Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
Takada Y et al. | Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist. | 1998 | Transplant. Proc. | pmid:9838621 |
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Woo J et al. | Kinetics of early T-cell repopulation in the mouse following syngeneic bone marrow transplantation: FK 506 causes a maturational defect of CD4+ CD8- T cells. | 1991 | Transplant. Proc. | pmid:1721313 |
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McCarthy SA et al. | Effects of FK 506 and cyclosporine on T-cell tolerance: inhibition of a "protective" mechanism that regulates activation-induced apoptosis in developing thymocytes. | 1991 | Transplant. Proc. | pmid:1721314 |
Ebbs A et al. | Tacrolimus treats ongoing allograft rejection by inhibiting interleukin-10 mediated functional cytotoxic cell infiltration. | 2002 | Transplant. Proc. | pmid:12176404 |
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Hohage H et al. | Differential effects of cyclosporine and tacrolimus on mycophenolate pharmacokinetics in patients with impaired kidney function. | 2005 | Transplant. Proc. | pmid:15919453 |
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Reis A et al. | Mycophenolate mofetil and FK506: two novel immunosuppressants in murine corneal transplantation. | 1998 | Transplant. Proc. | pmid:9865380 |
Emiroglu R et al. | Tacrolimus-related neurologic and renal complications in liver transplantation: A single-center experience. | 2006 | Transplant. Proc. | pmid:16549190 |
Martin Garcia D et al. | Tacrolimus-Basiliximab versus Cyclosporine-Basiliximab in renal transplantation "de novo": acute rejection and complications. | 2003 | Transplant. Proc. | pmid:12962761 |
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Nishi K et al. | The expression of intestinal CYP3A4 in the piglet model. | 2004 | Transplant. Proc. | pmid:15050159 |
Nishi K et al. | The colon displays an absorptive capacity of tacrolimus. | 2004 | Transplant. Proc. | pmid:15050160 |
Velio P et al. | Rejection and survival after total orthotopic liver-small bowel allotransplantation in pigs immunosuppressed with FK 506. | 1996 | Transplant. Proc. | pmid:8907936 |
Sonnenday CJ et al. | Preemptive therapy with plasmapheresis/intravenous immunoglobulin allows successful live donor renal transplantation in patients with a positive cross-match. | 2002 | Transplant. Proc. | pmid:12176507 |
Bardella MT et al. | FK 506 and cyclosporine: effect on D-xylose absorption in pigs with orthotopic liver-small bowel allotransplants. | 1996 | Transplant. Proc. | pmid:8907937 |
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Gringeri E et al. | Neoadjuvant therapy protocol and liver transplantation in combination with pancreatoduodenectomy for the treatment of hilar cholangiocarcinoma occurring in a case of primary sclerosing cholangitis: case report with a more than 8-year disease-free survival. | 2011 | Transplant. Proc. | pmid:21620084 |
Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
Ota K | Living donor kidney transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520622 |
Ueda D et al. | Influence of FK 506 on renal blood flow. | 1991 | Transplant. Proc. | pmid:1721377 |
Thomson AW et al. | The influence of FK 506 on the thymus: implications of drug-induced injury to thymic epithelial cells. | 1991 | Transplant. Proc. | pmid:1703361 |
Perico N et al. | FK 506 does not affect the glomerular filtration rate and renal plasma flow in the rat. | 1991 | Transplant. Proc. | pmid:1721378 |
Mieles L et al. | Glycemia and insulin need following FK 506 rescue therapy in liver transplant recipients. | 1991 | Transplant. Proc. | pmid:1703362 |
Rastellini C et al. | Prolonged survival of islet allografts following combined therapy with tacrolimus and leflunomide. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083278 |
Millis JM et al. | Tacrolimus treatment of steroid-resistant rejection provides economic advantages compared with OKT3 therapy. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123421 |
Klupp J et al. | New approach in drug development: whole blood pharmacodynamic assays reflect biological activities of tacrolimus. | 2001 | Transplant. Proc. | pmid:11377491 |
Mollison KW et al. | Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat. | 1996 | Transplant. Proc. | pmid:8962236 |
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