| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adrenal Insufficiency | D000309 | 3 associated lipids |
| Akinetic Mutism | D000405 | 1 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Alopecia Areata | D000506 | 6 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amenorrhea | D000568 | 4 associated lipids |
| Amputation, Traumatic | D000673 | 2 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Anemia, Hemolytic | D000743 | 4 associated lipids |
| Anemia, Hemolytic, Autoimmune | D000744 | 5 associated lipids |
| Anemia, Refractory | D000753 | 3 associated lipids |
| Anemia, Refractory, with Excess of Blasts | D000754 | 2 associated lipids |
| Aneurysm, Dissecting | D000784 | 2 associated lipids |
| Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alak AM et al. | An HPLC/MS/MS assay for tacrolimus in patient blood samples. Correlation with results of an ELISA assay. | 1997 | J Pharm Biomed Anal | pmid:9447546 |
| Singh N et al. | Predictors and outcome of early- versus late-onset major bacterial infections in liver transplant recipients receiving tacrolimus (FK506) as primary immunosuppression. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9447904 |
| duBell WH et al. | Effect of the immunosupressant FK506 on excitation-contraction coupling and outward K+ currents in rat ventricular myocytes. | 1997 | J. Physiol. (Lond.) | pmid:9218211 |
| de-la-Serna-Higuera C et al. | Tacrolimus-induced bone marrow suppression. | 1997 | Lancet | pmid:9291912 |
| Yoshikawa H et al. | Fc gammaRIII-mediated regulation of hematopoiesis in murine bone marrow cells by interleukin-3 and CD95 (Fas/Apo-1). | 1997 | Blood | pmid:9292524 |
| Jain A et al. | Pregnancy after liver transplantation under tacrolimus. | 1997 | Transplantation | pmid:9293865 |
| Garcia-Criado FJ et al. | Tacrolimus (FK506) down-regulates free radical tissue levels, serum cytokines, and neutrophil infiltration after severe liver ischemia. | 1997 | Transplantation | pmid:9293871 |
| Suzuki H et al. | Induction of transplantation tolerance in adult rats by vascularized spleen transplantation. | 1997 | Transplantation | pmid:9293881 |
| Alvaro D et al. | Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions. | 1997 | J. Clin. Invest. | pmid:9294100 |
| Ruzicka T et al. | A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. | 1997 | N. Engl. J. Med. | pmid:9295241 |
| Alevizopoulos A et al. | Regulation of the transforming growth factor beta-responsive transcription factor CTF-1 by calcineurin and calcium/calmodulin-dependent protein kinase IV. | 1997 | J. Biol. Chem. | pmid:9295299 |
| Lal SM et al. | De novo membranous glomerulopathy in a renal transplant patient treated with FK 506. The first reported case. | 1997 | Int J Artif Organs | pmid:9298410 |
| Cardoso CM et al. | Uncoupling of Ca2+ transport ATPase in muscle and blood platelets by diacylglycerol analogues and cyclosporin A antagonism. | 1997 | Biochem. J. | pmid:9581558 |
| Miwa S et al. | Effect of anti-intercellular adhesion molecule-1 and anti-leukocyte function associated antigen-1 monoclonal antibodies on rat-to-mouse cardiac xenograft rejection. | 1997 | Surgery | pmid:9186469 |
| Arbustini E et al. | Acute rejection and heart infection rates in FK 506- versus cyclosporine A-treated heart transplant recipients: an endomyocardial biopsy pathologic study. | 1997 | J. Heart Lung Transplant. | pmid:9322152 |
| Fujino H et al. | Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes. | 1997 | Mol. Pharmacol. | pmid:9187267 |
| Denecker G et al. | Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. | 1997 | Cytokine | pmid:9325011 |
| Hausen B and Morris RE | Review of immunosuppression for lung transplantation. Novel drugs, new uses for conventional immunosuppressants, and alternative strategies. | 1997 | Clin. Chest Med. | pmid:9187827 |
| Fujita T et al. | Prolonged survival of rat skin allograft by treatment with FK506 ointment. | 1997 | Transplantation | pmid:9326422 |
| Pratschke J et al. | Treatment of cyclosporine-related adverse effects by conversion to tacrolimus after liver transplantation. | 1997 | Transplantation | pmid:9326428 |
| Raufman JP et al. | Regulation of calcium-induced exocytosis from gastric chief cells by protein phosphatase-2B (calcineurin). | 1997 | Biochim. Biophys. Acta | pmid:9202177 |
| McGhee B et al. | Therapeutic use of an extemporaneously prepared oral suspension of tacrolimus in pediatric patients. | 1997 | Transplantation | pmid:9326429 |
| Mochizuki M | Immunotherapy for Behçet's disease. | 1997 | Int. Rev. Immunol. | pmid:9203026 |
| Braun F et al. | Pitfalls in monitoring tacrolimus (FK 506). | 1997 | Ther Drug Monit | pmid:9421102 |
| Nussenblatt RB | Uveitis in Behçet's disease. | 1997 | Int. Rev. Immunol. | pmid:9203027 |
| Salm P et al. | High-performance liquid chromatography-tandem mass spectrometry as a reference for analysis of tacrolimus to assess two immunoassays in patients with liver and renal transplants. | 1997 | Ther Drug Monit | pmid:9421113 |
| Araki T et al. | Age-related changes of sodium-dependent D-[3H]aspartate and [3H]FK506 binding in rat brain. | 1997 | J Neural Transm | pmid:9203087 |
| Moroda T et al. | Self-reactive forbidden clones are confined to pathways of intermediate T-cell receptor cell differentiation even under immunosuppressive conditions. | 1997 | Immunology | pmid:9203970 |
| Spencer CM et al. | Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation. | 1997 | Drugs | pmid:9421697 |
| Mrvos R et al. | Tacrolimus (FK 506) overdose: a report of five cases. | 1997 | J. Toxicol. Clin. Toxicol. | pmid:9204100 |
| Stegall MD et al. | Mycophenolate mofetil decreases rejection in simultaneous pancreas-kidney transplantation when combined with tacrolimus or cyclosporine. | 1997 | Transplantation | pmid:9422404 |
| Ferron GM et al. | Population pharmacokinetics of sirolimus in kidney transplant patients. | 1997 | Clin. Pharmacol. Ther. | pmid:9129559 |
| Kliem V et al. | Long-term results after primary successful FK 506 treatment of steroid- and OKT3-resistant rejection in renal transplant recipients. | 1997 | Transplant. Proc. | pmid:9365627 |
| Weil SJ et al. | Chemotaxis of macrophages by a peritoneal fluid protein in women with endometriosis. | 1997 | Fertil. Steril. | pmid:9130891 |
| Xu M et al. | Effect of peritransplant FTY720 alone or in combination with posttransplant FK 506 in a rat model of cardiac allotransplantation. | 1997 | Transplant. Proc. | pmid:9365631 |
| Karlsson H et al. | Energy levels in resting and mitogen-stimulated human lymphocytes during treatment with FK506 or cyclosporin A in vitro. | 1997 | Biochim. Biophys. Acta | pmid:9131051 |
| Gavlik A et al. | Mycophenolate mofetil rescue therapy in liver transplant recipients: an extended follow-up. | 1997 | Transplant. Proc. | pmid:9365633 |
| Pratt WB | The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase. | 1997 | Annu. Rev. Pharmacol. Toxicol. | pmid:9131255 |
| Lee CM et al. | Outcomes in diabetic patients after simultaneous pancreas-kidney versus kidney alone transplantation. | 1997 | Transplantation | pmid:9371670 |
| Niederstadt C et al. | Effect of FK506 on magnesium homeostasis after renal transplantation. | 1997 | Transplant. Proc. | pmid:9365709 |
| Filler G et al. | Transient diabetes mellitus and peripheral insulin resistance following Tacrolimus intoxication in a child after renal transplantation. | 1997 | Nephrol. Dial. Transplant. | pmid:9132657 |
| Migita K et al. | FK506 potentiates steroid-induced T-cell apoptosis. | 1997 | Transplantation | pmid:9371682 |
| Takao T et al. | [A case of recurrent IgA nephropathy following renal transplantation under tacrolimus (FK506)]. | 1997 | Hinyokika Kiyo | pmid:9365847 |
| Yap AS et al. | Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. | 1997 | Curr. Biol. | pmid:9133345 |
| Kloke O et al. | Rapamycin antagonizes interleukin-6 mediated growth arrest and differentiation of myeloblastic M1 cells. | 1997 | Immunol. Lett. | pmid:9373220 |
| Aoyama S et al. | [The effect of FK 506, an immunosuppressant, on cerebral infarction volume in focal cerebral ischemia in rats]. | 1997 | Nippon Ika Daigaku Zasshi | pmid:9366145 |
| Eberlein-König B et al. | Modulation of histamine release in vitro by FK506 and interleukin-3 is determined by sequence of incubation. | 1997 | Arch. Dermatol. Res. | pmid:9373722 |
| Ross DJ et al. | FK 506 'rescue' immunosuppression for obliterative bronchiolitis after lung transplantation. | 1997 | Chest | pmid:9367453 |
| Landström M and Funa K | Apoptosis in rat prostatic adenocarcinoma is associated with rapid infiltration of cytotoxic T-cells and activated macrophages. | 1997 | Int. J. Cancer | pmid:9139883 |
| Sandborn WJ | Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease. | 1997 | Am. J. Gastroenterol. | pmid:9149205 |
| Duddridge M and Powell RJ | Treatment of severe and difficult cases of systemic lupus erythematosus with tacrolimus. A report of three cases. | 1997 | Ann. Rheum. Dis. | pmid:9462174 |
| Katoh H et al. | Living related partial liver transplantation in biliary atresia: 11 cases of experience. | 1997 | Tohoku J. Exp. Med. | pmid:9149348 |
| Muramatsu K et al. | Longer survival of rat limb allograft. Combined immunosuppression of FK-506 and 15-deoxyspergualin. | 1997 | Acta Orthop Scand | pmid:9462361 |
| Danovitch GM | Cyclosporin or tacrolimus: which agent to choose? | 1997 | Nephrol. Dial. Transplant. | pmid:9269630 |
| Yoshikawa H et al. | FK506 prevents induction of rat experimental autoimmune myasthenia gravis. | 1997 | J. Autoimmun. | pmid:9080295 |
| Filler G et al. | Pharmacokinetics of tacrolimus (FK 506) in children and adolescents with renal transplants. | 1997 | Nephrol. Dial. Transplant. | pmid:9269646 |
| Sperr WR et al. | Inhibition of allergen-induced histamine release from human basophils by cyclosporine A and FK-506. | 1997 | Int. Arch. Allergy Immunol. | pmid:9303333 |
| Azuma H et al. | Atypical Epstein-Barr virus infection during and after intermittent FK506 therapy. | 1997 | Acta Paediatr Jpn | pmid:9141259 |
| Izuishi K et al. | Effects of an immunosuppressive agent, tacrolimus (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems in rat liver microsomes. | 1997 | Int. J. Biochem. Cell Biol. | pmid:9304807 |
| Tsuchida Y et al. | Vascularized bone marrow allotransplantation in rats prolongs a simultaneous skin allograft. | 1997 | Transplant. Proc. | pmid:9142252 |
| Jonas S et al. | De novo malignancies after liver transplantation using tacrolimus-based protocols or cyclosporine-based quadruple immunosuppression with an interleukin-2 receptor antibody or antithymocyte globulin. | 1997 | Cancer | pmid:9305716 |
| Costa A et al. | Small bowel myoelectrical activity after transplantation in pigs: motility versus ACR score. | 1997 | Transplant. Proc. | pmid:9142281 |
| Tze WJ et al. | Prolongation of pig islet xenograft survival in rats immunosuppressed with FK506. | 1997 | Diabetes Res. Clin. Pract. | pmid:9306035 |
| Soin AS et al. | Complement activation during rejection in experimental intestinal transplantation. | 1997 | Transplant. Proc. | pmid:9142282 |
| Tanaka H et al. | [Discovery and development of a novel immunosuppressant, tacrolimus hydrate]. | 1997 | Yakugaku Zasshi | pmid:9306728 |
| Rossi G et al. | Small bowel transplantation under oral immunosuppression: experimental study in the pig. | 1997 | Transplant. Proc. | pmid:9142285 |
| Kamada H et al. | Immunopharmacological studies on collagen-induced arthritis in dark Agouti (DA) rats. | 1997 | Jpn. J. Pharmacol. | pmid:9307327 |
| Spada M et al. | Tacrolimus and mycophenolate mofetil in pig small bowel transplantation: different protocols and their outcome. | 1997 | Transplant. Proc. | pmid:9142286 |
| Ito A et al. | Donor-specific tolerance by perioperative intrathymic injection of bone marrow cells in the rat cardiac allograft model: use of FK506 can shorten the necessary duration of pretransplant intrathymic conditioning. | 1997 | Transplantation | pmid:9311715 |
| Ronchetti F et al. | Intestinal damage evaluation in swine allograft small bowel through hyaluronic acid quantification. | 1997 | Transplant. Proc. | pmid:9142293 |
| Atkison PR et al. | Arteritis and increased intracellular calcium as a possible mechanism for tacrolimus-related cardiac toxicity in a pediatric transplant recipient. | 1997 | Transplantation | pmid:9311719 |
| Velio P et al. | Combined orthotopic liver-small bowel transplantation or small bowel transplantation in pigs: relations between survival, rejection, and mucosal morphometry. | 1997 | Transplant. Proc. | pmid:9142295 |
| Graef IA et al. | Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. | 1997 | EMBO J. | pmid:9312021 |
| Regazzi MB et al. | Pharmacokinetics of FK506 and mycophenolic acid in experimental and clinical intestinal transplantation. | 1997 | Transplant. Proc. | pmid:9142302 |
| Gold BG | FK506 and the role of immunophilins in nerve regeneration. | 1997 | Mol. Neurobiol. | pmid:9457703 |
| Mignat C | Clinically significant drug interactions with new immunosuppressive agents. | 1997 | Drug Saf | pmid:9113494 |
| Sabatini DM et al. | Neural roles of immunophilins and their ligands. | 1997 | Mol. Neurobiol. | pmid:9396011 |
| Su Y et al. | Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: cell type specificity and effects of extracellular matrix. | 1997 | J. Cell Biol. | pmid:9396758 |
| Bielefeldt K et al. | Tacrolimus (FK506) modulates calcium release and contractility of intestinal smooth muscle. | 1997 | Cell Calcium | pmid:9502200 |
| Yamaguchi Y et al. | Enhanced expression of cytokine-induced neutrophil chemoattractant in rat hepatic allografts during acute rejection. | 1997 | Hepatology | pmid:9397996 |
| Mollison KW et al. | Discovery of less nephrotoxic FK506 analogs and determining immunophilin dependence of immunosuppressant nephrotoxicity with a novel single-dose rat cisplatin potentiation assay. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9400028 |
| Mondragon A et al. | Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center. | 1997 | Biochemistry | pmid:9125515 |
| Murthy JN et al. | Identification of a 37 kDa tacrolimus, sirolimus and cyclosporine binding immunophilin possessing glyceraldehyde 3-phosphate dehydrogenase activity isolated from the Jurkat T cell line. | 1997 | Clin. Biochem. | pmid:9127694 |
| Bowman AR et al. | The role of testosterone in cyclosporine-induced osteopenia. | 1997 | J. Bone Miner. Res. | pmid:9101372 |
| High KP and Washburn RG | Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin). | 1997 | J. Infect. Dis. | pmid:8985226 |
| Yoshikai Y et al. | Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS. | 1997 | J. Virol. | pmid:8985410 |
| Jordan ML et al. | Tacrolimus rescue therapy for renal allograft rejection--five-year experience. | 1997 | Transplantation | pmid:9020321 |
| Mazariegos GV et al. | Weaning of immunosuppression in liver transplant recipients. | 1997 | Transplantation | pmid:9020325 |
| Marks WH et al. | Asialoglycoprotein/asialoglycoprotein receptor (AGP-AGPr) interaction is an important mechanism for the uptake of FK506 by hepatocytes. | 1997 | Transplantation | pmid:9020333 |
| Aiko S et al. | Effects of cyclosporine or FK506 in chronic colitis. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023326 |
| Noguchi N et al. | Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes. | 1997 | J. Biol. Chem. | pmid:9013543 |
| Ishizuka T et al. | Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9016789 |
| Bragado MJ et al. | p70s6k is activated by CCK in rat pancreatic acini. | 1997 | Am. J. Physiol. | pmid:9252447 |
| Lacaille F et al. | Life-threatening food allergy in a child treated with FK506. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9252915 |
| Bagnis C et al. | Comparative acute nephrotoxicity of FK-506 and ciclosporin in an isolated in situ autoperfused rat kidney model. | 1997 | Am. J. Nephrol. | pmid:9057948 |
| Newell KA et al. | Association between liver transplantation for Langerhans cell histiocytosis, rejection, and development of posttransplant lymphoproliferative disease in children. | 1997 | J. Pediatr. | pmid:9255199 |
| Ivery MT and Weiler L | Modeling the interaction between FK506 and FKBP12: a mechanism for formation of the calcineurin inhibitory complex. | 1997 | Bioorg. Med. Chem. | pmid:9061187 |
| Tsamandas AC et al. | Central venulitis in the allograft liver: a clinicopathologic study. | 1997 | Transplantation | pmid:9256183 |
| Sher LS et al. | Efficacy of tacrolimus as rescue therapy for chronic rejection in orthotopic liver transplantation: a report of the U.S. Multicenter Liver Study Group. | 1997 | Transplantation | pmid:9256184 |
| Rühlmann A and Nordheim A | Effects of the immunosuppressive drugs CsA and FK506 on intracellular signalling and gene regulation. | 1997 | Immunobiology | pmid:9442391 |