Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Jegasothy BV et al. | Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis. | 1992 | Arch Dermatol | pmid:1376102 |
Van Leent EJ et al. | Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis. | 1998 | Arch Dermatol | pmid:9681343 |
Passeron T et al. | Topical tacrolimus and the 308-nm excimer laser: a synergistic combination for the treatment of vitiligo. | 2004 | Arch Dermatol | pmid:15381545 |
Ehst BD and Warshaw EM | Alcohol-induced application site erythema after topical immunomodulator use and its inhibition by aspirin. | 2004 | Arch Dermatol | pmid:15313828 |
Eiling E et al. | Pimecrolimus: a novel treatment for cetuximab-induced papulopustular eruption. | 2008 | Arch Dermatol | pmid:18794482 |
Byrd JA et al. | Response of oral lichen planus to topical tacrolimus in 37 patients. | 2004 | Arch Dermatol | pmid:15611431 |
Santos-Juanes J et al. | Topical tacrolimus: an effective therapy for Zoon balanitis. | 2004 | Arch Dermatol | pmid:15611442 |
Yan AC et al. | The safety and efficacy of pimecrolimus, 1%, cream for the treatment of Netherton syndrome: results from an exploratory study. | 2010 | Arch Dermatol | pmid:20083693 |
Ciurea AM et al. | Complete and durable clinical response of malignant pyoderma to tacrolimus in combination with dapsone and prednisone. | 2010 | Arch Dermatol | pmid:20083712 |
Mikhail M et al. | Rapid enlargement of a malignant melanoma in a child with vitiligo vulgaris after application of topical tacrolimus. | 2008 | Arch Dermatol | pmid:18427063 |
Böhm M et al. | Successful treatment of anogenital lichen sclerosus with topical tacrolimus. | 2003 | Arch Dermatol | pmid:12873890 |
Yeh C et al. | Effect of FK506 on functional recovery after facial nerve injury in the rat. | 2007 Sep-Oct | Arch Facial Plast Surg | pmid:17875826 |
Geramizadeh B et al. | Post-transplantation lymphoproliferative disorder after liver transplantation: report of 5 cases among more than 550 liver transplants in Iran. | 2010 | Arch Iran Med | pmid:20804309 |
Dehghani SM et al. | Tacrolimus related hypertrophic cardiomyopathy in liver transplant recipients. | 2010 | Arch Iran Med | pmid:20187665 |
Rybojad M | [Atopic dermatitis]. | 2012 | Arch Pediatr | pmid:22796288 |
Monchaud C et al. | [Long lasting side effects of immunosuppressants in children]. | 2007 | Arch Pediatr | pmid:17442546 |
Sánchez Ferreiro AV and Muñoz Bellido L | [Tacrolimus in the treatment of atopic kerato-conjunctivitis]. | 2013 | Arch Soc Esp Oftalmol | pmid:23886369 |
RodrÃguez-AusÃn P et al. | Topical tacrolimus 0.03% for the treatment of ocular psoriasis. | 2016 | Arch Soc Esp Oftalmol | pmid:27130870 |
Fryer JP et al. | Bacterial translocation in a large-animal model of small-bowel transplantation. Portal vs systemic venous drainage and the effect of tacrolimus immunosuppression. | 1996 | Arch Surg | pmid:8546583 |
Harmon JV et al. | Experimental short-term immunosuppression after bowel transplantation and donor-specific bone marrow infusion. | 2001 | Arch Surg | pmid:11448397 |
Echigo Y et al. | Effects of cyclosporine and tacrolimus (FK 506) on acute pancreatitis in mice. | 1995 | Arch Surg | pmid:7528496 |
Freise CE et al. | Excellent short-term results with steroid-free maintenance immunosuppression in low-risk simultaneous pancreas-kidney transplantation. | 2003 | Arch Surg | pmid:14557130 |
Johnson MW et al. | Hepatitis C viral infection in liver transplantation. | 1996 | Arch Surg | pmid:8611094 |
Stötter H and Lotze MT | Human lymphokine-activated killer cell activity. Role of IL-2, IL-4, and IL-7. | 1991 | Arch Surg | pmid:1726819 |
Wen H et al. | Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. | 2012 | Arch. Biochem. Biophys. | pmid:22100703 |
Vincent SH et al. | In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. | 1992 | Arch. Biochem. Biophys. | pmid:1373595 |
Yin M and Ochs RS | Mechanism for the paradoxical inhibition and stimulation of calcineurin by the immunosuppresive drug tacrolimus (FK506). | 2003 | Arch. Biochem. Biophys. | pmid:14592464 |
Salowe SP and Hermes JD | Competitive and slow-binding inhibition of calcineurin by drug x immunophilin complexes. | 1998 | Arch. Biochem. Biophys. | pmid:9675023 |
Tomono M et al. | Inhibitors of calcineurin block expression of cyclins A and E induced by fibroblast growth factor in Swiss 3T3 fibroblasts. | 1998 | Arch. Biochem. Biophys. | pmid:9606972 |
Kakegawa T et al. | Rapamycin induces binding activity to the terminal oligopyrimidine tract of ribosomal protein mRNA in rats. | 2002 | Arch. Biochem. Biophys. | pmid:12051685 |
Mukerjee N et al. | Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells. | 2000 | Arch. Biochem. Biophys. | pmid:10898953 |
Borro JM et al. | Long-term success of combined kidney-lung transplantation in a patient with cystic fibrosis. | 2013 | Arch. Bronconeumol. | pmid:23427867 |
Reig Mezquida JP et al. | Thrombotic microangiopathy associated with tacrolimus in lung transplantation. | 2015 | Arch. Bronconeumol. | pmid:25138798 |
Zurbano F et al. | Maternity and lung transplantation: cases in Spain. | 2012 | Arch. Bronconeumol. | pmid:22771003 |
Nishimuta K and Ito Y | Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice. | 2003 | Arch. Dermatol. Res. | pmid:12624780 |
Ito F et al. | FK506 and cyclosporin A inhibit stem cell factor-dependent cell proliferation/survival, while inducing upregulation of c-kit expression in cells of the mast cell line MC/9. | 1999 | Arch. Dermatol. Res. | pmid:10367710 |
Lubaki LJ et al. | Time-kinetic study of repigmentation in vitiligo patients by tacrolimus or pimecrolimus. | 2010 | Arch. Dermatol. Res. | pmid:19547993 |
Eberlein-König B et al. | Modulation of histamine release in vitro by FK506 and interleukin-3 is determined by sequence of incubation. | 1997 | Arch. Dermatol. Res. | pmid:9373722 |
Hultsch T et al. | Direct evidence that FK506 inhibition of FcepsilonRI-mediated exocytosis from RBL mast cells involves calcineurin. | 1998 | Arch. Dermatol. Res. | pmid:9681677 |
GarcÃa-GarcÃa B et al. | Frosch' surface microscopy score for the assessment of steroid-induced atrophy. | 2014 | Arch. Dermatol. Res. | pmid:24402286 |
Paus R et al. | Hair growth control by immunosuppression. | 1996 | Arch. Dermatol. Res. | pmid:8818191 |
Furukawa F et al. | FK506: therapeutic effects on lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr mice. | 1995 | Arch. Dermatol. Res. | pmid:7487142 |
Ockenfels HM et al. | Cyclosporin A, FK506 and dithranol after tyrosine-specific protein phosphorylation in HaCaT keratinocytes. | 1995 | Arch. Dermatol. Res. | pmid:7541191 |
Yoon NY et al. | Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model. | 2015 | Arch. Dermatol. Res. | pmid:25786383 |
Hofmann M et al. | Validation of Dermaphot(®) for the assessment of steroid-induced skin atrophy. | 2013 | Arch. Dermatol. Res. | pmid:23242470 |
Toyota N et al. | Effects of FK506 and cyclosporin A on proliferation, histamine release and phenotype of murine mast cells. | 1996 | Arch. Dermatol. Res. | pmid:8844128 |
Engelhart K et al. | In vitro reproduction of clinical hallmarks of eczematous dermatitis in organotypic skin models. | 2005 | Arch. Dermatol. Res. | pmid:15952007 |
Hultsch T et al. | Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner. | 1998 | Arch. Dermatol. Res. | pmid:9808344 |
Lauerma AI et al. | Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig. | 1994 | Arch. Dermatol. Res. | pmid:7526805 |
Allen BR et al. | Systemic exposure, tolerability, and efficacy of pimecrolimus cream 1% in atopic dermatitis patients. | 2003 | Arch. Dis. Child. | pmid:14612358 |
Deckers-Kocken JM and Pasmans SG | Successful tacrolimus (FK506) therapy in a child with pyoderma gangrenosum. | 2005 | Arch. Dis. Child. | pmid:15851442 |
Hofman T et al. | Tacrolimus ointment does not affect the immediate response to vaccination, the generation of immune memory, or humoral and cell-mediated immunity in children. | 2006 | Arch. Dis. Child. | pmid:16798785 |
Lancia P et al. | Choosing the right dose of tacrolimus. | 2015 | Arch. Dis. Child. | pmid:25416736 |
Campo JV et al. | Tacrolimus toxic reaction associated with the use of nefazodone: paroxetine as an alternative agent. | 1998 | Arch. Gen. Psychiatry | pmid:9819077 |
Lenz O and Contreras G | Treatment options for severe lupus nephritis. | 2004 Sep-Oct | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:15507877 |
Nowaczyk M et al. | 2-Chlorodeoxyadenosine: lack of synergism with cyclosporine A and tacrolimus (FK 506). | 1995 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:8744655 |
GarcÃa-Roca P et al. | CYP3A5 polymorphism in Mexican renal transplant recipients and its association with tacrolimus dosing. | 2012 | Arch. Med. Res. | pmid:22704849 |
Saner FH et al. | Severe neurological events following liver transplantation. | 2007 | Arch. Med. Res. | pmid:17174727 |
Horne SM and Young KD | Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins. | 1995 | Arch. Microbiol. | pmid:7540828 |
Orange D et al. | Cellular immune suppression in paraneoplastic neurologic syndromes targeting intracellular antigens. | 2012 | Arch. Neurol. | pmid:22566506 |
Parashos SA et al. | Determinants of the timing of symptomatic treatment in early Parkinson disease: The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) Experience. | 2009 | Arch. Neurol. | pmid:19597081 |
Liang L et al. | Long-term outcomes of keratolimbal allograft for total limbal stem cell deficiency using combined immunosuppressive agents and correction of ocular surface deficits. | 2009 | Arch. Ophthalmol. | pmid:19901207 |
Murphy CC et al. | Cyclosporine vs tacrolimus therapy for posterior and intermediate uveitis. | 2005 | Arch. Ophthalmol. | pmid:15883282 |
Okada AA | Noninfectious uveitis: a scarcity of randomized clinical trials. | 2005 | Arch. Ophthalmol. | pmid:15883289 |
John SS et al. | Chronic localized fibrosing vasculitis of the eyelid. | 2009 | Arch. Ophthalmol. | pmid:19822864 |
Moura Penteado LA et al. | Evaluation of the effect of tacrolimus on periodontitis induced in rats. | 2017 | Arch. Oral Biol. | pmid:28399470 |
Gürkan A et al. | Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth. | 2014 | Arch. Oral Biol. | pmid:24581850 |
Gürkan A et al. | Gingival crevicular fluid transforming growth factor-beta1 in cyclosporine and tacrolimus treated renal transplant patients without gingival overgrowth. | 2008 | Arch. Oral Biol. | pmid:18342291 |
Guimarães MR et al. | Protective effects of Tacrolimus, a calcineurin inhibitor, in experimental periodontitis in rats. | 2007 | Arch. Oral Biol. | pmid:17367747 |
Cota LO et al. | Gingival overgrowth in cyclosporine, tacrolimus, or sirolimus-based immunosuppressive regimens and the single nucleotide IL-6 (-174 G/C) gene polymorphism. | 2010 | Arch. Oral Biol. | pmid:20430366 |
Emingil G et al. | GCF and serum myeloperoxidase and matrix metalloproteinase-13 levels in renal transplant patients. | 2010 | Arch. Oral Biol. | pmid:20637451 |
Türkoğlu O et al. | Are antimicrobial peptides related to cyclosporine A-induced gingival overgrowth? | 2015 | Arch. Oral Biol. | pmid:25555253 |
Deschler DG et al. | Posttransplantation lymphoproliferative disorder in patients under primary tacrolimus (FK 506) immunosuppression. | 1995 | Arch. Otolaryngol. Head Neck Surg. | pmid:7544136 |
Etzell JE and Wang E | Acquired Pelger-Huët anomaly in association with concomitant tacrolimus and mycophenolate mofetil in a liver transplant patient: a case report and review of the literature. | 2006 | Arch. Pathol. Lab. Med. | pmid:16390246 |
DiGiuseppe JA et al. | Tacrolimus-related posttransplant lymphoproliferative disorder presenting as autoimmune hemolytic anemia. | 1996 | Arch. Pathol. Lab. Med. | pmid:8629906 |
Steele BW et al. | A longitudinal replicate study of immunosuppressive drugs: a College of American Pathologists study. | 2003 | Arch. Pathol. Lab. Med. | pmid:12653570 |
Wang S et al. | A fast and simple high-performance liquid chromatography/mass spectrometry method for simultaneous measurement of whole blood tacrolimus and sirolimus. | 2005 | Arch. Pathol. Lab. Med. | pmid:15859639 |
Gorgan M et al. | Pulmonary hemorrhage with capillaritis secondary to mycophenolate mofetil in a heart-transplant patient. | 2013 | Arch. Pathol. Lab. Med. | pmid:24168511 |
Papadea C and Lage JM | Immunosuppressants testing in transplantation. | 2004 | Arch. Pathol. Lab. Med. | pmid:15578873 |
Linder MW and Elin RJ | Implications of methodologic bias for therapeutic drug monitoring. | 1999 | Arch. Pathol. Lab. Med. | pmid:10506447 |
Chung Y and Cho H | Preparation of highly water soluble tacrolimus derivatives: poly(ethylene glycol) esters as potential prodrugs. | 2004 | Arch. Pharm. Res. | pmid:15460452 |
Kwon M et al. | Bioequivalence of tacrolimus formulations with different dynamic solubility and in-vitro dissolution profiles. | 2015 | Arch. Pharm. Res. | pmid:24627339 |
Park YJ et al. | Physicochemical characterization of tacrolimus-loaded solid dispersion with sodium carboxylmethyl cellulose and sodium lauryl sulfate. | 2009 | Arch. Pharm. Res. | pmid:19557367 |
Seo YG et al. | Preparation and pharmaceutical evaluation of new tacrolimus-loaded solid self-emulsifying drug delivery system. | 2015 | Arch. Pharm. Res. | pmid:25134927 |
Park JS et al. | A rapid and sensitive method to determine tacrolimus in rat whole blood using liquid-liquid extraction with mild temperature ultrasonication and LC-MS/MS. | 2016 | Arch. Pharm. Res. | pmid:26589688 |
Choi D and Cho H | Effect of tacrolimus derivatives on immunosuppression. | 2009 | Arch. Pharm. Res. | pmid:19407973 |
Choi D et al. | Effects of water-soluble tacrolimus-PEG conjugate on insulin-dependent diabetes mellitus and systemic lupus erythematosus. | 2011 | Arch. Pharm. Res. | pmid:21910052 |
Hüser N et al. | Graft preconditioning with low-dose tacrolimus (FK506) and nitric oxide inhibitor aminoguanidine (AGH) reduces ischemia/reperfusion injury after liver transplantation in the rat. | 2009 | Arch. Pharm. Res. | pmid:19280151 |
Ellouk-Achard S et al. | Implication of CYP 3A in the toxicity of cyclosporin G (CsG), cyclosporin A (CsA) and FK506 on rat hepatocytes in primary culture. | 1997 | Arch. Toxicol. | pmid:9209689 |
Aam BB and Fonnum F | Carbon black particles increase reactive oxygen species formation in rat alveolar macrophages in vitro. | 2007 | Arch. Toxicol. | pmid:17119925 |
Kafert-Kasting S et al. | Safety assessment of intraportal liver cell application in New Zealand white rabbits under GLP conditions. | 2012 | Arch. Toxicol. | pmid:22532025 |
Massicot F et al. | Modulation of energy status and cytotoxicity induced by FK506 and cyclosporin A in a renal epithelial cell line. | 1997 | Arch. Toxicol. | pmid:9248632 |
Kimura Y et al. | Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. | 2018 | Arch. Toxicol. | pmid:29594315 |
Vandenbussche C et al. | Tacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation. | 2018 | Arch. Toxicol. | pmid:29362864 |
Ellouk-Achard S et al. | FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction. | 1998 | Arch. Toxicol. | pmid:9630010 |
Schaap MM et al. | A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. | 2015 | Arch. Toxicol. | pmid:25270620 |
Briggs CJ et al. | Comparison of the effect of FK506 and cyclosporin A on virus production in H9 cells chronically and newly infected by HIV-1. | 1999 | Arch. Virol. | pmid:10603169 |
Minder D et al. | Immunophilins and HIV-1 infection. | 2002 | Arch. Virol. | pmid:12181673 |
Hossain M et al. | Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. | 1994 | Arerugi | pmid:7520689 |
Nishimoto K et al. | [Case of organizing pneumonia associated with sweet's syndrome]. | 2014 | Arerugi | pmid:25163580 |