| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Genital Diseases, Female | D005831 | 7 associated lipids |
| Mouth Diseases | D009059 | 5 associated lipids |
| Meningococcal Infections | D008589 | 3 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ohye H et al. | Effects of immunosuppressant agents on growth hormone release and gene expression. | 1998 | Endocr. J. | pmid:9790238 |
| Casavilla FA et al. | Clinical outcome of patients infected with hepatitis C virus infection on survival after primary liver transplantation under tacrolimus. | 1998 | Liver Transpl Surg | pmid:9791154 |
| Toshima K et al. | Effect of FK506 on the activation state of hepatic macrophages in Propionibacterium acnes-treated rats. | 1998 | J. Gastroenterol. Hepatol. | pmid:9792034 |
| Sengoku T et al. | [Effects of tacrolimus ointment on type I (immediate and late) and IV (delayed) cutaneous allergic reactions in mice]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9793077 |
| Hashimoto Y et al. | Effects of intestinal and hepatic metabolism on the bioavailability of tacrolimus in rats. | 1998 | Pharm. Res. | pmid:9794505 |
| Kobayashi M et al. | Effects of FK506 on experimental membranous glomerulonephritis induced by cationized bovine serum albumin in rats. | 1998 | Nephrol. Dial. Transplant. | pmid:9794552 |
| Schaefer A et al. | Stimulation of the Ca2+-mediated egr-1 and c-fos expression in murine erythroleukaemia cells by cyclosporin A. | 1998 | Biochem. J. | pmid:9794788 |
| Whitcup SM et al. | Topical liposome-encapsulated FK506 for the treatment of endotoxin-induced uveitis. | 1998 | Ocul. Immunol. Inflamm. | pmid:9798194 |
| Sankary HN et al. | FK506 treatment in combination with leflunomide in hamster-to-rat heart and liver xenograft transplantation. | 1998 | Transplantation | pmid:9798690 |
| Garcia-Criado FJ et al. | Possible tacrolimus action mechanisms in its protector effects on ischemia-reperfusion injury. | 1998 | Transplantation | pmid:9798713 |
| Fisher NC | Renal failure after lung transplantation. | 1998 | Lancet | pmid:9800782 |
| Conti F et al. | Low level of interleukin 10 synthesis during liver allograft rejection. | 1998 | Lab. Invest. | pmid:9800954 |
| Reis A et al. | A comparative investigation of FK506 and cyclosporin A in murine corneal transplantation. | 1998 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:9801895 |
| Bieber T | Topical tacrolimus (FK 506): a new milestone in the management of atopic dermatitis. | 1998 | J. Allergy Clin. Immunol. | pmid:9802361 |
| Boguniewicz M et al. | A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children. Pediatric Tacrolimus Study Group. | 1998 | J. Allergy Clin. Immunol. | pmid:9802373 |
| Faure JD et al. | An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506. | 1998 | Plant J. | pmid:9807817 |
| Cardenas ME et al. | Signal-transduction cascades as targets for therapeutic intervention by natural products. | 1998 | Trends Biotechnol. | pmid:9807840 |
| Hultsch T et al. | Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner. | 1998 | Arch. Dermatol. Res. | pmid:9808344 |
| Cacciarelli TV et al. | Management of posttransplant lymphoproliferative disease in pediatric liver transplant recipients receiving primary tacrolimus (FK506) therapy. | 1998 | Transplantation | pmid:9808490 |
| Nakazawa Y et al. | Relationship between in vivo FK506 clearance and in vitro 13-demethylation activity in living-related liver transplantation. | 1998 | Transplantation | pmid:9808496 |
| Krähenbühl S et al. | Serious interaction between mibefradil and tacrolimus. | 1998 | Transplantation | pmid:9808502 |
| Marton MJ et al. | Drug target validation and identification of secondary drug target effects using DNA microarrays. | 1998 | Nat. Med. | pmid:9809554 |
| Walder B et al. | Tacrolimus (FK 506)-induced hemolytic uremic syndrome after heart transplantation. | 1998 | J. Heart Lung Transplant. | pmid:9811409 |
| Bachinger A et al. | [Immunosuppression with tacrolimus (FK 506) and cyclosporin A for preventing graft rejection after liver transplantation. Retrospective evaluation of medical costs based on the FG-O157 Study in 224 patients (Germany)]. | 1998 | Chirurg | pmid:9816454 |
| Shapiro R et al. | A prospective, randomized trial to compare tacrolimus and prednisone with and without mycophenolate mofetil in patients undergoing renal transplantation: first report. | 1998 | J. Urol. | pmid:9817305 |
| Wells WA | Coming full circle. Vertex Pharmaceuticals, Inc. | 1998 | Chem. Biol. | pmid:9818152 |
| Ader JL and Rostaing L | Cyclosporin nephrotoxicity: pathophysiology and comparison with FK-506. | 1998 | Curr. Opin. Nephrol. Hypertens. | pmid:9818201 |
| Perego C et al. | Evidence that SMS 201-995 enhances the immunosuppressive effect of FK506. | 1998 | Int. J. Immunopharmacol. | pmid:9818792 |
| Campo JV et al. | Tacrolimus toxic reaction associated with the use of nefazodone: paroxetine as an alternative agent. | 1998 | Arch. Gen. Psychiatry | pmid:9819077 |
| Igarashi K et al. | A novel indication of the activities of small molecule inhibitors of protein-protein interactions: application of the yeast two-hybrid system. | 1998 | J. Antibiot. | pmid:9820241 |
| Neylan JF et al. | Assessment of the frequency and costs of posttransplantation hospitalizations in patients receiving tacrolimus versus cyclosporine. | 1998 | Am. J. Kidney Dis. | pmid:9820446 |
| Patella V et al. | Endogenous superallergen protein Fv induces IL-4 secretion from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE. | 1998 | J. Immunol. | pmid:9820545 |
| Rossi FM and Blau HM | Recent advances in inducible gene expression systems. | 1998 | Curr. Opin. Biotechnol. | pmid:9821271 |
| Antoni FA et al. | Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory. | 1998 | J. Neurosci. | pmid:9822726 |
| Maghrabi K and Bohlega S | Cyclosporine-induced migraine with severe vomiting causing loss of renal graft. | 1998 | Clin Neurol Neurosurg | pmid:9822847 |
| Mitsuhashi H et al. | Sulfite is released by human neutrophils in response to stimulation with lipopolysaccharide. | 1998 | J. Leukoc. Biol. | pmid:9823763 |
| Papatheodoridis GV et al. | Ulcerative colitis has an aggressive course after orthotopic liver transplantation for primary sclerosing cholangitis. | 1998 | Gut | pmid:9824344 |
| Boillot O et al. | Reversal of early acute rejection with increased doses of tacrolimus in liver transplantation: a pilot study. | 1998 | Transplantation | pmid:9825815 |
| Jain AB et al. | Comparative incidence of de novo nonlymphoid malignancies after liver transplantation under tacrolimus using surveillance epidemiologic end result data. | 1998 | Transplantation | pmid:9825817 |
| Franz M et al. | Posttransplant hemolytic uremic syndrome in adult retransplanted kidney graft recipients: advantage of FK506 therapy? | 1998 | Transplantation | pmid:9825827 |
| Basile C et al. | Tacrolimus and gingival hyperplasia. | 1998 | Nephrol. Dial. Transplant. | pmid:9829526 |
| Fehrman-Ekholm I and Nisell H | A successful pregnancy in a kidney recipient with tacrolimus (Prograf, FK 506) therapy. | 1998 | Nephrol. Dial. Transplant. | pmid:9829528 |
| Armstrong VW et al. | Modified pentamer formation assay for measurement of tacrolimus and its active metabolites: comparison with liquid chromatography-tandem mass spectrometry and microparticle enzyme-linked immunoassay (MEIA-II). | 1998 | Clin. Chem. | pmid:9836720 |
| Carver LA et al. | Characterization of the Ah receptor-associated protein, ARA9. | 1998 | J. Biol. Chem. | pmid:9837941 |
| Takahashi N et al. | Nitric oxide generation in renal allograft recipients. | 1998 | Transplant. Proc. | pmid:9838306 |
| Yoshimura N et al. | Effect of local immunosuppressive therapy with FK 506 on renal allograft survival in the mongrel dog. | 1998 | Transplant. Proc. | pmid:9838372 |
| Ramirez CB et al. | Early steroid withdrawal after liver transplantation. | 1998 | Transplant. Proc. | pmid:9838406 |
| Ko WJ et al. | Clinical trial of FK506 in heart transplant patients in Taiwan: report of 7 cases with immunosuppression switch from cyclosporine to FK506. | 1998 | Transplant. Proc. | pmid:9838474 |
| Sasaki K et al. | Effect of FK 506 and splenectomy on orthotopic small bowel xenotransplantation in the hamster-to-rat animal models. | 1998 | Transplant. Proc. | pmid:9838521 |
| Takayama J et al. | Living related liver transplantation in patients with ABO incompatibility. | 1998 | Transplant. Proc. | pmid:9838537 |
| Wu MS et al. | Cyclosporine, but not FK 506 and rapamycin, enhances cell proliferation in mouse medullary thick ascending cultured cells. | 1998 | Transplant. Proc. | pmid:9838561 |
| Shu KH et al. | A multicenter trial of FK506 as rescue therapy for renal transplant recipients in Taiwan. | 1998 | Transplant. Proc. | pmid:9838570 |
| Lo CM et al. | Use of FK506 as primary or rescue therapy after liver transplantation in Hong Kong. | 1998 | Transplant. Proc. | pmid:9838571 |
| Hung CM et al. | Tacrolimus to rescue refractory hepatic allograft rejection: a collaborative study in Taiwan. | 1998 | Transplant. Proc. | pmid:9838572 |
| Cheng HM et al. | Primary prophylaxis with tacrolimus in kidney transplants in China. | 1998 | Transplant. Proc. | pmid:9838573 |
| Goh BL et al. | FK506 rescue therapy for acute renal allograft rejection. | 1998 | Transplant. Proc. | pmid:9838574 |
| Goh BL and Tan SY | FK506 "rescue" therapy complicated by renal tubular acidosis in renal allograft recipients. | 1998 | Transplant. Proc. | pmid:9838575 |
| Jeong HJ et al. | Vascular endothelin, TGF-beta, and PDGF expression in FK506 nephrotoxicity of rats. | 1998 | Transplant. Proc. | pmid:9838576 |
| Yura H et al. | Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate. | 1998 | Transplant. Proc. | pmid:9838577 |
| Yamauchi M et al. | Effects of FK506 on rat thymic microenvironment in thymocyte maturation, proliferation, and mobilization. | 1998 | Transplant. Proc. | pmid:9838578 |
| Watanabe K et al. | Prolongation effect of FK506 on the survival of 3-day preserved kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9838579 |
| Takada Y et al. | Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist. | 1998 | Transplant. Proc. | pmid:9838621 |
| Watanabe Y et al. | Enteric absorption of FK 506: estimation by a block liver perfusion technique in rats. | 1998 | Transplant. Proc. | pmid:9838656 |
| Hattori R et al. | FK 506 in cadaveric kidney transplantation from non-heart-beating donors. | 1998 | Transplant. Proc. | pmid:9838666 |
| Takeda M et al. | Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates. | 1998 | Transplant. Proc. | pmid:9838670 |
| Fukushima N et al. | Prolonged survival of pig cardiac xenografts in baboons by sequential cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9838671 |
| Nishimura Y et al. | A trial to obtain donor-specific immunotolerance using a vascularized thymus allograft. | 1998 | Transplant. Proc. | pmid:9838684 |
| Sanada O et al. | Establishment of chimerism in donors by intraportal injection of recipient-type bone marrow cells with concomitant administration of FK 506 before liver transplantation prolongs liver allograft survival in rats. | 1998 | Transplant. Proc. | pmid:9838689 |
| Sho M et al. | Simultaneous inoculation of donor lymphocyte subsets with transplantation in a rat cardiac allograft model. | 1998 | Transplant. Proc. | pmid:9838696 |
| Navarro-AntolÃn J et al. | CsA and FK506 up-regulate eNOS expression: role of reactive oxygen species and AP-1. | 1998 | Kidney Int. Suppl. | pmid:9839278 |
| del Castillo D et al. | Efficacy and safety of losartan in the treatment of hypertension in renal transplant recipients. | 1998 | Kidney Int. Suppl. | pmid:9839298 |
| Kass L et al. | Inhibition of the calcineurin-like protein phosphatase activity in Limulus ventral eye photoreceptor cells alters the characteristics of the spontaneous quantal bumps and the light-mediated inward currents, and enhances arrestin phosphorylation. | 1998 Nov-Dec | Vis. Neurosci. | pmid:9839968 |
| Hayashi M et al. | Characterization of allograft rejection in an experimental model of small intestinal transplantation. | 1998 Jul-Aug | J. Gastrointest. Surg. | pmid:9841989 |
| Wallemacq PE et al. | Pharmacokinetics of tacrolimus (FK506) in paediatric liver transplant recipients. | 1998 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:9842978 |
| duBell WH et al. | Independent inhibition of calcineurin and K+ currents by the immunosuppressant FK-506 in rat ventricle. | 1998 | Am. J. Physiol. | pmid:9843803 |
| Aoki Y et al. | CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku. | 1998 | Am. J. Physiol. | pmid:9843854 |
| Haug C et al. | Endothelin release by rabbit proximal tubule cells: modulatory effects of cyclosporine A, tacrolimus, HGF and EGF. | 1998 | Kidney Int. | pmid:9844139 |
| Jain AB et al. | A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil in primary adult liver transplant recipients: an interim report. | 1998 | Transplantation | pmid:9846530 |
| Sohn HW et al. | Engagement of CD99 induces apoptosis through a calcineurin-independent pathway in Ewing's sarcoma cells. | 1998 | Am. J. Pathol. | pmid:9846983 |
| Reddy RK et al. | High-molecular-weight FK506-binding proteins are components of heat-shock protein 90 heterocomplexes in wheat germ lysate. | 1998 | Plant Physiol. | pmid:9847114 |
| Laskow DA et al. | The role of tacrolimus in adult kidney transplantation: a review. | 1998 | Clin Transplant | pmid:9850440 |
| Nishida S et al. | Allograft rejection of small bowel transplantation in pigs. | 1998 | Surg. Today | pmid:9851621 |
| Gammie JS et al. | Tacrolimus-based partial conditioning produces stable mixed lymphohematopoietic chimerism and tolerance for cardiac allografts. | 1998 | Circulation | pmid:9852899 |
| Pou L et al. | Therapeutic drug monitoring of tacrolimus in liver transplantation, phase III FK506 multicenter Spanish Study Group: a two-year follow-up. | 1998 | Ther Drug Monit | pmid:9853973 |
| Brunet M et al. | Multicenter comparison of first- and second-generation IMx tacrolimus microparticle enzyme immunoassays in liver and kidney transplantation. | 1998 | Ther Drug Monit | pmid:9853987 |
| Hatori M et al. | Clinical and histopathologic examination of renal allografts treated with tacrolimus (FK506) for at least one year. | 1998 | Int. J. Urol. | pmid:9855119 |
| Olyaei AJ et al. | Interaction between tacrolimus and nefazodone in a stable renal transplant recipient. | 1998 Nov-Dec | Pharmacotherapy | pmid:9855339 |
| Hamilton GS and Steiner JP | Immunophilins: beyond immunosuppression. | 1998 | J. Med. Chem. | pmid:9857082 |
| Paul C and Ho VC | Ascomycins in dermatology. | 1998 | Semin Cutan Med Surg | pmid:9859912 |
| Shapiro VS et al. | Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP. | 1998 | J. Immunol. | pmid:9862666 |
| Maggi U et al. | Hepatitis B and C virus-induced diseases and acute rejection after liver transplantation. | 1998 | Transplant. Proc. | pmid:9865255 |
| Opelz G | Evaluation of immunosuppressive induction regimens in renal transplantation. Collaborative Transplant Study. | 1998 | Transplant. Proc. | pmid:9865286 |
| Moffatt SD et al. | Comparative efficacy of liposomal FK506 with FK506. | 1998 | Transplant. Proc. | pmid:9865297 |
| Brunet M et al. | Therapeutic drug monitoring of tacrolimus in kidney transplantation: 9-month follow-up. | 1998 | Transplant. Proc. | pmid:9865298 |
| Fleck PR et al. | Tacrolimus use in kidney-pancreas recipients is associated with less acute renal dysfunction than cyclosporine. | 1998 | Transplant. Proc. | pmid:9865299 |
| du Toit DF et al. | Tacrolimus (FK506) monotherapy provides potent and significant suppression of allogeneic foetal rat pancreatic allograft rejection. | 1998 | Transplant. Proc. | pmid:9865300 |
| Daoud AJ et al. | A comparison of the safety and efficacy of mycophenolate mofetil, prednisone and cyclosporine and mycophenolate mofetil, and prednisone and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865303 |
| Braun F et al. | How to handle mycophenolate mofetil in combination with tacrolimus? | 1998 | Transplant. Proc. | pmid:9865309 |
| Schorlemmer HU et al. | Long-term allograft survival and tolerance induction by the synergistic activity of malononitrilamides and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865312 |
| Metcalfe SM et al. | In vitro transcription and translation of the tumour suppressor protein P53: qualitative and quantitative effects of FK506 and rapamycin. | 1998 | Transplant. Proc. | pmid:9865315 |