Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Schorlemmer HU et al. | Long-term allograft survival and tolerance induction by the synergistic activity of malononitrilamides and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865312 |
Felser I et al. | Changes in quality of life following conversion from CyA to FK 506 in orthotopic liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721350 |
Chiereghin A et al. | Monitoring cytomegalovirus T-cell immunity in small bowel/multivisceral transplant recipients. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172283 |
Nanni G et al. | Lack of correlation between serum levels of mycophenolate mofetil and kidney transplant outcome in tacrolimus-based immunosupression. | 2002 | Transplant. Proc. | pmid:12270323 |
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Walgenbach KJ et al. | Increased presence of mast cells and interleukin-4 during chronic rejection of rat intestinal allografts. | 1996 | Transplant. Proc. | pmid:8907896 |
Miyagi M et al. | Comparison of the therapeutic effects between CsA and FK506 on chronic renal allograft injury and TGF-beta expression. | 2002 | Transplant. Proc. | pmid:12176497 |
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Malaise J et al. | Immunosuppressive drugs after simultaneous pancreas-kidney transplantation. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182827 |
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Oishi M et al. | Successful swine small bowel transplantation using FK506: effect on endotoxin translocation. | 1994 | Transplant. Proc. | pmid:7520629 |
Moutabarrik A et al. | FK 506 mechanism of nephrotoxicity: stimulatory effect on endothelin secretion by cultured kidney cells and tubular cell toxicity in vitro. | 1991 | Transplant. Proc. | pmid:1721382 |
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Citterio F et al. | Steroid withdrawal from tacrolimus-based therapy in renal transplant patients. | 2002 | Transplant. Proc. | pmid:12176545 |
Han DJ et al. | A 39-month follow-up study to evaluate the safety and efficacy in kidney transplant recipients treated with modified-release tacrolimus (FK506E)-based immunosuppression regimen. | 2012 | Transplant. Proc. | pmid:22310592 |
Chang HR et al. | Lack of hepatotoxicity upon sirolimus addition to a calcineurin inhibitor-based regimen in hepatitis virus-positive renal transplant recipients. | 2007 | Transplant. Proc. | pmid:17580178 |
Jiang H et al. | IL-10: a tacrolimus-specific cytotoxic mediator in ongoing allograft rejection. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266931 |
Ohtsuka S et al. | The effect of short-term FK 506 therapy on pancreas transplantation in rats. | 1991 | Transplant. Proc. | pmid:1721413 |
Tanabe K et al. | Diabetes mellitus after renal transplantation under FK 506 (tacrolimus) as primary immunosuppression. | 1996 | Transplant. Proc. | pmid:8658670 |
Cirocco RE et al. | Kidney recipient CMV incidence in the gancyclovir era: monitoring viral DNA by a CMV-PCR assay. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083604 |
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Fábrega E et al. | Effect of immunosuppressant blood levels on serum concentration of interleukin-17 and -23 in stable liver transplant recipients. | 2009 | Transplant. Proc. | pmid:19376417 |
Tahir W et al. | Diffuse Alveolar haemorrhage: a fatal complication after alemtuzumab induction therapy in renal transplantation. | Transplant. Proc. | pmid:25645795 | |
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Lin CY et al. | Effects of FK 506 on the biochemical markers in canine lung allograft rejection. | 1991 | Transplant. Proc. | pmid:1721445 |
Morales E et al. | Conversion from cyclosporine to FK 506 as rescue therapy in renal transplantation with poorly steroid-responsive acute rejection. | 1999 | Transplant. Proc. | pmid:10500562 |
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Miyata Y et al. | Development of xenogeneic microchimerism correlated with graft outcome in hamster-to-rat heart xenotransplantation. | 1998 | Transplant. Proc. | pmid:9723548 |
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