| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adrenal Insufficiency | D000309 | 3 associated lipids |
| Akinetic Mutism | D000405 | 1 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Alopecia Areata | D000506 | 6 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amenorrhea | D000568 | 4 associated lipids |
| Amputation, Traumatic | D000673 | 2 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Anemia, Hemolytic | D000743 | 4 associated lipids |
| Anemia, Hemolytic, Autoimmune | D000744 | 5 associated lipids |
| Anemia, Refractory | D000753 | 3 associated lipids |
| Anemia, Refractory, with Excess of Blasts | D000754 | 2 associated lipids |
| Aneurysm, Dissecting | D000784 | 2 associated lipids |
| Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Roth D et al. | A prospective study of hepatitis C virus infection in renal allograft recipients. | 1996 | Transplantation | pmid:8623154 |
| Koprak S et al. | Depletion of the mature CD4+8- thymocyte subset by FK506 analogs correlates with their immunosuppressive and calcineurin inhibitory activities. | 1996 | Transplantation | pmid:8623162 |
| Ciancio G et al. | Current advantage of FK 506 in cadaveric kidney transplantation. | 1996 | Transplant. Proc. | pmid:8623207 |
| Pham SM et al. | Tacrolimus (FK 506) in clinical cardiac transplantation: a five-year experience. | 1996 | Transplant. Proc. | pmid:8623208 |
| Satomura K et al. | Pharmacokinetics of FK 506 in living-related liver transplantation. | 1996 | Transplant. Proc. | pmid:8623209 |
| Loss M et al. | Glucose and lipid metabolism in liver transplant patients under long-term tacrolimus (FK 506) monotherapy. | 1996 | Transplant. Proc. | pmid:8623210 |
| Bechstein WO et al. | Tacrolimus (FK 506) therapy is associated with a significant reduction in immunosuppressive treatment failures following primary liver transplantation. | 1996 | Transplant. Proc. | pmid:8623211 |
| Sher LS et al. | Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation. | 1996 | Transplant. Proc. | pmid:8623212 |
| Harrison DM et al. | Reduction in hospital stay after liver transplantation. | 1996 | Transplant. Proc. | pmid:8623451 |
| Andrews WS et al. | Comparison of cyclosporine- vs tacrolimus-based immunosuppression in pediatric liver transplantation. | 1996 | Transplant. Proc. | pmid:8623452 |
| Ketel BL et al. | Tacrolimus-based vs cyclosporine-based immunotherapy in combined kidney-pancreas transplantation. | 1996 | Transplant. Proc. | pmid:8623453 |
| Kyo M et al. | Results with histological diagnosis in kidney transplant rejections treated with 15-deoxyspergualin. | 1996 | Transplant. Proc. | pmid:8623457 |
| D'Silva M et al. | Immunosuppressive effect of RS-61443 on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623467 |
| Pirenne J et al. | Bone marrow augmentation of kidney allografts can cause graft-versus-host disease in immunosuppressed recipients. | 1996 | Transplant. Proc. | pmid:8623472 |
| Ciancio G et al. | Human donor bone marrow cells can enhance hyporeactivity in renal transplantation using maintenance FK 506 and OKT3 induction therapy. | 1996 | Transplant. Proc. | pmid:8623473 |
| Muraoka K et al. | Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy. | 1996 | J. Clin. Invest. | pmid:8647935 |
| Kawashima M et al. | Tacrolimus concentrations in blood during topical treatment of atopic dermatitis. | 1996 | Lancet | pmid:8898050 |
| Brunke M et al. | Luciferase assembly after transport into mammalian microsomes involves molecular chaperones and peptidyl-prolyl cis/trans-isomerases. | 1996 | J. Biol. Chem. | pmid:8798557 |
| Drake M et al. | The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. | 1996 | Acta Physiol. Scand. | pmid:8899062 |
| Zhang Q et al. | Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8799169 |
| Spencer DM et al. | Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. | 1996 | Curr. Biol. | pmid:8805308 |
| Franke EK and Luban J | Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction. | 1996 | Virology | pmid:8806510 |
| Ichikawa Y et al. | Three-times-daily monotherapy with tacrolimus (FK 506) in kidney transplantation. | 1996 | Int. J. Urol. | pmid:8776613 |
| Mugiya S et al. | Renal blood flow and serotonin metabolism in tacrolimus treated rats. | 1996 | Int. J. Urol. | pmid:8776615 |
| Dmitrewski J et al. | Recurrence of primary biliary cirrhosis in the liver allograft: the effect of immunosuppression. | 1996 | J. Hepatol. | pmid:8778189 |
| Schwarz A | [Drug-induced kidney damage]. | 1996 | Z Arztl Fortbild (Jena) | pmid:8779233 |
| Sugitani A et al. | Intestinal neurons in acute and chronic rejection after small bowel transplantation in dogs. | 1996 | Transplant. Proc. | pmid:8907941 |
| Ronchetti F et al. | Mucosal hyaluronic acid quantification in small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907950 |
| Costa A et al. | Stimulatory effect of FK506 and erythromycin on pig intestinal motility. | 1996 | Transplant. Proc. | pmid:8907957 |
| Cicalese L et al. | Effect of FK506 on the mucosal perfusion of the rat intestinal allograft. | 1996 | Transplant. Proc. | pmid:8907959 |
| Reggiani P et al. | Oral administration of FK 506 in a swine model of liver-small bowel allotransplantation. | 1996 | Transplant. Proc. | pmid:8907965 |
| Spada M et al. | Bacterial translocation is enhanced in pig intestinal transplantation when the colon is included in the graft. | 1996 | Transplant. Proc. | pmid:8907997 |
| Alessiani M et al. | Intestinal transplantation with and without the colon in FK 506 immunosuppressed pigs. | 1996 | Transplant. Proc. | pmid:8908021 |
| Asfar S et al. | Small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8908039 |
| Woodle ES et al. | A multicenter trial of FK506 (tacrolimus) therapy in refractory acute renal allograft rejection. A report of the Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplantation | pmid:8830821 |
| Reyes J et al. | Intestinal transplantation in children: five-year experience. | 1996 | Transplant. Proc. | pmid:8908042 |
| Tanaka M et al. | Effect of anticomplement agent K76 COOH on hamster-to-rat and guinea pig-to-rat heart xenotransplantation. | 1996 | Transplantation | pmid:8830837 |
| Opelz G | Comparison of FK506 and cyclosporine. | 1996 | Transplantation | pmid:8830844 |
| Ho S et al. | The mechanism of action of cyclosporin A and FK506. | 1996 | Clin. Immunol. Immunopathol. | pmid:8811062 |
| Nishino H et al. | 3-Nitropropionic acid produces striatum selective lesions accompanied by iNOS expression. | 1996 | J. Chem. Neuroanat. | pmid:8811425 |
| Sonatore LM et al. | The utility of FK506-binding protein as a fusion partner in scintillation proximity assays: application to SH2 domains. | 1996 | Anal. Biochem. | pmid:8811923 |
| Jonas S et al. | Posttransplant malignancy and newer immunosuppressive protocols after liver transplantation. | 1996 | Transplant. Proc. | pmid:8962257 |
| Guérette B et al. | Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506. | 1996 | Muscle Nerve | pmid:8965835 |
| Sharkey J et al. | Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats. | 1996 | Stroke | pmid:8969794 |
| Hedayat S et al. | Relationship of whole-blood FK506 concentrations to rejection and toxicity in liver and kidney transplants. | 1996 | J Biopharm Stat | pmid:8969977 |
| Taler SJ et al. | Role of steroid dose in hypertension early after liver transplantation with tacrolimus (FK506) and cyclosporine. | 1996 | Transplantation | pmid:8970613 |
| Shinozuka N et al. | Correlation between simplified immunocompetence assay and clinical graft states in kidney or liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8658649 |
| Nishimura Y et al. | Whole organ vascularized thymus allografting effectively modulates cardiac rejection. | 1996 | Transplant. Proc. | pmid:8658660 |
| Tanabe K et al. | Diabetes mellitus after renal transplantation under FK 506 (tacrolimus) as primary immunosuppression. | 1996 | Transplant. Proc. | pmid:8658670 |
| Sugito K et al. | A comparative study of clinicopathologic characteristics of renal allografts under cyclosporine and FK506 immunosuppression. | 1996 | Transplant. Proc. | pmid:8658683 |
| Degawa H et al. | Blocking of ICAM-1 and LFA-1 in rat liver transplantation. | 1996 | Transplant. Proc. | pmid:8658695 |
| Watanabe K et al. | Immunosuppressive effect of bactobolamine in rat liver allotransplantation. | 1996 | Transplant. Proc. | pmid:8658697 |
| Tojimbara T et al. | Cyclosporine and tacrolimus both suppress activation of Kupffer cells in vitro. | 1996 | Transplant. Proc. | pmid:8658704 |
| Yuzawa K et al. | Topical immunosuppression in skin grafting with FK 506 ointment. | 1996 | Transplant. Proc. | pmid:8658707 |
| Cai W et al. | Transcription-modulating drugs: mechanism and selectivity. | 1996 | Curr. Opin. Biotechnol. | pmid:8939643 |
| Freiberg RA et al. | Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. | 1996 | J. Biol. Chem. | pmid:8940187 |
| Poon M et al. | Rapamycin inhibits vascular smooth muscle cell migration. | 1996 | J. Clin. Invest. | pmid:8941644 |
| Rokaw MD et al. | Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells. | 1996 | J. Biol. Chem. | pmid:8943313 |
| Matsui A et al. | Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation. | 1996 | Acta Paediatr Jpn | pmid:9002314 |
| Adachi M et al. | Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain. | 1996 | Blood | pmid:8943845 |
| DeCenzo MT et al. | FK506-binding protein mutational analysis: defining the active-site residue contributions to catalysis and the stability of ligand complexes. | 1996 | Protein Eng. | pmid:9005438 |
| Przepiorka D et al. | Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after matched unrelated donor marrow transplantation. | 1996 | Blood | pmid:8943876 |
| Blecher O et al. | A novel plant peptidyl-prolyl-cis-trans-isomerase (PPIase): cDNA cloning, structural analysis, enzymatic activity and expression. | 1996 | Plant Mol. Biol. | pmid:8980498 |
| McCall E et al. | Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. | 1996 | Circ. Res. | pmid:8943949 |
| Winkler M et al. | Evaluation of the Pro-Trac tacrolimus monoclonal whole-blood enzyme-linked immunosorbent assay for monitoring of tacrolimus levels in patients after kidney, heart, and liver transplantation. | 1996 | Ther Drug Monit | pmid:8946659 |
| Thompson PA and Mosley CA | Tacrolimus-phenytoin interaction. | 1996 | Ann Pharmacother | pmid:8740340 |
| Christophers E | Psoriasis: mechanisms and entry points for possible therapeutic interventions. | 1996 | Australas. J. Dermatol. | pmid:8713012 |
| Alak AM and Lizak P | Stability of FK506 in blood samples. | 1996 | Ther Drug Monit | pmid:8721287 |
| Yu C et al. | Tacrolimus (FK506) and methotrexate regimens to prevent graft-versus-host disease after unrelated dog leukocyte antigen (DLA) nonidentical marrow transplantation. | 1996 | Bone Marrow Transplant. | pmid:8722370 |
| Fealy MJ and Press BH | Pinpointing the moment of allograft rejection. | 1996 | J Hand Surg Am | pmid:8724501 |
| Hall MN | The TOR signalling pathway and growth control in yeast. | 1996 | Biochem. Soc. Trans. | pmid:8674674 |
| Small SL et al. | Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506) | 1996 | Ann. Neurol. | pmid:8871576 |
| Stempfle HU | [Osteoporosis following heart transplantation. Pathogenesis and therapy]. | 1996 | Dtsch. Med. Wochenschr. | pmid:8846757 |
| Sadakane Y and Nakashima H | Light-induced phase shifting of the circadian conidiation rhythm is inhibited by calmodulin antagonists in Neurospora crassa. | 1996 | J. Biol. Rhythms | pmid:8872595 |
| Akashi T et al. | Quantitative determination of tautomeric FK506 by reversed-phase liquid chromatography. | 1996 | J Pharm Biomed Anal | pmid:8851758 |
| Jordan ML et al. | The use of tacrolimus in renal transplantation. | 1996 | World J Urol | pmid:8873438 |
| Wada Y et al. | BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor. | 1996 | Artif Organs | pmid:8853794 |
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| Lochmüller H et al. | Transient immunosuppression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice. | 1996 | Gene Ther. | pmid:8854096 |
| DiMartini AF et al. | Prospective study of FK506 side effects: anxiety or akathisia? | 1996 | Biol. Psychiatry | pmid:8874843 |
| Horn F and Gross J | A role for calcineurin in Dictyostelium discoideum development. | 1996 | Differentiation | pmid:8855370 |
| Lu YF et al. | Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus. | 1996 | Brain Res. | pmid:8874888 |
| Barkholt LM et al. | Epstein-Barr virus DNA in serum after liver transplantation--surveillance of viral activity during treatment with different immunosuppressive agents. | 1996 | Transpl. Int. | pmid:8875785 |
| Shapiro R et al. | Tacrolimus in pediatric renal transplantation. | 1996 | Transplantation | pmid:8990356 |
| Vincenti F et al. | One-year follow-up of an open-label trial of FK506 for primary kidney transplantation. A report of the U.S. Multicenter FK506 Kidney Transplant Group. | 1996 | Transplantation | pmid:8669100 |
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| Przepiorka D et al. | Allogeneic transplantation for advanced leukemia: improved short-term outcome with blood stem cell grafts and tacrolimus. | 1996 | Transplantation | pmid:8990368 |
| Uchikoshi F et al. | Restoration of immune abnormalities in diabetic BB rats after pancreas transplantation. I. Macrochimerism of donor-graft-derived RT6+ T cells responsible for restoration of immune responsiveness and suppression of autoimmune reaction. | 1996 | Transplantation | pmid:8669109 |
| Dhar DK et al. | FK506 maintains cellular calcium homeostasis in ischemia-reperfusion injury of the canine liver. | 1996 | J. Surg. Res. | pmid:8592405 |
| Kay JE | Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases. | 1996 | Biochem. J. | pmid:8670043 |
| Schmaldienst S and Horl WH | Bacterial infections during immunosuppression - immunosuppressive agents interfere not only with immune response, but also with polymorphonuclear cell function. | 1996 | Nephrol. Dial. Transplant. | pmid:8672015 |
| Taylor PJ et al. | Sensitive, specific quantitative analysis of tacrolimus (FK506) in blood by liquid chromatography-electrospray tandem mass spectrometry. | 1996 | Clin. Chem. | pmid:8595724 |
| Hartley AD et al. | cAMP inhibits bud growth in a yeast strain compromised for Ca2+ influx into the Golgi. | 1996 | Mol. Gen. Genet. | pmid:8709962 |
| Tokime T et al. | Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. | 1996 | Neurosci. Lett. | pmid:8710192 |
| Dan Y et al. | IL-3 augments TCR-mediated responses of type 2 CD4 T cells. | 1996 | J. Immunol. | pmid:8598473 |
| Soubrane O and Houssin D | [Liver transplantation. Current aspects]. | 1996 | Presse Med | pmid:8728904 |
| Lampen A et al. | Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. | 1996 | Br. J. Pharmacol. | pmid:8732283 |
| Beretta L et al. | Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. | 1996 | EMBO J. | pmid:8599949 |
| Inomata Y et al. | The evolution of immunosuppression with FK506 in pediatric living-related liver transplantation. | 1996 | Transplantation | pmid:8600632 |
| Gruessner RW et al. | A multicenter analysis of the first experience with FK506 for induction and rescue therapy after pancreas transplantation. | 1996 | Transplantation | pmid:8600635 |