Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Djamali A et al. | Nox2 is a mediator of chronic CsA nephrotoxicity. | 2012 | Am. J. Transplant. | pmid:22568654 |
Cavadas PC et al. | Bilateral trans-humeral arm transplantation: result at 2 years. | 2011 | Am. J. Transplant. | pmid:21521475 |
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Krämer BK et al. | Tacrolimus once daily (ADVAGRAF) versus twice daily (PROGRAF) in de novo renal transplantation: a randomized phase III study. | 2010 | Am. J. Transplant. | pmid:20840480 |
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Wang Q et al. | Biodegradable microsphere-loaded tacrolimus enhanced the effect on mice islet allograft and reduced the adverse effect on insulin secretion. | 2004 | Am. J. Transplant. | pmid:15084166 |
Schubert M et al. | Pharmacokinetics of sirolimus and tacrolimus in pediatric transplant patients. | 2004 | Am. J. Transplant. | pmid:15084173 |
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Borrows R et al. | Steroid sparing with tacrolimus and mycophenolate mofetil in renal transplantation. | 2004 | Am. J. Transplant. | pmid:15476485 |
Hernández-Fisac I et al. | Tacrolimus-induced diabetes in rats courses with suppressed insulin gene expression in pancreatic islets. | 2007 | Am. J. Transplant. | pmid:17725683 |
Budde K et al. | Sotrastaurin, a novel small molecule inhibiting protein kinase C: first clinical results in renal-transplant recipients. | 2010 | Am. J. Transplant. | pmid:20121745 |
Artz MA et al. | Conversion from cyclosporine to tacrolimus improves quality-of-life indices, renal graft function and cardiovascular risk profile. | 2004 | Am. J. Transplant. | pmid:15147428 |
Hamdy AF et al. | Comparison of sirolimus with low-dose tacrolimus versus sirolimus-based calcineurin inhibitor-free regimen in live donor renal transplantation. | 2005 | Am. J. Transplant. | pmid:16162204 |
Hesselink DA et al. | Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2. | 2005 | Am. J. Transplant. | pmid:15816878 |
Byrne GW et al. | Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function. | 2005 | Am. J. Transplant. | pmid:15816881 |
Lucey MR et al. | A comparison of tacrolimus and cyclosporine in liver transplantation: effects on renal function and cardiovascular risk status. | 2005 | Am. J. Transplant. | pmid:15816894 |
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Schold JD | The burden of proof in the design of early phase clinical trials. | 2013 | Am. J. Transplant. | pmid:23802723 |
Chisholm-Burns MA et al. | Improving outcomes of renal transplant recipients with behavioral adherence contracts: a randomized controlled trial. | 2013 | Am. J. Transplant. | pmid:23819827 |
Muthusamy AS et al. | Alemtuzumab induction and steroid-free maintenance immunosuppression in pancreas transplantation. | 2008 | Am. J. Transplant. | pmid:18828772 |
Van Laecke S et al. | Posttransplantation hypomagnesemia and its relation with immunosuppression as predictors of new-onset diabetes after transplantation. | 2009 | Am. J. Transplant. | pmid:19624560 |
Tydén G et al. | ABO incompatible kidney transplantations without splenectomy, using antigen-specific immunoadsorption and rituximab. | 2005 | Am. J. Transplant. | pmid:15636623 |
Woodle ES et al. | A multicenter pilot study of early (4-day) steroid cessation in renal transplant recipients under simulect, tacrolimus and sirolimus. | 2005 | Am. J. Transplant. | pmid:15636625 |
Mian AN et al. | Mycoplasma hominis septic arthritis in a pediatric renal transplant recipient: case report and review of the literature. | 2005 | Am. J. Transplant. | pmid:15636628 |
Gregoor PS and Weimar W | Tacrolimus and pure red-cell aplasia. | 2005 | Am. J. Transplant. | pmid:15636632 |
RodrÃguez-Perálvarez M et al. | Tacrolimus exposure after liver transplantation in randomized controlled trials: too much for too long. | 2013 | Am. J. Transplant. | pmid:23621166 |
Vanhove T et al. | Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients. | 2017 | Am. J. Transplant. | pmid:28224698 |
Momper JD et al. | The impact of conversion from prograf to generic tacrolimus in liver and kidney transplant recipients with stable graft function. | 2011 | Am. J. Transplant. | pmid:21714845 |
Lemahieu WP et al. | CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus. | 2004 | Am. J. Transplant. | pmid:15307840 |
Shihab F et al. | Association of Clinical Events With Everolimus Exposure in Kidney Transplant Patients Receiving Low Doses of Tacrolimus. | 2017 | Am. J. Transplant. | pmid:28141897 |
O'Connell PJ et al. | Multicenter Australian trial of islet transplantation: improving accessibility and outcomes. | 2013 | Am. J. Transplant. | pmid:23668890 |
Russ GR et al. | Efficacy of sotrastaurin plus tacrolimus after de novo kidney transplantation: randomized, phase II trial results. | 2013 | Am. J. Transplant. | pmid:23668931 |
RodrÃguez-Perálvarez M et al. | Tacrolimus trough levels, rejection and renal impairment in liver transplantation: a systematic review and meta-analysis. | 2012 | Am. J. Transplant. | pmid:22703529 |
Luan FL et al. | Comparative risk of impaired glucose metabolism associated with cyclosporine versus tacrolimus in the late posttransplant period. | 2008 | Am. J. Transplant. | pmid:18786231 |
Chen G et al. | Anti-CD45RB monoclonal antibody prolongs renal allograft survival in cynomolgus monkeys. | 2007 | Am. J. Transplant. | pmid:17227555 |
Woywodt A et al. | Different preparations of tacrolimus and medication errors. | 2008 | Am. J. Transplant. | pmid:18786238 |
Servais A et al. | Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image analysis. | 2011 | Am. J. Transplant. | pmid:21672152 |
Senior PA et al. | Changes in renal function after clinical islet transplantation: four-year observational study. | 2007 | Am. J. Transplant. | pmid:17227560 |
Levi Z et al. | Switching from tacrolimus to sirolimus halts the appearance of new sebaceous neoplasms in Muir-Torre syndrome. | 2007 | Am. J. Transplant. | pmid:17229076 |
Ogawa T et al. | Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model. | 2007 | Am. J. Transplant. | pmid:17229077 |
Miriuka SG et al. | mTOR inhibition induces endothelial progenitor cell death. | 2006 | Am. J. Transplant. | pmid:16796720 |
Mazariegos GV et al. | Dendritic cell subset ratio in tolerant, weaning and non-tolerant liver recipients is not affected by extent of immunosuppression. | 2005 | Am. J. Transplant. | pmid:15643991 |
Bahra M et al. | MMF and calcineurin taper in recurrent hepatitis C after liver transplantation: impact on histological course. | 2005 | Am. J. Transplant. | pmid:15644002 |
Levy G et al. | REFINE: a randomized trial comparing cyclosporine A and tacrolimus on fibrosis after liver transplantation for hepatitis C. | 2014 | Am. J. Transplant. | pmid:24456049 |
Triñanes J et al. | Deciphering Tacrolimus-Induced Toxicity in Pancreatic β Cells. | 2017 | Am. J. Transplant. | pmid:28432716 |
Ciancio G et al. | Advantage of rapamycin over mycophenolate mofetil when used with tacrolimus for simultaneous pancreas kidney transplants: randomized, single-center trial at 10 years. | 2012 | Am. J. Transplant. | pmid:22946986 |
Pallet N et al. | Long-Term Clinical Impact of Adaptation of Initial Tacrolimus Dosing to CYP3A5 Genotype. | 2016 | Am. J. Transplant. | pmid:26990694 |
Miller LW | Cardiovascular toxicities of immunosuppressive agents. | 2002 | Am. J. Transplant. | pmid:12392286 |