tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Diekmann F et al. | Conversion to rapamycin in renal allograft recipients with biopsy-proven calcineurin inhibitor-induced nephrotoxicity. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750386 |
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| Ramos-Cebrián M et al. | Conversion from tacrolimus to cyclosporine could improve control of posttransplant diabetes mellitus after renal transplantation. | 2007 | Transplant. Proc. | pmid:17889154 |
| van Duijnhoven E et al. | Tacrolimus dosing requirements in diabetic and nondiabetic patients calculated from pretransplantation data. | 1998 | Transplant. Proc. | pmid:9636514 |
| López Lago AM et al. | Evolution of hepatorenal syndrome after orthotopic liver transplantation: comparative analysis with patients who developed acute renal failure in the early postoperative period of liver transplantation. | 2007 | Transplant. Proc. | pmid:17889176 |
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| Spinelli GA et al. | Lipid profile changes during the first year after kidney transplantation: risk factors and influence of the immunosuppressive drug regimen. | 2011 | Transplant. Proc. | pmid:22172836 |
| Kedzierska K et al. | Oxidative stress indices in rats under immunosuppression. | 2011 | Transplant. Proc. | pmid:22172876 |
| Pascual J and Ortuño J | Simple tacrolimus-based immunosuppressive regimens following renal transplantation: a large multicenter comparison between double and triple therapy. | 2002 | Transplant. Proc. | pmid:11959198 |
| Mac Guad R et al. | Effects of CYP3A5 Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Renal Transplant Recipients. | Transplant. Proc. | pmid:26915847 | |
| Pascual J et al. | One-center comparison between primary immunosuppression based on neoral cyclosporine and tacrolimus for renal transplantation. | 2002 | Transplant. Proc. | pmid:11959200 |
| Lian Y et al. | Suppression of Delayed Xenograft Rejection by Resveratrol in a Hamster-to-Rat Cardiac Transplantation Model. | Transplant. Proc. | pmid:28736027 | |
| Ericzon BG et al. | Pancreaticoduodenal allotransplantation with FK 506 in the cynomolgus monkey. | 1990 | Transplant. Proc. | pmid:1689905 |
| Moochhala SM et al. | Inhibition of drug metabolism in rat and human liver microsomes by FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1721277 |
| Wakizaka Y et al. | Xenotransplantation of hamster liver into Gunn rats reserves congenital hyperbilirubinemia. | 1996 | Transplant. Proc. | pmid:8623372 |
| Pan F et al. | Effect of tacrolimus and splenectomy on engraftment and GVHD after bone marrow xenotransplantation in the reciprocal hamster to rat animal models. | 1996 | Transplant. Proc. | pmid:8623373 |
| Pratschke J et al. | Treatment of cyclosporine-related adverse effects by conversion to tacrolimus after liver transplantation: long-term results. | 1998 | Transplant. Proc. | pmid:9636575 |
| Vathsala A et al. | Inhibition of apoptosis in anti-CD3-treated peripheral blood lymphocytes by immunosuppressive drugs. | 2000 | Transplant. Proc. | pmid:11120034 |
| Oltean M et al. | Transplantation of preconditioned intestinal grafts is associated with lower inflammatory activation and remote organ injury in rats. | 2006 Jul-Aug | Transplant. Proc. | pmid:16908278 |
| Tan HP et al. | Steroid-free tacrolimus monotherapy after pretransplantation thymoglobulin or Campath and laparoscopy in living donor renal transplantation. | 2005 | Transplant. Proc. | pmid:16387087 |
| Nishimori H et al. | Combination therapy with FK 506 and splenectomy may induce tolerance in cardiac xenografts. | 1994 | Transplant. Proc. | pmid:7518102 |
| Schwartz M et al. | FK 506 in liver transplantation: correlation of whole blood levels with efficacy and toxicity. The US Multicenter FK 506 Dose Optimization. | 1995 | Transplant. Proc. | pmid:7533355 |
| Katz HR et al. | Mast cell biochemical and functional heterogeneity. | 1991 | Transplant. Proc. | pmid:1721308 |
| Yasuhara M et al. | Pharmacokinetics and pharmacodynamics of FK 506 in pediatric patients receiving living-related donor liver transplantations. | 1995 | Transplant. Proc. | pmid:7533356 |
| Oppenheimer F | Steroid withdrawal in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:10686314 |
| Lentine KL et al. | Variation in Comedication Use According to Kidney Transplant Immunosuppressive Regimens: Application of Integrated Registry and Pharmacy Claims Data. | Transplant. Proc. | pmid:26915843 | |
| de Paulis A et al. | Antiinflammatory effect of FK 506 on human basophils. | 1991 | Transplant. Proc. | pmid:1721309 |
| Tamura A et al. | Combination effect of tacrolimus and FTY720 in liver transplantation in rats. | 1999 | Transplant. Proc. | pmid:10578290 |
| Kita J et al. | Effects of tacrolimus on small and large bowel anastomoses in the rat. | 1999 | Transplant. Proc. | pmid:10578292 |
| Florman S et al. | Conversion of stable liver transplant recipients from a twice-daily Prograf-based regimen to a once-daily modified release tacrolimus-based regimen. | 2005 | Transplant. Proc. | pmid:15848672 |
| Kato T et al. | Steroid-free induction and preemptive antiviral therapy for liver transplant recipients with hepatitis C: a preliminary report from a prospective randomized study. | 2005 | Transplant. Proc. | pmid:15848674 |
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| Gagliano N et al. | A therapeutic dose of FK506 does not affect collagen turnover pathways in healthy human gingival fibroblasts. | 2008 | Transplant. Proc. | pmid:18589121 |
| Figueras J et al. | Steroid-free regimen with daclizumab, mycophenolate mofetil, and tacrolimus in liver transplant recipients. | 2002 | Transplant. Proc. | pmid:12176461 |
| Grochowicz PM et al. | Synergism of castanospermine and FK 506. | 1995 | Transplant. Proc. | pmid:7533408 |
| Reding R et al. | Compassionate use of FK 506 in pediatric liver transplantation: a pilot study. | 1991 | Transplant. Proc. | pmid:1721341 |
| Bäckman L et al. | Steroid-free immunosuppression in kidney transplant recipients and prograf monotherapy: an interim analysis of a prospective multicenter trial. | 2006 | Transplant. Proc. | pmid:17098029 |
| Lee KK et al. | Comparison of short-term immunosuppressive therapy with cyclosporine and FK 506 in small-bowel transplantation. | 1990 | Transplant. Proc. | pmid:1702239 |
| Rintala JM et al. | The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta. | 2006 | Transplant. Proc. | pmid:17098049 |
| Takahashi K et al. | Successful results after 5 years of tacrolimus therapy in ABO-incompatible kidney transplantation in Japan. | 2005 | Transplant. Proc. | pmid:15919471 |
| Foroncewicz B et al. | Safety and efficacy of steroid-free immunosuppression with tacrolimus and daclizumab in liver transplant recipients: 6-year follow-up in a single center. | 2009 | Transplant. Proc. | pmid:19857686 |
| Zhou W et al. | Calcineurin inhibitors block B-1 cell differentiation: the relevance to immunosuppressive treatment in ABO-incompatible transplantation. | 2005 | Transplant. Proc. | pmid:15919474 |
| Niel OR et al. | Long-term glomerular filtration rate in liver allograft recipients according to the type of calcineurin inhibitors. | 2009 | Transplant. Proc. | pmid:19857743 |
| Soin AS et al. | Complement activation during rejection in experimental intestinal transplantation. | 1997 | Transplant. Proc. | pmid:9142282 |
| Lin YH et al. | The 4-week serum creatinine level predicts long-term renal dysfunction after adult living donor liver transplantation. | 2012 | Transplant. Proc. | pmid:22483492 |
| Charco R et al. | Low incidence of hypercholesterolemia among liver transplant patients under tacrolimus monotherapy immunosuppression. | 2002 | Transplant. Proc. | pmid:12176482 |
| Kitamura M et al. | Clinical experience of FK 506 for renal allograft transplantation. | 1994 | Transplant. Proc. | pmid:7520611 |
| Chen CL et al. | FK 506 used as rescue therapy for refractory liver allograft rejection. | 1994 | Transplant. Proc. | pmid:7520612 |
| Hung CM et al. | Tacrolimus to rescue refractory hepatic allograft rejection: a collaborative study in Taiwan. | 1998 | Transplant. Proc. | pmid:9838572 |
| Fung JJ et al. | Adverse effects associated with the use of FK 506. | 1991 | Transplant. Proc. | pmid:1721372 |
| Cheng HM et al. | Primary prophylaxis with tacrolimus in kidney transplants in China. | 1998 | Transplant. Proc. | pmid:9838573 |
| Omar G et al. | FK 506 inhibition of cyclosporine metabolism by human liver microsomes. | 1991 | Transplant. Proc. | pmid:1703356 |
| Hebert MF et al. | Efficacy and toxicity of FK 506 for the treatment of resistant rejection in liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721373 |
| Miller J | Tacrolimus and mycophenolate mofetil in renal transplant recipients: one year results of a multicenter, randomized dose ranging trial. FK506/MMF Dose-Ranging Kidney Transplant Study Group. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083106 |
| Eiras G et al. | Effects of FK 506 and cyclosporine on T-cell activation: integrin-mediated adhesion of T cells, proliferation, and maturation of cytotoxic T cells. | 1991 | Transplant. Proc. | pmid:1703357 |
| Undre NA et al. | Low systemic exposure to tacrolimus correlates with acute rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083114 |
| Pisitkun T et al. | The roles of C4 and AUC0-4 in monitoring of tacrolimus in stable kidney transplant patients. | 2002 | Transplant. Proc. | pmid:12493410 |
| Gavlik A et al. | Mycophenolate mofetil rescue therapy in liver transplant recipients. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123124 |
| Guleria S et al. | Generic tacrolimus (Pan Graf) in renal transplantation: an experience of 155 recipients in India. | 2008 | Transplant. Proc. | pmid:18790202 |
| Tanabe K et al. | Improved outcome of minor-mismatched living renal allografts under tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176528 |
| Chen WY et al. | Betel Nut Chewing Is Associated With Reduced Tacrolimus Concentration in Taiwanese Liver Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28219593 |
| Kim JD et al. | Single-Center Experience of ABO-Incompatible Living-Donor Liver Transplantation With a New Simplified Intravenous Immunoglobulin Protocol: A Propensity Score-Matching Analysis. | 2016 | Transplant. Proc. | pmid:27320573 |
| Kato H et al. | Long-Term Influence of CYP3A5 Gene Polymorphism on Pharmacokinetics of Tacrolimus and Patient Outcome After Living Donor Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27320564 |
| Abu-Elmagd KM et al. | Acute hemolytic anemia in liver and bone marrow transplant patients under FK 506 therapy. | 1991 | Transplant. Proc. | pmid:1721404 |
| Yamada K et al. | FK 506-induced juxtaglomerular apparatus hyperplasia and tubular damage in rat kidney--morphologic and biologic analysis. | 1992 | Transplant. Proc. | pmid:1379756 |
| Melter M et al. | Successful reconversion from tacrolimus to cyclosporine A Neoral in pediatric liver recipients. | 1996 | Transplant. Proc. | pmid:8769224 |
| Zanker B et al. | Comparison of MPA trough levels in patients with severe diabetes mellitus and from non-diabetics after transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083521 |
| Adams CK and Famili P | A study of the effects of the drug FK 506 on gingival tissues. | 1991 | Transplant. Proc. | pmid:1721405 |
| Fukuse T et al. | Optimal dose of FK 506 in canine lung allotransplantation. | 1992 | Transplant. Proc. | pmid:1379757 |
| Tanaka M et al. | Reduction of immunosuppressive agents after living related donor liver transplantation. | 1996 | Transplant. Proc. | pmid:8769268 |
| Mohamed MA et al. | The effect of cyclosporin A and tacrolimus on cultured human epithelial cells: the role of TGF-beta. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083523 |
| Ishibashi M et al. | Immunopharmacologic effects of immunosuppressive agents explored by a new effector monocyte generation assay. | 1989 | Transplant. Proc. | pmid:2469228 |
| Starzl TE et al. | Liver transplantation: an unfinished product. | 1989 | Transplant. Proc. | pmid:2469232 |
| Ohdan H et al. | Prolongation of hamster-to-rat liver xenograft survival by donor bone marrow augmentation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123589 |
| Yamagami S et al. | Rejection mechanism and immunosuppression by FK 506 and anti-leukocyte function associated antigen-1 antibody in concordant corneal xenotransplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123598 |
| Langrehr JM et al. | Quadruple versus dual tacrolimus-based induction after liver transplantation: a prospective, randomized trial. | 2001 | Transplant. Proc. | pmid:11377549 |
| Uber PA et al. | Steroid weaning in heart transplantation is associated with decreased B-type natriuretic peptide: surrogate evidence for cardiac adaptation. | 2002 | Transplant. Proc. | pmid:12176598 |
| Nagashima N et al. | Immunocompetence assay for net effect of combined immunosuppression. | 2001 | Transplant. Proc. | pmid:11377556 |
| Baran DA et al. | Tacrolimus and cardiac transplantation: a comparison of monotherapy and steroid-dependent patients. | 2002 | Transplant. Proc. | pmid:12176599 |
| Luke PP et al. | IVIG rescue therapy in renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267206 |
| Kuroki H et al. | Synergistic effect of FK 506 and donor-specific blood transfusion on rat skin but not on composite tissue (limb) allograft survival. | 1991 | Transplant. Proc. | pmid:1721436 |
| Ersoy A et al. | Diabetic ketoacidosis following development of de novo diabetes in renal transplant recipient associated with tacrolimus. | 2004 | Transplant. Proc. | pmid:15251345 |
| Todo S et al. | Orthotopic liver transplantation in dogs receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445079 |
| Vanrenterghem Y | Tacrolimus (FK 506) in kidney transplantation. | 1998 | Transplant. Proc. | pmid:9723431 |
| Eberlin M et al. | Increased medication compliance of liver transplant patients switched from a twice-daily to a once-daily tacrolimus-based immunosuppressive regimen. | 2013 Jul-Aug | Transplant. Proc. | pmid:23726723 |
| Gatti S et al. | Graft-versus-host reaction and graft rejection after liver, small bowel or small bowel allotransplantation in the pig. | 1998 | Transplant. Proc. | pmid:9745509 |
| Toyoki Y et al. | Primary immunosuppression regimen of rapid steroid withdrawal after living related liver transplantation: a single-center experience. | 2004 | Transplant. Proc. | pmid:15561218 |
| Jordan ML et al. | Steroid withdrawal for pancreas transplants under tacrolimus immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267456 |
| Lo A et al. | Outcome of simultaneous kidney-pancreas transplantation in African-American recipients: a case control study. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267465 |
| Li S et al. | Intrathymic inoculation of donor bone marrow at the time of transplantation plus a short course of tacrolimus induce long-term acceptance to rat lung allografts. | 1998 | Transplant. Proc. | pmid:9636431 |
| Pinho-Apezzato ML et al. | Multiple clinical presentations of lymphoproliferative disorders in pediatric liver transplant recipients: a single-center experience. | 2010 | Transplant. Proc. | pmid:20620519 |
| Tsujimura K et al. | Effect of Influenza Vaccine in Patients With Kidney Transplant. | 2018 | Transplant. Proc. | pmid:30316375 |
| Miki T et al. | Tacrolimus enhances the immunosuppressive effect of cyclophosphamide but not that of leflunomide or mycophenolate mofetil in a model of discordant liver xenotransplantation. | 1998 | Transplant. Proc. | pmid:9636444 |
| Shullo MA et al. | Elevated tacrolimus levels associated with intravenous azithromycin and ceftriaxone: a case report. | 2010 | Transplant. Proc. | pmid:20620540 |
| Rao V et al. | A non-induction renal sparing approach after liver transplantation: high dose mycophenolate mofetil with delayed, low-dose tacrolimus. | 2013 Jan-Feb | Transplant. Proc. | pmid:23267806 |
| Kahu J et al. | Impact of mycophenolate mofetil intolerance on early results of kidney transplantation. | 2005 | Transplant. Proc. | pmid:16298571 |
| Xie L et al. | Pretransplantation Risk Factors Associated With New-onset Diabetes After Living-donor Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27931572 |
| Mohsin N et al. | Pharmacokinetics of mycophenolate mofetil in Omani patients on cyclosporine or tacrolimus. | 2015 | Transplant. Proc. | pmid:26036534 |
| Stratta RJ et al. | Preliminary experience with FK 506 in pancreas transplant recipients. | 1995 | Transplant. Proc. | pmid:8539823 |