| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adrenal Insufficiency | D000309 | 3 associated lipids |
| Akinetic Mutism | D000405 | 1 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Alopecia Areata | D000506 | 6 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amenorrhea | D000568 | 4 associated lipids |
| Amputation, Traumatic | D000673 | 2 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Anemia, Hemolytic | D000743 | 4 associated lipids |
| Anemia, Hemolytic, Autoimmune | D000744 | 5 associated lipids |
| Anemia, Refractory | D000753 | 3 associated lipids |
| Anemia, Refractory, with Excess of Blasts | D000754 | 2 associated lipids |
| Aneurysm, Dissecting | D000784 | 2 associated lipids |
| Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qin J et al. | Radiological and clinical findings of 25 patients with invasive pulmonary aspergillosis: retrospective analysis of 2150 liver transplantation cases. | 2012 | Br J Radiol | pmid:22496071 |
| Anoopkumar-Dukie S et al. | Mitochondrial modulation of oxygen-dependent radiosensitivity in some human tumour cell lines. | 2009 | Br J Radiol | pmid:19366737 |
| Murphy GJ et al. | Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. | 2003 | Br J Surg | pmid:12808614 |
| Middleton SJ et al. | Adult small intestinal transplantation in England and Wales. | 2003 | Br J Surg | pmid:12808622 |
| Morris-Stiff GJ et al. | Sequential changes in plasma selenium concentration after cadaveric renal transplantation. | 2004 | Br J Surg | pmid:14991636 |
| Wilson CH et al. | Randomized clinical trial of daclizumab induction and delayed introduction of tacrolimus for recipients of non-heart-beating kidney transplants. | 2005 | Br J Surg | pmid:15856479 |
| Waller JR et al. | Effects of the combination of rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia. | 2002 | Br J Surg | pmid:12390379 |
| Brook NR et al. | Fibrosis-associated gene expression in renal transplant glomeruli after acute renal allograft rejection. | 2003 | Br J Surg | pmid:12905557 |
| Jain S et al. | Tacrolimus has less fibrogenic potential than cyclosporin A in a model of renal ischaemia-reperfusion injury. | 2000 | Br J Surg | pmid:11091246 |
| Bicknell GR et al. | Differential effects of cyclosporin and tacrolimus on the expression of fibrosis-associated genes in isolated glomeruli from renal transplants. | 2000 | Br J Surg | pmid:11091247 |
| White DJ | Immunosuppression for heart transplantation. | 1993 | Br. J. Biomed. Sci. | pmid:7694717 |
| Reichert TE et al. | The role of endogenous interleukin-2 in proliferation of human carcinoma cell lines. | 1999 | Br. J. Cancer | pmid:10555752 |
| Andersson Y et al. | Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo. | 2009 | Br. J. Cancer | pmid:19773757 |
| Chambers CA | Topical tacrolimus for cutaneous lupus erythematosus. | 2003 | Br. J. Dermatol. | pmid:12752154 |
| Ludwig E et al. | New treatment modalities for granuloma faciale. | 2003 | Br. J. Dermatol. | pmid:14511001 |
| Vecchietti G et al. | Topical tacrolimus (FK506) for relapsing erosive stomatitis in paraneoplastic pemphigus. | 2003 | Br. J. Dermatol. | pmid:12752158 |
| Bens G et al. | Topical treatment of Netherton's syndrome with tacrolimus ointment without significant systemic absorption. | 2003 | Br. J. Dermatol. | pmid:12890237 |
| Danby SG and Cork MJ | The effects of pimecrolimus on the innate immune response in atopic dermatitis. | 2013 | Br. J. Dermatol. | pmid:23362967 |
| Murrell DF et al. | A randomized controlled trial of pimecrolimus cream 1% in adolescents and adults with head and neck atopic dermatitis and intolerant of, or dependent on, topical corticosteroids. | 2007 | Br. J. Dermatol. | pmid:17935515 |
| Liao YH et al. | Comparison of cutaneous tolerance and efficacy of calcitriol 3 microg g(-1) ointment and tacrolimus 0.3 mg g(-1) ointment in chronic plaque psoriasis involving facial or genitofemoral areas: a double-blind, randomized controlled trial. | 2007 | Br. J. Dermatol. | pmid:17935517 |
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| Clayton TH and Harrison PV | Successful treatment of chronic ulcerated necrobiosis lipoidica with 0.1% topical tacrolimus ointment. | 2005 | Br. J. Dermatol. | pmid:15787840 |
| RodrÃguez GarcÃa F et al. | Generalized pustular psoriasis successfully treated with topical tacrolimus. | 2005 | Br. J. Dermatol. | pmid:15787845 |
| Braza TJ et al. | Tacrolimus 0.1% ointment for seborrhoeic dermatitis: an open-label pilot study. | 2003 | Br. J. Dermatol. | pmid:12828755 |
| Lan CC et al. | FK506 (tacrolimus) and endothelin combined treatment induces mobility of melanoblasts: new insights into follicular vitiligo repigmentation induced by topical tacrolimus on sun-exposed skin. | 2011 | Br. J. Dermatol. | pmid:21039414 |
| Chung BY et al. | The proactive treatment of atopic dermatitis with tacrolimus ointment in Korean patients: a comparative study between once-weekly and thrice-weekly applications. | 2013 | Br. J. Dermatol. | pmid:23110605 |
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| Pitt M et al. | A cost-utility analysis of pimecrolimus vs. topical corticosteroids and emollients for the treatment of mild and moderate atopic eczema. | 2006 | Br. J. Dermatol. | pmid:16704646 |
| Kanekura T et al. | Efficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosus. | 2003 | Br. J. Dermatol. | pmid:12588393 |
| Walker SL et al. | The effect of topical tacrolimus on severe recalcitrant chronic discoid lupus erythematosus. | 2002 | Br. J. Dermatol. | pmid:12174136 |
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| Ueda M et al. | Successful treatment of amyopathic dermatomyositis with topical tacrolimus. | 2003 | Br. J. Dermatol. | pmid:12653761 |
| Lan CC et al. | FK506 independently upregulates transforming growth factor beta and downregulates inducible nitric oxide synthase in cultured human keratinocytes: possible mechanisms of how tacrolimus ointment interacts with atopic skin. | 2004 | Br. J. Dermatol. | pmid:15377358 |
| Fricain JC et al. | Long-term efficacy of topical tacrolimus on oral lesions of chronic graft-versus-host disease. | 2007 | Br. J. Dermatol. | pmid:17300261 |
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| Reitamo S et al. | 0.03% Tacrolimus ointment applied once or twice daily is more efficacious than 1% hydrocortisone acetate in children with moderate to severe atopic dermatitis: results of a randomized double-blind controlled trial. | 2004 | Br. J. Dermatol. | pmid:15030341 |
| Chuh AA | The application of topical tacrolimus in vesicular pemphigoid. | 2004 | Br. J. Dermatol. | pmid:15030368 |
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| Erdogan M et al. | Liposomal tacrolimus lotion as a novel topical agent for treatment of immune-mediated skin disorders: experimental studies in a murine model. | 2002 | Br. J. Dermatol. | pmid:12072063 |
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| Mashiko M et al. | A case of angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment. | 2006 | Br. J. Dermatol. | pmid:16536847 |
| Ko MJ and Chu CY | Topical tacrolimus therapy for localized bullous pemphigoid. | 2003 | Br. J. Dermatol. | pmid:14632824 |
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| Hickey JR et al. | Does topical tacrolimus induce lentigines in children with atopic dermatitis? A report of three cases. | 2005 | Br. J. Dermatol. | pmid:15656817 |
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