of FK 506 and anti-CD4 monoclonal antibody treatment on xenografts of organ-cultured fetal pig pancreas and host lymphoid populations. | 1993 | Transplant. Proc. | pmid:7692650 |
| Lemster B et al. | FK 506 inhibits cytokine gene and adhesion molecule expression in psoriatic skin lesions. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509134 |
| Tamura K et al. | Inhibitory effect of FK 506 on autoimmune thyroid disease in the PVG rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509135 |
| Ochiai T et al. | Combination of immunosuppressive drugs for organ transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509136 |
| Wiederrecht G et al. | The mechanism of action of FK-506 and cyclosporin A. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509138 |
| Natazuka T et al. | FK506 and cyclosporin a regulate proliferation and proto-oncogene expression in HTLV-1-associated myelopathy/tropical-spastic-paraparesis-derived T cells. | 1993 | Int. J. Cancer | pmid:7683633 |
| Mukai H et al. | FKBP12-FK506 complex inhibits phosphatase activity of two mammalian isoforms of calcineurin irrespective of their substrates or activation mechanisms. | 1993 | J. Biochem. | pmid:7683641 |
| Jachez B et al. | Reversion of the P-glycoprotein-mediated multidrug resistance of cancer cells by FK-506 derivatives. | 1993 | Anticancer Drugs | pmid:7683935 |
| Shapiro R et al. | FK 506 interaction with danazol. | 1993 | Lancet | pmid:7684106 |
| Hibbins M et al. | Inhibition of PHA induced mononuclear cell proliferation by FK506 in combination with cyclosporine, methylprednisolone, 6-mercaptopurine and mycophenolic acid. | 1993 | Transpl. Immunol. | pmid:7521736 |
| Thomson AW et al. | Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures. | 1993 | Transpl. Immunol. | pmid:7521738 |
| Calne RY et al. | Intestinal transplant for recurring mesenteric desmoid tumour. | 1993 | Lancet | pmid:7686241 |
| Langer A et al. | Humoral and cellular immunopathology of hepatic and cardiac hamster-into-rat xenograft rejection. Marked stimulation of IgM++bright/IgD+dull splenic B cells. | 1993 | Am. J. Pathol. | pmid:7686346 |
| Fujisawa T et al. | Dose study of the immunosuppression of FK 506 in canine lung allo-transplantation. | 1993 | Surg. Today | pmid:7686416 |
| Taylor-Fishwick DA et al. | Evidence that rapamycin has differential effects of IL-4 function. Multiple IL-4 signaling pathways and implications for in vivo use. | 1993 | Transplantation | pmid:7689258 |
| Shaefer MS et al. | Falsely elevated FK-506 levels caused by sampling through central venous catheters. | 1993 | Transplantation | pmid:7689264 |
| Valdivia LA et al. | Dendritic cell replacement in long-surviving liver and cardiac xenografts. | 1993 | Transplantation | pmid:7689265 |
| Cetinkale O et al. | The use of FK506 and skin allografting for the treatment of severe burns in an animal model. | 1993 | Br J Plast Surg | pmid:7690295 |
| Hom JT and Estridge T | FK506 and rapamycin modulate the functional activities of human peripheral blood eosinophils. | 1993 | Clin. Immunol. Immunopathol. | pmid:7690315 |
| Olivera DL et al. | Divergent effects of rapamycin on mouse and rat cells following mitogenic stimulation. | 1993 | Clin. Immunol. Immunopathol. | pmid:7690317 |