| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Genital Diseases, Female | D005831 | 7 associated lipids |
| Mouth Diseases | D009059 | 5 associated lipids |
| Meningococcal Infections | D008589 | 3 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dusting GJ et al. | Cyclosporin A and tacrolimus (FK506) suppress expression of inducible nitric oxide synthase in vitro by different mechanisms. | 1999 | Br. J. Pharmacol. | pmid:10510443 |
| Bas E et al. | Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses. | 2012 | Br. J. Pharmacol. | pmid:22320124 |
| Pahl A et al. | Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. | 2002 | Br. J. Pharmacol. | pmid:11959794 |
| Jakobovits SL and Travis SP | Management of acute severe colitis. | 2005 | Br. Med. Bull. | pmid:16847166 |
| Sato Y et al. | Acute encephalitis with refractory, repetitive partial seizures: Pathological findings and a new therapeutic approach using tacrolimus. | 2016 | Brain Dev. | pmid:26906012 |
| Takahashi Y et al. | Immunomodulatory therapy versus surgery for Rasmussen syndrome in early childhood. | 2013 | Brain Dev. | pmid:23433490 |
| Kakisaka Y et al. | Successful treatment of a 2-year-old girl with intractable myasthenia gravis using tacrolimus. | 2006 | Brain Dev. | pmid:16564661 |
| Ishigaki K et al. | Benefits of FK 506 for refractory eye symptoms in a young child with ocular myasthenia gravis. | 2009 | Brain Dev. | pmid:18845408 |
| Mori T et al. | Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus. | 2013 | Brain Dev. | pmid:22840813 |
| Bennett PC et al. | Novel effects on memory observed following unilateral intracranial administration of okadaic acid, cyclosporin A, FK506 and [MeVal4]CyA. | 2003 | Brain Res. | pmid:14519526 |
| Wright AK et al. | Microglial activation is not prevented by tacrolimus but dopamine neuron damage is reduced in a rat model of Parkinson's disease progression. | 2008 | Brain Res. | pmid:18495090 |
| Morioka M et al. | Activities of calcineurin and phosphatase 2A in the hippocampus after transient forebrain ischemia. | 1999 | Brain Res. | pmid:10320733 |
| Takano H et al. | Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization. | 2003 | Brain Res. | pmid:12543454 |
| Kuroda S et al. | The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats. | 1999 | Brain Res. | pmid:10415369 |
| Takadera T and Ohyashiki T | Caspase-dependent apoptosis induced by calcineurin inhibitors was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical cells. | 2007 | Brain Res. | pmid:17166486 |
| Okubo S et al. | FK-506 extended the therapeutic time window for thrombolysis without increasing the risk of hemorrhagic transformation in an embolic rat stroke model. | 2007 | Brain Res. | pmid:17316578 |
| Terashima A et al. | Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and rapamycin. | 1998 | Brain Res. | pmid:9555045 |
| Manev H et al. | Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate. | 1993 | Brain Res. | pmid:7504570 |
| Manáková S et al. | Failure of FK506 (tacrolimus) to alleviate apomorphine-induced circling in rat Parkinson model in spite of some cytoprotective effects in SH-SY5Y dopaminergic cells. | 2005 | Brain Res. | pmid:15748876 |
| Furuichi Y et al. | Neuroprotective action of tacrolimus (FK506) in focal and global cerebral ischemia in rodents: dose dependency, therapeutic time window and long-term efficacy. | 2003 | Brain Res. | pmid:12591130 |
| Herr I et al. | FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. | 1999 | Brain Res. | pmid:10224298 |
| Nito C et al. | Mild hypothermia enhances the neuroprotective effects of FK506 and expands its therapeutic window following transient focal ischemia in rats. | 2004 | Brain Res. | pmid:15145754 |
| Sasaki T et al. | FK506 abrogates delayed neuronal death via suppression of nitric oxide production in rats. | 2004 | Brain Res. | pmid:15120581 |
| Shichinohe H et al. | FK506 reduces infarct volume due to permanent focal cerebral ischemia by maintaining BAD turnover and inhibiting cytochrome c release. | 2004 | Brain Res. | pmid:14972653 |
| Martin L et al. | Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A. | 2009 | Brain Res. | pmid:19071093 |
| Yu Y et al. | Calcineurin-independent inhibition of the delayed rectifier K+ current by the immunosuppressant FK506 in rat hippocampal neurons. | 2007 | Brain Res. | pmid:17355875 |
| Hodgkiss JP and Kelly JS | Only 'de novo' long-term depression (LTD) in the rat hippocampus in vitro is blocked by the same low concentration of FK506 that blocks LTD in the visual cortex. | 1995 | Brain Res. | pmid:8821755 |
| Yoshimoto T et al. | Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat. | 2001 | Brain Res. | pmid:11311876 |
| Wakita H et al. | Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia. | 1998 | Brain Res. | pmid:9593846 |
| Phillis JW et al. | Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. | 2002 | Brain Res. | pmid:12443975 |
| Yao W et al. | Aβ induces acute depression of excitatory glutamatergic synaptic transmission through distinct phosphatase-dependent mechanisms in rat CA1 pyramidal neurons. | 2013 | Brain Res. | pmid:23583290 |
| Bennett PC et al. | Cyclosporin A, FK506 and rapamycin produce multiple, temporally distinct, effects on memory following single-trial, passive avoidance training in the chick. | 2002 | Brain Res. | pmid:11821011 |
| Cardoso SM and Oliveira CR | The role of calcineurin in amyloid-beta-peptides-mediated cell death. | 2005 | Brain Res. | pmid:15975561 |
| Shibazaki Y et al. | Effect of the immunosuppressant drug FK506 on neonatal cerebral mitochondrial function and energy metabolism after transient intrauterine ischemia in rats. | 2001 | Brain Res. | pmid:11172783 |
| Maeda M et al. | Tacrolimus (FK506) suppresses rt-PA-induced hemorrhagic transformation in a rat thrombotic ischemia stroke model. | 2009 | Brain Res. | pmid:19101526 |
| Trajković V et al. | Cyclosporin A inhibits activation of inducible nitric oxide synthase in C6 glioma cell line. | 1999 | Brain Res. | pmid:9878697 |
| Moia LJ et al. | Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat. | 1994 | Brain Res. | pmid:7522929 |
| Park CH et al. | Calcineurin mediates AKT dephosphorylation in the ischemic rat retina. | 2008 | Brain Res. | pmid:18703031 |
| Yoshimoto T and Siesjö BK | Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia. | 1999 | Brain Res. | pmid:10519051 |
| Tanaka K et al. | FK506 ameliorates the discrimination learning impairment due to preventing the rarefaction of white matter induced by chronic cerebral hypoperfusion in rats. | 2001 | Brain Res. | pmid:11430878 |
| Rahimian R et al. | Tropisetron ameliorates ischemic brain injury in an embolic model of stroke. | 2011 | Brain Res. | pmid:21447327 |
| Furuichi Y et al. | Multiple modes of action of tacrolimus (FK506) for neuroprotective action on ischemic damage after transient focal cerebral ischemia in rats. | 2004 | Brain Res. | pmid:15212998 |
| Tanaka K et al. | Immunosuppressive (FK506) and non-immunosuppressive (GPI1046) immunophilin ligands activate neurotrophic factors in the mouse brain. | 2003 | Brain Res. | pmid:12706270 |
| Nagatomo I et al. | Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. | 2001 | Brain Res. | pmid:11150489 |
| Masumura C et al. | Unilateral vestibular deafferentation-induced changes in calcium signaling-related molecules in the rat vestibular nuclear complex. | 2007 | Brain Res. | pmid:17275794 |
| Lu YF et al. | Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus. | 1996 | Brain Res. | pmid:8874888 |
| Sakai K et al. | The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents. | 1991 | Brain Res. | pmid:1723023 |
| Reeves TM et al. | Preferential neuroprotective effect of tacrolimus (FK506) on unmyelinated axons following traumatic brain injury. | 2007 | Brain Res. | pmid:17481596 |
| Winter C et al. | MAP kinase phosphatase 1 is expressed and enhanced by FK506 in surviving mamillary, but not degenerating nigral neurons following axotomy. | 1998 | Brain Res. | pmid:9729383 |
| Tanaka K et al. | Immunosuppressive and non-immunosuppressive immunophilin ligands improve H(2)O(2)-induced cell damage by increasing glutathione levels in NG108-15 cells. | 2001 | Brain Res. | pmid:11166708 |
| Macleod MR et al. | Serum withdrawal causes apoptosis in SHSY 5Y cells. | 2001 | Brain Res. | pmid:11166724 |
| Hernández-Espinosa D and Morton AJ | Calcineurin inhibitors cause an acceleration of the neurological phenotype in a mouse transgenic for the human Huntington's disease mutation. | 2006 | Brain Res. Bull. | pmid:16716837 |
| Luo J et al. | Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain. | 2008 | Brain Res. Bull. | pmid:18534252 |
| Avramut M et al. | The immunosuppressant drug FK506 is a potent trophic agent for human fetal neurons. | 2001 | Brain Res. Dev. Brain Res. | pmid:11744119 |
| Domañska-Janik K et al. | Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm. | 2004 | Brain Res. Mol. Brain Res. | pmid:14969736 |
| Noto T et al. | Neuroprotective effect of tacrolimus (FK506) on ischemic brain damage following permanent focal cerebral ischemia in the rat. | 2004 | Brain Res. Mol. Brain Res. | pmid:15337315 |
| Ikegami S et al. | A facilitatory effect on the induction of long-term potentiation in vivo by chronic administration of antisense oligodeoxynucleotides against catalytic subunits of calcineurin. | 1996 | Brain Res. Mol. Brain Res. | pmid:8883951 |
| Badr R et al. | Assessment of global ischemic/reperfusion and Tacrolimus administration on CA1 region of hippocampus: gene expression profiles of BAX and BCL2 genes. | 2016 | Bratisl Lek Listy | pmid:27546370 |
| Yang LM et al. | Experimental research on end-to-side anastomosis of peripheral nerves and effect of FK506 on end-to-side anastomosis. | 2014 | Bratisl Lek Listy | pmid:25573729 |
| Varga M et al. | Tacrolimus inhibits intimal hyperplasia in arterialised veins in rats. | 2012 | Bratisl Lek Listy | pmid:22380493 |
| Henrique Pinto C et al. | Targeted preemptive therapy according to perceived risk of CMV infection after kidney transplantation. | Braz J Infect Dis | pmid:27643978 | |
| Kubiça TF et al. | Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates. | Braz J Infect Dis | pmid:27697432 | |
| Nassar CA et al. | Biochemical evaluation of glycemic levels of long-term tacrolimus therapy in rats. | 2007 Oct-Dec | Braz Oral Res | pmid:18060253 |
| Silva LA et al. | Impact of initial exposure to calcineurin inhibitors on kidney graft function of patients at high risk to develop delayed graft function. | 2006 | Braz. J. Med. Biol. Res. | pmid:16400463 |
| Souza DS et al. | Death switch for gene therapy: application to erythropoietin transgene expression. | 2010 | Braz. J. Med. Biol. Res. | pmid:20499015 |
| Cui W et al. | Therapy of tacrolimus combined with corticosteroids in idiopathic membranous nephropathy. | 2017 | Braz. J. Med. Biol. Res. | pmid:28355356 |
| Giordani F et al. | Tacrolimus (FK506) reduces ischemia-induced hippocampal damage in rats: a 7- and 30-day study. | 2003 | Braz. J. Med. Biol. Res. | pmid:12700828 |
| Denardi LB et al. | Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates. | 2015 | Braz. J. Microbiol. | pmid:26221097 |
| Mackesy MM et al. | Immunosuppressant-induced acneiform eruption of the breast. | Breast J | pmid:25229395 | |
| Aoki M et al. | [Histological observations of immunosuppressive effects of FK-506 in canine lung allotransplantation]. | 1989 | Bull Chest Dis Res Inst Kyoto Univ | pmid:2482787 |
| Radwan-Oczko M et al. | Clinical evaluation of marginal parodontium condition in patients after kidney graft treated with calcineurine inhibitors and calcium channel blockers. | 2004 May-Dec | Bull Group Int Rech Sci Stomatol Odontol | pmid:16335621 |
| Ohe M and Bohgaki T | A Case of Adult-Onset Still's Disease Treated with Monitoring of Serum Tacrolimus Levels. | 2015 | Bull Hosp Jt Dis (2013) | pmid:26535602 |
| Cordonnier M | [Visual cortes--is it a concern?]. | 2007 | Bull Soc Belge Ophtalmol | pmid:17718224 |
| Sarnacki S et al. | [Pathophysiology of intestinal grafts]. | 2012 | Bull. Acad. Natl. Med. | pmid:23420958 |
| Borel JF and Baumann G | Molecular mechanisms of immunosuppressive agents. | 1994 | Bull. Mem. Acad. R. Med. Belg. | pmid:7531051 |
| Cetinkale O et al. | Modulating the functions of neutrophils and lipid peroxidation by FK506 in a rat model of thermal injury. | 1999 | Burns | pmid:10208383 |
| Renoir JM et al. | [Effect of immunosuppressants FK506 and rapamycin on the function of progesterone receptor: protein "p59-HBI", intersection between immunology and endocrinology?]. | 1992 | C. R. Acad. Sci. III, Sci. Vie | pmid:1284044 |
| Renoir JM et al. | Immunological identification of a 50 kDa Mr FK506-binding immunophilin as a component of the non-DNA binding, hsp90 and hsp70 containing, heterooligomeric form of the chick oviduct progesterone receptor. | 1993 | C. R. Acad. Sci. III, Sci. Vie | pmid:7522118 |
| Jung-Testas I et al. | [Inhibition of the anti-glucocorticosteroid effect of RU486 on the growth of mouse fibroblasts in culture by the immunosuppressor kf506]]. | 1993 | C. R. Acad. Sci. III, Sci. Vie | pmid:7522119 |
| Jung-Testas I et al. | Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:7583777 |
| Guerra Junior AA et al. | [Cyclosporine versus tacrolimus in kidney transplants in Brazil: a cost comparison]. | 2010 | Cad Saude Publica | pmid:20209220 |
| Spolidorio LC et al. | Conversion of immunosuppressive monotherapy from cyclosporin a to tacrolimus reverses bone loss in rats. | 2007 | Calcif. Tissue Int. | pmid:17612778 |
| Monegal A et al. | Bone mass and mineral metabolism in liver transplant patients treated with FK506 or cyclosporine A. | 2001 | Calcif. Tissue Int. | pmid:11310351 |
| Shui C et al. | The immunosuppressant rapamycin, alone or with transforming growth factor-beta, enhances osteoclast differentiation of RAW264.7 monocyte-macrophage cells in the presence of RANK-ligand. | 2002 | Calcif. Tissue Int. | pmid:12202955 |
| New drugs. | 2004 | Can Fam Physician | pmid:15508372 | |
| Nevers W et al. | Safety of tacrolimus in pregnancy. | 2014 | Can Fam Physician | pmid:25316742 |
| Mathieu P et al. | Conversion of cyclosporine A to tacrolimus following heart transplantation. | 1999 | Can J Cardiol | pmid:10579737 |
| Kamiya H et al. | Calcineurin inhibitor attenuates cardiac hypertrophy due to energy metabolic disorder. | 2001 | Can J Cardiol | pmid:11773940 |
| Al-Maawali AK et al. | Modern Treatments and Stem Cell Therapies for Perianal Crohn's Fistulas. | 2016 | Can J Gastroenterol Hepatol | pmid:28053967 |
| Yoshida EM et al. | Remission of multiple sclerosis post-liver transplantation. | 2004 | Can J Neurol Sci | pmid:15595263 |
| Tepperman E et al. | Surgical biology for the clinician: vascular effects of immunosuppression. | 2010 | Can J Surg | pmid:20100415 |
| Kim PT et al. | Colonic malakoplakia in a liver transplant recipient. | 2007 | Can. J. Gastroenterol. | pmid:18026580 |
| Yoshida EM | Post-liver transplantation immunosuppression: the song does not remain the same. | 2002 | Can. J. Gastroenterol. | pmid:11826341 |
| Rosenfeld GA et al. | Severe and extensive enteritis following colectomy for ulcerative colitis. | 2012 | Can. J. Gastroenterol. | pmid:23248782 |
| Lee SK et al. | Overexpression of the putative extracytoplasmic function sigma (σ) factor FujE enhances FK506 production in Streptomyces sp. strain KCCM 11116P. | 2014 | Can. J. Microbiol. | pmid:24869633 |
| Sarikcioglu L et al. | Effect of intrathecal FK506 administration on intraorbital optic nerve crush: an ultrastructural study. | 2009 | Can. J. Ophthalmol. | pmid:19606164 |
| Hamzah S et al. | Pharmacogenotyping of CYP3A5 in predicting dose-adjusted trough levels of tacrolimus among Malaysian kidney-transplant patients. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24383873 |
| Yoshihara S et al. | Modification of sarcoplasmic reticulum (SR) Ca2+ release by FK506 induces defective excitation-contraction coupling only when SR Ca2+ recycling is disturbed. | 2005 | Can. J. Physiol. Pharmacol. | pmid:15877110 |
| Misseghers BS et al. | Clinical observations of the treatment of canine perianal fistulas with topical tacrolimus in 10 dogs. | 2000 | Can. Vet. J. | pmid:10945128 |
| Gaballa S et al. | Results of a 2-arm, phase 2 clinical trial using post-transplantation cyclophosphamide for the prevention of graft-versus-host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation. | 2016 | Cancer | pmid:27404668 |