Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Weng LC et al. | Association between use of FK506 and prevalence of post-transplantation diabetes mellitus in kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24656004 |
Wang SS et al. | Clinical experience of tacrolimus with everolimus in heart transplantation. | 2012 | Transplant. Proc. | pmid:22564581 |
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Okamura N et al. | Enhanced liver regeneration by FK 506 can be blocked by interleukin-1 alpha and interleukin-2. | 1992 | Transplant. Proc. | pmid:1371624 |
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Garcia-Donaire JA et al. | Tacrolimus as basic immunosuppression in pregnancy after renal transplantation. A single-center experience. | 2005 | Transplant. Proc. | pmid:16386528 |
Argudo A et al. | Liver Transplant Patient Carriers of Polymorphism Cyp3a5*1 Donors May Need More Doses of Tacrolimus From the First Month After Transplantation. | 2015 | Transplant. Proc. | pmid:26518936 |
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DiLella AG and Craig RJ | Characterization of the human FKBP-12 gene and related pseudogenes. | 1991 | Transplant. Proc. | pmid:1721302 |
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Burke GW et al. | Use of tacrolimus and mycophenolate mofetil for pancreas-kidney transplantation with or without OKT3 induction. | 1998 | Transplant. Proc. | pmid:9636627 |
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Platz KP et al. | FK 506 and mycofenolate mofetil rescue for acute steroid-resistant and chronic rejection after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365598 |
Gozdowska J et al. | Tolerance of enteric-coated mycophenolate sodium in combination with calcineurin inhibitor in kidney transplant recipients: Polish experience. | 2011 | Transplant. Proc. | pmid:21996197 |
Platz KP et al. | Indications for mycofenolate mofetil therapy after liver transplantation. | 1997 | Transplant. Proc. | pmid:9365601 |
Shibutani S et al. | FK 506 abrogates induction of regulatory cells after intratracheal delivery of alloantigen. | 2002 | Transplant. Proc. | pmid:12176432 |
Lee TK et al. | Bacterial translocation and the role of postoperative selective bowel decontamination in small intestinal transplantation. | 1994 | Transplant. Proc. | pmid:7518154 |
Santiago SF et al. | Effect of short-term immunosuppressive therapy with FK 506 or CyA on the donor in small intestine allotransplantation in rats. | 1992 | Transplant. Proc. | pmid:1376520 |
Tanaka M et al. | Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig-to-rat xenotransplantation. | 1995 | Transplant. Proc. | pmid:7533392 |
Winkler M et al. | Use of FK 506 for treatment of chronic rejection after liver transplantation. | 1991 | Transplant. Proc. | pmid:1721334 |
Hasegawa A et al. | Improvement of quality of life in tacrolimus-based pediatric renal transplant recipients and their caregivers, including donors. | 2005 | Transplant. Proc. | pmid:15919461 |
Wilson C et al. | Evaluation of daclizumab to reduce delayed graft function in non-heart-beating renal transplantation: a prospective, randomized trial. | 2005 | Transplant. Proc. | pmid:15919462 |
Tzakis AG et al. | Campath-1H in intestinal and multivisceral transplantation: preliminary data. | 2002 | Transplant. Proc. | pmid:12034248 |
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Ciftci HS et al. | Influence of Proton Pump Inhibitors on Mycophenolic Acid Pharmacokinetics in Patients With Renal Transplantation and the Relationship With Cytochrome 2C19 Gene Polymorphism. | 2017 | Transplant. Proc. | pmid:28340819 |
Rodrigues N et al. | Serum Magnesium and Related Factors in Long-Term Renal Transplant Recipients: An Observational Study. | 2017 | Transplant. Proc. | pmid:28457398 |
Woo J et al. | FK 506 treatment following syngeneic bone marrow transplantation does not inhibit clonal deletion of V beta 5+ or V beta 11+ T cells. | 1992 | Transplant. Proc. | pmid:1281583 |
Sasaki K et al. | Effect of FK 506 and splenectomy on orthotopic small bowel xenotransplantation in the hamster-to-rat animal models. | 1998 | Transplant. Proc. | pmid:9838521 |
Jabiry-Zieniewicz Z et al. | Outcome of four high-risk pregnancies in female liver transplant recipients on tacrolimus immunosuppression. | 2006 Jan-Feb | Transplant. Proc. | pmid:16504718 |
Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration. Japanese FK 506 Study Group. | 1991 | Transplant. Proc. | pmid:1721367 | |
Starzl TE et al. | Selected topics on FK 506, with special references to rescue of extrahepatic whole organ grafts, transplantation of "forbidden organs," side effects, mechanisms, and practical pharmacokinetics. | 1991 | Transplant. Proc. | pmid:1703351 |
Moreno JM et al. | Effectiveness and safety of mycophenolate mofetil as monotherapy in liver transplantation. | 2003 | Transplant. Proc. | pmid:12962831 |
Marino IR et al. | Preoperative assessment of risk in liver transplantation: a multivariate analysis in 2376 cases of the UW era. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123079 |
Spada M et al. | Bacterial translocation is enhanced in pig intestinal transplantation when the colon is included in the graft. | 1996 | Transplant. Proc. | pmid:8907997 |
Shapiro R et al. | A pilot trial of tacrolimus, sirolimus, and steroids in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176521 |
Marcus EA et al. | Successful term pregnancy in an intestine-pancreas transplant recipient with chronic graft dysfunction and parenteral nutrition dependence: a case report. | 2015 | Transplant. Proc. | pmid:25724255 |
Townamchai N et al. | A Simple Novel Technique to Estimate Tacrolimus Dosages During the Early Post Kidney Transplantation Period. | 2015 | Transplant. Proc. | pmid:26518946 |
Masaki Y et al. | Cellular basis of immunologic tolerance following total bowel transplantation in rats. II. Dominant role of suppressor T cells in adoptive transfer of acquired tolerance to vascularized allografts. | 1995 | Transplant. Proc. | pmid:7536972 |
Suzuki H et al. | Spleen grafting might induce transplantation tolerance in rats. | 1995 | Transplant. Proc. | pmid:7536973 |
Jordán de Luna C et al. | Pharmacogenetic study of ABCB1 and CYP3A5 genes during the first year following heart transplantation regarding tacrolimus or cyclosporine levels. | 2011 Jul-Aug | Transplant. Proc. | pmid:21839244 |
Klupp J et al. | Mycophenolate mofetil in combination with tacrolimus versus Neoral after liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083497 |
Castel MA et al. | Primary immunosuppression and outcome differences after heart transplantation: tacrolimus versus cyclosporine. | 2011 Jul-Aug | Transplant. Proc. | pmid:21839245 |
Yang HC et al. | Tacrolimus/"low-dose" mycophenolate mofetil versus microemulsion cyclosporine/"low-dose" mycophenolate mofetil after kidney transplantation--1-year follow-up of a prospective, randomized clinical trial. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083501 |
Sakamoto K et al. | Analysis of long-term acceptance of xenografts in rats induced by short-term administration of FK506. | 1989 | Transplant. Proc. | pmid:2468222 |
Moutabarrik A et al. | Use of FK 506 in kidney transplantation. | 1993 | Transplant. Proc. | pmid:7685946 |
Bunnapradist S and Takemoto SK | Controlling treatment allocation bias in a registry analysis when comparing calcineurin inhibitors. | 2003 | Transplant. Proc. | pmid:14611971 |
Nakajima K et al. | Effects of 15-deoxyspergualin and FK506 on the histology and survival of hamster-to-rat cardiac xenotransplantation. | 1989 | Transplant. Proc. | pmid:2468223 |
Balbontin FG et al. | Tacrolimus monitoring by simplified sparse sampling under the concentration time curve. | 2003 | Transplant. Proc. | pmid:14611982 |
Saracino A et al. | Multidrug-resistance 1 gene single-nucleotide polymorphisms do not influence long-term graft survival after kidney transplantation. | 2014 | Transplant. Proc. | pmid:25242754 |
Alessiani M et al. | Morphological and functional changes in small-bowel allografts of pigs under combined tacrolimus and mycophenolate mofetil immunosuppression. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123483 |
Galvao FH et al. | Experimental animal model of graft-versus-host disease (GVHD) after small-bowel transplantation: characteristics of the model and application to developing treatment strategies. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123488 |
Salizzoni M et al. | Tacrolimus-based dual therapy is as efficacious and safe as the conventional tacrolimus-based triple therapy in liver transplantation. | 2001 | Transplant. Proc. | pmid:11377521 |
El Haggan W et al. | One year evolution of bone mineral density in kidney transplant recipients receiving tacrolimus versus cyclosporine. | 2002 | Transplant. Proc. | pmid:12176589 |
Langrehr JM et al. | Chronic rejection after orthotopic liver transplantation is increased under induction therapy with interleukin-2 receptor antibody BT563. | 2001 | Transplant. Proc. | pmid:11377531 |
Tanabe K et al. | Prospective analysis of thrombotic microangiopathy after renal transplantation: comparison between cyclosporine and tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176590 |
Bhagavati S et al. | Chronic sensorimotor polyneuropathy associated with tacrolimus immunosuppression in renal transplant patients: case reports. | 2007 | Transplant. Proc. | pmid:18089409 |
Zaltzman J et al. | Tacrolimus, MMF, steroid, and ALG immunotherapy for high immunological risk renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267183 |
de Bruin RW et al. | Fulminant graft-versus-host disease after FK 506 treatment in fully allogeneic small bowel transplantation. | 1991 | Transplant. Proc. | pmid:1721429 |
Kawabe A et al. | Anti-adhesion (anti-ICAM-1 and anti-LFA-1) therapy in a rat pancreas transplantation model. | 1996 | Transplant. Proc. | pmid:8658893 |
Goto T et al. | Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. | 1987 | Transplant. Proc. | pmid:2445072 |
Burrows L et al. | Conversion to tacrolimus to ameliorate cyclosporine toxicity in kidney recipients. | 1998 | Transplant. Proc. | pmid:9723378 |
Fuchs U et al. | Clinical outcome in cardiac transplant recipients receiving tacrolimus retard. | 2013 | Transplant. Proc. | pmid:23769094 |
Koc-Zorawska E et al. | Vascular adhesion protein-1, a novel molecule, in kidney and heart allograft recipients. | 2013 | Transplant. Proc. | pmid:23769096 |
Rabkin JM et al. | Pharmacoeconomic study of tacrolimus-based versus cyclosporine-based immunosuppressive therapy following liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267411 |
Uber PA et al. | Ethnic disparities in the pharmacologic characteristics of tacrolimus in heart transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267428 |
Kim SH et al. | Outcomes of Early Conversion From Prograf to Generic Tacrolimus in Adult Living Donor Liver Transplant Recipients. | Transplant. Proc. | pmid:26293073 | |
Falconer SJ et al. | Early or Late Conversion From Tac-BD to Tac-BD in Renal Transplantation: When is the Right Time? | Transplant. Proc. | pmid:26293044 | |
Shi G et al. | Variation of CD4CD25Foxp3 Regulatory T Cells and Th17 Cells in the Peripheral Blood of Human Liver Allograft Patients With Long-term Survival. | 2017 | Transplant. Proc. | pmid:28923634 |
Deguchi K et al. | Effects of FK 506 on acute experimental allergic encephalomyelitis. | 1991 | Transplant. Proc. | pmid:1721461 |
Bolton C | The ability of myelin basic protein-sensitised leukocytes to adoptively transfer experimental allergic encephalomyelitis following coculture with FK 506, cyclosporine, or prednisolone. | 1991 | Transplant. Proc. | pmid:1721462 |
Isobe M et al. | Downregulation of endothelin expression in allograft coronary arteries after gene therapy targeting Cdk2 kinase. | 1998 | Transplant. Proc. | pmid:9636407 |
Duzova A et al. | Triple immunosuppression with tacrolimus in pediatric renal transplantation: single-center experience. | 2008 Jan-Feb | Transplant. Proc. | pmid:18261567 |
Blume C et al. | Conversion from cyclosporine to tacrolimus prevents transplant function loss due to acute steroid-resistant or chronic rejection in renal allograft recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750357 |
Han SY et al. | Effect of tacrolimus on the production of oxygen free radicals in hepatic mitochondria. | 2006 | Transplant. Proc. | pmid:16980054 |
Jørgensen KA et al. | Optimal time for determination of blood tacrolimus level. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750358 |
Deleuze S et al. | New onset dyslipidemia after renal transplantation: is there a difference between tacrolimus and cyclosporine? | 2006 | Transplant. Proc. | pmid:16980075 |
Kuroki H et al. | Morphological and immunological analysis of rats with long-term-surviving limb allografts induced by a short course of FK 506 or cyclosporine. | 1991 | Transplant. Proc. | pmid:1703697 |
White SA et al. | Effect of acute rejection on expression of fibrosis associated genes in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:10700949 |
Martins L et al. | Cyclosporine versus tacrolimus in kidney transplantation: are there differences in nephrotoxicity? | 2004 | Transplant. Proc. | pmid:15194300 |
Morris RE et al. | Use of rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on host-versus-graft and graft-versus-host reactions. | 1991 | Transplant. Proc. | pmid:1703698 |
Busque S et al. | Conversion from Neoral (cyclosporine) to tacrolimus of kidney transplant recipients for gingival hyperplasia or hypertrichosis. | 1998 | Transplant. Proc. | pmid:9636507 |
Braun F et al. | Living-related versus living-unrelated kidney transplantation using tacrolimus initial immunosuppression. | 2000 | Transplant. Proc. | pmid:10700989 |
Finni PE et al. | Is hepatitis C a risk factor to posttransplant diabetes mellitus after renal transplantation in patients using tacrolimus? | 2004 | Transplant. Proc. | pmid:15194303 |
Loss GE et al. | Reversal of delayed hyperacute renal allograft rejection with a tacrolimus-based therapeutic regimen. | 1998 | Transplant. Proc. | pmid:9636508 |