| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Genital Diseases, Female | D005831 | 7 associated lipids |
| Mouth Diseases | D009059 | 5 associated lipids |
| Meningococcal Infections | D008589 | 3 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Albano L et al. | OSAKA trial: a randomized, controlled trial comparing tacrolimus QD and BD in kidney transplantation. | 2013 | Transplantation | pmid:23982340 |
| Tsapepas D et al. | Sublingual tacrolimus: a pharmacokinetic evaluation pilot study. | 2013 | Pharmacotherapy | pmid:23307542 |
| Tanoue Y and Tominaga R | [Donor heart preservation with University of Wisconsin solution and immunosuppressive therapy with drip-infusion of tacrolimus]. | 2013 | Kyobu Geka | pmid:23985403 |
| Zhou YN et al. | Effect of amlodipine on the pharmacokinetics of tacrolimus in rats. | 2013 | Xenobiotica | pmid:23312000 |
| Landy J and Hart AL | Commentary: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis. | 2013 | Aliment. Pharmacol. Ther. | pmid:23336680 |
| Hirai F et al. | Letter: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis. | 2013 | Aliment. Pharmacol. Ther. | pmid:23336690 |
| Schmidt KJ et al. | Letter: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis - authors' reply. | 2013 | Aliment. Pharmacol. Ther. | pmid:23336691 |
| Heavner MS et al. | Clinical outcomes associated with conversion from brand-name to generic tacrolimus in hospitalized kidney transplant recipients. | 2013 | Am J Health Syst Pharm | pmid:23943182 |
| Siepmann D et al. | Evaluation of the antipruritic effects of topical pimecrolimus in non-atopic prurigo nodularis: results of a randomized, hydrocortisone-controlled, double-blind phase II trial. | 2013 | Dermatology (Basel) | pmid:24281309 |
| Becker S et al. | Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus, and everolimus by liquid chromatography-tandem mass spectrometric assay. | 2013 | Ther Drug Monit | pmid:23188181 |
| Narayanan M et al. | Outcomes in African American kidney transplant patients receiving tacrolimus and mycophenolic acid immunosuppression. | 2013 | Transplantation | pmid:23423268 |
| Øzbay LA et al. | The effects of calcineurin inhibitors on prostanoid synthesis: a randomized cross-over study in healthy humans. | 2013 | Transpl. Int. | pmid:23190385 |
| Gaber AO et al. | Acute rejection characteristics from a prospective, randomized, double-blind, placebo-controlled multicenter trial of early corticosteroid withdrawal. | 2013 | Transplantation | pmid:23423269 |
| Tempestilli M et al. | Low plasma concentrations of albumin influence the affinity column-mediated immunoassay method for the measurement of tacrolimus in blood during the early period after liver transplantation. | 2013 | Ther Drug Monit | pmid:23191996 |
| Guethoff S et al. | Ten-year results of a randomized trial comparing tacrolimus versus cyclosporine a in combination with mycophenolate mofetil after heart transplantation. | 2013 | Transplantation | pmid:23423270 |
| Mattar T et al. | Effect of rhBMP-2 and VEGF in a vascularized bone allotransplant experimental model based on surgical neoangiogenesis. | 2013 | J. Orthop. Res. | pmid:23192572 |
| Levitsky J et al. | Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients. | 2013 | Hepatology | pmid:22234876 |
| Hao D et al. | Lymphocytic infiltration of the eyelid: two cases responding to tacrolimus and topical glucocorticoid. | 2013 | Acta Derm. Venereol. | pmid:23423497 |
| Fang Y et al. | T-cell acute lymphoblastic leukaemia after liver transplantation: post-transplant lymphoproliferative disorder or coincidental de novo leukaemia? | 2013 | Hematol Oncol | pmid:22618860 |
| White M et al. | Cardiac signaling molecules and plasma biomarkers after cardiac transplantation: impact of tacrolimus versus cyclosporine. | 2013 | J. Heart Lung Transplant. | pmid:24263023 |
| Silva HT et al. | Planned randomized conversion from tacrolimus to sirolimus-based immunosuppressive regimen in de novo kidney transplant recipients. | 2013 | Am. J. Transplant. | pmid:24266969 |
| Ricciardelli I et al. | Rapid generation of EBV-specific cytotoxic T lymphocytes resistant to calcineurin inhibitors for adoptive immunotherapy. | 2013 | Am. J. Transplant. | pmid:24266973 |
| Chen YP et al. | [The clinical efficacy and safety of tacrolimus in patients with myasthenia gravis]. | 2013 | Zhonghua Nei Ke Za Zhi | pmid:24266997 |
| Frassetto L et al. | Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. | 2013 | Biopharm Drug Dispos | pmid:24030928 |
| Chen D et al. | FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation. | 2013 | J. Bacteriol. | pmid:23435975 |
| Schmidt KJ et al. | Short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis - experience in 130 patients. | 2013 | Aliment. Pharmacol. Ther. | pmid:23121200 |
| TruneÄka P | [Immunosuppression after liver transplant, now and in future]. | 2013 | Vnitr Lek | pmid:24007221 |
| Bendezú GarcÃa RA et al. | Biological therapy for Crohn's disease in a liver transplant patient. | 2013 | J Dig Dis | pmid:23437819 |
| Ogawa K et al. | A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. | 2013 | Xenobiotica | pmid:23153054 |
| Zuo XC et al. | Effect of CYP3A5*3 polymorphism on pharmacokinetic drug interaction between tacrolimus and amlodipine. | 2013 | Drug Metab. Pharmacokinet. | pmid:23438946 |
| Barraclough KA et al. | A differential impact of mycophenolic acid, prednisolone, and tacrolimus exposure on sCD30 levels in adult kidney transplant recipients. | 2013 | Ther Drug Monit | pmid:23503451 |
| Muthukumar T et al. | HIV-infected kidney graft recipients managed with an early corticosteroid withdrawal protocol: clinical outcomes and messenger RNA profiles. | 2013 | Transplantation | pmid:23503504 |
| Manojlovic Z et al. | Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis. | 2013 | PLoS ONE | pmid:23755290 |
| Shimmura-Tomita M et al. | Keratoplasty postoperative treatment update. | 2013 | Cornea | pmid:24104936 |
| Annesley TM et al. | Standardization of LC-MS for therapeutic drug monitoring of tacrolimus. | 2013 | Clin. Chem. | pmid:23902823 |
| Pawinski T et al. | Development and validation of limited sampling strategies for the estimation of mycophenolic acid area under the curve in adult kidney and liver transplant recipients receiving concomitant enteric-coated mycophenolate sodium and tacrolimus. | 2013 | Ther Drug Monit | pmid:24192641 |
| Yates CJ et al. | Screening for new-onset diabetes after kidney transplantation: limitations of fasting glucose and advantages of afternoon glucose and glycated hemoglobin. | 2013 | Transplantation | pmid:23902993 |
| Kim BR et al. | A case of tacrolimus-induced supraventricular arrhythmia after kidney transplantation. | 2013 | Sao Paulo Med J | pmid:23903271 |
| Zirbs M et al. | Demodicidosis associated with psoriasis therapy--two case reports. | 2013 | Australas. J. Dermatol. | pmid:23905976 |
| Carmona A et al. | Distinct deleterious effects of cyclosporine and tacrolimus and combined tacrolimus-sirolimus on endothelial cells: protective effect of defibrotide. | 2013 | Biol. Blood Marrow Transplant. | pmid:23845694 |
| Yoshida T et al. | Effect of aminoalkyl methacrylate copolymer E/HCl on in vivo absorption of poorly water-soluble drug. | 2013 | Drug Dev Ind Pharm | pmid:23062024 |
| Mizuno S et al. | Combination assays for evaluation of immune function and CYP3A5 genotype to identify the risk of infectious complications and mortality in living donor liver transplant patients. | 2013 | Ann. Transplant. | pmid:23845965 |
| Perez-Simón JA et al. | The combination of sirolimus plus tacrolimus improves outcome after reduced-intensity conditioning, unrelated donor hematopoietic stem cell transplantation compared with cyclosporine plus mycofenolate. | 2013 | Haematologica | pmid:23065527 |
| Sánchez Ferreiro AV and Muñoz Bellido L | [Tacrolimus in the treatment of atopic kerato-conjunctivitis]. | 2013 | Arch Soc Esp Oftalmol | pmid:23886369 |
| Tokunaga M et al. | Hereditary spastic paraplegia protein spartin is an FK506-binding protein identified by mRNA display. | 2013 | Chem. Biol. | pmid:23890011 |
| Nakagaki T et al. | FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. | 2013 | Autophagy | pmid:23800841 |
| Kapoor K et al. | Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70. | 2013 | J. Biol. Chem. | pmid:24064216 |
| Sun W et al. | [Association factors analysis of diarrhea in patients receiving kidney transplantation]. | 2013 | Beijing Da Xue Xue Bao | pmid:24136278 |
| Maguire O et al. | Nuclear translocation of nuclear factor of activated T cells (NFAT) as a quantitative pharmacodynamic parameter for tacrolimus. | 2013 | Cytometry A | pmid:24136923 |
| de Heus C et al. | Analysis of EGF receptor oligomerization by homo-FRET. | 2013 | Methods Cell Biol. | pmid:24143984 |
| Hengge UR | [Off-label indications for topical tacrolimus]. | 2013 | Hautarzt | pmid:24150824 |
| Thin LW et al. | Oral tacrolimus for the treatment of refractory inflammatory bowel disease in the biologic era. | 2013 | Inflamm. Bowel Dis. | pmid:23615528 |
| Choi JY and Kwon OJ | Post-transplant diabetes mellitus: is it associated with poor allograft outcomes in renal transplants? | 2013 | Transplant. Proc. | pmid:24156999 |
| Chapin RW et al. | Case report: imaging features in a renal transplant patient with calcineurin inhibitor-induced pain syndrome (CIPS). | 2013 | Skeletal Radiol. | pmid:23615775 |
| Radu CD et al. | Cotton-made cellulose support for anti-allergic pajamas. | 2013 | Carbohydr Polym | pmid:23618296 |
| First MR et al. | New-onset diabetes after transplantation (NODAT): an evaluation of definitions in clinical trials. | 2013 | Transplantation | pmid:23619735 |
| RodrÃguez-Perálvarez M et al. | Tacrolimus exposure after liver transplantation in randomized controlled trials: too much for too long. | 2013 | Am. J. Transplant. | pmid:23621166 |
| Madeleine MM et al. | HPV-related cancers after solid organ transplantation in the United States. | 2013 | Am. J. Transplant. | pmid:24119294 |
| Lehner GM and Linek M | A case of vesicular cutaneous lupus erythematosus in a Border collie successfully treated with topical tacrolimus and nicotinamide-tetracycline. | 2013 | Vet. Dermatol. | pmid:24118370 |
| Ã…sberg A et al. | Inclusion of CYP3A5 genotyping in a nonparametric population model improves dosing of tacrolimus early after transplantation. | 2013 | Transpl. Int. | pmid:24118301 |
| Ogata H | Response to Roblin and Del Tedesco. | 2013 | Inflamm. Bowel Dis. | pmid:23538853 |
| Ho ET et al. | Once-daily extended-release versus twice-daily standard-release tacrolimus in kidney transplant recipients: a systematic review. | 2013 | Transplantation | pmid:23542469 |
| Zhu L et al. | A limited sampling strategy for tacrolimus in liver transplant patients. | 2013 | Int J Clin Pharmacol Ther | pmid:23547852 |
| MartÃn-Cano FE et al. | mTOR pathway and Ca²⺠stores mobilization in aged smooth muscle cells. | 2013 | Aging (Albany NY) | pmid:23661091 |
| Yadav DK et al. | Tacrolimus-induced severe cholestasis complicating renal transplantation. | 2013 | Ren Fail | pmid:23560366 |
| de Jonge H and Kuypers DR | Response to "CYP3A5 genotype, but not CYP3A4*1b, CYP3A4*22, or hematocrit, predicts tacrolimus dose requirements in Brazilian renal transplant patients". | 2013 | Clin. Pharmacol. Ther. | pmid:23665867 |
| Saint-Marcoux F et al. | Lessons from routine dose adjustment of tacrolimus in renal transplant patients based on global exposure. | 2013 | Ther Drug Monit | pmid:23666572 |
| Spierings N et al. | CYP3A5 genotype had no impact on intrapatient variability of tacrolimus clearance in renal transplant recipients. | 2013 | Ther Drug Monit | pmid:23666583 |
| O'Connell PJ et al. | Multicenter Australian trial of islet transplantation: improving accessibility and outcomes. | 2013 | Am. J. Transplant. | pmid:23668890 |
| Fan L et al. | Tacrolimus is an alternative therapy option for the treatment of adult steroid-resistant nephrotic syndrome: a prospective, multicenter clinical trial. | 2013 | Int Urol Nephrol | pmid:22684795 |
| Viana RA et al. | Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast. | 2013 | Genetics | pmid:23934882 |
| Dufty NE et al. | Pharmacokinetic interaction of maraviroc with tacrolimus in a patient coinfected with HIV and hepatitis B virus following hepatic transplant due to hepatocellular carcinoma. | 2013 | J. Antimicrob. Chemother. | pmid:23249840 |
| Fuchs U et al. | Clinical outcome in cardiac transplant recipients receiving tacrolimus retard. | 2013 | Transplant. Proc. | pmid:23769094 |
| Gauthier AS et al. | [Galenic and analytic development of tacrolimus 0.06% eye drops]. | 2013 | J Fr Ophtalmol | pmid:23218600 |
| Koc-Zorawska E et al. | Vascular adhesion protein-1, a novel molecule, in kidney and heart allograft recipients. | 2013 | Transplant. Proc. | pmid:23769096 |
| Akhi SN et al. | Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus. | 2013 | Fertil. Steril. | pmid:23218920 |
| Kymionis GD et al. | Treatment of superior limbic keratoconjunctivitis with topical tacrolimus 0.03% ointment. | 2013 | Cornea | pmid:23770977 |
| Yan L et al. | Immunomodulatory effectiveness of tacrolimus in preventing epidural scar adhesion after laminectomy in rat model. | 2013 | Eur. J. Pharmacol. | pmid:23220162 |
| Ju MK et al. | Mizoribine versus mycophenolate mofetil in combination therapy with tacrolimus for de novo kidney transplantation: evaluation of efficacy and safety. | 2013 | Transplant. Proc. | pmid:23726602 |
| Bradford J and Fischer G | Management of vulvovaginal lichen planus: a new approach. | 2013 | J Low Genit Tract Dis | pmid:23222048 |
| Slatinska J et al. | Long-term follow-up of stable kidney transplant recipients after conversion from tacrolimus twice daily immediate release to tacrolimus once-daily prolonged release: a large single-center experience. | 2013 | Transplant. Proc. | pmid:23726604 |
| Miyauchi T et al. | Therapeutic targeting of the axonal and microvascular change associated with repetitive mild traumatic brain injury. | 2013 | J. Neurotrauma | pmid:23796228 |
| Jakes AD et al. | Case report: Guillain-BarreÌ syndrome following renal transplantation--a diagnostic dilemma. | 2013 | Nephron Clin Pract | pmid:24503667 |
| Nakane S et al. | Successful treatment of stiff person syndrome with sequential use of tacrolimus. | 2013 | J. Neurol. Neurosurg. Psychiatr. | pmid:23715915 |
| Mehta SJ et al. | Review article: strategies for the management of chronic unremitting ulcerative colitis. | 2013 | Aliment. Pharmacol. Ther. | pmid:23718288 |
| Kurasawa T et al. | Successful treatment of class IV+V lupus nephritis with combination therapy of high-dose corticosteroids, tacrolimus and intravenous cyclophosphamide. | 2013 | Intern. Med. | pmid:23676603 |
| Peng Y et al. | Donor-derived mesenchymal stem cells combined with low-dose tacrolimus prevent acute rejection after renal transplantation: a clinical pilot study. | 2013 | Transplantation | pmid:23263506 |
| Güngör S et al. | Squamous cell carcinoma on the lower lip after using topical calcineurin inhibitor. | 2013 | J Dtsch Dermatol Ges | pmid:23763692 |
| Kuypers DR et al. | Improved adherence to tacrolimus once-daily formulation in renal recipients: a randomized controlled trial using electronic monitoring. | 2013 | Transplantation | pmid:23263559 |
| Wang Z et al. | L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/Hâ‚‚S pathway. | 2013 | Neuroscience | pmid:23376738 |
| Cantisani C et al. | Generalized morphea successfully treated with tacrolimus 0.1% ointment. | 2013 | J Drugs Dermatol | pmid:23377321 |
| Lee KY et al. | Endothelin-1 enhances the proliferation of normal human melanocytes in a paradoxical manner from the TNF-α-inhibited condition, but tacrolimus promotes exclusively the cellular migration without proliferation: a proposed action mechanism for combination therapy of phototherapy and topical tacrolimus in vitiligo treatment. | 2013 | J Eur Acad Dermatol Venereol | pmid:22404745 |
| Herbst S et al. | A new and clinically relevant murine model of solid-organ transplant aspergillosis. | 2013 | Dis Model Mech | pmid:23264562 |
| Millán O et al. | Intracellular IFN-γ and IL-2 expression monitoring as surrogate markers of the risk of acute rejection and personal drug response in de novo liver transplant recipients. | 2013 | Cytokine | pmid:23265966 |
| Kitahama M et al. | Efficacy of adjunct tacrolimus treatment in patients with rheumatoid arthritis with inadequate responses to methotrexate. | 2013 | Mod Rheumatol | pmid:22975732 |
| Wojtusciszyn A et al. | Continuous glucose monitoring after kidney transplantation in non-diabetic patients: early hyperglycaemia is frequent and may herald post-transplantation diabetes mellitus and graft failure. | 2013 | Diabetes Metab. | pmid:23999231 |
| Herzer K et al. | [HCV reinfection after liver transplantation - management and first experiences with telaprevir-based triple therapy]. | 2013 | Dtsch. Med. Wochenschr. | pmid:24002874 |
| Roblin X and Del Tedesco E | Tacrolimus in the management of hospitalized patients with steroid-refractory ulcerative colitis: don't forget cytomegalovirus! | 2013 | Inflamm. Bowel Dis. | pmid:23314247 |
| Chhabra D et al. | Impact of calcineurin-inhibitor conversion to mTOR inhibitor on renal allograft function in a prednisone-free regimen. | 2013 | Am. J. Transplant. | pmid:24007570 |
| Pham PT and Reddy UG | Transplantation: Immunosuppression and risk of polyomavirus BK replication. | 2013 | Nat Rev Nephrol | pmid:23399577 |