tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Mouth Diseases D009059 5 associated lipids
Meningococcal Infections D008589 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Authors Title Published Journal PubMed Link
Fujii H et al. Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. 2013 Cell Rep pmid:23602566
Matsa E et al. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. 2016 Cell Stem Cell pmid:27545504
Sun B et al. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. 2009 Cell Stem Cell pmid:19951690
Mohri T et al. Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A. 1998 Cell Struct. Funct. pmid:9872566
Kano Y et al. Immunosuppressant FK506 induces sustained activation of MAP kinase and promotes neurite outgrowth in PC12 mutant cells incapable of differentiating. 2002 Cell Struct. Funct. pmid:12502894
Papaccio G et al. The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin. 1994 Cell Tissue Res. pmid:7525068
Kotobuki N et al. In vivo survival and osteogenic differentiation of allogeneic rat bone marrow mesenchymal stem cells (MSCs). 2008 Cell Transplant pmid:18819258
Johnson JD et al. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. 2009 Cell Transplant pmid:19500470
Yook S et al. Molecularly engineered islet cell clusters for diabetes mellitus treatment. 2012 Cell Transplant pmid:22613624
Almawi WY et al. Inhibition of cytokine production and cytokine-stimulated T-cell activation by FK506 (tacrolimus)1. 2001 Cell Transplant pmid:11714196
Sugiyama K et al. Comparative study of the cellular pharmacodynamics of tacrolimus in renal transplant recipients treated with and without basiliximab. 2012 Cell Transplant pmid:22793066
Ponte GM et al. Resolution of severe atopic dermatitis after tacrolimus withdrawal. 2007 Cell Transplant pmid:17436852
Ding L et al. Clinical Immunosuppressants Inhibit Inflammatory, Proliferative, and Reprogramming Potential, But Not Angiogenesis of Human Pancreatic Duct Cells. 2015 Cell Transplant pmid:25198311
Orr C et al. Quantifying Insulin Therapy Requirements to Preserve Islet Graft Function Following Islet Transplantation. 2016 Cell Transplant pmid:25853639
Mijiti A et al. Increased sensitivities of peripheral blood mononuclear cells to immunosuppressive drugs in cirrhosis patients awaiting liver transplantation. 2006 Cell Transplant pmid:17299993
Guérette B et al. Control of inflammatory damage by anti-LFA-1: increase success of myoblast transplantation. 1997 Mar-Apr Cell Transplant pmid:9142441
Hara K et al. Implantation of xenogeneic transgenic neural plate tissues into parkinsonian rat brain. 1997 Sep-Oct Cell Transplant pmid:9331504
Del Castillo JM et al. Antiapoptotic effect of tacrolimus on cytokine-challenged human islets. 2009 Cell Transplant pmid:19660176
Tian C et al. Differentiation of murine embryonic stem cells in skeletal muscles of mice. 2008 Cell Transplant pmid:18522235
Hefferan MP et al. Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS. 2011 Cell Transplant pmid:21669047
Odorico JS et al. Improved solitary pancreas transplant graft survival in the modern immunosuppressive era. 2000 Nov-Dec Cell Transplant pmid:11202579
Froud T et al. Resolution of neurotoxicity and beta-cell toxicity in an islet transplant recipient following substitution of tacrolimus with MMF. 2006 Cell Transplant pmid:17176613
Kokudo N et al. Allogeneic hepatocyte and fetal liver transplantation and xenogeneic hepatocyte transplantation for Nagase's analbuminemic rats. 1996 Sep-Oct Cell Transplant pmid:8889223
Furukawa M et al. Analysis of PCR microchimerism induced by intrathymic inoculation of donor alloantigens in rats. 1996 Sep-Oct Cell Transplant pmid:8889237
Tashiro H et al. Monitoring for engraftment following rat orthotopic liver transplantation by in vitro amplification of Y-chromosome gene using polymerase chain reaction. 1995 Cell Transplant pmid:7540919
Han D et al. Choice of immunosuppression influences cytomegalovirus DNAemia in cynomolgus monkey (Macaca fascicularis) islet allograft recipients. 2010 Cell Transplant pmid:20587138
Perry SS et al. Direct effects of cyclosporin A on proliferation of hematopoietic stem and progenitor cells. 1999 Jul-Aug Cell Transplant pmid:10478713
Serrano T et al. The effects of immunosuppressive agents on the function of human hepatocytes in vitro. 2006 Cell Transplant pmid:17269448
Markus PM et al. Allogeneic hepatocyte transplantation using FK 506. 1997 Jan-Feb Cell Transplant pmid:9040958
Alemdar AY et al. Liposomal formulations of tacrolimus and rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts. 2004 Cell Transplant pmid:15191164
Kihara Y et al. Comparative study of the cellular pharmacodynamics of calcineurin inhibitors between patients with chronic renal failure awaiting renal transplantation and cirrhosis patients awaiting liver transplantation. 2009 Cell Transplant pmid:19775526
Mijiti A et al. Clinical significance of the cellular pharmacodynamics of tacrolimus in living-donor liver transplantation. 2009 Cell Transplant pmid:19775528
Akita K et al. Effect of FK506 and anti-CD4 therapy on fetal pig pancreas xenografts and host lymphoid cells in nod/Lt, CBA, and BALB/c mice. 1994 Jan-Feb Cell Transplant pmid:7512875
Yasunami Y et al. Donor-specific unresponsiveness induced by intraportal grafting and FK506 in rat islet allografts: importance of low temperature culture and transplant site on induction and maintenance. 1994 Jan-Feb Cell Transplant pmid:7512876
Yasunami Y and Ikeda S Induction of donor specific unresponsiveness in rat islet allografts by intraportal grafting and FK506. 1994 Cell Transplant pmid:7512877
Kumar S et al. A cytokine promoter/yellow fluorescent protein reporter transgene serves as an early activation marker of lymphocyte subsets. 2005 Cell. Immunol. pmid:16405934
Genestier L et al. Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line. 1994 Cell. Immunol. pmid:7514101
Aagaard-Tillery KM and Jelinek DF Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin. 1994 Cell. Immunol. pmid:7517796
Keicho N et al. Effects of an immunosuppressant, FK506, on interleukin 1 alpha production by human macrophages and a macrophage-like cell line, U937. 1991 Cell. Immunol. pmid:1703047
Soldevila G et al. Analysis of the individual role of the TCRzeta chain in transgenic mice after conditional activation with chemical inducers of dimerization. 2001 Cell. Immunol. pmid:12088411
Metcalfe S et al. FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal. 1994 Cell. Immunol. pmid:7522130
Staruch MJ et al. Distinctive calcineurin-dependent (FK506-sensitive) mechanisms regulate the production of the CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES vs IL-2 and TNF-alpha by activated human T cells. 1998 Cell. Immunol. pmid:9878113
Dumont FJ et al. Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma. 1995 Cell. Immunol. pmid:7538911
Prud'homme GJ et al. Effects of cyclosporin A, rapamycin, and FK520 on peripheral T-cell deletion and anergy. 1995 Cell. Immunol. pmid:7543371
Lin CS et al. FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes. 1991 Cell. Immunol. pmid:1707760
Adachi S and Iwata M Duration of calcineurin and Erk signals regulates CD4/CD8 lineage commitment of thymocytes. 2002 Cell. Immunol. pmid:12142035
Haasch D et al. T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC. 2002 May-Jun Cell. Immunol. pmid:12426003
Pores-Fernando AT et al. Calcineurin-dependent lytic granule exocytosis in NK-92 natural killer cells. 2009 Cell. Immunol. pmid:18762287
Kay JE et al. The mechanism of action of the immunosuppressive drug FK-506. 1989 Cell. Immunol. pmid:2478301
Hidaka M et al. Involvement of intestinal intraepithelial lymphocytes in turnover of intestinal epithelial cells: morphological and functional alterations due to daily administration of FK506. 2012 Cell. Immunol. pmid:23228594
Hattori Y and Nakanishi N Effects of cyclosporin A and FK506 on nitric oxide and tetrahydrobiopterin synthesis in bacterial lipopolysaccharide-treated J774 macrophages. 1995 Cell. Immunol. pmid:7545550
Gong N et al. Immunoregulatory effects of sirolimus vs. tacrolimus treatment in kidney allograft recipients. 2015 Cell. Immunol. pmid:26205091
Koprak S et al. Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin. 2003 Cell. Immunol. pmid:12914753
Tsuji-Takayama K et al. Interleukin-18 induces interferon-gamma production through NF-kappaB and NFAT activation in murine T helper type 1 cells. 1999 Cell. Immunol. pmid:10486154
Kaiser E et al. FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells. 2012 Cell. Microbiol. pmid:22420783
Stasik I et al. The mitochondrial localization of RelB and NFATx in immature T cells. 2008 Cell. Mol. Biol. Lett. pmid:18463795
Fernandes JB et al. Comparative investigation of the effects of the immunosuppressants cyclosporine A, cyclosporine G, and FK-506 on platelet activation. 1993 Cell. Mol. Biol. Res. pmid:7507391
Zhang X et al. SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection. 2012 Cell. Mol. Immunol. pmid:22922441
Göthel SF and Marahiel MA Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. 1999 Cell. Mol. Life Sci. pmid:10228556
Sanchez-Perez I et al. FK506 sensitizes mammalian cells to high osmolarity by modulating p38 MAP kinase activation. 2004 Cell. Mol. Life Sci. pmid:15052412
Yamauchi A et al. Tacrolimus-induced neurotoxicity and nephrotoxicity is ameliorated by administration in the dark phase in rats. 2004 Cell. Mol. Neurobiol. pmid:15485139
Liu G et al. FK506 Attenuates the Inflammation in Rat Spinal Cord Injury by Inhibiting the Activation of NF-κB in Microglia Cells. 2017 Cell. Mol. Neurobiol. pmid:27572744
Saxena K et al. FK506 protects neurons following peripheral nerve injury via immunosuppression. 2007 Cell. Mol. Neurobiol. pmid:18080746
Saganová K et al. Effects of long-term FK506 administration on functional and histopathological outcome after spinal cord injury in adult rat. 2009 Cell. Mol. Neurobiol. pmid:19350383
Tang J et al. ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts. 2016 Cell. Physiol. Biochem. pmid:27771715
Schenk LK et al. Cyclosporin-A induced toxicity in rat renal collecting duct cells: interference with enhanced hypertonicity induced apoptosis. 2010 Cell. Physiol. Biochem. pmid:21220920
Niederer KE et al. Cypermethrin blocks a mitochondria-dependent apoptotic signal initiated by deficient N-linked glycosylation within the endoplasmic reticulum. 2005 Cell. Signal. pmid:15494209
Ranta F et al. Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis. 2008 Cell. Signal. pmid:18611438
Matta C et al. Ser/Thr-phosphoprotein phosphatases in chondrogenesis: neglected components of a two-player game. 2014 Cell. Signal. pmid:25007994
Eguchi R et al. FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway. 2013 Cell. Signal. pmid:23707520
Rajapurohitam V et al. Leptin-induced cardiomyocyte hypertrophy reveals both calcium-dependent and calcium-independent/RhoA-dependent calcineurin activation and NFAT nuclear translocation. 2012 Cell. Signal. pmid:22917533
Cho CS et al. Modulation of the electrophoretic mobility of the linker for activation of T cells (LAT) by the calcineurin inhibitors CsA and FK506: LAT is a potential substrate for PKC and calcineurin signaling pathways. 2003 Cell. Signal. pmid:12401523
Walzel H et al. Galectin-induced activation of the transcription factors NFAT and AP-1 in human Jurkat T-lymphocytes. 2002 Cell. Signal. pmid:12135707
Caneguim BH et al. Immunosuppressant prograf® (tacrolimus) induces histopathological disorders in the peritubular tissue of rat testes. 2011 Cells Tissues Organs (Print) pmid:21293102
Duricová J and Grundmann M [Cytochrome P450 3A polymorphism and its importance in cyclosporine and tacrolimus therapy in transplanted patients]. 2007 Ceska Slov Farm pmid:18064802
Wong WR et al. Efficacy and safety of topically applied tacrolimus ointment in patients with moderate to severe atopic dermatitis. 2003 Chang Gung Med J pmid:14515971
Todd MH Computer-aided organic synthesis. 2005 Chem Soc Rev pmid:15726161
Sche PP et al. Display cloning: functional identification of natural product receptors using cDNA-phage display. 1999 Chem. Biol. pmid:10508685
Kley N Chemical dimerizers and three-hybrid systems: scanning the proteome for targets of organic small molecules. 2004 Chem. Biol. pmid:15157871
Pruschy MN et al. Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. 1994 Chem. Biol. pmid:9383386
Chakraborty TK et al. Design and synthesis of a rapamycin-based high affinity binding FKBP12 ligand. 1995 Chem. Biol. pmid:9383417
McPherson M et al. Drug receptor identification from multiple tissues using cellular-derived mRNA display libraries. 2002 Chem. Biol. pmid:12079780
Tokunaga M et al. Hereditary spastic paraplegia protein spartin is an FK506-binding protein identified by mRNA display. 2013 Chem. Biol. pmid:23890011
Stockwell BR and Schreiber SL TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins. 1998 Chem. Biol. pmid:9662508
Sche PP et al. Corrigendum to: "Display cloning: functional identification of natural product receptors using cDNA-phage display" [Chemistry & Biology 6 (1999) 707-716]. 2001 Chem. Biol. pmid:11325595
Wells WA Coming full circle. Vertex Pharmaceuticals, Inc. 1998 Chem. Biol. pmid:9818152
Butcher RA and Schreiber SL A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae. 2003 Chem. Biol. pmid:12837385
Clemons PA et al. Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors. 2002 Chem. Biol. pmid:11841938
Mayer TU and Marx A Five molecules we would take to a remote island. 2010 Chem. Biol. pmid:20609405
Michnick SW Chemical biology beyond binary codes. 2000 Chem. Biol. pmid:11137822
Finney NS Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. 1998 Chem. Biol. pmid:9571210
Rahman S et al. Nordihydroguiaretic acid attenuates skin tumorigenesis in Swiss albino mice with the condition of topical co-administration of an immunosuppressant. 2015 Chem. Biol. Interact. pmid:25770929
Kon OM Novel immunosuppressants in asthma. 2000 Chem. Immunol. pmid:12847724
Bierer BE Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action. 1994 Chem. Immunol. pmid:7524531
Pathak S et al. Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-co-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method. 2016 Chem. Pharm. Bull. pmid:26833445
Liang TT et al. Modeling Analysis of Potential Target of Dolastatin 16 by Computational Virtual Screening. 2018 Chem. Pharm. Bull. pmid:29863061
Shenton JM et al. Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat. 2005 Chem. Res. Toxicol. pmid:16359170
Pessah IN et al. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). 2006 Chem. Res. Toxicol. pmid:16411661
Hur J et al. Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. 2015 Chem. Res. Toxicol. pmid:25811541
Masson MJ and Uetrecht JP Tolerance induced by low dose D-penicillamine in the brown Norway rat model of drug-induced autoimmunity is immune-mediated. 2004 Chem. Res. Toxicol. pmid:14727922