| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Genital Diseases, Female | D005831 | 7 associated lipids |
| Mouth Diseases | D009059 | 5 associated lipids |
| Meningococcal Infections | D008589 | 3 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Delaney CP et al. | Allogeneic hematolymphoid microchimerism and prevention of autoimmune disease in the rat. A relationship between allo- and autoimmunity. | 1996 | J. Clin. Invest. | pmid:8550837 |
| Regazzi MB et al. | Interaction between FK 506 and diltiazem in an animal model. | 1996 | Transplant. Proc. | pmid:8623215 |
| Hashikura Y et al. | Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation. | 1996 | Transplant. Proc. | pmid:8623218 |
| Tomikawa S et al. | Immunosuppressive effects of bactobolamine in vitro and in vivo. | 1996 | Transplant. Proc. | pmid:8623223 |
| Nakajima H and Oka T | The inhibition of T-cell-receptor-induced Fas ligand upregulation by cyclosporine and FK 506. | 1996 | Transplant. Proc. | pmid:8623224 |
| Ko S et al. | Different immunosuppressive effects of liposomal FK506 in liver and kidney transplantation. | 1996 | Transplant. Proc. | pmid:8623229 |
| Morozumi K et al. | A comparative study of morphological characteristics of renal injuries of tacrolimus (FK506) and cyclosporin (CyA) in renal allografts: are the morphologic characteristics of FK506 and CyA nephrotoxicity similar? | 1996 | Transplant. Proc. | pmid:8623232 |
| Takada S et al. | HGF prevents tacrolimus (FK 506)-induced nephrotoxicity in SHR rats. | 1996 | Transplant. Proc. | pmid:8623236 |
| Elmer DS et al. | Use of FK506 immunosuppressive therapy in pancreas transplantation. | 1996 | J Transpl Coord | pmid:9188369 |
| Butt TR et al. | Molecular basis of immunosuppressive drug action: regulation of steroid receptor-mediated transcription by FK 506. | 1996 | Transplant. Proc. | pmid:8623486 |
| Troppmann C et al. | Perioperative immunosuppression as a critical determinant of early outcome after discordant xenoislet transplantation: a comparative study. | 1996 | Transplant. Proc. | pmid:8623487 |
| McKenna BA et al. | Tacrolimus (FK 506): a whole blood assay as measured on the Abbott IMx analyzer. | 1996 | Transplant. Proc. | pmid:8623491 |
| Stratta RJ et al. | FK 506 induction and rescue therapy in pancreas transplant recipients. | 1996 | Transplant. Proc. | pmid:8623492 |
| Birk PE et al. | Preliminary experience with FK 506 in pediatric renal transplant recipients: a single-center report. | 1996 | Transplant. Proc. | pmid:8623493 |
| Alloway RR et al. | Conversion from cyclosporine to tacrolimus in kidney, kidney/pancreas, and pancreas alone transplant recipients: the Memphis experience. | 1996 | Transplant. Proc. | pmid:8623494 |
| Chudek J et al. | [The role of endothelin in the physiology and pathophysiology of the circulatory system and kidneys]. | 1996 | Pol. Arch. Med. Wewn. | pmid:9139279 |
| Murao K et al. | Immunosuppressant agent FK506 stimulates growth hormone (GH) secretion and gene expression of hypothalamic GH-releasing hormone in the rat. | 1996 | Endocrinology | pmid:8603582 |
| Fay JW et al. | FK506 (Tacrolimus) monotherapy for prevention of graft-versus-host disease after histocompatible sibling allogenic bone marrow transplantation. | 1996 | Blood | pmid:8605372 |
| Greeno EW et al. | Exchange transfusion the hard way: massive hemolysis following transplantation of bone marrow with minor ABO incompatibility. | 1996 | Transfusion | pmid:8607158 |
| Suzuki S et al. | Pure red cell aplasia induced by FK506. | 1996 | Transplantation | pmid:8607191 |
| Busuttil RW et al. | General guidelines for the use of tacrolimus in adult liver transplant patients. | 1996 | Transplantation | pmid:8607197 |
| Kaplan B et al. | Frequency of hyperkalemia in recipients of simultaneous pancreas and kidney transplants with bladder drainage. | 1996 | Transplantation | pmid:8900321 |
| Min DI et al. | Circadian variation of tacrolimus disposition in liver allograft recipients. | 1996 | Transplantation | pmid:8900327 |
| Brazelton TR and Morris RE | Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide. | 1996 | Curr. Opin. Immunol. | pmid:8902398 |
| Corrigan CJ et al. | Glucocorticoid resistant asthma: T-lymphocyte steroid metabolism and sensitivity to glucocorticoids and immunosuppressive agents. | 1996 | Eur. Respir. J. | pmid:8902470 |
| Sakane T and Miura K | [Research for basic and clinical aspects of Behcet's disease--recent advance and future--]. | 1996 | Nippon Rinsho | pmid:8904250 |
| Weinzweig N et al. | Peripheral-nerve allotransplantation in rats immunosuppressed with transient or long-term FK-506. | 1996 | J Reconstr Microsurg | pmid:8905545 |
| Nagai H et al. | The role of interleukin-5 (IL-5) in allergic airway hyperresponsiveness in mice. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906215 |
| Tsunoda SM and Aweeka FT | The use of therapeutic drug monitoring to optimise immunosuppressive therapy. | 1996 | Clin Pharmacokinet | pmid:8906895 |
| Craescu CT et al. | Three-dimensional structure of the immunophilin-like domain of FKBP59 in solution. | 1996 | Biochemistry | pmid:8780506 |
| Singh N and Yu VL | Prophylaxis for cytomegalovirus disease after liver transplant. | 1996 | Clin. Infect. Dis. | pmid:8783744 |
| Sperr WR et al. | Effects of cyclosporin A and FK-506 on stem cell factor-induced histamine secretion and growth of human mast cells. | 1996 | J. Allergy Clin. Immunol. | pmid:8757216 |
| Venkataraman L et al. | Differential regulation of c-Rel translocation in activated B and T cells. | 1996 | J. Immunol. | pmid:8757620 |
| Brunner T et al. | Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506. | 1996 | Int. Immunol. | pmid:8757947 |
| Gusev AI et al. | A quantitative study of in vitro hepatic metabolism of tacrolimus (FK506) using secondary ion and matrix-assisted laser desorption/ionization mass spectrometry. | 1996 | Rapid Commun. Mass Spectrom. | pmid:8759330 |
| Rokaw MD et al. | FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells. | 1996 | Am. J. Physiol. | pmid:8760046 |
| Alper G and Small SL | Cerebrospinal fluid after organ transplantation. | 1996 | Transplant. Proc. | pmid:8908142 |
| Hisanaga Y et al. | Implication of nitric oxide synthase activity in the genesis of water immersion stress-induced gastric lesions in rats: the protective effects of FK506. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971291 |
| Namieno T and Uchino J | Comparative study of the effects of cyclosporine and FK 506 on rat hepatocytes cocultured with nonparenchymal liver cells. | 1996 | Transplant. Proc. | pmid:8908147 |
| Corey HE et al. | Improved renal allograft survival in children treated with FK 506 (tacrolimus) rescue therapy. | 1996 | Pediatr. Nephrol. | pmid:8971888 |
| Williams R et al. | Two-year data from the European multicentre tacrolimus (FK506) liver study. | 1996 | Transpl. Int. | pmid:8959812 |
| Jonas S et al. | Indications for tacrolimus anti-rejection therapy in liver allograft recipients. | 1996 | Transpl. Int. | pmid:8959817 |
| James DG | A new immunosuppressant: tacrolimus. | 1996 | Postgrad Med J | pmid:8977938 |
| Gruessner RW et al. | Use of FK 506 in pancreas transplantation. | 1996 | Transpl. Int. | pmid:8959841 |
| Fändrich F et al. | Circumvention of natural killer cell and T-cell mediated allogeneic target killing with tacrolimus (FK506) in small bowel transplantation related graft-vs-host disease. | 1996 | Transpl. Int. | pmid:8959843 |
| Antoniou E et al. | Effect of RS61443 in combination with leflunomide or FK506 on rat heart allograft survival. | 1996 | Transpl. Int. | pmid:8959858 |
| Golbaekdal K et al. | The acute effects of FK-506 on renal haemodynamics, water and sodium excretion and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide and vasopressin in pigs. | 1996 | J. Pharm. Pharmacol. | pmid:8961168 |
| Ichinari H et al. | Effects of portal venous inoculation with donor splenocytes on lung allograft survival in dogs. | 1996 | J. Thorac. Cardiovasc. Surg. | pmid:8751494 |
| Sunyecz JA et al. | Lymphoproliferative disorder involving the cervix in a patient being treated with FK-506. | 1996 | Gynecol. Oncol. | pmid:8751565 |
| Ho SN et al. | Dimeric ligands define a role for transcriptional activation domains in reinitiation. | 1996 | Nature | pmid:8752278 |
| Motamedi H et al. | Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. | 1996 | J. Bacteriol. | pmid:8752344 |
| Yamashita M et al. | Non-T cell-derived IL-4 plays an important role in IgE production induced by antigen resensitization and is resistant to FK506. | 1996 | J. Immunol. | pmid:8752921 |
| Silva ND and Prendergast FG | Tryptophan dynamics of the FK506 binding protein: time-resolved fluorescence and simulations. | 1996 | Biophys. J. | pmid:8785272 |
| Wagenknecht T et al. | Cryoelectron microscopy resolves FK506-binding protein sites on the skeletal muscle ryanodine receptor. | 1996 | Biophys. J. | pmid:8785329 |
| Laskow DA et al. | An open-label, concentration-ranging trial of FK506 in primary kidney transplantation: a report of the United States Multicenter FK506 Kidney Transplant Group. | 1996 | Transplantation | pmid:8878381 |
| Woodle ES et al. | Tacrolimus therapy for refractory acute renal allograft rejection: definition of the histologic response by protocol biopsies. | 1996 | Transplantation | pmid:8878382 |
| Kershner RP and Fitzsimmons WE | Relationship of FK506 whole blood concentrations and efficacy and toxicity after liver and kidney transplantation. | 1996 | Transplantation | pmid:8878385 |
| Nolan TJ and Schad GA | Tacrolimus allows autoinfective development of the parasitic nematode Strongyloides stercoralis. | 1996 | Transplantation | pmid:8878405 |
| Devine SM et al. | Tacrolimus (FK506)-induced cerebral blindness following bone marrow transplantation. | 1996 | Bone Marrow Transplant. | pmid:8879619 |
| Taylor P et al. | Conformational polymorphism in peptidic and nonpeptidic drug molecules. | 1996 | Biopolymers | pmid:9101762 |
| Ikegami S et al. | A facilitatory effect on the induction of long-term potentiation in vivo by chronic administration of antisense oligodeoxynucleotides against catalytic subunits of calcineurin. | 1996 | Brain Res. Mol. Brain Res. | pmid:8883951 |
| Soldin SJ | Receptor assays in the clinical laboratory. | 1996 | Clin. Biochem. | pmid:8884064 |
| Yoshida Y et al. | Effect of lipoprostaglandin E1 in concordant xenografts. | 1996 | Transplant. Proc. | pmid:8658716 |
| Kawauchi M et al. | Which are the target vessels of xeno- and allo-lung rejection?--a primate single lung transplantation study. | 1996 | Transplant. Proc. | pmid:8658719 |
| Sakimoto H et al. | Administration of tacrolimus (FK506) in hamster-to-rat pancreas xenotransplantation. | 1996 | Transplant. Proc. | pmid:8658727 |
| Takeda M et al. | Pretreatment with splenectomy and FK506 in xeno-lung transplantation. | 1996 | Transplant. Proc. | pmid:8658728 |
| Zou XM et al. | Immunosuppressive effect of FK506 on orthotopic liver and small bowel xenotransplantation (xenoOLTx and SBTx). | 1996 | Transplant. Proc. | pmid:8658729 |
| Kokado Y et al. | Hypertension in renal transplant recipients and its effect on long-term renal allograft survival. | 1996 | Transplant. Proc. | pmid:8658802 |
| Park KM et al. | Bone loss after orthotopic liver transplantation: FK 506 versus cyclosporine. | 1996 | Transplant. Proc. | pmid:8658863 |
| Kakefuda T et al. | Detection of nitrosylhemoglobin in liver allograft in rats by using near-infrared spectroscopy. | 1996 | Transplant. Proc. | pmid:8658885 |
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| Sempuku T et al. | Osteogenic potential of allogeneic rat marrow cells in porous hydroxyapatite ceramics: a histological study. | 1996 | J. Orthop. Res. | pmid:8982133 |
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| McMichael J et al. | Computer-guided randomized concentration-controlled trials of tacrolimus in autoimmunity: multiple sclerosis and primary biliary cirrhosis. | 1996 | Ther Drug Monit | pmid:8857564 |
| Bartlett ST et al. | Equivalent success of simultaneous pancreas kidney and solitary pancreas transplantation. A prospective trial of tacrolimus immunosuppression with percutaneous biopsy. | 1996 | Ann. Surg. | pmid:8857849 |
| Takuma T et al. | Dephosphorylation of cofilin in parotid acinar cells. | 1996 | J. Biochem. | pmid:8864841 |
| Yamada A et al. | Long-term acceptance of major histocompatibility complex-mismatched cardiac allograft induced by a low dose of CTLA4IgM plus FK506. | 1996 | Microbiol. Immunol. | pmid:8865157 |
| Christians U et al. | Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. | 1996 | Br J Clin Pharmacol | pmid:8866917 |
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| Adams DH and Liu Q | FK506 inhibits human lymphocyte migration and the production of lymphocyte chemotactic factors in liver allograft recipients. | 1996 | Hepatology | pmid:8675167 |
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| Benelli U et al. | FK-506 delays corneal graft rejection in a model of corneal xenotransplantation. | 1996 | J Ocul Pharmacol Ther | pmid:8951679 |
| Ueda S et al. | In-vitro metabolic studies of tacrolimus using precision-cut rat and human liver slices. | 1996 | J Pharm Biomed Anal | pmid:8951695 |
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| Villalba L and Adams EM | Update on therapy for refractory dermatomyositis and polymyositis. | 1996 | Curr Opin Rheumatol | pmid:9018458 |
| Asante-Korang A et al. | Experience of FK506 immune suppression in pediatric heart transplantation: a study of long-term adverse effects. | 1996 | J. Heart Lung Transplant. | pmid:8732602 |
| Vilquin JT et al. | Partial laminin alpha2 chain restoration in alpha2 chain-deficient dy/dy mouse by primary muscle cell culture transplantation. | 1996 | J. Cell Biol. | pmid:8601607 |
| Schuetz EG et al. | Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. | 1996 | Mol. Pharmacol. | pmid:8632764 |
| Sun S et al. | Effect of tacrolimus on hemodynamics and absorption of experimental small intestinal transplants. | 1996 | Transplantation | pmid:8633368 |
| Kashu Y et al. | The effect of combination splenectomy and low-dose FK506 therapy on graft survival after liver allograft transplantation in rats. | 1996 | Transplantation | pmid:8633382 |
| Yoshimura N et al. | A case report of pregnancy in renal transplant recipient treated with FK506 (tacrolimus). | 1996 | Transplantation | pmid:8633388 |
| Ohtomo Y et al. | C-peptide stimulates rat renal tubular Na+, K(+)-ATPase activity in synergism with neuropeptide Y. | 1996 | Diabetologia | pmid:8635672 |