tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen CH et al. | Comparison of tuberculosis infection rates in a national database of renal transplant patients with data from a single center in Taiwan. | 2014 | Transplant. Proc. | pmid:24656019 |
| Tanaka K et al. | Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases. | 2014 | J. Hum. Genet. | pmid:24352002 |
| Kim EJ et al. | Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. | 2014 | Am. J. Transplant. | pmid:24354871 |
| Huang K et al. | Novel role for NFAT3 in ERK-mediated regulation of CXCR4. | 2014 | PLoS ONE | pmid:25514788 |
| Cho JH et al. | Development of novel fast-dissolving tacrolimus solid dispersion-loaded prolonged release tablet. | 2014 | Eur J Pharm Sci | pmid:24388864 |
| Frassetto LA et al. | Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. | 2014 | Transplantation | pmid:24389906 |
| Furian L et al. | Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors. | 2014 | Transplant. Proc. | pmid:25498057 |
| Singh K et al. | Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. | 2014 | Am. J. Transplant. | pmid:25359003 |
| Siebelt M et al. | FK506 protects against articular cartilage collagenous extra-cellular matrix degradation. | 2014 | Osteoarthr. Cartil. | pmid:24561282 |
| Tang Q | Pharmacokinetics of therapeutic Tregs. | 2014 | Am. J. Transplant. | pmid:25358900 |
| Pedroso JA et al. | Elderly kidney transplant recipient with intermittent fever: a case report of leishmaniasis with acute kidney injury during liposomal amphotericin B therapy. | 2014 | Transplant. Proc. | pmid:25242789 |
| Pereira MJ et al. | Cyclosporine A and tacrolimus reduce the amount of GLUT4 at the cell surface in human adipocytes: increased endocytosis as a potential mechanism for the diabetogenic effects of immunosuppressive agents. | 2014 | J. Clin. Endocrinol. Metab. | pmid:25004245 |
| Torres IB et al. | The Interplay between inflammation and fibrosis in kidney transplantation. | 2014 | Biomed Res Int | pmid:24991565 |
| Shilbayeh S | The impact of genetic polymorphisms on time required to attain the target tacrolimus levels and subsequent pharmacodynamic outcomes in pediatric kidney transplant patients. | 2014 | Saudi J Kidney Dis Transpl | pmid:24625991 |
| Sagiroglu T et al. | Protective effect of everolimus on renal ischemia reperfusion injury in rats. | 2014 | Saudi J Kidney Dis Transpl | pmid:24625994 |
| Wang XZ et al. | Increased intracellular adenosine triphosphate level as an index to predict acute rejection in kidney transplant recipients. | 2014 | Transpl. Immunol. | pmid:24211610 |
| Shimizu M et al. | Successful multitarget therapy using mizoribine and tacrolimus for refractory Takayasu arteritis. | 2014 | Rheumatology (Oxford) | pmid:24609060 |
| Højfeldt JW et al. | Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor. | 2014 | Mol. Endocrinol. | pmid:24422633 |
| Golubović B et al. | Total plasma protein effect on tacrolimus elimination in kidney transplant patients--population pharmacokinetic approach. | 2014 | Eur J Pharm Sci | pmid:24184751 |
| Hu YM et al. | Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24610957 |
| Wada A et al. | Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules. | 2014 | Anal. Chem. | pmid:24380432 |
| Bäckman L and Persson CA | An observational study evaluating tacrolimus dose, exposure, and medication adherence after conversion from twice- to once-daily tacrolimus in liver and kidney transplant recipients. | 2014 | Ann. Transplant. | pmid:24637379 |
| Mekaj AY et al. | Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process. | 2014 | J Orthop Surg Res | pmid:25303779 |
| Satoh S et al. | Pharmacokinetic and CYP3A5 pharmacogenetic differences between once- and twice-daily tacrolimus from the first dosing day to 1 year after renal transplantation. | 2014 | Pharmacogenomics | pmid:25303300 |
| Meyer KC et al. | An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. | 2014 | Eur. Respir. J. | pmid:25359357 |
| Souto-RodrÃguez R et al. | Differences in the incidence and clinical evolution of early neurotoxicity after liver transplantation based on tacrolimus formulation used in the immunosuppressive induction protocol. | 2014 | Transplant. Proc. | pmid:25420839 |
| de la Fuente S et al. | Long-term survivors after pediatric liver transplatation are at increased risk for development of cardiovascular disease events: analysis of 30 cases. | 2014 | Transplant. Proc. | pmid:25420837 |
| Masson P et al. | Belatacept for kidney transplant recipients. | 2014 | Cochrane Database Syst Rev | pmid:25416857 |
| Salehi-Najafabadi Z et al. | The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24562179 |
| Lalić J et al. | Immunosuppressive medication adherence in kidney transplant patients. | 2014 | Med Princ Pract | pmid:24923773 |
| Czubkowski P et al. | Cardiovascular risk factors after conversion from cyclosporine to tacrolimus in children after liver transplantation. | 2014 | Ann. Transplant. | pmid:25409773 |
| Gijsen VM et al. | P450 oxidoreductase *28 (POR*28) and tacrolimus disposition in pediatric kidney transplant recipients--a pilot study. | 2014 | Ther Drug Monit | pmid:24089076 |
| Guitard J et al. | An unexpected diagnosis in a renal-transplant patient with proteinuria treated with everolimus: AL amyloidosis. | 2014 | Clin. Nephrol. | pmid:24040781 |
| Schlegel A et al. | Hypothermic Oxygenated Perfusion (HOPE) downregulates the immune response in a rat model of liver transplantation. | 2014 | Ann. Surg. | pmid:25243553 |
| Spagnoletti G et al. | Conversion from Prograf to Advagraf in stable kidney transplant recipients: better renal function after 3-year follow-up. | 2014 | Transplant. Proc. | pmid:25242756 |
| Rahman Z et al. | Determination of tacrolimus crystalline fraction in the commercial immediate release amorphous solid dispersion products by a standardized X-ray powder diffraction method with chemometrics. | 2014 | Int J Pharm | pmid:25173870 |
| Jia JJ et al. | ''Minimizing tacrolimus'' strategy and long-term survival after liver transplantation. | 2014 | World J. Gastroenterol. | pmid:25170223 |
| Hao JC et al. | Effect of low-dose tacrolimus with mycophenolate mofetil on renal function following liver transplantation. | 2014 | World J. Gastroenterol. | pmid:25170222 |
| Peng L et al. | The calcineurin inhibitor tacrolimus reduces proteinuria in membranous nephropathy accompanied by a decrease in angiopoietin-like-4. | 2014 | PLoS ONE | pmid:25165975 |
| Favennec C et al. | Consideration of the switch from twice-daily to once-daily tacrolimus in pediatric kidney transplant in daily clinical practice: pharmacokinetic parameters, patient satisfaction and medical practices. | 2014 | Pediatr Transplant | pmid:25164065 |
| Gupta AK et al. | Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. | 2014 | PLoS ONE | pmid:24819773 |
| Elens L et al. | Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. | 2014 | Ther Drug Monit | pmid:24061445 |
| Imataki O et al. | Reversible cerebral vasoconstriction syndrome resulted in cerebral infarction after allogeneic stem cell transplantation: a case report. | 2014 | Ann. Hematol. | pmid:24061786 |
| Hagihara Y et al. | Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease. | 2014 | J Crohns Colitis | pmid:24011513 |
| Kilinc S et al. | The effects of preoperative immunosuppressive therapy on ischemia and reperfusion (I/R) injury in healthy rats. | 2014 | Int Urol Nephrol | pmid:24014133 |
| Vattemi G et al. | Polymyositis in solid organ transplant recipients receiving tacrolimus. | 2014 | J. Neurol. Sci. | pmid:25130930 |
| Narabayashi K et al. | Oral tacrolimus for megacolon in patients with severe ulcerative colitis. | 2014 | Intern. Med. | pmid:25130105 |
| Amanova A et al. | Colchicine levels in chronic kidney diseases and kidney transplant recipients using tacrolimus. | 2014 | Clin Transplant | pmid:25125128 |
| Schmid S et al. | Volatility of serum creatinine relative to tacrolimus levels predicts kidney transplant rejection. | 2014 | Ann. Transplant. | pmid:25123847 |
| Farkas K et al. | Ability of different rescue therapies to save the bowel in acute, severe, steroid-refractory ulcerative colitis. | 2014 | Expert Rev Gastroenterol Hepatol | pmid:24738535 |
| Aulagnon F et al. | Diarrhea after kidney transplantation: a new look at a frequent symptom. | 2014 | Transplantation | pmid:25073040 |
| Bica L et al. | Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation. | 2014 | PLoS ONE | pmid:24587210 |
| Han JS et al. | Tacrolimus 0.1% ointment in the treatment of allergic contact dermatitis: a new approach. | 2014 | Int. J. Dermatol. | pmid:25070257 |
| Li T et al. | Effect of FK506 nanospheres on regeneration of allogeneic nerve after transplant. | 2014 | Asian Pac J Trop Med | pmid:25066398 |
| Verghese PS et al. | Calcineurin inhibitors in HLA-identical living related donor kidney transplantation. | 2014 | Nephrol. Dial. Transplant. | pmid:24414376 |
| Bergmann TK et al. | Population pharmacokinetics of tacrolimus in adult kidney transplant patients: impact of CYP3A5 genotype on starting dose. | 2014 | Ther Drug Monit | pmid:24089074 |
| Da-Long S et al. | Tacrolimus on Kimura's disease: a case report. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:22939325 |
| Izumi Y et al. | Safety of tacrolimus treatment during pregnancy and lactation in systemic lupus erythematosus: a report of two patients. | 2014 | Tohoku J. Exp. Med. | pmid:25175032 |
| van Gelder T et al. | Pharmacogenetics and immunosuppressive drugs in solid organ transplantation. | 2014 | Nat Rev Nephrol | pmid:25247332 |
| Tapirdamaz Ö et al. | Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney disease after liver transplantation. | 2014 | Pharmacogenet. Genomics | pmid:25014506 |
| Helmschrott M et al. | Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen. | 2014 | Drug Des Devel Ther | pmid:25246772 |
| Matta C et al. | Ser/Thr-phosphoprotein phosphatases in chondrogenesis: neglected components of a two-player game. | 2014 | Cell. Signal. | pmid:25007994 |
| Parvizi Z et al. | Association between E23K variant in KCNJ11 gene and new-onset diabetes after liver transplantation. | 2014 | Mol. Biol. Rep. | pmid:24996284 |
| Hara H et al. | Hematopoietic chimerism following allotransplantation of the spleen, splenocytes or kidney in pigs. | 2014 | Transpl. Immunol. | pmid:25245436 |
| Lunde I et al. | The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients. | 2014 | Eur. J. Clin. Pharmacol. | pmid:24658827 |
| Picchianti-Diamanti A et al. | P-glycoprotein and drug resistance in systemic autoimmune diseases. | 2014 | Int J Mol Sci | pmid:24658440 |
| Wannhoff A et al. | Increased levels of rivaroxaban in patients after liver transplantation treated with cyclosporine A. | 2014 | Transplantation | pmid:25022236 |
| Sureshkumar KK and Chopra B | In search of an optimal induction agent in kidney transplantation. | 2014 | Transplantation | pmid:24978038 |
| Welberry Smith MP and Baker RJ | The author's reply. | 2014 | Transplantation | pmid:24978039 |
| Singla AK et al. | Cerulomycin Caerulomycin [corrected] A: a potent novel immunosuppressive agent. | 2014 | Transplantation | pmid:24949498 |
| Urbanowicz T et al. | Comparison of conventional tacrolimus versus prolong release formula as initial therapy in heart transplantation. | 2014 | Ann. Transplant. | pmid:24949728 |
| Fuchs U et al. | Incidence of malignant neoplasia after heart transplantation--a comparison between cyclosporine a and tacrolimus. | 2014 | Ann. Transplant. | pmid:24953848 |
| Andrade-Sierra J et al. | Early steroid withdrawal in a renal transplant cohort treated with tacrolimus, mycophenolate mofetil and basiliximab. | 2014 | Nefrologia | pmid:24658197 |
| Wolfram D et al. | Insights from computational modeling in inflammation and acute rejection in limb transplantation. | 2014 | PLoS ONE | pmid:24926998 |
| Zhao X et al. | [A retrospective cohort study regarding the effect of sirolimus-based immunosuppression protocol on the long-term survival of hepatocellular carcinoma patients after liver transplantation]. | 2014 | Zhonghua Wai Ke Za Zhi | pmid:24924566 |
| Kanyshkova T et al. | Regionally specific expression of high-voltage-activated calcium channels in thalamic nuclei of epileptic and non-epileptic rats. | 2014 | Mol. Cell. Neurosci. | pmid:24914823 |
| Hebral AL et al. | Pregnancy after kidney transplantation: outcome and anti-human leucocyte antigen alloimmunization risk. | 2014 | Nephrol. Dial. Transplant. | pmid:24914091 |
| Lin T et al. | A Chinese girl with novel PLCE1 mutations and proliferation of the mesangium responded to tacrolimus therapy. | 2014 | Nephrology (Carlton) | pmid:24533735 |
| Li H et al. | A promising approach of overcoming the intrinsic resistance of Candida krusei to fluconazole (FLC)--combining tacrolimus with FLC. | 2014 | FEMS Yeast Res. | pmid:24830342 |
| Wang YB et al. | In vitro and in vivo performance of dry powder inhalation formulations: comparison of particles prepared by thin film freezing and micronization. | 2014 | AAPS PharmSciTech | pmid:24824172 |
| Oda K et al. | In vitro experimental system for evaluating inhibitory effect of investigational drugs on P-glycoprotein-mediated transcellular transport of tacrolimus (FK506). | 2014 | Biopharm Drug Dispos | pmid:24822242 |
| Wang Z et al. | Influence of TLR4 rs1927907 locus polymorphisms on tacrolimus pharmacokinetics in the early stage after liver transplantation. | 2014 | Eur. J. Clin. Pharmacol. | pmid:24820765 |
| Akchurin OM et al. | Medication adherence in the transition of adolescent kidney transplant recipients to the adult care. | 2014 | Pediatr Transplant | pmid:24820521 |
| Yang LM et al. | Experimental research on end-to-side anastomosis of peripheral nerves and effect of FK506 on end-to-side anastomosis. | 2014 | Bratisl Lek Listy | pmid:25573729 |
| Colom H et al. | Pharmacokinetic modeling of enterohepatic circulation of mycophenolic acid in renal transplant recipients. | 2014 | Kidney Int. | pmid:24402086 |
| Castronovo G et al. | The effect of nonsurgical periodontal treatment on the severity of drug-induced gingival overgrowth in transplant patients. | 2014 | Quintessence Int | pmid:24389563 |
| Bergmann TK et al. | Comparison of the influence of cyclosporine and tacrolimus on the pharmacokinetics of prednisolone in adult male kidney transplant recipients. | 2014 | Clin Drug Investig | pmid:24385281 |
| Yap DY et al. | Long-term data on tacrolimus treatment in lupus nephritis. | 2014 | Rheumatology (Oxford) | pmid:24996908 |
| Jin L et al. | Dipeptidyl peptidase IV inhibitor MK-0626 attenuates pancreatic islet injury in tacrolimus-induced diabetic rats. | 2014 | PLoS ONE | pmid:24959755 |
| Taube D et al. | Generic tacrolimus in solid organ transplantation. | 2014 | Clin Transplant | pmid:24750309 |
| Varghese J et al. | Tacrolimus-related adverse effects in liver transplant recipients: its association with trough concentrations. | 2014 | Indian J Gastroenterol | pmid:24740447 |
| Mitsides N et al. | Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought. | 2014 | Transpl Infect Dis | pmid:24215452 |
| Calabrese B et al. | Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms. | 2014 | PLoS ONE | pmid:24740405 |
| Kawaguch K et al. | Successful treatment with allogenic hematopoietic stem cell transplantation of a severe congenital neutropenia patient harboring a novel ELANE mutation. | 2014 | Rinsho Ketsueki | pmid:25501410 |
| Lesche D et al. | CYP3A5*3 and POR*28 genetic variants influence the required dose of tacrolimus in heart transplant recipients. | 2014 | Ther Drug Monit | pmid:24739669 |
| Wan XC and Dimov V | Pharmacokinetic evaluation of topical calcineurin inhibitors for treatment of allergic conjunctivitis. | 2014 | Expert Opin Drug Metab Toxicol | pmid:24490943 |
| Cvetkovic TP et al. | Gender differences in oxidative and nitrosative stress parameters in kidney transplant patients on tacrolimus-based immunosuppression. | 2014 | Int Urol Nephrol | pmid:24101297 |
| Langers P et al. | Limited sampling model for advanced mycophenolic acid therapeutic drug monitoring after liver transplantation. | 2014 | Ther Drug Monit | pmid:24081208 |
| da Cunha Filho RR et al. | "Angular" plasma cell cheilitis. | 2014 | Dermatol. Online J. | pmid:24656273 |
| Nakamura A et al. | Effects of elevated tacrolimus trough levels in association with infectious enteritis on graft function in renal transplant recipients. | 2014 | Transplant. Proc. | pmid:24656020 |