| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Genital Diseases, Female | D005831 | 7 associated lipids |
| Mouth Diseases | D009059 | 5 associated lipids |
| Meningococcal Infections | D008589 | 3 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moxey-Mims MM et al. | Increased incidence of insulin-dependent diabetes mellitus in pediatric renal transplant patients receiving tacrolimus (FK506) | 1998 | Transplantation | pmid:9521193 |
| Mizunuma M et al. | Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. | 1998 | Nature | pmid:9521328 |
| Matsuda T et al. | Immunosuppressants decrease neutrophil chemoattractant and attenuate ischemia/reperfusion injury of the liver in rats. | 1998 | J Trauma | pmid:9529174 |
| Briffa N and Morris RE | Immunosuppressive drugs after lung transplantation. | 1998 | BMJ | pmid:9529396 |
| Venkataraman C et al. | Activation of lyn, blk, and btk but not syk in CD72-stimulated B lymphocytes. | 1998 | J. Immunol. | pmid:9531290 |
| Walensky LD et al. | The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. | 1998 | J. Cell Biol. | pmid:9531554 |
| First MR | Clinical application of immunosuppressive agents in renal transplantation. | 1998 | Surg. Clin. North Am. | pmid:9531936 |
| Corry RJ et al. | Pancreas transplantation without antibody therapy. | 1998 | Transplant. Proc. | pmid:9532050 |
| Kahl A et al. | First results with a quadruple therapy regimen including tacrolimus and mycophenolate mofetil in patients after combined pancreas and kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532149 |
| Bruce DS et al. | Effects of tacrolimus, mycophenolate mofetil, and cyclosporine microemulsion on rejection incidence in synchronous pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532150 |
| Peddi VR et al. | Tacrolimus eliminates acute rejection as a major complication following simultaneous kidney and pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532151 |
| Burke GW et al. | Cholesterol control: long-term benefit of pancreas-kidney transplantation with FK 506 immunosuppression. | 1998 | Transplant. Proc. | pmid:9532153 |
| Büsing M et al. | Mycophenolate mofetil/tacrolimus/single-shot versus azathioprine/cyclosporine/ATG in pancreas-kidney transplantation: results of a prospective randomized single-center study. | 1998 | Transplant. Proc. | pmid:9532155 |
| Gruessner RW et al. | Mycophenolate mofetil and tacrolimus for induction and maintenance therapy after pancreas transplantation. | 1998 | Transplant. Proc. | pmid:9532156 |
| Corry RJ et al. | Tacrolimus without antilymphocyte induction therapy prevents pancreas loss from rejection in 123 consecutive patients. | 1998 | Transplant. Proc. | pmid:9532157 |
| Elmer DS et al. | Metabolic effects of FK 506 (tacrolimus) versus cyclosporine in portally drained pancreas allografts. | 1998 | Transplant. Proc. | pmid:9532159 |
| Burke GW et al. | Tacrolimus-related microangiopathy in kidney and simultaneous pancreas-kidney recipients: evidence of endothelin and cytokine involvement. | 1998 | Transplant. Proc. | pmid:9532223 |
| Ochiai M et al. | Islet toxicity of FK506 measured in canine autografts. | 1998 | Transplant. Proc. | pmid:9532224 |
| Wiederrecht G and Siekierka JJ | Yeast immunophilins: purification and assay of yeast FKBP12. | 1998 | Meth. Enzymol. | pmid:9534152 |
| Mattoo AK | Peptidylprolyl cis-trans-isomerases from plant organelles. | 1998 | Meth. Enzymol. | pmid:9534153 |
| Cichon G and Strauss M | Transient immunosuppression with 15-deoxyspergualin prolongs reporter gene expression and reduces humoral immune response after adenoviral gene transfer. | 1998 | Gene Ther. | pmid:9536268 |
| Schäffer MR et al. | Tacrolimus impairs wound healing: a possible role of decreased nitric oxide synthesis. | 1998 | Transplantation | pmid:9539093 |
| Anderson PO | Tacrolimus and breastfeeding. | 1998 | Transplantation | pmid:9539100 |
| Hiroi J et al. | Effect of tacrolimus hydrate (FK506) ointment on spontaneous dermatitis in NC/Nga mice. | 1998 | Jpn. J. Pharmacol. | pmid:9541280 |
| Bassing CH et al. | FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. | 1998 | Cell Growth Differ. | pmid:9543388 |
| Lopez-Ilasaca M et al. | Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor. | 1998 | J. Biol. Chem. | pmid:9545268 |
| Matsuoka S et al. | [Severe hepatic veno-occlusive disease (VOD) which was successfully treated with supportive therapy, but subsequently developed late-recurrence]. | 1998 | Rinsho Ketsueki | pmid:9545827 |
| Endrich MM and Gehring H | The V3 loop of human immunodeficiency virus type-1 envelope protein is a high-affinity ligand for immunophilins present in human blood. | 1998 | Eur. J. Biochem. | pmid:9546659 |
| Trull AK | Therapeutic monitoring of tacrolimus. | 1998 | Ann. Clin. Biochem. | pmid:9547889 |
| ten Berge RJ and Schellekens PT | [Immunology in clinical practice. VI. Current immunosuppressive drugs]. | 1997 | Ned Tijdschr Geneeskd | pmid:9550813 |
| Epstein A et al. | Cyclosporine, but not FK506, selectively induces renal and coronary artery smooth muscle contraction. | 1998 | Surgery | pmid:9551073 |
| Matsuda T and Baba A | [Response of Na+/Ca2+ antiporter to ischemia and glial/neuronal death]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9551468 |
| Hashimoto T et al. | [Involvement of calcineurin A alpha and A beta in neuronal death in a gerbil model of cerebral ischemia]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9551469 |
| Wiederrecht GJ et al. | Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. | 1995 | Prog Cell Cycle Res | pmid:9552353 |
| Terashima A et al. | Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and rapamycin. | 1998 | Brain Res. | pmid:9555045 |
| D'Incà R et al. | Tacrolimus to treat pyoderma gangrenosum resistant to cyclosporine. | 1998 | Ann. Intern. Med. | pmid:9556483 |
| Antonysamy MA et al. | Flt-3 ligand increases microchimerism but can prevent the therapeutic effect of donor bone marrow in transiently immunosuppressed cardiac allograft recipients. | 1998 | J. Immunol. | pmid:9558122 |
| Ku YM and Min DI | An abbreviated area-under-the-curve monitoring for tacrolimus in patients with liver transplants. | 1998 | Ther Drug Monit | pmid:9558138 |
| Jubran RF and Dinndorf PA | Successful therapy of refractory graft versus host disease with tacrolimus and Psoralen plus ultraviolet light. | 1998 | Ther Drug Monit | pmid:9558141 |
| Taylor PJ et al. | Therapeutic drug monitoring of tacrolimus (FK506) using tandem mass spectrometry. | 1998 | Ther Drug Monit | pmid:9558142 |
| Main ER et al. | Context-dependent nature of destabilizing mutations on the stability of FKBP12. | 1998 | Biochemistry | pmid:9558354 |
| Takaoka Y et al. | Cyclosporin A and FK-506 inhibit development of superantigen-potentiated collagen-induced arthritis in mice. | 1998 | Gen. Pharmacol. | pmid:9559334 |
| Cicalese L et al. | Phenotypic and functional characteristics of intestinal intraepithelial lymphocytes during acute rejection of small intestinal allografts. | 1998 | Transpl. Int. | pmid:9561676 |
| Fernández-Miranda C et al. | Lipid abnormalities in stable liver transplant recipients--effects of cyclosporin, tacrolimus, and steroids. | 1998 | Transpl. Int. | pmid:9561680 |
| Jain A et al. | Incidence and severity of acute allograft rejection in liver transplant recipients treated with alfa interferon. | 1998 | Liver Transpl Surg | pmid:9563957 |
| Hayashi M et al. | Allograft rejection after liver transplantation for autoimmune liver diseases. | 1998 | Liver Transpl Surg | pmid:9563959 |
| Yuzawa K and Fukao K | Topical FK506 ointment for skin grafting. | 1998 | Transplantation | pmid:9565111 |
| Kennedy AP et al. | Polyomavirus middle T antigen as a probe for T cell antigen receptor-coupled signaling pathways. | 1998 | J. Biol. Chem. | pmid:9565564 |
| Pizzolato GP et al. | Cerebral vasculitis during FK 506 treatment in a liver transplant patient. | 1998 | Neurology | pmid:9566415 |
| Salerno A et al. | The effect of cyclosporin A, FK506 and rapamycin on the murine contact sensitivity reaction. | 1998 | Clin. Exp. Immunol. | pmid:9566798 |
| Mollison KW et al. | Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. | 1998 | Toxicology | pmid:9570331 |
| Araki T et al. | Post-ischemic alterations in [3H]FK506 binding in the gerbil and rat brains. | 1998 | Metab Brain Dis | pmid:9570636 |
| Finney NS | Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. | 1998 | Chem. Biol. | pmid:9571210 |
| Matsuda T et al. | Involvement of calcineurin in Ca2+ paradox-like injury of cultured rat astrocytes. | 1998 | J. Neurochem. | pmid:9572286 |
| Barinaga M | Signaling path may lead to better heart-failure therapies. | 1998 | Science | pmid:9575084 |
| Miyasaka N | [Recent findings on etiological mechanism of autoimmune diseases]. | 1998 | Nippon Naika Gakkai Zasshi | pmid:9577564 |
| Sakane T | [Physiopathology and therapy of Behcet's syndrome]. | 1998 | Nippon Naika Gakkai Zasshi | pmid:9577569 |
| Sugi-Ikai N et al. | Increased frequencies of interleukin-2- and interferon-gamma-producing T cells in patients with active Behçet's disease. | 1998 | Invest. Ophthalmol. Vis. Sci. | pmid:9579479 |
| Cardoso CM et al. | Uncoupling of Ca2+ transport ATPase in muscle and blood platelets by diacylglycerol analogues and cyclosporin A antagonism. | 1997 | Biochem. J. | pmid:9581558 |
| Abu-Elmagd K et al. | Clinical intestinal transplantation: new perspectives and immunologic considerations. | 1998 | J. Am. Coll. Surg. | pmid:9583691 |
| Zervos XA et al. | Comparison of tacrolimus with microemulsion cyclosporine as primary immunosuppression in hepatitis C patients after liver transplantation. | 1998 | Transplantation | pmid:9583863 |
| Muraki T et al. | Effects of cyclosporine and FK506 on in vitro high shear-induced platelet reactivity in rat and human non-anticoagulated blood. | 1998 | Transplantation | pmid:9583878 |
| Kadry Z et al. | Kaposi's sarcoma in liver transplant recipients on FK506. | 1998 | Transplantation | pmid:9583882 |
| Chiba K et al. | FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. | 1998 | J. Immunol. | pmid:9590253 |
| Hebebrand D et al. | Limb xenotransplantation using FK506 and RS61443 immunosuppression. | 1998 | J Reconstr Microsurg | pmid:9590615 |
| Wakita H et al. | Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia. | 1998 | Brain Res. | pmid:9593846 |
| Marone G et al. | Immunopharmacology of human mast cells and basophils. | 1998 | Int. J. Clin. Lab. Res. | pmid:9594358 |
| Weis M et al. | Impact of immunosuppression on coronary endothelial function after cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9595131 |
| Gregory CR | Immunosuppressive approaches to the prevention of graft vascular disease. | 1998 | Transplant. Proc. | pmid:9595134 |
| Koyama T et al. | [Effects of various drugs on IL-8 production by eosinophils collected from patients with allergic inflammation]. | 1998 | Jpn J Antibiot | pmid:9597507 |
| Wagner R et al. | 32-Ascomycinyloxyacetic acid derived immunosuppressants. Independence of immunophilin binding and immunosuppressive potency. | 1998 | J. Med. Chem. | pmid:9599228 |
| Hueros G et al. | A maize FK506-sensitive immunophilin, mzFKBP-66, is a peptidylproline cis-trans-isomerase that interacts with calmodulin and a 36-kDa cytoplasmic protein. | 1998 | Planta | pmid:9599809 |
| Oyanagui Y | Immunosuppressants enhance superoxide radical/nitric oxide-dependent dexamethasone suppression of ischemic paw edema in mice. | 1998 | Eur. J. Pharmacol. | pmid:9600660 |
| Jurcevic S et al. | A new enzyme-linked immunosorbent assay to measure anti-endothelial antibodies after cardiac transplantation demonstrates greater inhibition of antibody formation by tacrolimus compared with cyclosporine. | 1998 | Transplantation | pmid:9603168 |
| Beatty PR et al. | Effect of cyclosporine and tacrolimus on the growth of Epstein-Barr virus-transformed B-cell lines. | 1998 | Transplantation | pmid:9603175 |
| Shapiro R et al. | Alopecia as a consequence of tacrolimus therapy. | 1998 | Transplantation | pmid:9603186 |
| Capone D et al. | Therapeutic monitoring of tacrolimus in pediatric and adult transplanted patients. | 1998 | J Chemother | pmid:9603651 |
| Chang RK et al. | Marked left ventricular hypertrophy in children on tacrolimus (FK506) after orthotopic liver transplantation. | 1998 | Am. J. Cardiol. | pmid:9604971 |
| Homey B et al. | Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses. | 1998 | J. Immunol. | pmid:9605132 |
| Tomura N et al. | Transient neurotoxicity associated with FK506: MR findings. | 1998 May-Jun | J Comput Assist Tomogr | pmid:9606397 |
| Tomono M et al. | Inhibitors of calcineurin block expression of cyclins A and E induced by fibroblast growth factor in Swiss 3T3 fibroblasts. | 1998 | Arch. Biochem. Biophys. | pmid:9606972 |
| Singer NG and McCune WJ | Update on immunosuppressive therapy. | 1998 | Curr Opin Rheumatol | pmid:9608317 |
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| Idilman R et al. | Immunosuppressive drug-induced leukoencephalopathy in patients with liver transplant. | 1998 | Eur J Gastroenterol Hepatol | pmid:9619393 |
| Kikuchi M et al. | Protective effects of FK506 against glutamate-induced neurotoxicity in retinal cell culture. | 1998 | Invest. Ophthalmol. Vis. Sci. | pmid:9620083 |
| Lampen A et al. | Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines. | 1998 | Xenobiotica | pmid:9622846 |
| Schulman SL et al. | Interaction between tacrolimus and chloramphenicol in a renal transplant recipient. | 1998 | Transplantation | pmid:9625026 |
| Pruvot FR and Noel C | Comment on "Pregnancy after liver transplantation under tacrolimus" by Jain et al. | 1998 | Transplantation | pmid:9625033 |
| Takada Y et al. | Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. | 1998 | Surgery | pmid:9626320 |
| Ellouk-Achard S et al. | FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction. | 1998 | Arch. Toxicol. | pmid:9630010 |
| Starzl TE et al. | Tacrolimus (FK506) and the pharmaceutical/academic/regulatory gauntlet. | 1998 | Am. J. Kidney Dis. | pmid:9631858 |
| Al-Awwa IA et al. | Importance of allograft biopsy in renal transplant recipients: correlation between clinical and histological diagnosis. | 1998 | Am. J. Kidney Dis. | pmid:9631859 |
| Tredger JM et al. | Therapeutic monitoring of tacrolimus (FK506) with the first- and second-generation microparticle enzyme immunoassays: performance and results in four patient populations. | 1998 | Ther Drug Monit | pmid:9631923 |
| Nicholson ML et al. | Is TGF-beta a profibrotic cytokine in human renal transplants? | 1998 | Transplant. Proc. | pmid:9636384 |
| Ginevri F et al. | Expression of collagen by renal fibroblasts treated with FK 506 in vitro. | 1998 | Transplant. Proc. | pmid:9636387 |
| Hutchinson IV et al. | Differences in the mode of action of cyclosporine and FK 506. | 1998 | Transplant. Proc. | pmid:9636388 |
| Müller V et al. | Effect of mycophenolate mofetil on the in vivo infiltration of lymphocytes in the rat remnant kidney. | 1998 | Transplant. Proc. | pmid:9636396 |